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Allergen specificity of early peanut consumption and effect on development of allergic disease in the Learning Early About Peanut Allergy study cohort
Early introduction of dietary peanut in high-risk infants with severe eczema, egg allergy, or both prevented peanut allergy at 5  years of age in the Learning Early About Peanut Allergy (LEAP) study. The protective effect persisted after 12 months of avoiding peanuts in the 12-month extension of the LEAP study (LEAP-On). It is unclear whether this benefit is allergen and allergic disease specific.
Source: Journal of Allergy and Clinical Immunology - October 30, 2017 Category: Allergy & Immunology Authors: George du Toit, Peter H. Sayre, Graham Roberts, Kaitie Lawson, Michelle L. Sever, Henry T. Bahnson, Helen R. Fisher, Mary Feeney, Suzana Radulovic, Monica Basting, Marshall Plaut, Gideon Lack, Immune Tolerance Network Learning Early About Peanut Allergy s Tags: Food allergy and gastrointestinal disease Source Type: research

Reaction phenotypes in IgE-mediated food allergy and anaphylaxis.
CONCLUSION: Data are emerging to confirm our clinical experience that many food-allergic patients experience stereotypical symptoms following allergen exposure, both in the community and at supervised oral food challenge, in a manner that varies from one patient to another. Integrating datasets from different cohorts and applying unbiased machine-learning analyses may demonstrate specific food allergy endotypes, in a similar way to asthma. Whether this results in improvements in patient management (e.g. through facilitating risk stratification or impacting on the decision to prescribe EAI and, perhaps, the number of device...
Source: Annals of Allergy, Asthma and Immunology - January 6, 2020 Category: Allergy & Immunology Authors: Chong KW, Ruiz-Garcia M, Patel N, Boyle RJ, Turner PJ Tags: Ann Allergy Asthma Immunol Source Type: research

Allergen specificity of early peanut consumption and effect on development of allergic disease in the Learning Early About Peanut Allergy study cohort
Early introduction of dietary peanut in high-risk infants with severe eczema, egg allergy, or both prevented peanut allergy at 5  years of age in the Learning Early About Peanut Allergy (LEAP) study. The protective effect persisted after 12 months of avoiding peanuts in the 12-month extension of the LEAP study (LEAP-On). It is unclear whether this benefit is allergen and allergic disease specific.
Source: Journal of Allergy and Clinical Immunology - October 30, 2017 Category: Allergy & Immunology Authors: George du Toit, Peter H. Sayre, Graham Roberts, Kaitie Lawson, Michelle L. Sever, Henry T. Bahnson, Helen R. Fisher, Mary Feeney, Suzana Radulovic, Monica Basting, Marshall Plaut, Gideon Lack, Immune Tolerance Network Learning Early About Peanut Allergy s Source Type: research

Association of Staphylococcus aureus colonization with food allergy occurs independently of eczema severity
Staphylococcus aureus has been implicated in the pathophysiology of eczema, allergic rhinitis, asthma, and food allergy. S aureus is a marker of more severe eczema, which is a risk factor for food sensitization/allergy. Therefore it might be that the association between S aureus and food allergy in eczematous patients is related to eczema severity.
Source: Journal of Allergy and Clinical Immunology - May 30, 2019 Category: Allergy & Immunology Authors: Olympia Tsilochristou, George du Toit, Peter H. Sayre, Graham Roberts, Kaitie Lawson, Michelle L. Sever, Henry T. Bahnson, Suzana Radulovic, Monica Basting, Marshall Plaut, Gideon Lack, Immune Tolerance Network Learning Early About Peanut Allergy Study Te Source Type: research

Early Peanut Exposure Reduces Allergy, LEAP-On ConfirmsEarly Peanut Exposure Reduces Allergy, LEAP-On Confirms
New extension data from the Learning Early About Peanut Allergy (LEAP) trial show that children exposed to peanuts in infancy retain high levels of tolerance at age 6. Medscape Medical News
Source: Medscape Allergy Headlines - March 7, 2016 Category: Allergy & Immunology Tags: Allergy & Clinical Immunology News Source Type: news

Food allergy 2020: learning from the past, looking to the future.
PMID: 32336459 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - April 28, 2020 Category: Allergy & Immunology Authors: Nowak-Wegrzyn A Tags: Ann Allergy Asthma Immunol Source Type: research

Probiotics in food allergy
Purpose of review To perform a nonsystematic review of the literature on the possible role of probiotics for food allergy (FA). Recent findings Animal model and in vitro evidence suggest that the gut microbiome could protect against FA and that probiotics could be a valid instrument. There is no consistent evidence in identifying the specific species, the dosage, and the optimal duration to obtain the correct immunomodulation. Early life supplementation with specific ‘missing’ immunomodulatory microbes – derived from machine learning approach to birth cohort studies – might represent a novel approach to ...
Source: Current Opinion in Allergy and Clinical Immunology - April 30, 2021 Category: Allergy & Immunology Tags: FOOD ALLERGY: Edited by Alessandro Fiocchi and Motohiro Ebisawa Source Type: research

A potential breakthrough for peanut allergy treatment
Peanut allergies are among the most rapidly growing food allergies in the United States. Millions of children are currently living with the condition, with new cases being diagnosed daily. (A recent study shows the number of reported peanut allergies tripled in just over a decade.) And because allergic reactions to peanuts tend to be the most severe—80 to 95 percent of all food allergy deaths are peanut or tree nut related—the trend is a serious cause for concern. But a small pilot study published by the Journal of Allergy and Clinical Immunology, may offer hope for the hundred of thousands of families living with the ...
Source: Thrive, Children's Hospital Boston - November 4, 2013 Category: Pediatrics Authors: Tripp Underwood Tags: All posts Food allergies Kids' safety Milk allergies Parenting clinical trial food allergy Dale Umetsu Lynda Schneider peanut allergies Rima Rachid Source Type: news

Primary Care Provider-Reported Prevalence of Vaccine and Polyethylene-Glycol Allergy in Canada
CONCLUSION: This is the first study to estimate the prevalence of vaccine and PEG allergy in a national cohort that utilizes PCP documentation, demonstrating a low reported rate of vaccine allergy and PEG allergy.PMID:34004274 | DOI:10.1016/j.anai.2021.05.011
Source: Annals of Allergy, Asthma and Immunology - May 18, 2021 Category: Allergy & Immunology Authors: Elissa M Abrams Matthew Greenhawt Marcus Shaker Leanne Kosowan Alexander G Singer Source Type: research

Change in Allergy Practice during the COVID-19 Pandemic
Conclusions: Allergists in Turkey have been using telemedicine at a high rate during the COVID-19 pandemic for asthma and rhinitis. The continuation rate of SCIT was low while the discontinuation rate of biologicals and systemic steroid use in asthma was high in Turkey.Our study results and learning from the experiences of other countries and specialties may help to optimize allergy practice and compatibility with international guidelines.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - October 15, 2020 Category: Allergy & Immunology Source Type: research

Re: “Addendum guidelines for the prevention of peanut allergy in the United States: report of the National Institute of Allergy and Infectious Diseases–sponsored expert panel”
The Learning Early About Peanut Allergy (LEAP) Study has shed light on a growing prevalence of allergy to peanuts. The trial concluded that early exposure to peanuts in a child's diet decreases the frequency of developing peanut allergy.1 Based on this trial and expert opinion, the new addendum guidelines2 –4 help tailor the introduction of peanut into the diet of children who are at high risk of developing allergy. Although decreasing the incidence of severe peanut allergy is of significant importance, the public has to be equally aware of the danger of allowing the ingestion of solid peanuts in ch ildren younger than 2...
Source: Annals of Allergy, Asthma and Immunology - April 1, 2017 Category: Allergy & Immunology Authors: Faisal Zawawi, Paolo Campisi Tags: Correspondence Source Type: research

Global perspectives on food allergy
The prevalence of childhood food allergy has increassed sharply during the past 2 decades. Up to 8% of children in the United States and 11% of Australian infants are food allergic, and the prevalence of peanut allergy is between 1% and 3% in these countries.1 Allergy research has shifted its focus in recent years toward measures aimed at the primary prevention of food allergy in children, such as through dietary interventions in early life. The Learning Early About Peanut Allergy (LEAP) randomized clinical trial enrolled 640 high-risk infants between the ages of 4 and 11 months in the United Kingdom who had severe atopic ...
Source: Annals of Allergy, Asthma and Immunology - February 2, 2018 Category: Allergy & Immunology Authors: Elizabeth Huiwen Tham, Donald Y.M. Leung Tags: Perspective Source Type: research

Global perspectives on food allergy: One size doesn't fit all
The prevalence of childhood food allergy has increassed sharply during the past 2 decades. Up to 8% of children in the United States and 11% of Australian infants are food allergic, and the prevalence of peanut allergy is between 1% and 3% in these countries.1 Allergy research has shifted its focus in recent years toward measures aimed at the primary prevention of food allergy in children, such as through dietary interventions in early life. The Learning Early About Peanut Allergy (LEAP) randomized clinical trial enrolled 640 high-risk infants between the ages of 4 and 11 months in the United Kingdom who had severe atopic ...
Source: Annals of Allergy, Asthma and Immunology - February 2, 2018 Category: Allergy & Immunology Authors: Elizabeth Huiwen Tham, Donald Y.M. Leung Tags: Perspectives Source Type: research

Preventing Peanut Allergy: Where Are We Now?
Publication date: February 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 2Author(s): Helen R. Fisher, Corinne A. Keet, Gideon Lack, George du ToitPeanut allergy affects 1% to 3% of the Western world, usually begins in early childhood, is rarely outgrown, and has no currently approved treatment. The identification and application of prevention strategies is therefore essential. In 2015, the Learning Early About Peanuts study findings found that early consumption of peanut protein was effective in preventing peanut allergy in high-risk children as compared with peanut avoidance. The...
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 2, 2019 Category: Allergy & Immunology Source Type: research

Food allergy in adults in Europe: what can we learn from geographical differences?
Purpose of review The aim of this article is to characterize the present state-of-the-art on the topic of food allergies across Europe. Recent findings A systematic review and metaanalysis on the epidemiology of food allergy in Europe have been performed by the Food Allergy and Anaphylaxis Guidelines Group of the European Academy of Allergology and Clinical Immunology. The authors had made an extensive search of four different electronic databases which retrieved thousands of hits. A critical appraisal of the documents reduced their number to just over 100 articles covering the period 2000–2012, revealing striking m...
Source: Current Opinion in Allergy and Clinical Immunology - February 28, 2020 Category: Allergy & Immunology Tags: GENETICS AND EPIDEMIOLOGY: Edited by Isabella Annesi-Maesano and Antonella Cianferoni Source Type: research