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Infectious Disease: Coronavirus
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Total 72349 results found since Jan 2013.
The role of Pannexin-1 channels, ATP, and purinergic receptors in the pathogenesis of HIV and SARS-CoV-2
Curr Opin Pharmacol. 2023 Sep 19;73:102404. doi: 10.1016/j.coph.2023.102404. Online ahead of print.ABSTRACTInfectious agents such as human immune deficiency virus-1 (HIV) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) use host proteins to infect, replicate, and induce inflammation within the host. A critical component of these diseases is the axis between pannexin-1 channels, extracellular ATP, and purinergic receptors. Here, we describe the potential therapeutic role of Pannexin-1/purinergic approaches to prevent or reduce the devastating consequences of these pathogens.PMID:37734241 | DOI:10.1016/j.coph.2023.102404
Source: Current Opinion in Pharmacology - September 21, 2023 Category: Drugs & Pharmacology Authors: Cristian A Hernandez Eliseo A Eugenin Source Type: research
Nervous system-related tropism of SARS-CoV-2 and autoimmunity in COVID-19 infection
This article is protected by copyright. All rights reserved.PMID:37733584 | DOI:10.1002/eji.202250230
Source: European Journal of Immunology - September 21, 2023 Category: Allergy & Immunology Authors: Robert Weissert Source Type: research
Neonatal erythema multiforme associated with a rotavirus infection: A case report
CONCLUSION: The possibility of rotavirus, a major cause of pediatric gastrointestinal infections, being a trigger for neonatal EM should be considered.PMID:37727716 | PMC:PMC10506005 | DOI:10.12998/wjcc.v11.i24.5749
Source: Herpes - September 20, 2023 Category: Infectious Diseases Authors: Jung Jae Kim Joon Kee Lee Source Type: research
Efficient trapping and destruction of SARS-CoV-2 using PECO-assisted Molekule air purifiers in the laboratory and real-world settings
Ecotoxicol Environ Saf. 2023 Sep 18;264:115487. doi: 10.1016/j.ecoenv.2023.115487. Online ahead of print.ABSTRACTSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted human-to-human via aerosols and air-borne droplets. Therefore, capturing and destroying viruses from indoor premises are essential to reduce the probability of human exposure and virus transmission. While the heating, ventilation, and air conditioning (HVAC) systems help in reducing the indoor viral load, a targeted approach is required to effectively remove SARS-CoV-2 from indoor air to address human exposure concerns. The present study...
Source: Ecotoxicology and Environmental Safety - September 20, 2023 Category: Environmental Health Authors: Arpan Acharya Kerri Surbaugh Michellie Thurman Chatura Wickramaratne Philip Myers Rajat Mittal Kabita Pandey Elizabeth Klug Sarah J Stein Ashley R Ravnholdt Vicki L Herrera Danielle N Rivera Paul Williams Joshua L Santarpia Ajeet Kaushik Jaspreet S Dhau S Source Type: research
HPC-Atlas: Computationally Constructing A Comprehensive Atlas of Human Protein Complexes
Genomics Proteomics Bioinformatics. 2023 Sep 18:S1672-0229(23)00103-1. doi: 10.1016/j.gpb.2023.05.001. Online ahead of print.ABSTRACTA fundamental principle of biology is that proteins tend to form complexes to play significant roles in the core functions of cells. For a complete understanding of human cellular functions, it is crucial to have a comprehensive atlas of human protein complexes. Unfortunately, we still lack such a comprehensive atlas of experimentally validated protein complexes, which prevents us from gaining a complete understanding of the compositions and functions of human protein complexes and biological...
Source: Genomics Proteomics ... - September 20, 2023 Category: Genetics & Stem Cells Authors: Yuliang Pan Ruiyi Li Wengen Li Liuzhenghao Lv Jihong Guan Shuigeng Zhou Source Type: research
Novel inflammatory biomarkers in the prognosis of COVID-19
CONCLUSIONS: In summary, this meta-analysis provides the most up-to-date and comprehensive evidence for the role of the mentioned novel inflammatory biomarkers in the prognosis of COVID-19, especially in evaluating death and other poor prognoses, with most biomarkers showing a better discriminatory ability.PMID:37727063 | DOI:10.1177/17534666231199679
Source: Adv Data - September 20, 2023 Category: Epidemiology Authors: Kegang Zhan Luhan Wang Hao Lin Xiaoyu Fang Hong Jia Xiangyu Ma Source Type: research
Neonatal erythema multiforme associated with a rotavirus infection: A case report
CONCLUSION: The possibility of rotavirus, a major cause of pediatric gastrointestinal infections, being a trigger for neonatal EM should be considered.PMID:37727716 | PMC:PMC10506005 | DOI:10.12998/wjcc.v11.i24.5749
Source: Herpes - September 20, 2023 Category: Infectious Diseases Authors: Jung Jae Kim Joon Kee Lee Source Type: research
Exploring the Access and Use of Social Technologies by Older Adults in Support of Their Mental Health During the COVID-19 Pandemic: A Rapid Review
This study aimed to explore the accessibility, outcomes, and challenges of social technology use among community-dwelling older adults, older adults in long-term care, older adults with neurocognitive disorder, and older adults with pre-frailty and frailty, to help guide future research in this area. A rapid review was conducted, and articles were retrieved from four online databases, including Medline, AgeLine, EconLit and CINAHL, and grey literature from Google Scholar. Of the 131 articles retrieved, 24 were included in this review. The positive outcomes of social technology use include improved mental and physical healt...
Source: Canadian Journal on Aging - September 20, 2023 Category: Geriatrics Authors: Joelle R DesCh âtelets Asif R Khowaja Kristin Mechelse Henriette Koning Dominic Ventresca Source Type: research
Social Connectedness Between Family Caregivers and Older Adults Living in Long-Term Care Homes in the Context of COVID-19
Can J Aging. 2023 Sep 20:1-12. doi: 10.1017/S0714980823000351. Online ahead of print.ABSTRACTThe coronavirus disease (COVID-19) pandemic and resulting restrictions on physical access to long-term care homes culminated in health declines for older adults living there and their families. Knowledge gaps exist regarding maintaining social connectedness when physically separated. The study aimed to explore family members' perceptions of the impact that restrictions on physical access to long-term care homes had on the experience of social connectedness between family members and older adults living in long-term care. The method...
Source: Canadian Journal on Aging - September 20, 2023 Category: Geriatrics Authors: Anna Garnett Hannah Pollock Natalie Floriancic Kristin Prentice Lorie Donelle Carri Hand Abe Oudshoorn Yolanda Babenko-Mould Cheryl Forchuk Source Type: research
Exploring the Access and Use of Social Technologies by Older Adults in Support of Their Mental Health During the COVID-19 Pandemic: A Rapid Review
This study aimed to explore the accessibility, outcomes, and challenges of social technology use among community-dwelling older adults, older adults in long-term care, older adults with neurocognitive disorder, and older adults with pre-frailty and frailty, to help guide future research in this area. A rapid review was conducted, and articles were retrieved from four online databases, including Medline, AgeLine, EconLit and CINAHL, and grey literature from Google Scholar. Of the 131 articles retrieved, 24 were included in this review. The positive outcomes of social technology use include improved mental and physical healt...
Source: Canadian Journal on Aging - September 20, 2023 Category: Geriatrics Authors: Joelle R DesCh âtelets Asif R Khowaja Kristin Mechelse Henriette Koning Dominic Ventresca Source Type: research
Social Connectedness Between Family Caregivers and Older Adults Living in Long-Term Care Homes in the Context of COVID-19
Can J Aging. 2023 Sep 20:1-12. doi: 10.1017/S0714980823000351. Online ahead of print.ABSTRACTThe coronavirus disease (COVID-19) pandemic and resulting restrictions on physical access to long-term care homes culminated in health declines for older adults living there and their families. Knowledge gaps exist regarding maintaining social connectedness when physically separated. The study aimed to explore family members' perceptions of the impact that restrictions on physical access to long-term care homes had on the experience of social connectedness between family members and older adults living in long-term care. The method...
Source: Canadian Journal on Aging - September 20, 2023 Category: Geriatrics Authors: Anna Garnett Hannah Pollock Natalie Floriancic Kristin Prentice Lorie Donelle Carri Hand Abe Oudshoorn Yolanda Babenko-Mould Cheryl Forchuk Source Type: research
The Pathogenesis of COVID-19-Related Taste Disorder and Treatments
J Dent Res. 2023 Sep 20:220345231182926. doi: 10.1177/00220345231182926. Online ahead of print.ABSTRACTCOVID-19, mainly manifested as acute respiratory distress syndrome, has afflicted millions of people worldwide since 2019. Taste dysfunction is a common early-stage symptom of COVID-19 infection that burdens patients for weeks or even permanently in some cases. Owing to its subjectivity and complexity, the mechanism of taste disorder is poorly studied. Previous studies have reported that the COVID-19 entry receptors are highly expressed in taste buds, thereby intensifying the cytocidal effect. Taste receptor cells are vul...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: J Wang R Liu H Ma W Zhang Source Type: research
Cinnamaldehyde inhibits cytokine storms induced by the ORF3a protein of SARS-CoV-2 via ROS-elimination in activated T cells
Phytother Res. 2023 Sep 19. doi: 10.1002/ptr.8016. Online ahead of print.ABSTRACTCytokine storms are the cause of complications in patients with severe COVID-19, and it becomes the target of therapy. Several natural compounds were selected to screen the inhibitory effect on T-cell proliferation by Fluorescence-Activated Cell Sorting (FACS) and cytokine production by enzyme-linked immunosorbent assay (ELISA). Open reading frame 3a (ORF3a) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stimulates the specific T-cell activation model in vivo and in vitro. The coculture system included the macrophage cell line...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: Jing Ma Xu Chen Rui Xue Fei Wang Jun Dong Ning Tao Zhihai Qin Source Type: research
How does the Immunological System Change during the SARS-COV-2 Attack? A Clue for the New Immunotherapy Discovery
Curr Med Chem. 2023 Sep 18. doi: 10.2174/0929867331666230918092749. Online ahead of print.ABSTRACTThe COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-COV-2) is one of the biggest unsolved global problems of the 21st century for which there has been no definitive cure yet. Like other respiratory viruses, SARS-COV-2 triggers the host immunity dramatically, causing dysfunction in the immune system, both innate and adaptive, which is a common feature of COVID-19 patients. Evidence shows that in the early stages of COVID-19, the immune system is suppressed while it is overactive in severe p...
Source: Current Medicinal Chemistry - September 19, 2023 Category: Chemistry Authors: Mohammad Mahdi Hajihasani Najmeh Kaffash Farkhad Ali Mahmoudi Amirhossein Sahebkar Source Type: research
