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Therapy: Gene Therapy

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Total 130 results found since Jan 2013.

Adenovirus-mediated Gene Therapy for Allergy.
Abstract Allergy poses a heavy health burden in modern society. Other than symptom-relieving medications, the only available treatment approach is allergen-specific immunotherapy, which in spite of offering a potential cure, requires a long treatment duration with multiple doses of allergen administration and carries a risk of anaphylaxis. Gene therapy has shown advantages in experimental studies for treatment of tumors, genetic diseases, chronic infections, and allergy. To date, adenovirus has been the most extensively used gene transfer vector, and offers high efficiency and safety. Here, we review studies of ad...
Source: Iranian Journal of Allergy, Asthma and Immunology - December 1, 2018 Category: Allergy & Immunology Authors: Ma S, Guan J Tags: Iran J Allergy Asthma Immunol Source Type: research

Use of biologics in severe food allergies
Purpose of review: Severe cases of food allergy account for the majority of the burden in terms of risks, quality of life, and resource expenditure. The traditional approach to these forms has been strict avoidance. More recently, Oral ImmunoTherapy (OIT) has gained a role in their management. However, in severe food allergies OIT is often infeasible. Recent findings: Case reports, observational, and prospective studies have recently proposed different approaches to severe food allergy. The majority of them include the use of biologics. Omalizumab has been the most studied drug for severe food allergies, and its role as a...
Source: Current Opinion in Allergy and Clinical Immunology - April 27, 2017 Category: Allergy & Immunology Tags: FOOD ALLERGY: Edited by Alessandro Fiocchi and Motohiro Ebisawa Source Type: research

Historic Change Imminent in Food Allergy, Asthma Treatments Historic Change Imminent in Food Allergy, Asthma Treatments
Biologics, gene therapy, alterations to the microbiome, and immunotherapy are all dramatically changing the way allergy and asthma will be treated.Medscape Medical News
Source: Medscape Medical News Headlines - February 13, 2019 Category: Consumer Health News Tags: Allergy & Clinical Immunology News Source Type: news

In Vitro Generation of IL-35-expressing Human Wharton's Jelly-derived Mesenchymal Stem Cells Using Lentiviral Vector.
Abstract Human Wharton's Jelly-derived Mesenchymal Stem Cells (hWJ-MSCs) are easily available cells without transplant rejection problems or ethical concerns compared to bone-marrow-derived MSCs for prospective clinical applications. These cells display immunosuppressive properties and may be able to play an important role in autoimmune disorders. Regulatory T-cells (Treg) are important to prevent autoimmune disease development. Interleukin 35 (IL-35) induces the proliferation of Treg cell populations and reduces the activity of T helper 17 (Th17) and T helper 1 (Th1) cells, which play a central role in initiation...
Source: Iranian Journal of Allergy, Asthma and Immunology - August 1, 2015 Category: Allergy & Immunology Authors: Amari A, Ebtekar M, Moazzeni S, Soleimani M, Mohammadi-Amirabad L, Tahoori M, Massumi M Tags: Iran J Allergy Asthma Immunol Source Type: research

Recent Advances in Gene Therapy and Modeling of Chronic Granulomatous Disease.
Abstract The Chronic granulomatous disease (CGD) is a primary immunodeficiency that characterized by mutations in phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, resulting in deficient antimicrobial activity of phagocytic cells and recurrent childhood infections. Hematopoietic stem cell transplantation (HSCT) is a curative option for patients with human leukocyte antigen (HLA) matched donor, when conventional cares and therapies fail. However, in many cases when the patients have not an HLA-matched donor, they need to a method to recapitulate the function of the affected gene within the pati...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 31, 2019 Category: Allergy & Immunology Authors: Jafarian A, Shokri G, Shokrollahi Barough M, Moin M, Pourpak Z, Soleimani M Tags: Iran J Allergy Asthma Immunol Source Type: research

Clinical Applications of Interleukin-37: A Key Player in the Immunopathogenesis of Immune Disorders.
Abstract Recently, the era of medicine has been encountered with the exponential growth of special seroimmunobiomarkers in clinical trials. Lately, Interleukin-37 (IL-37) has attracted a wide range of basic medical scientists' attention due to its controversial functions in physiologic or pathologic microenvironments. In this research, an updated overview of immunobiological functions and clinical applications of IL-37 in a wide range of diseases, are discussed in order to highlight the role of recent laboratory-based results of IL-37. Data of this systematic review article were collected from initial 237 articles...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 22, 2020 Category: Allergy & Immunology Authors: Khosh E, Bahmaie N, Elahi R, Esmaeilzadeh A Tags: Iran J Allergy Asthma Immunol Source Type: research

Blood Test Might Help Tell When Peanut Allergy Is Gone
Findings might one day benefit patients who go through therapy to build up resistance to allergen Source: HealthDay Related MedlinePlus Pages: Food Allergy, Genes and Gene Therapy
Source: MedlinePlus Health News - January 31, 2014 Category: Consumer Health News Source Type: news

Childhood Peanut Allergy May Be Linked to Skin Gene Mutation
Study bolsters the dual-allergen-exposure theory, expert says Source: HealthDay Related MedlinePlus Pages: Food Allergy, Genes and Gene Therapy, Skin Conditions
Source: MedlinePlus Health News - October 24, 2014 Category: Consumer Health News Source Type: news

Positive Family History, Infection, Low Absolute Lymphocyte Count (ALC), and Absent Thymic Shadow: Diagnostic Clues for All Molecular Forms of Severe Combined Immunodeficiency (SCID)
Conclusions Infants with SCID appear normal at birth but later present with failure to thrive and/or recurrent fungal, viral, and bacterial infections. Low ALCs and an absent thymic shadow on chest x-ray are key diagnostic clues. The absence of T-cell function confirms the diagnosis.
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 30, 2015 Category: Allergy & Immunology Source Type: research

Anti-hIgE gene therapy of peanut-induced anaphylaxis in a humanized murine model of peanut allergy
Peanuts are the most common food to provoke fatal or near-fatal anaphylactic reactions. Treatment with an anti-hIgE mAb is efficacious but requires frequent parenteral administration.
Source: Journal of Allergy and Clinical Immunology - June 28, 2016 Category: Allergy & Immunology Authors: Odelya E. Pagovich, Bo Wang, Maria J. Chiuchiolo, Stephen M. Kaminsky, Dolan Sondhi, Clarisse L. Jose, Christina C. Price, Sarah F. Brooks, Jason G. Mezey, Ronald G. Crystal Source Type: research

Gene Therapy for C1 Esterase Inhibitor Deficiency in a Murine Model of Hereditary Angioedema
Allergy,Volume 0, Issue ja, -Not available-.
Source: Allergy - July 30, 2018 Category: Allergy & Immunology Authors: Ting Qiu , Maria J. Chiuchiolo , Adele S. Whaley , Anthony R. Russo , Dolan Sondhi , Stephen M. Kaminsky , Ronald G. Crystal , Odelya E. Pagovich Source Type: research

T-cell gene therapy for perforin deficiency corrects  cytotoxicity defects and prevents hemophagocytic lymphohistiocytosis manifestations
Mutations in the perforin 1 (PRF1) gene account for up to 58% of familial hemophagocytic lymphohistiocytosis syndromes. The resulting defects in effector cell cytotoxicity lead to hypercytokinemia and hyperactivation with inflammation in various organs.
Source: Journal of Allergy and Clinical Immunology - January 17, 2018 Category: Allergy & Immunology Authors: Sujal Ghosh, Marlene Carmo, Miguel Calero-Garcia, Ida Ricciardelli, Juan Carlos Bustamante Ogando, Michael P. Blundell, Axel Schambach, Philip G. Ashton-Rickardt, Claire Booth, Stephan Ehl, Kai Lehmberg, Adrian J. Thrasher, H. Bobby Gaspar Tags: Mechanisms of allergy/immunology Source Type: research

Successful SCID Gene Therapy in Infant with Disseminated BCG
Publication date: Available online 16 September 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Gabriela Maron, Sue Kaste, Armita Bahrami, Michael Neel, Harry L. Malech, Jennifer M. Puck, Morton J. Cowan, Stephen Gottschalk, Ewelina Mamcarz
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 17, 2020 Category: Allergy & Immunology Source Type: research

Mechanism of Kruppel-Like Factor 4 in Pyroptosis of Nasal Mucosal Epithelial Cells in Mice With Allergic Rhinitis
CONCLUSION: KLF4 bound to the NLRP3 promoter and promoted pyroptosis of NEpCs in AR mice via activating NLRP3.PMID:36799547 | DOI:10.1177/19458924221148568
Source: American Journal of Rhinology and Allergy - February 17, 2023 Category: ENT & OMF Authors: Jiaoli Yao Qingfeng Kong Yin Wang Yanting Zhang Qinxue Wang Source Type: research