Adenovirus-mediated Gene Therapy for Allergy.
Adenovirus-mediated Gene Therapy for Allergy. Iran J Allergy Asthma Immunol. 2018 Dec 01;17(6):502-516 Authors: Ma S, Guan J Abstract Allergy poses a heavy health burden in modern society. Other than symptom-relieving medications, the only available treatment approach is allergen-specific immunotherapy, which in spite of offering a potential cure, requires a long treatment duration with multiple doses of allergen administration and carries a risk of anaphylaxis. Gene therapy has shown advantages in experimental studies for treatment of tumors, genetic diseases, chronic infections, and allergy. To date, adenovirus has been the most extensively used gene transfer vector, and offers high efficiency and safety. Here, we review studies of adenovirus-mediated gene therapy targeting different steps in the development of allergic diseases. Adenovirus-mediated gene therapy might be a promising add-on therapy for allergy treatment. PMID: 30644694 [PubMed - in process]
Conclusion: STAT6 may act as a prognostic biomarker and provide useful information for immunotherapy in thyroid carcinoma. PMID: 32940081 [PubMed - in process]
Publication date: Available online 18 September 2020Source: Life SciencesAuthor(s): Nosayba Al-Azzam, Lina Elsalem
Abstract Mammalian cells are the main tool for the production of therapeutic proteins, viruses for gene therapy, and cells for cell therapy. In production processes cell metabolism is the main driver that causes changes in the growth environment and affects productivity and product quality. Of all nutrients, glucose has the most prominent impact on bioprocesses. We summarize recent findings on the regulation of glucose and energy metabolism in cultured cells. Local allosteric regulations and post-translational modifications of enzymes in metabolic networks interplay with global signaling and transcriptional regula...
Publication date: December 2020Source: Journal of Transport &Health, Volume 19Author(s): Haidar Nadrian, Hassan Mahmoodi, Mohammad Hossein Taghdisi, Mehran Aghemiri, Towhid Babazadeh, Bahjat Ansari, Asaad Fathipour
Authors: Mandlik DS, Mandlik SK Abstract Asthma is the most common, long-lasting inflammatory airway disease that affects more than 10% of the world population. It is characterized by bronchial narrowing, airway hyperresponsiveness, vasodilatation, airway edema and stimulation of sensory nerve endings that lead to recurring events of breathlessness, wheezing, chest tightness and coughing. It is the main reason for global morbidity and occurs as a result of the weakening of the immune system in response to exposure to allergens or environmental exposure. In asthma condition, it results in the activation of numerous ...
The wildfires blazing in the West could hinder developing lungs, worsen asthma and even lead to the condition in those who don ’t have it but are genetically disposed to it.
President Trump acknowledged that an authorized vaccine for ‘every American’ may not be distributed until next year. An Iranian official says the country has become a “red zone” as cases and deaths surge.
Publication date: October 2020Source: Trends in Pharmacological Sciences, Volume 41, Issue 10Author(s): Yishun Yang, Jianfeng Guo, Leaf Huang
Publication date: Available online 18 September 2020Source: Biochimica et Biophysica Acta (BBA) - Reviews on CancerAuthor(s): Yongheng Shu, Ping Cheng
Publication date: Available online 17 September 2020Source: Cancer CellAuthor(s): Adham S. Bear, Robert H. Vonderheide, Mark H. O'Hara