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Infectious Disease: Influenza

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Total 16141 results found since Jan 2013.

A fully integrated duplex RT-LAMP device for the detection of viral infections
In this study, we showed and evaluated a prototype of a microfluidic system, and showed that duplex RT-LAMP can detect and distinguish between the two viruses, with LoDs of 2,000 copies/ml for bovine coronavirus and 200 copies/ml for influenza A/X-31 virus.PMID:37682413 | PMC:PMC10491696 | DOI:10.1007/s10544-023-00676-w
Source: Biomedical Microdevices - September 8, 2023 Category: Biomedical Engineering Authors: Nicolas Mytzka Skaiste Arbaciauskaite Natalia Sandetskaya Kai Mattern Dirk Kuhlmeier Source Type: research

Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection
Dev Cell. 2023 Aug 28:S1534-5807(23)00409-4. doi: 10.1016/j.devcel.2023.08.013. Online ahead of print.ABSTRACTReprogramming lipid metabolic pathways is a critical feature of activating immune responses to infection. However, how these reconfigurations occur is poorly understood. Our previous screen to identify cellular deubiquitylases (DUBs) activated during influenza virus infection revealed Usp25 as a prominent hit. Here, we show that Usp25-deleted human lung epithelial A549 cells display a >10-fold increase in pathogenic influenza virus production, which was rescued upon reconstitution with the wild type but not the ...
Source: Developmental Cell - September 8, 2023 Category: Cytology Authors: Qi Wen Teo Ho Him Wong Tiaan Heunis Viktoriya Stancheva Asmaa Hachim Huibin Lv Lewis Siu Julian Ho Yun Lan Chris Ka Pun Mok Rachel Ulferts Sumana Sanyal Source Type: research

A discussion about influenza from the perspective of "latent dryness"
J Tradit Chin Med. 2023 Oct;43(5):839-840. doi: 10.19852/j.cnki.jtcm.2023.05.001.NO ABSTRACTPMID:37679970 | PMC:PMC10465827 | DOI:10.19852/j.cnki.jtcm.2023.05.001
Source: Journal of Traditional Chinese Medicine - September 8, 2023 Category: Complementary Medicine Authors: Wang Yongyan W U Shengxian Source Type: research

The neuropathogenesis of highly pathogenic avian influenza H5Nx viruses in mammalian species including humans
Trends Neurosci. 2023 Sep 6:S0166-2236(23)00190-X. doi: 10.1016/j.tins.2023.08.002. Online ahead of print.ABSTRACTCirculation of highly pathogenic avian influenza (HPAI) H5Nx viruses of the A/Goose/Guangdong/1/96 lineage in birds regularly causes infections of mammals, including humans. In many mammalian species, infections are associated with severe neurological disease, a unique feature of HPAI H5Nx viruses compared with other influenza A viruses. Here, we provide an overview of the neuropathogenesis of HPAI H5Nx virus infection in mammals, centered on three aspects: neuroinvasion, neurotropism, and neurovirulence. We fo...
Source: Trends in Neurosciences - September 8, 2023 Category: Neuroscience Authors: Lisa Bauer Feline F W Benavides Edwin J B Veldhuis Kroeze Emmie de Wit Debby van Riel Source Type: research

Optimisation of SARS-CoV-2 peptide stimulation and measurement of cytokine output by intracellular flow cytometry and bio-Plex analysis
J Immunol Methods. 2023 Sep 6:113556. doi: 10.1016/j.jim.2023.113556. Online ahead of print.ABSTRACTOur study was conducted to optimise a peptide stimulation and an intracellular cytokine staining protocol, alongside Bio-Plex supernatant analysis, for use in patients who had previously contracted SARS-CoV-2 or received vaccination against this virus in a clinical laboratory setting. Peripheral Blood Mononuclear Cell extraction and cryopreservation allowed for cells to be stored long term and enhanced logistical processing of samples. Viability and functionality of cells were analysed by flow cytometric methodology using vi...
Source: Journal of Immunological Methods - September 8, 2023 Category: Allergy & Immunology Authors: Jemma Victoria Taylor Emma Louise Callery Anthony Rowbottom Source Type: research

HVT-vectored H7 vaccine protects chickens from lethal infection with the highly pathogenic H7N9 Avian in ﬂuenza virus
Vet Microbiol. 2023 Aug 20;285:109852. doi: 10.1016/j.vetmic.2023.109852. Online ahead of print.ABSTRACTSince mid-2016, the highly pathogenic H7N9 subtype avian influenza virus (AIV) has threatened both public health and the poultry industry. Although a vaccination strategy has been deemed imperative to manage the virus, the most commonly used inactivated vaccines today are susceptible to interference from maternal antibodies and associated with an over-reliance on humoral immunity. In response, we developed a recombination vaccine with the herpesvirus of turkeys (HVT) as the vector to squeeze HPAI H7N9 and assessed its pr...
Source: Herpes - September 8, 2023 Category: Infectious Diseases Authors: Yi-Qun Chen Guan-Ming Su Jia-Hao Zhang Bo Li Kai-Xiong Ma Xu Zhang Li-Hong Huang Ming Liao Wen-Bao Qi Source Type: research

Global burden of influenza lower respiratory tract infections in older people from 1990 to 2019
CONCLUSION: Efforts to improve vaccination for influenza are needed for preparedness of another influenza pandemic, especially in low-SDI regions.PMID:37682492 | DOI:10.1007/s40520-023-02553-1
Source: Aging Clinical and Experimental Research - September 8, 2023 Category: Geriatrics Authors: Jing-Nan Feng Hou-Yu Zhao Si-Yan Zhan Source Type: research

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