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Total 517 results found since Jan 2013.

Prevalence of gastro-esophageal reflux disease in suspected laryngo-pharingeal reflux unresponsive to proton-pump inhibitors
CONCLUSIONS: This study found that the real prevalence of GERD in patients with a recent laryngoscopic diagnosis of LPR, and unresponsive to PPI, is low. Moreover, more than 40% of them did not show any of the investigated diseases in real-life.PMID:34365960 | DOI:10.2174/1574887116666210806092038
Source: Reviews on Recent Clinical Trials - August 9, 2021 Category: Cancer & Oncology Authors: Antonio Tursi Antonio Pio Palieri Michele Tiano Walter Elisei Source Type: research

Nasal endoscopy, room filtration, and aerosol concentrations during live outpatient encounters: a prospective, case ‐control study
ConclusionUsing advanced instrumentation and a comparative study design, aerosol concentration was shown to be no greater during nasal endoscopy versus no endoscopy encounters. HEPA filter utilization reduced aerosol concentrations significantly faster than no HEPA filter.
Source: International Forum of Allergy and Rhinology - August 6, 2021 Category: Allergy & Immunology Authors: Amarbir S. Gill, Kamaljeet Kaur, Paige Shipman, Jorgen Sumsion, Marc Error, Kerry Kelly, Jeremiah A. Alt Tags: ORIGINAL ARTICLE Source Type: research

Cumulative comorbidity burden does not worsen outcomes in management of chronic rhinosinusitis
ConclusionAlthough cumulative comorbidity burden, as measured by FCI, is associated with worse baseline SNOT-22 and SF-6D scores, it does not appear to limit posttreatment improvement in either outcome measure. On average, patients with high comorbidity burden report substantial improvement in both QOL and health utility after CRS treatment, similar to those with fewer comorbidities.
Source: International Forum of Allergy and Rhinology - July 14, 2021 Category: Allergy & Immunology Authors: Amarbir S. Gill, Jess C. Mace, Ryan Rimmer, Vijay R. Ramakrishnan, Daniel M. Beswick, Zachary M. Soler, James Manor, Richard R. Orlandi, Timothy L. Smith, Jeremiah A. Alt Tags: ORIGINAL ARTICLE Source Type: research

Feasibility of a deep learning ‐based algorithm for automated detection and classification of nasal polyps and inverted papillomas on nasal endoscopic images
ConclusionsThe trained CNN model appears to reliably classify NP and IP of the nasal cavity from nasal endoscopic images; it also yields a reliable reference for diagnosing nasal cavity mass lesions during nasal endoscopy. However, further studies with more test data are warranted to improve the diagnostic accuracy of our CNN model.
Source: International Forum of Allergy and Rhinology - June 21, 2021 Category: Allergy & Immunology Authors: Benton Girdler, Hyun Moon, Mi Rye Bae,, Sung Seok Ryu, Jihye Bae, Myeong Sang Yu Tags: ORIGINAL ARTICLE Source Type: research

Effects of implants with steroids after endoscopic sinus surgery: A systematic review with meta ‐analysis of randomized controlled trials
ConclusionsCollectively, steroid implant decreases LKE and POSE among patients receiving ESS in the short term, but long-term effects remain unclear. Patient-based outcomes are worth further discussion in the future.
Source: International Forum of Allergy and Rhinology - June 16, 2021 Category: Allergy & Immunology Authors: Yi ‐Lin Kao, Yi‐Chen Huang, Shao‐Chen Tsai, Ming‐Tang Lai, Yi‐No Kang Tags: ORIGINAL ARTICLE Source Type: research

Id: 3526039 food allergy sensitivity test (fast) with endomicroscopy of the duodenum enables tailored exclusion diet in patients with irritable bowel syndrome
Patients suffering from irritable bowel syndrome have an increased prevalence of typical and atypical food allergies. Endomicroscopy with food exposition during ongoing upper endoscopy (Food Allergy Sensitivity Test - FAST) is a new diagnostic method for food associates symptoms (Gastroenterology 2019 Jul;157(1):109-118).
Source: Gastrointestinal Endoscopy - May 26, 2021 Category: Gastroenterology Authors: Ralf Kiesslich, Hanan Adib-Tezer, Daniel Teubner, Thomas Frieling, Christiane Bayerl, Nina K. Wenda, Jan Gosepath Tags: Sunday, May 23, 2021 Source Type: research

Janssen Presents Results of First Head-to-Head Study of Biologic Therapies in Patients with Moderate to Severe Crohn ’s Disease
SPRING HOUSE, PENNSYLVANIA, May 23, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced efficacy and safety data for STELARA® (ustekinumab) in Crohn’s disease (CD) and ulcerative colitis (UC),1-4including data from the SEAVUE study, the first head-to-head study of biologic therapies in patients with CD, presented in a Clinical Science Late-Breaking Abstract Plenary session.1 SEAVUE data showed treatment with STELARA demonstrated high rates of clinical remission, corticosteroid-free remission, clinical response and endoscopic response through one year in biologic-naïve patients with mo...
Source: Johnson and Johnson - May 24, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Effects of large volume, isotonic nasal saline irrigation for acute rhinosinusitis: a randomized controlled study
ConclusionThe add-on isotonic nasal saline irrigation using a large volume, positive pressure device did not add benefits equally for all ARS patients. The benefits of irrigation on quality of life and nasal symptoms were only observed in the common cold patient subgroup.
Source: International Forum of Allergy and Rhinology - May 18, 2021 Category: Allergy & Immunology Authors: Wirach Chitsuthipakorn, Angsuthorn Thanaphiphatsatja, Peeravuit Doungbuppha, Saranath Lawpoolsri, Kachorn Seresirikachorn, Kornkiat Snidvongs Tags: ORIGINAL ARTICLE Source Type: research

The Role of Nasal Endoscopy in Allergic Rhinitis and House Dust Mite Sublingual Immunotherapy
Conclusions: In addition to commonly utilized subjective assessments (TMS, TNSS, and VAS), our results of endoscopic examination and the MLK scores consistently confirmed that SLIT is an effective therapeutic modality for AR patients. The MLK scores might be considered as an auxiliary tool to evaluate efficacy of SLIT in clinical practice and outcomes research.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - May 17, 2021 Category: Allergy & Immunology Source Type: research

Comorbidities Known to Affect Physical Function Negatively Impact Baseline Health-Related Quality-of-Life in Patients With Chronic Rhinosinusitis
CONCLUSIONS: Major medical comorbidities known to affect physical function are associated with worse SNOT-22 scores in patients with CRS as measured by the FCI.PMID:33906469 | DOI:10.1177/19458924211013610
Source: American Journal of Rhinology and Allergy - April 28, 2021 Category: ENT & OMF Authors: Amarbir S Gill Shaelene Ashby Gretchen M Oakley Toby O Steele Dennis Menjivar Richard R Orlandi Jeremiah A Alt Source Type: research

Disease control after surgery for chronic rhinosinusitis: prospective, multi ‐institutional validation of the Sinus Control Test
ConclusionImprovement in disease control following ESS as measured by the SCT correlated with improvements in SNOT ‐22 and endoscopy scores. The SCT is an easily administered instrument that provides information complementary to existing patient‐reported and objective measures of disease severity.
Source: International Forum of Allergy and Rhinology - February 22, 2021 Category: Allergy & Immunology Authors: Ryan E. Little, Rodney J. Schlosser, Timothy L. Smith, Kristina A. Storck, Jeremiah A. Alt, Daniel M. Beswick, Jess C. Mace, Jose L. Mattos, Vijay R. Ramakrishnan, Zachary M. Soler Tags: ORIGINAL ARTICLE Source Type: research

Medical and surgical treatment outcomes in patients with chronic rhinosinusitis and immunodeficiency: a systematic review
ConclusionPatients with CRS and immunodeficiency likely benefit from ESS based on the available evidence. Data supporting medical therapy in this targeted population is limited overall, but there may be a potential role for immunoglobulin therapy in patients with PID and CRS.
Source: International Forum of Allergy and Rhinology - February 22, 2021 Category: Allergy & Immunology Authors: Shireen Samargandy, Elysia Grose, Yvonne Chan, Eric Monteiro, John M. Lee, Jonathan Yip Tags: ORIGINAL ARTICLE Source Type: research