Filtered By:
Education: Grants

This page shows you your search results in order of relevance.

Order by Relevance | Date

Total 571 results found since Jan 2013.

The role of epigenetics in allergy and asthma development
Purpose of review Epigenetic mechanisms are known to play a crucial role in the pathogenesis of asthma, allergic rhinitis, atopic dermatitis, food allergy, and other allergic disorders, especially through mediating the effects of the environmental factors, well recognized allergy-risk modifiers. The aim of this work was to provide a concise but comprehensive review of the recent progress in the epigenetics of allergic diseases. Recent findings Recent few years have substantially expanded our knowledge on the role of epigenetics in the pathogenesis and clinical picture of allergies. Specifically, it has been shown that...
Source: Current Opinion in Allergy and Clinical Immunology - January 3, 2020 Category: Allergy & Immunology Tags: MECHANISMS OF ALLERGY AND ADULT ASTHMA: Edited by J. Andrew Grant and Enrico Heffler Source Type: research

Mechanisms of allergy and adult asthma
Purpose of review Allergic asthma reflects the interplay between inflammatory mediators and immune, airway epithelial, and other cells. This review summarizes key insights in these areas over the past year. Recent findings Key findings over the past year demonstrate that epithelial cells mediate tight junction breakdown to facilitate the development of asthma-like disease in mice. Innate lymph lymphoid cells (ILC), while previously shown to promote allergic airway disease, have now been shown to inhibit the development of severe allergic disease in mice. Fibrinogen cleavage products (previously shown to mediate allerg...
Source: Current Opinion in Allergy and Clinical Immunology - January 3, 2020 Category: Allergy & Immunology Tags: MECHANISMS OF ALLERGY AND ADULT ASTHMA: Edited by J. Andrew Grant and Enrico Heffler Source Type: research

4th Pediatric Allergy and Asthma Meeting (PAAM)
DISCUSSION SESSION 1: Food allergy (PD01 –PD05)PD01 Allergen-specific humoral and cellular responses in children who fail egg oral immunotherapy due to allergic reactionsMarta Vazquez-Ortiz, Mariona Pascal, Ana Maria Plaza, Manel JuanPD02 FoxP3 epigenetic features in children with cow milk allergyLorella Paparo, Rita Nocerino, Rosita Aitoro, Ilaria Langella, Antonio Amoroso, Alessia Amoroso, Carmen Di Scala, Roberto Berni CananiPD04 Combined milk and egg allergy in early childhood: let them eat cake?Santanu Maity, Giuseppina Rotiroti, Minal GandhiPD05 Introduction of complementary foods in relation to allergy and gut mic...
Source: Clinical and Translational Allergy - October 31, 2016 Category: Allergy & Immunology Source Type: research

A streamlined approach to optimize perioperative antibiotic prophylaxis in the setting of penicillin allergy labels
ConclusionUsing a streamlined algorithm, we were able to significantly reduce the use of second-line antibiotics in penicillin-allergic surgical patients without severe adverse reactions.
Source: The Journal of Allergy and Clinical Immunology: In Practice - December 28, 2019 Category: Allergy & Immunology Source Type: research

Penicillin allergy delabelling in a pediatric primary care setting
We report the initial results of a prospective pilot study of pediatric primary care-driven direct amoxicillin challenges in delabeling penicillin allergy.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: G. Patel, J. Feng, T. Chow, D. Khan Tags: 2021 Community Grant Recipient Source Type: research

The Future Of Omics For Clinical Practice.
Abstract Dr. Kari Nadeau: Dr. Nadeau receives grant support from NIAID, Food Allergy Research & Education (FARE), End Allergies Together, Allergenis, Ukko; personal Fees from Regeneron, AstraZeneca, ImmuneWorks, Cour; sponsored research from Novartis, Sanofi, Astellas, Nestle; Sponsored research for clinical trials from Genentech, Aimmune Therapeutics, DBV Technologies, AnaptysBio, Stallergenes-Greer, Regeneron, and Adare Pharmaceuticals; Data and Safety Monitoring Board member at Novartis and NHLBI; co-founded Before Brands, Alladapt Immunotherapeutics, and ForTra; grant awardee for NIAID, NHLBI, NIEHS, and E...
Source: Annals of Allergy, Asthma and Immunology - July 24, 2019 Category: Allergy & Immunology Authors: Long A, Bunning B, Borro M, Sampath V, Nadeau KC Tags: Ann Allergy Asthma Immunol Source Type: research

Analysis of psychological variables - depression levels, anxiety and mood traits - in patients with asthma, chronic urticaria and Hymenoptera venom allergy
Conclusions: Among the analysed groups, patients with asthma reached highest BDI score and trait and state anxiety levels. An interesting phenomenon observed in this study, which need further examination, are higher BDI scores in healthy individuals than in CU and HVA groups.This study was financially supported by a grant from Medical University of Lodz (no.564/1-000-00/564-20-026)
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Kardas, G., Daszynska-Kardas, A., Ambrozewicz, M., Gabryelska, A., Wujcik, R., Kuna, P., Panek, M. Tags: Allergy and immunology Source Type: research

Delabeling antibiotic allergy: real-world experience from a pediatric cohort
Antibiotic allergy is commonly reported in childhood and is associated with increased risk for use of broad-spectrum antibiotics, antibiotic resistance, duration of hospitalization and healthcare costs for patients and families1,2,3. However, the majority who carry this label can successfully pass a drug challenge1. Oral drug challenges are the gold standard for both diagnosis and delabeling of IgE-mediated drug allergies4. We examine the safety of antibiotic allergy delabeling in a pediatric population presenting to allergy clinics at Texas Children's Hospital during a 2-year period.
Source: Annals of Allergy, Asthma and Immunology - June 30, 2023 Category: Allergy & Immunology Authors: Grant Pickett, Meera Gupta, Aikaterini Anagnostou Tags: Letters Source Type: research

A streamlined approach to optimize perioperative antibiotic prophylaxis in the setting of penicillin allergy labels
Patients with penicillin allergy labels often receive alternative antibiotics for peri-operative prophylaxis, as opposed to first-line cephalosporins (cefazolin/cefuroxime). Provider misconceptions about the risk of cross-reactivity likely drive this prescribing behavior, which is problematic because due to association with an increased risk of surgical site infections. We created and implemented an algorithm intended to guide appropriate peri-operative antibiotic selection in the setting of penicillin allergy.
Source: Journal of Allergy and Clinical Immunology - January 31, 2020 Category: Allergy & Immunology Authors: Merin Kuruvilla, Mary Elizabeth Sexton, Zanthia Wiley, Terry Langfitt, Grant Lynde, Francis Wolf Source Type: research

The hygiene hypothesis in allergy and asthma: an update
Purpose of review: It has been hypothesized that increased cleanliness, reduced family size, and subsequent decreased microbial exposure could explain the increases in global asthma prevalence. This review considers the recent evidence for and against the ‘hygiene hypothesis’. Recent findings: Recent evidence does not provide unequivocal support for the hygiene hypothesis: the hygiene hypothesis specifically relates to atopic asthma, but some of the protective effects (e.g. farm exposures) appear to apply to both atopic and nonatopic asthma; asthma prevalence has begun to decline in some western countries, but there is...
Source: Current Opinion in Allergy and Clinical Immunology - January 24, 2013 Category: Allergy & Immunology Tags: MECHANISMS OF ALLERGY AND ADULT ASTHMA: Edited by Stephen T. Holgate and J. Andrew Grant Source Type: research

Ketotifen in the management of chronic urticaria: resurrection of an old drug.
PMID: 24267353 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - November 29, 2013 Category: Allergy & Immunology Authors: Sokol KC, Amar NK, Starkey J, Grant JA Tags: Ann Allergy Asthma Immunol Source Type: research

Allergen-encoded signals that control allergic responses
Purpose of review: The purpose is to review the important recent advances made in how innate immune cells, microbes, and the environment contribute to the expression of allergic disease, emphasizing the allergen-related signals that drive allergic responses. Recent findings: The last few years have seen crucial advances in how innate immune cells such as innate lymphoid cells group 2 and airway epithelial cells and related molecular pathways through organismal proteinases and innate immune cytokines, such as thymic stromal lymphopoietin, IL-25, and IL-33 contribute to allergy and asthma. Simultaneously with these advances,...
Source: Current Opinion in Allergy and Clinical Immunology - December 23, 2015 Category: Allergy & Immunology Tags: MECHANISMS OF ALLERGY AND ADULT ASTHMA: Edited by J. Andrew Grant and Peter Howarth Source Type: research

The personal financial burden of chronic rhinosinusitis: A Canadian perspective.
CONCLUSION: Total OOPEs incurred from the treatment of CRS may amount to CAD $607.10 [U.S. $614.06] per patient per year, within the context of a single-payer health care system. Managing clinicians should be aware of patient groups with a greater perceived financial burden and consider counseling them on strategies to offset expenses, including obtaining travel grants, using telemedicine for follow-up assessments, providing drug samples, and streamlining diagnostic testing with medical visits. PMID: 28716171 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - July 1, 2017 Category: ENT & OMF Authors: Yip J, Vescan AD, Witterick IJ, Monteiro E Tags: Am J Rhinol Allergy Source Type: research

Strategies to reduce corticosteroid-related adverse events in asthma
Purpose of review Severe asthmatics, despite the chronic use of high inhaled corticosteroids (ICS) doses and frequent intake of systemic corticosteroids, remains clinically and/or functionally uncontrolled. These patients are also often affected by rhinitis or chronic rhinosinusitis requiring frequent use of intranasal corticosteroids. Therefore, severe asthmatics are exposed to an overload of corticosteroids that is frequently associated with relevant and costly adverse events. This clinical problem and the strategies to overcome it are here summarized. Recent findings Different therapeutic options may help in reduci...
Source: Current Opinion in Allergy and Clinical Immunology - December 20, 2018 Category: Allergy & Immunology Tags: MECHANISMS OF ALLERGY AND ADULT ASTHMA: Edited by J. Andrew Grant and Enrico Heffler Source Type: research

Association of Prescription Opioid Use for Chronic Pain Syndromes with Asthma and Allergy
Opioids have, in addition to analgesic properties, immune altering effects including upregulation of Th2 responses. Whether this has clinical expression in altering asthma and allergic responses has not been determined. We hypothesize that in patients with chronic pain conditions, there is an increased prevalence of asthma and allergy when prescribed opioid medications.
Source: Journal of Allergy and Clinical Immunology - February 1, 2019 Category: Allergy & Immunology Authors: Roshni Naik, Grant Goodrich, Deepti Vellaichamy Manian, Anmol Goyal, Karina Rotella, Taha Al-Shaikhly, Rauno Joks Source Type: research