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Therapy: Chemotherapy
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Total 70002 results found since Jan 2013.
Value of ultrasound in assessing response to neoadjuvant chemotherapy in breast cancer
CONCLUSION: This study has shown significance in reducing LD measurements on ultrasound as a predictor of PCR and RCB class. This adds weight to the current practice of using ultrasound at the start, mid and end of chemotherapy cycles to monitor NACT responses.PMID:37734976 | DOI:10.1016/j.crad.2023.07.010
Source: Clinical Genitourinary Cancer - September 21, 2023 Category: Cancer & Oncology Authors: H F Lim A Sharma C Gallagher P Hall Source Type: research
Differential benefit of metronomic chemotherapy among triple negative breast cancer subtypes treated in the IBCSG Trial 22-00
CONCLUSIONS: Our results show a differential benefit of low-dose CM therapy across different TNBC subtypes. Low-dose CM therapy could be considered as a potential immunomodulatory strategy for TNBC tumors with IM subtype in the early-disease setting.PMID:37733800 | DOI:10.1158/1078-0432.CCR-23-1267
Source: Clinical Genitourinary Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Andrea Joaquin Garcia Mattia Rediti David Venet Samira Majjaj Roswitha Kammler Elisabetta Munzone Lorenzo Gianni Beat Th ürlimann Istv án Láng Marco Colleoni Sherene Loi Giuseppe Viale Meredith M Regan Laurence Buisseret Fran çoise Rothé Christos Sot Source Type: research
Near-infrared spectral tomography for predicting residual cancer burden during early stage neoadjuvant chemotherapy for breast cancer
CONCLUSION: NIRST holds promise as a potential clinical tool that can be seamlessly integrated into existing clinical workflow within the infusion suite. By providing early assessment of RCB, NIRST has potential to improve breast cancer patient management strategies.PMID:37733788 | DOI:10.1158/1078-0432.CCR-23-1593
Source: Clinical Genitourinary Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Xu Cao Kristen E Muller Mary D Chamberlin Jiang Gui Peter A Kaufman Gary N Schwartz Roberta M DiFlorio-Alexander Brian W Pogue Keith D Paulsen Shudong Jiang Source Type: research
Identification of a TRP channel-related risk model for predicting prognosis and therapeutic effects of patients with hepatocellular carcinoma
CONCLUSIONS: We successfully established a highly accurate prognostic model for predicting overall survival and therapeutic effects using TRP channel-related genes.PMID:37733242 | DOI:10.1007/s00432-023-05394-7
Source: Clinical Genitourinary Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Chong Pang Zhe Xu Jilong Han Fujun Li Hongyan Zhu Jiaqi Zhang Dong Wang Xundi Xu Source Type: research
Traumatic sigmoid colon rupture due to breast cancer metastasis: a case report
Clin J Gastroenterol. 2023 Sep 21. doi: 10.1007/s12328-023-01859-x. Online ahead of print.ABSTRACTThe metastasis of breast cancer to the gastrointestinal tract is rare. Herein, we presented the case of an 85-year-old woman who had a history of invasive lobular carcinoma and experienced complete colon rupture due to relatively low-energy trauma. The patient underwent bilateral total mastectomy and axillary dissection following preoperative chemotherapy 6 years ago. She had a local recurrence 2 years after the surgery and underwent chemotherapy. Subsequently, the cancer metastasized to the thoracolumbar area and retroperiton...
Source: Clinical Genitourinary Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Tomonori Yoshida Munenori Ide Kazuhisa Katayama Mitsuhiro Yanai Ryo Kurosaki Hisashi Shimizu Kazuhisa Arakawa Tatsuya Miyazaki Hiroshi Saeki Ken Shirabe Source Type: research
Deuterium Magnetic Resonance Imaging Using Deuterated Water-Induced 2H-Tissue Labeling Allows Monitoring Cancer Treatment at Clinical Field Strength
CONCLUSIONS: Deuterium MRI at 1.5T proved feasibility to track 2H distribution throughout mouse tissues during D2O administration and revealed a higher 2H accumulation in the tumor xenografts. This research demonstrated a promising successful method for preliminary assessment of radiotherapy and chemotherapy of cancer.PMID:37732903 | DOI:10.1158/1078-0432.CCR-23-1635
Source: Clinical Colorectal Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Hirofumi Asano Abdelazim Elsayed Elhelaly Fuminori Hyodo Ryota Iwasaki Yoshifumi Noda Hiroki Kato Koki Ichihashi Hiroyuki Tomita Masaharu Murata Takashi Mori Masayuki Matsuo Source Type: research
Collision tumor of primary malignant lymphoma and adenocarcinoma in the colon diagnosed by molecular pathology: A case report and literature review
CONCLUSION: Based on pathological and genetic analysis, surgery combined with chemotherapy or chemoradiotherapy may have good therapeutic effects for collision tumor.PMID:37731579 | PMC:PMC10507543 | DOI:10.12998/wjcc.v11.i26.6289
Source: Clinical Colorectal Cancer - September 21, 2023 Category: Cancer & Oncology Authors: Meng Jiang Xiao-Ping Yuan Source Type: research
Pharmacodynamics of ATI-2307 in a rabbit model of cryptococcal meningoencephalitis
In this study, the efficacy of ATI-2307 was tested in a rabbit model of CM. ATI-2307 demonstrated significant fungicidal activity at dosages between 1 and 2 mg/kg/d, and these results were superior to fluconazole and similar to amphotericin B treatment. When ATI-2307 was combined with fluconazole, the antifungal effect was greater than either therapy alone. While ATI-2307 has potent anticryptococcal activity in the subarachnoid space, its ability to reduce yeasts in the brain parenchyma was relatively less over the same study period. This new drug, with its unique mechanism of fungicidal action and ability to positively in...
Source: Antimicrobial Agents and Chemotherapy - September 20, 2023 Category: Microbiology Authors: Charles D Giamberardino Jennifer L Tenor Dena L Toffaletti Julia R Palmucci Wiley Schell Jane-Valeriane K Boua Choiselle Marius Katharine E Stott Shelby L Steele William Hope Don Cilla John R Perfect Source Type: research
Diethylcarbamazine elicits Ca < sup > 2+ < /sup > signals through TRP-2 channels that are potentiated by emodepside in < em > Brugia malayi < /em > muscles
Antimicrob Agents Chemother. 2023 Sep 20:e0041923. doi: 10.1128/aac.00419-23. Online ahead of print.ABSTRACTFilarial nematode infections are a major health concern in several countries. Lymphatic filariasis is caused by Wuchereria bancrofti and Brugia spp. affecting over 120 million people. Heavy infections can lead to elephantiasis, which has serious effects on individuals' lives. Although current anthelmintics are effective at killing microfilariae in the bloodstream, they have little to no effect against adult parasites found in the lymphatic system. The anthelmintic diethylcarbamazine is one of the central pillars of l...
Source: Antimicrobial Agents and Chemotherapy - September 20, 2023 Category: Microbiology Authors: Paul D E Williams Sudhanva S Kashyap Alan P Robertson Richard J Martin Source Type: research
A US-based national surveillance study for the susceptibility and epidemiology of < em > Clostridioides difficile < /em > isolates with special reference to ridinilazole: 2020-2021
Antimicrob Agents Chemother. 2023 Sep 20:e0034923. doi: 10.1128/aac.00349-23. Online ahead of print.ABSTRACTWe have previously reported on the susceptibility and epidemiology of Clostridioides difficile isolates from six geographically dispersed medical centers in the United States. This current survey was conducted with isolates collected in 2020-2021 from six geographically dispersed medical centers in the United States, with specific attention to susceptibility to ridinilazole as well as nine comparators. C. difficile isolates or stools from patients with C. difficile antibiotic-associated diarrhea were collected and re...
Source: Antimicrobial Agents and Chemotherapy - September 20, 2023 Category: Microbiology Authors: D R Snydman L A McDermott C M Thorpe E J C Goldstein A N Schuetz S Johnson D N Gerding L Gluck D Bourdas K C Carroll C K Lancaster K W Garey Q Wang S T Walk E Duperchy Source Type: research
Analysis of Prognoses according to Breast MRI Results in Patients with Axillary Lymph Node Metastases from an Unknown Primary Origin
CONCLUSION: The prognoses of MR-negative patients with ACUPax who received ALND and WBRT followed by chemotherapy were as good as those of patients with MRI-detected primary breast cancers.PMID:37727923 | DOI:10.3349/ymj.2023.0181
Source: Yonsei Medical Journal - September 20, 2023 Category: Universities & Medical Training Authors: E-Ryung Choi Ok Hee Woo Eun Young Ko Boo-Kyung Han Ji Soo Choi Eun Sook Ko Haejung Kim Myoung Kyoung Kim Jeong Eon Lee Source Type: research
Characterization of tumor microenvironment and sensitive chemotherapy drugs based on cuproptosis-related signatures in renal cell carcinoma
Aging (Albany NY). 2023 Sep 19;15. doi: 10.18632/aging.205043. Online ahead of print.ABSTRACTCuproptosis is a novel type of copper-induced cell death and is considered as a new therapeutic target for many cancers. Distant metastases occur in about 40% of patients with advanced renal cell carcinoma (RCC), with a poor 5-year prognosis of about 10%. Through a series of comprehensive analyses, four differentially expressed cuproptosis-related lncRNAs (DECRLs) were identified as candidate biomarkers for RCC. The risk model constructed by using these four DECRLs can better predict the prognosis of patients with RCC, which is det...
Source: Aging - September 20, 2023 Category: Biomedical Science Authors: Jiefu Tang Fan Yao Zhiyong Yao Xiao-Liang Xing Source Type: research
Cisplatin-induced DNA crosslinks trigger neurotoxicity in C. elegans
Biochim Biophys Acta Mol Cell Res. 2023 Sep 18:119591. doi: 10.1016/j.bbamcr.2023.119591. Online ahead of print.ABSTRACTThe anticancer drug cisplatin (CisPt) injures post-mitotic neuronal cells, leading to neuropathy. Furthermore, CisPt triggers cell death in replicating cells. Here, we aim to unravel the relevance of different types of CisPt-induced DNA lesions for evoking neurotoxicity. To this end, we comparatively analyzed wild-type and loss of function mutants of C. elegans lacking key players of specific DNA repair pathways. Deficiency in ercc-1, which is essential for nucleotide excision repair (NER) and interstrand...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Fabian Wynen Johannes Krautstrunk Lisa Marie M üller Viktoria Graf Vanessa Brinkmann Gerhard Fritz Source Type: research
Harnessing autologous immune effector mechanisms in acute myeloid leukemia: 2023 update of trials and tribulations
Leuk Res. 2023 Sep 14;134:107388. doi: 10.1016/j.leukres.2023.107388. Online ahead of print.ABSTRACTNumerous recent advances have been made in therapeutic approaches toward acute myeloid leukemia (AML). Since 2017, we have seen eleven novel Food & Drug Administration (FDA)-approved medications for AML, all of which extend beyond the classical cytarabine-based cytostatic chemotherapy. In the recent two decades, the role of immune surveillance in AML has been intensively investigated. The power of one's own innate and adaptive immunity has been harnessed pharmacologically toward the goal of clearance of AML cells. Specif...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Shyam A Patel Elisa Bello Andrew Wilks Jonathan M Gerber Narayanan Sadagopan Jan Cerny Source Type: research
The inherited KRAS-variant as a biomarker of Cetuximab Response in NSCLC
CONCLUSIONS/DISCUSSION: Although an overall survival advantage was not achieved in KRAS-variant patients, there is potential impact of cetuximab for this genetic subset of patients. In contrast, cetuximab seems to harm non-variant patients. These findings further support the importance of genetic patient selection in trials studying the addition of systemic agents to radiotherapy.PMID:37728512 | DOI:10.1158/2767-9764.CRC-23-0084
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Joanne B Weidhaas Chen Hu Ritsuko Komaki Gregory A Masters George R Blumenschein Joe Y Chang Bo Lu Adam P Dicker Jeffrey A Bogart Yolanda I Garces Samir Narayan Clifford G Robinson Vivek S Kavadi Joel S Greenberger Christopher D Koprowski James W Welsh El Source Type: research
