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BTEX in Ambient Air of Zarand, the Industrial City in Southeast of Iran: Concentration, Spatio-temporal Variation and Health Risk Assessment
Bull Environ Contam Toxicol. 2023 Aug 12;111(2):25. doi: 10.1007/s00128-023-03778-6.ABSTRACTThe existence of several industries in Zarand, a city in Southeastern Iran, caused challenges for the residents about air pollutants and associated health effects. In the present study, the concentration of benzene, toluene, ethylbenzene, and xylene (BTEX), spatio-temporal distribution and related health risks were evaluated. Passive samplers were used to collect 30 samples in the over the hot and cold periods in 2020. The ordinary Kriging method was used to predict the spatio-temporal distribution of BTEXs. Also, the Monte Carlo si...
Source: Bulletin of Environmental Contamination and Toxicology - August 12, 2023 Category: Environmental Health Authors: Sobhan Maleky Maryam Faraji Source Type: research
P16 Expression in Human Breast Carcinoma and its Relationship to Clinicopathological Parameters
CONCLUSION: p16 seems to have a rather significant expression in breast cancer in comparison to normal breast parenchyma. However, among clinicopathological parameters, we found only a direct relationship between lymph node involvement and intensity of p16 expression.PMID:37564443 | PMC:PMC10410420 | DOI:10.4103/abr.abr_180_22
Source: Cancer Control - August 11, 2023 Category: Cancer & Oncology Authors: Fereshteh Mohammadizadeh Farnaz Nasri Source Type: research
Molecular identification and biofilm formation of aerobic and anaerobic coinfection bacterial isolated from cystic fibrosis patients in southwest Iran from 2014 to 2022
CONCLUSION: In conclusion, P. aeruginosa was found to be the most frequently isolated bacterium from patients with CF, and many of these bacteria could form biofilms. Additionally, the high prevalence of antibiotic resistance indicates the urgent need for increased attention to antibiotic preparation and patient screening concerning bacterial coinfections and the virulence and adhesion factors of these bacteria. Furthermore, the present study demonstrates that the coinfection of bacteria with high antibiotic resistance and a high capacity for biofilm formation can pose a life-threatening risk to CF patients, mainly due to ...
Source: Molecular Biology Reports - August 11, 2023 Category: Molecular Biology Authors: Sasan Moogahi Fateme Tadi Beni Mohammad Hashemzadeh Aram Asareh Zadegan Dezfuli Source Type: research
Limb-Girdle Muscular Dystrophy Type 2B (LGMD2B) caused by Pathogenic Splice and Missense Variants of < em > DYSF < /em > Gene among Iranians with Muscular Dystrophy
CONCLUSION: Conclusively, the current report introduced eight variants including a novel frameshift in DYSF gene with noticeable pathogenic effects. This study significantly can broaden the diagnostic spectrum of LGMD2B in combination with previous reports about DYSF mutations and may pave the way for a rapidly high-ranked identification of the accurate type of dysferlinopathy.PMID:37564451 | PMC:PMC10410417 | DOI:10.4103/abr.abr_131_22
Source: Biomed Res - August 11, 2023 Category: Research Authors: Fatemeh Arab Najmeh Ahangari Hadis Malek Mohammad Doosti Paria Najarzadeh Torbati Ehsan Ghayoor Karimiani Source Type: research
Exploring the anticancer properties of the gum of < em > Ferula gummosa < /em > : impact on cytotoxicity, caspase 3/7 activity and apoptosis, and gene expression in SW-480 cells
This study aimed to identify the chemical components of the gum of F. gummosa and investigate its effects on SW-480 cells. The experiments included MTT, clonogenic, micronucleus formation, acridine orange/ethidium bromide stain, DNA degradation, caspase 3/7 activity assay, and in vitro wound-healing experiment and investigating the expression of BAX, BCL2, MTOR, and PTEN genes. Chemical analysis using GC/MS identified 102 compounds. The gum had a significant cytotoxic effect on SW-480 cells, with an IC50 value of 1.8 µg/ml for 48 hours. The gum induced apoptosis. Microscopic observations revealed a decrease in cell prolif...
Source: Cell Research - August 11, 2023 Category: Cytology Authors: Parisa Bahavar Majid Tafrihi Source Type: research
Assessment of Bcl-xL, TAX, and HBZ gene expression in ATLL patients
CONCLUSION: It is proposed that this anti-apoptotic pathway may not be directly involved in the development of ATLL lymphoma. TAX, HBZ gene expression, and PVL can be utilized as prognostic markers.PMID:37565279 | DOI:10.1089/AID.2023.0025
Source: Cell Research - August 11, 2023 Category: Cytology Authors: Zahra Farjami Mohammad Mehdi Akbarin Houshang Rafatpanah Samaneh Ramezani Hosein Rahimi Seyed Abdolrahim Rezaee Source Type: research
Limb-Girdle Muscular Dystrophy Type 2B (LGMD2B) caused by Pathogenic Splice and Missense Variants of < em > DYSF < /em > Gene among Iranians with Muscular Dystrophy
CONCLUSION: Conclusively, the current report introduced eight variants including a novel frameshift in DYSF gene with noticeable pathogenic effects. This study significantly can broaden the diagnostic spectrum of LGMD2B in combination with previous reports about DYSF mutations and may pave the way for a rapidly high-ranked identification of the accurate type of dysferlinopathy.PMID:37564451 | PMC:PMC10410417 | DOI:10.4103/abr.abr_131_22
Source: Biomed Res - August 11, 2023 Category: Research Authors: Fatemeh Arab Najmeh Ahangari Hadis Malek Mohammad Doosti Paria Najarzadeh Torbati Ehsan Ghayoor Karimiani Source Type: research
Comparison of clinical outcomes, demographic, and laboratory characteristics of hospitalized COVID-19 patients during major three waves driven by Alpha, Delta, and Omicron variants in Tehran, Iran
CONCLUSIONS: Although the Omicron variant caused less severe disease, in older patients who were hospitalized due to Omicron infection, longer hospital and ICU stays were reported, which could be attributed to their old age. In particular, elderly patients are more vulnerable to severe COVID-19; otherwise, as expected, other laboratory parameters and clinical outcomes were in accordance with differences in pathogenicity and infectivity of these variants.PMID:37565071 | PMC:PMC10410233 | DOI:10.1111/irv.13184
Source: Respiratory Care - August 11, 2023 Category: Respiratory Medicine Authors: Zahra Heydarifard Nazanin-Zahra Shafiei-Jandaghi Moslem Safaei Forough Tavakoli Somayeh Shatizadeh Malekshahi Source Type: research
P16 Expression in Human Breast Carcinoma and its Relationship to Clinicopathological Parameters
CONCLUSION: p16 seems to have a rather significant expression in breast cancer in comparison to normal breast parenchyma. However, among clinicopathological parameters, we found only a direct relationship between lymph node involvement and intensity of p16 expression.PMID:37564443 | PMC:PMC10410420 | DOI:10.4103/abr.abr_180_22
Source: Cell Research - August 11, 2023 Category: Cytology Authors: Fereshteh Mohammadizadeh Farnaz Nasri Source Type: research
Phytochemicals, essential oil composition and antioxidant activity of Astragalus spp., Phlomis olivieri and Daphne mucronata in habitats of central Iran
This study evaluated secondary metabolites, essential oil compositions, and antioxidant activity in four medicinal plants that originated in Isfahan rangelands. The species were Astragalus verus, Astragalus adscendens, Daphne mucronata, and Phlomis olivieri. Thirty-two genotypes of these species were evaluated for different biochemical traits. Based on the evaluation of EO compounds, GC-MS analysis revealed the total number of identified compounds. These compounds were 25, 22, 12, and 22 for A. adscendens, A. verus, D. mucronata, and P. olivieri, respectively. The dominant compounds were phthalate (59.88%) in A. adscendens...
Source: Chemistry and Biodiversity - August 11, 2023 Category: Biochemistry Authors: Leila Ghorbani Pooran Golkar Reza Jafary Mohsen Ahmadi Alireza Allafchian Source Type: research
Comparative Analysis and Identification of Spike Mutations in Iranian COVID-19 Samples from the First Three Waves of Disease
CONCLUSIONS: Our findings suggest that developing effective vaccines requires identifying the predominant variants of SARS-CoV-2 in each community.PMID:37564431 | PMC:PMC10410413 | DOI:10.4103/abr.abr_171_22
Source: Cell Research - August 11, 2023 Category: Cytology Authors: Parisa Shoaei Mohammad M Ranjbar Samaneh Tokhanbigli Behrouz Ataei Abbas Alibakhshi Shaghayegh Haghjooy Javanmard Shahrzad Ahangarzadeh Source Type: research
P16 Expression in Human Breast Carcinoma and its Relationship to Clinicopathological Parameters
CONCLUSION: p16 seems to have a rather significant expression in breast cancer in comparison to normal breast parenchyma. However, among clinicopathological parameters, we found only a direct relationship between lymph node involvement and intensity of p16 expression.PMID:37564443 | PMC:PMC10410420 | DOI:10.4103/abr.abr_180_22
Source: Biomed Res - August 11, 2023 Category: Research Authors: Fereshteh Mohammadizadeh Farnaz Nasri Source Type: research
Comparative Analysis and Identification of Spike Mutations in Iranian COVID-19 Samples from the First Three Waves of Disease
CONCLUSIONS: Our findings suggest that developing effective vaccines requires identifying the predominant variants of SARS-CoV-2 in each community.PMID:37564431 | PMC:PMC10410413 | DOI:10.4103/abr.abr_171_22
Source: Biomed Res - August 11, 2023 Category: Research Authors: Parisa Shoaei Mohammad M Ranjbar Samaneh Tokhanbigli Behrouz Ataei Abbas Alibakhshi Shaghayegh Haghjooy Javanmard Shahrzad Ahangarzadeh Source Type: research
