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Therapy: Antibiotic Therapy

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Total 169 results found since Jan 2013.

Impact of a clinical guideline for prescribing antibiotics to inpatients reporting penicillin or cephalosporin allergy.
CONCLUSION: The implementation of an inpatient antibiotic prescribing guideline for patients with penicillin or cephalosporin allergy was associated with an almost 7-fold increase in the number of test doses to β-lactams without increased adverse drug reactions. Patients assessed with guideline-driven test doses were observed to have significantly decreased alternative antibiotic exposure. PMID: 26070805 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - June 9, 2015 Category: Allergy & Immunology Authors: Blumenthal KG, Shenoy ES, Varughese CA, Hurwitz S, Hooper DC, Banerji A Tags: Ann Allergy Asthma Immunol Source Type: research

The cost of self-reported penicillin allergy: a systematic review
Conclusions Evaluations of clinical and economic outcomes of PCN allergy are primarily observational and focus on inpatient populations. Long-term relationships between PCN allergy and clinical and economic outcomes are unknown.
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 31, 2018 Category: Allergy & Immunology Source Type: research

The Cost of Self-Reported Penicillin Allergy: A Systematic Review
ConclusionsEvaluations of clinical and economic outcomes of PCN allergy are primarily observational and focus on inpatient populations. Long-term relationships between PCN allergy and clinical and economic outcomes are unknown.
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 6, 2018 Category: Allergy & Immunology Source Type: research

The role of the gut microbiota in food allergy
Purpose of review: The rise in the prevalence of food allergy over the past decades has focused attention of factors that may impact disease development, most notably the gut microbiota. The gut microbial communities play a crucial role in promoting oral tolerance. Their alteration by such factors as Cesarean section delivery, diet and antibiotics may influence disease development. This review highlights recent progress in our understanding of the role of the gut microbiota in the development of food allergy. Recent findings: Food allergy is associated with alterations in the gut microbiota or dysbiosis early in life that...
Source: Current Opinion in Pediatrics - November 4, 2016 Category: Pediatrics Tags: ALLERGY, IMMUNOLOGY AND RELATED DISORDERS: Edited by Talal Chatila Source Type: research

Use of a Penicillin Allergy Screening Algorithm and Penicillin Skin Testing for Transitioning Hospitalized Patients to First-Line Antibiotic Therapy
Conclusions The use of the PAHA and subsequent PST is a safe, effective multidisciplinary intervention that facilitates the transition to β-lactam antibiotics. Our approach is unique in that it prioritizes patients based on the use of second-line antibiotics, and then applies an algorithm to determine eligibility for PST.
Source: The Journal of Allergy and Clinical Immunology: In Practice - December 16, 2017 Category: Allergy & Immunology Source Type: research

Penicillin allergy as a public health measure
Penicillin allergy is self-reported by approximately 10% of the population. Therefore physicians are often faced with having to choose antibiotic therapy for patients with a history of penicillin allergy. When surveyed physicians are presented theoretic scenarios of antibiotic treatment in patients with a history of penicillin allergy, it is not surprising that they frequently choose non–β-lactam antibiotics, such as quinolones, vancomycin, and macrolides. Studies of prescribing patterns in both hospital and clinic settings have shown that patients labeled as having “penicillin allergy” are more likely to be treated...
Source: Journal of Allergy and Clinical Immunology - December 10, 2013 Category: Allergy & Immunology Authors: Roland Solensky Tags: Related editorial Source Type: research

Implementing a referral protocol for penicillin allergy testing of pregnant women
Recent American College of Obstetrics and Gynecology (ACOG) guidelines advocate for the safety of penicillin allergy testing in pregnant women. Penicillin allergy de-labeling allows for preferred peripartum antibiotic therapy for Group B Streptococcus (GBS) prophylaxis and reduces IV antibiotics and neonatal ICU (NICU) care for newborns. Yet, there remains widespread hesitance to perform penicillin allergy testing on pregnant women.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: M. Patel, E. Stephen, L. Laursen, S. Bandi Tags: P205 Source Type: research

Penicillin Allergy Testing and Clearance in the Operational Setting: A Proof of Concept
Direct oral challenge for penicillin allergy has increasingly become a safe, cost-effective option especially in healthcare systems with limited access to allergy subspecialists. The military healthcare system has unique constraints in not only a paucity of allergists but "Authorized Medical Allowance Lists" aboard carriers/amphibious assault ships that carry principally penicillin antibiotics. Sailors with penicillin allergy are historically treated with often substandard antimicrobial therapy and even medically evacuated from ships while deployed, leading to costly and potentially dangerous patient transfers.
Source: Journal of Allergy and Clinical Immunology - February 1, 2023 Category: Allergy & Immunology Authors: William Day, Allyson Burkhart DeNora, Daniel Shields, Taylor Banks Source Type: research

Bacteriophage reduces biofilm of Staphylococcus aureus ex vivo isolates from chronic rhinosinusitis patients.
CONCLUSION: This study indicates that phage cocktail CT-SA can effectively eliminate S. aureus, in planktonic and biofilm forms, from the great majority of CIs from this hospital setting. In addition, its potential effect in preventing the emergence of BIMs was also established. Thus, CT-SA has the potential to treat S. aureus infection and biofilm in CRS patients. PMID: 24717868 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - January 1, 2014 Category: ENT & OMF Authors: Drilling A, Morales S, Jardeleza C, Vreugde S, Speck P, Wormald PJ Tags: Am J Rhinol Allergy Source Type: research

Effects of Methylprednisolone Pulse Therapy on Refractory Mycoplasma pneumoniae Pneumonia in Children.
CONCLUSIONS: Three-day methylprednisolone pulse therapy could be applied to treatment of refractory M. pneumoniae pneumonia despite appropriate antibiotic therapy and appeared to be efficacious and well-tolerated. PMID: 24404389 [PubMed]
Source: Allergy, Asthma and Immunology Research - November 16, 2014 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

New strategies for dealing with Staphylococcus aureus colonization and the emerging methicillin-resistant Staphylococcus aureus epidemic in atopic dermatitis.
Authors: Boguniewicz M Abstract Atopic dermatitis is a common inflammatory skin disease and a global health problem. Patients are often colonized or infected by Staphylococcus aureus, usually by toxin-producing strains. Methicillin-resistant S. aureus (MRSA) has emerged as an important pathogen. Community-acquired MRSA, a frequent cause of skin and soft tissue infections has become epidemic. Basic skin care measures emphasizing repair and protection of the skin barrier reduce microbial colonization and decrease the need for specific antimicrobial therapy even in patients colonized by MRSA. Novel approaches directed...
Source: Chemical Immunology and Allergy - December 2, 2014 Category: Allergy & Immunology Tags: Chem Immunol Allergy Source Type: research

Short-term morbidity after the endoscopic modified Lothrop (Draf-III) procedure compared with Draf-IIa.
CONCLUSION: Draf-III is associated with more postoperative clinic visits, debridements, and antibiotic therapy days. The patients who underwent Draf-III demonstrated worsening of extranasal symptoms at the first postoperative visit and less improvement in the ear/facial score at the second and third visits. Informed consent and counseling patients who may require Draf-III should include a detailed discussion of the burden of postoperative care and recovery. PMID: 28716178 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - July 1, 2017 Category: ENT & OMF Authors: Jafari A, Tringale KR, Panuganti BA, Acevedo JR, Pang J, DeConde AS Tags: Am J Rhinol Allergy Source Type: research

How to Manage Antibiotic Allergy in Cystic Fibrosis? Epidemiologic, Diagnostic, and Therapeutic Aspects
AbstractPurpose of studyCystic fibrosis (CF) is a complex genetic disease with high mortality, of which 85% is a result of lung disease characterized by serious endobronchial infections.Recent findingsAntibiotic therapy is one of the main treatments of CF, both during acute exacerbations and as chronic maintenance medications, contributing to a prolonged survival. Since neonatal CF screening programs have been implemented universally and the longevity of patients with CF steadily increases, antibiotic hypersensitivity reactions (HSRs) are becoming more important. HSR to antibiotics in CF has been reported since the 1980s a...
Source: Current Treatment Options in Allergy - February 6, 2018 Category: Allergy & Immunology Source Type: research