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Infectious Disease: Influenza

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The re-emergence of influenza following the COVID-19 pandemic in Victoria, Australia, 2021 to 2022
ConclusionEnhanced testing for respiratory viruses during the COVID-19 pandemic provided a more complete picture of influenza virus transmission compared with previous seasons. Returned international travellers were important drivers of influenza reemergence, as were young adults, a group whose role has previously been under-recognised in the establishment of seasonal influenza epidemics. Targeting interventions, including vaccination, to these groups could reduce future influenza transmission.PMID:37707981 | DOI:10.2807/1560-7917.ES.2023.28.37.2300118
Source: Euro Surveill - September 14, 2023 Category: Infectious Diseases Authors: Catherine Ga Pendrey Janet Strachan Heidi Peck Ammar Aziz Jean Moselen Rob Moss Md Rezanur Rahaman Ian G Barr Kanta Subbarao Sheena G Sullivan Source Type: research

Interim Effectiveness Estimates of 2023 Southern Hemisphere Influenza Vaccines in Preventing Influenza-Associated Hospitalizations - REVELAC-i Network, March-July 2023
MMWR Morb Mortal Wkly Rep. 2023 Sep 15;72(37):1010-1015. doi: 10.15585/mmwr.mm7237e1.NO ABSTRACTPMID:37708084 | DOI:10.15585/mmwr.mm7237e1
Source: MMWR Morb Mortal Wkl... - September 14, 2023 Category: Epidemiology Authors: Ashley L Fowlkes Francisco Nogareda Annette Regan Sergio Loayza Jose Mendez Mancio Lindsey M Duca Paula Couto Juliana Leite Angel Rodriguez Daniel Salas Eduardo Azziz-Baumgartner REVELAC –i Network Source Type: research

Wastewater Surveillance Data as a Complement to Emergency Department Visit Data for Tracking Incidence of Influenza A and Respiratory Syncytial Virus - Wisconsin, August 2022-March 2023
MMWR Morb Mortal Wkly Rep. 2023 Sep 15;72(37):1005-1009. doi: 10.15585/mmwr.mm7237a2.ABSTRACTWastewater surveillance has been used to assist public health authorities in tracking local transmission of SARS-CoV-2. The usefulness of wastewater surveillance to track community spread of other respiratory pathogens, including influenza virus and respiratory syncytial virus (RSV), is less clear. During the 2022-23 respiratory diseases season, concentrations of influenza A virus and RSV in wastewater samples in three major Wisconsin cities were compared with emergency department (ED) visits associated with these pathogens. In all...
Source: MMWR Morb Mortal Wkl... - September 14, 2023 Category: Epidemiology Authors: Peter M DeJonge Carly Adams Ian Pray Melissa K Schussman Rebecca B Fahney Martin Shafer Dagmara S Antkiewicz Ad élaïde Roguet Source Type: research

Interim Effectiveness Estimates of 2023 Southern Hemisphere Influenza Vaccines in Preventing Influenza-Associated Hospitalizations - REVELAC-i Network, March-July 2023
MMWR Morb Mortal Wkly Rep. 2023 Sep 15;72(37):1010-1015. doi: 10.15585/mmwr.mm7237e1.NO ABSTRACTPMID:37708084 | PMC:PMC10511266 | DOI:10.15585/mmwr.mm7237e1
Source: MMWR Morb Mortal Wkl... - September 14, 2023 Category: Epidemiology Authors: Ashley L Fowlkes Francisco Nogareda Annette Regan Sergio Loayza Jose Mendez Mancio Lindsey M Duca Paula Couto Juliana Leite Angel Rodriguez Daniel Salas Eduardo Azziz-Baumgartner REVELAC –i Network Source Type: research

Wastewater Surveillance Data as a Complement to Emergency Department Visit Data for Tracking Incidence of Influenza A and Respiratory Syncytial Virus - Wisconsin, August 2022-March 2023
MMWR Morb Mortal Wkly Rep. 2023 Sep 15;72(37):1005-1009. doi: 10.15585/mmwr.mm7237a2.ABSTRACTWastewater surveillance has been used to assist public health authorities in tracking local transmission of SARS-CoV-2. The usefulness of wastewater surveillance to track community spread of other respiratory pathogens, including influenza virus and respiratory syncytial virus (RSV), is less clear. During the 2022-23 respiratory diseases season, concentrations of influenza A virus and RSV in wastewater samples in three major Wisconsin cities were compared with emergency department (ED) visits associated with these pathogens. In all...
Source: MMWR Morb Mortal Wkl... - September 14, 2023 Category: Epidemiology Authors: Peter M DeJonge Carly Adams Ian Pray Melissa K Schussman Rebecca B Fahney Martin Shafer Dagmara S Antkiewicz Ad élaïde Roguet Source Type: research

The re-emergence of influenza following the COVID-19 pandemic in Victoria, Australia, 2021 to 2022
ConclusionEnhanced testing for respiratory viruses during the COVID-19 pandemic provided a more complete picture of influenza virus transmission compared with previous seasons. Returned international travellers were important drivers of influenza reemergence, as were young adults, a group whose role has previously been under-recognised in the establishment of seasonal influenza epidemics. Targeting interventions, including vaccination, to these groups could reduce future influenza transmission.PMID:37707981 | DOI:10.2807/1560-7917.ES.2023.28.37.2300118
Source: Euro Surveill - September 14, 2023 Category: Infectious Diseases Authors: Catherine Ga Pendrey Janet Strachan Heidi Peck Ammar Aziz Jean Moselen Rob Moss Md Rezanur Rahaman Ian G Barr Kanta Subbarao Sheena G Sullivan Source Type: research

Interim Effectiveness Estimates of 2023 Southern Hemisphere Influenza Vaccines in Preventing Influenza-Associated Hospitalizations - REVELAC-i Network, March-July 2023
MMWR Morb Mortal Wkly Rep. 2023 Sep 15;72(37):1010-1015. doi: 10.15585/mmwr.mm7237e1.NO ABSTRACTPMID:37708084 | DOI:10.15585/mmwr.mm7237e1
Source: MMWR Morb Mortal Wkl... - September 14, 2023 Category: Epidemiology Authors: Ashley L Fowlkes Francisco Nogareda Annette Regan Sergio Loayza Jose Mendez Mancio Lindsey M Duca Paula Couto Juliana Leite Angel Rodriguez Daniel Salas Eduardo Azziz-Baumgartner REVELAC –i Network Source Type: research

Wastewater Surveillance Data as a Complement to Emergency Department Visit Data for Tracking Incidence of Influenza A and Respiratory Syncytial Virus - Wisconsin, August 2022-March 2023
MMWR Morb Mortal Wkly Rep. 2023 Sep 15;72(37):1005-1009. doi: 10.15585/mmwr.mm7237a2.ABSTRACTWastewater surveillance has been used to assist public health authorities in tracking local transmission of SARS-CoV-2. The usefulness of wastewater surveillance to track community spread of other respiratory pathogens, including influenza virus and respiratory syncytial virus (RSV), is less clear. During the 2022-23 respiratory diseases season, concentrations of influenza A virus and RSV in wastewater samples in three major Wisconsin cities were compared with emergency department (ED) visits associated with these pathogens. In all...
Source: MMWR Morb Mortal Wkl... - September 14, 2023 Category: Epidemiology Authors: Peter M DeJonge Carly Adams Ian Pray Melissa K Schussman Rebecca B Fahney Martin Shafer Dagmara S Antkiewicz Ad élaïde Roguet Source Type: research

Alzheimer's Disease as A Viral Infectious Disease: Revisiting the Infectious Hypothesis
Ageing Res Rev. 2023 Sep 11:102068. doi: 10.1016/j.arr.2023.102068. Online ahead of print.ABSTRACTAlzheimer's disease (AD) represents the most frequent type of dementia in elderly people. Two major forms of the disease exist: sporadic - the causes of which have not yet been fully understood - and familial - inherited within families from generation to generation, with a clear autosomal dominant transmission of mutations in Presenilin 1 (PSEN1), 2 (PSEN2) or Amyloid Precursors Protein (APP) genes. The main hallmark of AD consists of extracellular deposits of amyloid-beta (Aβ) peptide and intracellular deposits of the hyper...
Source: Ageing Research Reviews - September 13, 2023 Category: Genetics & Stem Cells Authors: Francesco Bruno Paolo Abondio Rossella Bruno Leognano Ceraudo Ersilia Pararazzo Luigi Citrigno Donata Luiselli Amalia C Bruni Giuseppe Passarino Rosanna Colao Raffaele Maletta Alberto Montesanto Source Type: research

AMFR promotes innate immunity activation and proteasomal degradation of HMGCR in response to influenza virus infection in A549  cells
Virology. 2023 Aug 31;587:109875. doi: 10.1016/j.virol.2023.109875. Online ahead of print.ABSTRACTDifferential regulation of the 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), which is considered the rate-limiting enzyme of the cholesterol biosynthesis pathway, has been reported in case of infection with many viruses. In our study, we have found that influenza virus infection decreases total cellular cholesterol level which is directly related to the downregulation of HMGCR protein. We found that HMGCR is degraded through ubiquitination and proteasomal-mediated pathway upon viral infection. Upregulation of Autocr...
Source: Virology - September 13, 2023 Category: Virology Authors: Devendra Nath Tewari Asim Biswas Alok Kumar Chakrabarti Shanta Dutta Source Type: research

Disease ecology: When a GPS logger tells you more than a blood sample
Curr Biol. 2023 Sep 11;33(17):R907-R909. doi: 10.1016/j.cub.2023.08.018.ABSTRACTLong-term movement tracking revealed sublethal effects of avian influenza infection in vultures, adding an important element to our understanding of the subtleties of the feedback loop between host movement and pathogen transmission.PMID:37699348 | DOI:10.1016/j.cub.2023.08.018
Source: Current Biology - September 12, 2023 Category: Biology Authors: Amandine Gamble Source Type: research

Comparative effectiveness of mRNA-1273 and BNT162b2 COVID-19 vaccines in immunocompromised individuals: a systematic review and meta-analysis using the GRADE framework
ConclusionThis GRADE meta-analysis based on a large number of consistent observational studies showed that the mRNA-1273 COVID-19 vaccine is associated with improved clinical effectiveness in IC populations compared with BNT162b2.
Source: Frontiers in Immunology - September 12, 2023 Category: Allergy & Immunology Source Type: research