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Preventing breastfeeding-associated hypernatraemia: an argument for supplemental feeding
The benefits of breastfeeding are unquestionable. Breast milk provides the ideal nourishment for infant growth and development. In addition, it has numerous health benefits for both infant and mother. Breastfeeding decreases the incidence of acute infections such as otitis media, respiratory tract infections and gastroenteritis; chronic diseases such as type 1 diabetes, asthma and inflammatory bowel disease, and childhood leukaemia and lymphoma; and sudden infant death syndrome. In addition, it improves neurodevelopmental outcomes for the infant. Breastfeeding benefits the mother by improving infant-maternal bonding, facil...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - August 18, 2013 Category: Perinatology & Neonatology Authors: Moritz, M. L. Tags: Infection (gastroenterology), Oncology, Immunology (including allergy), Foodborne infections, Otitis, TB and other respiratory infections, Coma and raised intracranial pressure, Epilepsy and seizures, Childhood nutrition, Contraception, Family planning, R Source Type: research

Association between maternal breastfeeding and risk of systemic neoplasms of offspring
ConclusionsThe evidences demonstrated that breastfeeding have a potential protective role in preventing selective childhood cancer growth, especially for ALL, AML, cancer of nervous and urinary systems. This study recommended that breastfeeding be extended for as long as possible or maintained for at least 6  months to prevent selective childhood cancer growth.
Source: Italian Journal of Pediatrics - June 16, 2022 Category: Pediatrics Source Type: research

Computer-aided search for 5-arylideneimidazolone anticancer agents able to overcome ABCB1-based multidrug resistance
ChemMedChem. 2021 Apr 30. doi: 10.1002/cmdc.202100252. Online ahead of print.ABSTRACTABCB1 modulation is an interesting strategy in search for new anticancer agents overcoming multidrug resistance (MDR). Hence, 17 new 5-arylideneimidazolones containing amine moiety, as potential ABCB1 inhibitors was designed, synthesized, and investigated. The series was tested in both, parental (PAR) and multidrug resistant (MDR) overproducing ABCB1, T-lymphoma cancer cells using cytotoxicity assay. The ABCB1 modulating activity was examined in the rhodamine 123 accumulation test, followed by Pgp-Glo™ Assay to determine an influence of ...
Source: ChemMedChem - April 30, 2021 Category: Chemistry Authors: Aneta Kaczor Nikoletta Szemer édi Katarzyna Kucwaj-Brysz Monika D ąbrowska Ma łgorzata Starek Gniewomir Latacz Gabriella Spengler Jadwiga Handzlik Source Type: research

CD177 Expression on Neutrophils: In Search of a Clonal Assay for Myeloid Neoplasia by Flow Cytometry.
Conclusions: Skewed low neutrophil CD177(%) is highly associated with clonal myeloid disorders, particularly myelodysplasia, and may be useful for detecting clonal myeloid disorders. PMID: 24124144 [PubMed - as supplied by publisher]
Source: American Journal of Clinical Pathology - October 15, 2013 Category: Pathology Authors: Meyerson HJ, Osei E, Schweitzer K, Blidaru G, Edinger A, Balog A Tags: Am J Clin Pathol Source Type: research

The Search for Surrogate Endpoints in Trials in Diffuse Large B-Cell Lymphoma: The Surrogate Endpoints for Aggressive Lymphoma Project.
PMID: 28798271 [PubMed - as supplied by publisher]
Source: The Oncologist - August 10, 2017 Category: Cancer & Oncology Authors: Sargent DJ, Shi Q, Flowers CR, Schmitz N, Habermann TM, Flament J, Fu T, Coiffier B, SEAL group Tags: Oncologist Source Type: research

Molecules, Vol. 25, Pages 2258: Search for ABCB1 Modulators Among 2-Amine-5-arylideneimidazolones As a New Perspective to Overcome Cancer Multidrug Resistance
a Handzlik Multidrug resistance (MDR) is a severe problem in the treatment of cancer with overexpression of glycoprotein P (Pgp, ABCB1) as a reason for chemotherapy failure. A series of 14 novel 5-arylideneimidazolone derivatives containing the morpholine moiety, with respect to two different topologies (groups A and B), were designed and obtained in a three- or four-step synthesis, involving the Dimroth rearrangement. The new compounds were tested for their inhibition of the ABCB1 efflux pump in both sensitive (parental (PAR)) and ABCB1-overexpressing (MDR) T-lymphoma cancer cells in a rhodamine 123 accumulation assay...
Source: Molecules - May 10, 2020 Category: Chemistry Authors: Aneta Kaczor M árta Nové Annam ária Kincses Gabriella Spengler Ewa Szyma ńska Gniewomir Latacz Jadwiga Handzlik Tags: Article Source Type: research

Pulmonary arterial hypertension in a patient with multiple myeloma during carfilzomib treatment: in search of better management.
CONCLUSION: The mechanism responsible for cardiac and vascular events during carfilzomib therapy is unclear. This case report highlights that it is important to define at baseline the appropriate screening of patients undergoing carfilzomib therapy with specific monitoring and symptom management and that future large prospective controlled studies are needed to define the correct monitoring strategy in refractory and relapsed multiple myeloma and the potential mechanism of vascular events. PMID: 33525991 [PubMed - as supplied by publisher]
Source: Tumori - February 4, 2021 Category: Cancer & Oncology Tags: Tumori Source Type: research

IJERPH, Vol. 18, Pages 4008: Development of a Questionnaire for the Search for Occupational Causes in Patients with Non-Hodgkin Lymphoma: The RHELYPRO Study
In conclusion, this questionnaire appears as a useful tool to identify NHL patients for a specialized consultation, in order to ask for compensation for occupational disease.
Source: International Journal of Environmental Research and Public Health - April 11, 2021 Category: Environmental Health Authors: Mireille Matrat Murielle Gain Corinne Haioun Fabien Le Bras Catherine Nisse Franck Morschhauser B énédicte Clin Isabelle Baldi Catherine Verdun-Esquer Robert Garnier Herv é Laborde-Castérot Fabrice H érin Yolande Esquirol Pascal Andujar Milia Belacel Tags: Article Source Type: research

Development of a Questionnaire for the Search for Occupational Causes in Patients with Non-Hodgkin Lymphoma: The RHELYPRO Study
In conclusion, this questionnaire appears as a useful tool to identify NHL patients for a specialized consultation, in order to ask for compensation for occupational disease.PMID:33920383 | DOI:10.3390/ijerph18084008
Source: Clinical Lymphoma and Myeloma - April 30, 2021 Category: Cancer & Oncology Authors: Mireille Matrat Murielle Gain Corinne Haioun Fabien Le Bras Catherine Nisse Franck Morschhauser B énédicte Clin Isabelle Baldi Catherine Verdun-Esquer Robert Garnier Herv é Laborde-Castérot Fabrice H érin Yolande Esquirol Pascal Andujar Milia Belacel Source Type: research

Seleno-vs. thioether triazine derivatives in search for new anticancer agents overcoming multidrug resistance in lymphoma
Eur J Med Chem. 2022 Sep 19;243:114761. doi: 10.1016/j.ejmech.2022.114761. Online ahead of print.ABSTRACTLymphomas are still difficult to treat even with modern therapies as, among others, multidrug resistance (MDR) is often counteracting a successful cancer therapy. P-gp/ABC-transporters are well-known for their crucial role in the main tumour MDR mechanism, eliminating drugs and cytotoxic substances from the cancer cell by efflux, and their modulators are promising for innovative therapy, but none has been approved in the pharmaceutical market yet. Herein, we have designed, synthesised and analysed 30 novel seleno- and t...
Source: European Journal of Medicinal Chemistry - September 30, 2022 Category: Chemistry Authors: Wesam Ali Sabrina Garbo Annam ária Kincses M árta Nové Gabriella Spengler Elisabetta Di Bello Ewelina Honkisz-Orzechowska Tadeusz Karcz Ewa Szyma ńska Ewa Żesławska Ma łgorzata Starek Monika D ąbrowska Wojciech Nitek Katarzyna Kucwaj-Brysz Patryk Source Type: research

Viruses, Vol. 13, Pages 1753: Work-Related Human T-lymphotropic Virus 1 and 2 (HTLV-1/2) Infection: A Systematic Review
ero Lovreglio Human T-lymphotropic virus 1 and 2 (HTLV-1/2) belong to the delta group of retroviruses which may cause a life-long infection in humans, HTLV-1 leading to adult T-cell leukemia/lymphoma and other diseases. Different transmission modes have been described, such as breastfeeding, and, as for other blood-borne pathogens, unsafe sexual activity, intravenous drug usage, and blood transfusion and transplantation. The present systematic review was conducted to identify all peer-reviewed studies concerning the work-related infection by HTLV-1/2. A literature search was conducted from January to May 2021, accordin...
Source: Viruses - September 2, 2021 Category: Virology Authors: Angela Stufano Hamid Reza Jahantigh Francesco Cagnazzo Francesca Centrone Daniela Loconsole Maria Chironna Piero Lovreglio Tags: Review Source Type: research

Lactation and maternal cardiovascular disease risk in later life
Lactation is the process of secretion of milk from the mammary glands as well as the period when the mother lactates to feed her offspring. In humans, lactation (also called breastfeeding or nursing) is recommended for at least the first 6 months of the infant ’s life [1], with introduction of the appropriate complementary foods whilst breastfeeding until 1 year or longer, as mutually desired by the mother and the infant. Breastfeeding is beneficial for both child and maternal health. The short-term advantages for the infant include the decrease in th e incidence of respiratory tract infections and otitis media, non-sp...
Source: Maturitas - January 23, 2019 Category: Primary Care Authors: Georgia Zachou, Eleni Armeni, Irene Lambrinoudaki Source Type: research