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Infectious Disease: Gastroenteritis
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Total 36196 results found since Jan 2013.
Metronidazole-Loaded Camphor-Based In Situ Forming Matrix for Periodontitis Treatment
AAPS PharmSciTech. 2023 Sep 12;24(7):185. doi: 10.1208/s12249-023-02640-6.ABSTRACTPeriodontitis is a widespread oral health problem caused by bacterial infections that lead to tooth loss and other systemic diseases. The aim of this study was to provide an alternative treatment for periodontitis by developing a metronidazole-loaded in situ forming matrix (ISM) using camphor as its matrix former. Five-percent w/w metronidazole dissolved in N-methyl pyrrolidone (NMP) with varying concentrations of camphor (30-50% w/w) and triacetin (0-25% w/w) were used. The physicochemical properties and antimicrobial activities of formulati...
Source: AAPS PharmSciTech - September 12, 2023 Category: Drugs & Pharmacology Authors: Kritamorn Jitrangsri Nutdanai Lertsuphotvanit Ngamsil Kabthong Thawatchai Phaechamud Source Type: research
Phosphatase A1 accessory protein PlaS from Serratia marcescens controls cell membrane permeability, fluidity, hydrophobicity, and fatty acid composition in Escherichia coli BL21
Int J Biol Macromol. 2023 Sep 10:126776. doi: 10.1016/j.ijbiomac.2023.126776. Online ahead of print.ABSTRACTPhospholipase A1 (PlaA) plays a pivotal role in diverse applications within the food and biochemical medical industries. Herein, we investigate the impact of the accessory protein encoded by plaS from Serratia marcescens on PlaA activity in Escherichia coli. Notably, PlaS demonstrates the ability to enhance PlaA activity while concurrently exhibiting inhibitory effects on the growth of E. coli BL21 (DE3). Our study revolves around probing the inhibitory action of PlaS on E. coli BL21 (DE3). PlaS exhibits a propensity...
Source: International Journal of Biological Macromolecules - September 12, 2023 Category: Biochemistry Authors: Xiangfei Li Jie Zhou Rumeng Han Fei Yu Kun Liu Ming Zhao Yan Liu Zhenglian Xue Shiguang Zhao Source Type: research
Longitudinal analysis of differences and similarities in antimicrobial resistance among commensal Escherichia coli isolated from market swine and sows at slaughter in the United States of America, 2013-2019
Int J Food Microbiol. 2023 Sep 7;407:110388. doi: 10.1016/j.ijfoodmicro.2023.110388. Online ahead of print.ABSTRACTThe emergence of antimicrobial resistance in swine enteric bacteria poses a significant public health challenge. Our study evaluated publicly available data collected by the National Antimicrobial Resistance Monitoring System for Enteric Bacteria (NARMS) between 2013 and 2019 at slaughter plants across the United States of America, focusing on commensal E. coli isolated from swine cecal contents originating from two distinct swine production systems: market hogs (n = 2090) and sows (n = 1147). In both producti...
Source: International Journal of Food Microbiology - September 12, 2023 Category: Food Science Authors: Hamid Reza Sodagari Isha Agrawal Setyo Yudhanto Csaba Varga Source Type: research
Metronidazole-Loaded Camphor-Based In Situ Forming Matrix for Periodontitis Treatment
AAPS PharmSciTech. 2023 Sep 12;24(7):185. doi: 10.1208/s12249-023-02640-6.ABSTRACTPeriodontitis is a widespread oral health problem caused by bacterial infections that lead to tooth loss and other systemic diseases. The aim of this study was to provide an alternative treatment for periodontitis by developing a metronidazole-loaded in situ forming matrix (ISM) using camphor as its matrix former. Five-percent w/w metronidazole dissolved in N-methyl pyrrolidone (NMP) with varying concentrations of camphor (30-50% w/w) and triacetin (0-25% w/w) were used. The physicochemical properties and antimicrobial activities of formulati...
Source: AAPS PharmSciTech - September 12, 2023 Category: Drugs & Pharmacology Authors: Kritamorn Jitrangsri Nutdanai Lertsuphotvanit Ngamsil Kabthong Thawatchai Phaechamud Source Type: research
Characterization of bifunctional alginate lyase Aly644 and antimicrobial activity of enzymatic hydrolysates
Appl Microbiol Biotechnol. 2023 Sep 12. doi: 10.1007/s00253-023-12745-4. Online ahead of print.ABSTRACTAn alginate lyase gene aly644 encoding a member of polysaccharide lyase family 6 was obtained from a metagenome of Antarctic macroalgae-associated microbes. The gene was expressed heterologously in Escherichia coli, and the recombinant protein was purified using a Ni-NTA His Tag Kit. With sodium alginate as the substrate, recombinant Aly644 exhibited an optimum reaction temperature of 50°C and an optimum reaction pH of 7.0. The Vmax and Km values of Aly644 toward sodium alginate were 112.36 mg/mL·min and 16.75 mg/mL, re...
Source: Applied Microbiology and Biotechnology - September 12, 2023 Category: Microbiology Authors: Ao Zhang Zhe Cao Luying Zhao Qian Zhang Liping Fu Jiang Li Tao Liu Source Type: research
Longitudinal analysis of differences and similarities in antimicrobial resistance among commensal Escherichia coli isolated from market swine and sows at slaughter in the United States of America, 2013-2019
Int J Food Microbiol. 2023 Sep 7;407:110388. doi: 10.1016/j.ijfoodmicro.2023.110388. Online ahead of print.ABSTRACTThe emergence of antimicrobial resistance in swine enteric bacteria poses a significant public health challenge. Our study evaluated publicly available data collected by the National Antimicrobial Resistance Monitoring System for Enteric Bacteria (NARMS) between 2013 and 2019 at slaughter plants across the United States of America, focusing on commensal E. coli isolated from swine cecal contents originating from two distinct swine production systems: market hogs (n = 2090) and sows (n = 1147). In both producti...
Source: International Journal of Food Microbiology - September 12, 2023 Category: Food Science Authors: Hamid Reza Sodagari Isha Agrawal Setyo Yudhanto Csaba Varga Source Type: research
Metronidazole-Loaded Camphor-Based In Situ Forming Matrix for Periodontitis Treatment
AAPS PharmSciTech. 2023 Sep 12;24(7):185. doi: 10.1208/s12249-023-02640-6.ABSTRACTPeriodontitis is a widespread oral health problem caused by bacterial infections that lead to tooth loss and other systemic diseases. The aim of this study was to provide an alternative treatment for periodontitis by developing a metronidazole-loaded in situ forming matrix (ISM) using camphor as its matrix former. Five-percent w/w metronidazole dissolved in N-methyl pyrrolidone (NMP) with varying concentrations of camphor (30-50% w/w) and triacetin (0-25% w/w) were used. The physicochemical properties and antimicrobial activities of formulati...
Source: AAPS PharmSciTech - September 12, 2023 Category: Drugs & Pharmacology Authors: Kritamorn Jitrangsri Nutdanai Lertsuphotvanit Ngamsil Kabthong Thawatchai Phaechamud Source Type: research
Evaluation of the Potential Therapeutic Properties of Liquidambar orientalis Oil
In conclusion, the oil from the Sigla tree offers promising therapeutic potential and warrants further exploration.PMID:37699128 | DOI:10.1002/cbdv.202300291
Source: Chemistry and Biodiversity - September 12, 2023 Category: Biochemistry Authors: Mehmet Cengiz Baloglu Lutfiye Yildiz Ozer Buket Pirci Gokhan Zengin Abdullahi Ibrahim Uba Yasemin Celik Altunoglu Source Type: research
Oral administration of a 2-aminopyrimidine robenidine analogue (NCL195) significantly reduces < em > Staphylococcus aureus < /em > infection and reduces < em > Escherichia coli < /em > infection in combination with sub-inhibitory colistin concentrations in a bioluminescent mouse model
In this study, we examined the efficacy of oral treatment with NCL195 (± low-dose colistin) in comparison to oral moxifloxacin in bioluminescent Staphylococcus aureus and Escherichia coli peritonitis-sepsis models. Four oral doses of 50 mg/kg NCL195, commencing immediately post-infection, were administered at 4 h intervals in the S. aureus peritonitis-sepsis model. We used a combination of four oral doses of 50 mg/kg NCL195 and four intraperitoneal doses of colistin at 0.125 mg/kg, 0.25 mg/kg, or 0.5 mg/kg in the E. coli peritonitis-sepsis model. Subsequently, the dose rates of four intraperitoneal doses of colistin were ...
Source: Antimicrobial Agents and Chemotherapy - September 11, 2023 Category: Microbiology Authors: Hang Thi Nguyen Henrietta Venter Lucy Woolford Kelly A Young Adam McCluskey Sanjay Garg Sylvia S Sapula Stephen W Page Abiodun David Ogunniyi Darren J Trott Source Type: research
Green synthesis of silver nanoparticles from discarded shells of velvet tamarind (Dialium cochinchinense) and their antimicrobial synergistic potentials and biofilm inhibition properties
In this study, discarded shell of velvet tamarind fruit is explored as a potent reducing agent for biogenic synthesis of silver nanoparticles (VeV-AgNPs). Silver nanoparticles were formed in minutes under sunlight exposure, which was considerably fast compared to under ambient conditions. The optical, structural and morphological studies revealed that the nanoparticle colloidal solution consisted of particles with quasi-spherical and rodlike morphologies. To investigate antimicrobial properties, eight microorganisms were exposed to the VeV-AgNPs. The results indicated that VeV-AgNPs had enhanced antimicrobial activity, wit...
Source: Biometals - September 11, 2023 Category: Biochemistry Authors: Bright Ankudze David Neglo Francis Nsiah Source Type: research
Prevalence and Antimicrobial-Resistant Features of < em > Shigella < /em > Species in East Africa from 2015-2022: A Systematic Review and Meta-Analysis
CONCLUSION: The pooled estimate indicates high burden of Shigella infection in East Africa, as well as a high proportion of drug resistance pattern to tetracycline, ampicillin, chloramphenicol, and amoxicillin. Therefore, initiating and scale-up of performing drug susceptibility test for each shigellosis case need to be considered and strengthened.PMID:37692062 | PMC:PMC10492654 | DOI:10.1155/2023/8277976
Source: Interdisciplinary Perspectives on Infectious Diseases - September 11, 2023 Category: Infectious Diseases Authors: Basha Ayele Getenet Beyene Mekdelawit Alemayehu Aman Dekebo Zeleke Mekonnen Gashaw Nigussie Source Type: research
< em > Salvia dumetorum < /em > essential oil: GC-MS analysis, antibacterial activity and effect on the formation of < em > Streptococcus mutans < /em > biofilms
In this study SDEO was screened for its antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Candida albicans and the amount of biofilm formed by Streptococcus mutans bacteria. For the first time the chemical composition of SDEO growing in Central Kazakhstan was established. The results obtained from GC-MS showed the predominance of sesquiterpenoids (54.15%). The antibacterial study results showed that SDEO exhibited strong antibacterial activity against B. subtilis and S. aureus in vitro and also demonstrated an inhibitory effect on S. mutans biofilm formation on 1% sucrose medium...
Source: Natural Product Research - September 11, 2023 Category: Biochemistry Authors: Yana К Levaya Gayane А Atazhanova Тomas Kacergius Svetlana А Ivasenko Alexandr B Marchenko Margarita Yu Ishmuratova Мarlen К Smagulov Source Type: research
Decoding SEC24 Homolog D, COPII coat complex component accuracy as a signature gene in three human cancers
In this study, we conducted an extensive investigation of SEC24D, aiming to elucidate its potential role and underlying mechanisms across multiple human tumors. Our analysis relied on data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. To validate our findings, we employed RNA sequencing (RNA-seq), targeted bisulfite sequencing (bisulfite-seq) molecular techniques. Our findings revealed elevated mRNA (Messenger RNA) and protein levels of SEC24D in different tumor tissues. However, the up-regulation of SEC24D was significantly correlated with shorter overall survival (OS), metastasis, and v...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Weiwei Du Yang Sun Wentao Ji Tian Luo Dandan Zhang Weihong Guo Jianping Liang Yanhua Lv Mengwei Dong Kaixin Li Source Type: research
Mannan oligosaccharides selenium ameliorates intestinal mucosal barrier, and regulate intestinal microbiota to prevent Enterotoxigenic Escherichia coli -induced diarrhea in weaned piglets
In conclusion, our study showed that dietary MOSS supplementation ameliorated intestinal mucosa barrier, and regulated intestinal microbiota to prevent ETEC induced diarrhea in weaned piglets.PMID:37696080 | DOI:10.1016/j.ecoenv.2023.115448
Source: Ecotoxicology and Environmental Safety - September 11, 2023 Category: Environmental Health Authors: Andong Zha Ruiqi Tu Ming Qi Jing Wang Bie Tan Peng Liao Chenchen Wu Yulong Yin Source Type: research
