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Total 109399 results found since Jan 2013.
Comparative Studies of Essential Oil Composition and Biological Activities of Callistemon citrinus from western Himalaya
Chem Biodivers. 2023 Sep 20:e202301129. doi: 10.1002/cbdv.202301129. Online ahead of print.ABSTRACTThis work described a comprehensive study to estimate chemical constituents of essential oils (EOs) extracted from different parts of the Callistemon citrinus viz: fruits, leaves and aerial part. The EOs were characterized using physicochemical parameters, and GC-FID/MS. It was observed that among different parts, aerial part has the highest oil yield (0.90%) followed by leaves and fruits. Further, seventeen compounds were characterized, and represented total amount (97.2-99.5%) with domination of monoterpenes (12.5-34.6%) an...
Source: Chemistry and Biodiversity - September 20, 2023 Category: Biochemistry Authors: Sachin Vashisath Smita Kapoor Vandana Kumari Shabana Butt Dinesh Kumar Source Type: research
The Warburg effect on radioresistance: Survival beyond growth
Biochim Biophys Acta Rev Cancer. 2023 Sep 17:188988. doi: 10.1016/j.bbcan.2023.188988. Online ahead of print.ABSTRACTThe Warburg effect is a phenomenon in which cancer cells rely primarily on glycolysis rather than oxidative phosphorylation, even in the presence of oxygen. Although evidence of its involvement in cell proliferation has been discovered, the advantages of the Warburg effect in cancer cell survival under treatment have not been fully elucidated. In recent years, the metabolic characteristics of radioresistant cancer cells have been evaluated, enabling an extension of the original concept of the Warburg effect....
Source: Biochimica et Biophysica Acta - September 19, 2023 Category: Biochemistry Authors: Hyunkoo Kang Byeongsoo Kim Junhyeong Park HyeSook Youn BuHyun Youn Source Type: research
Importance of aspartate 4 in the Mg < sup > 2+ < /sup > dependent regulation of Leishmania major PAS domain-containing phosphoglycerate kinase
Biochim Biophys Acta Proteins Proteom. 2023 Sep 17:140964. doi: 10.1016/j.bbapap.2023.140964. Online ahead of print.ABSTRACTMagnesium is an important divalent cation for the regulation of catalytic activity. Recently, we have described that the Mg2+ binding through the PAS domain inhibits the phosphoglycerate kinase (PGK) activity in PAS domain-containing PGK from Leishmania major (LmPAS-PGK) at neutral pH 7.5, but PGK activity is derepressed at acidic pH 5.5. The acidic residue within the PAS domain of LmPAS-PGK is expected to bind the cofactor Mg2+ ion at neutral pH, but which specific acidic residue(s) is/are responsibl...
Source: Biochimica et Biophysica Acta - September 19, 2023 Category: Biochemistry Authors: Gaurab Chowdhury Saroj Biswas Yuthika Dholey Puja Panja Sumit Das Subrata Adak Source Type: research
Long-term intake of α-glycerophosphocholine (GPC) suppresses microglial inflammation and blood-brain barrier (BBB) disruption and promotes neurogenesis in senescence-accelerated mice prone 8 (SAMP8)
Biosci Biotechnol Biochem. 2023 Sep 18:zbad135. doi: 10.1093/bbb/zbad135. Online ahead of print.ABSTRACTWe evaluated the effects of long-term glycerophosphocholine (GPC) intake on microglia, the blood-brain barrier (BBB), and neurogenesis in senescence-accelerated mice prone 8 (SAMP8). The GPC intake suppressed microglial activation and BBB disruption and sustained doublecortin (DCX)-positive cells in the hippocampus. The results indicate that GPC intake exerts anti-inflammatory and neuroprotective effects in the brain of aged mice.PMID:37723613 | DOI:10.1093/bbb/zbad135
Source: Bioscience, Biotechnology, and Biochemistry - September 19, 2023 Category: Biochemistry Authors: Mitsuki Umino Mayumi Okuda Takeshi Ohkubo Tsutomu Fujii Kiminori Matsubara Source Type: research
Metallic trace elements in marine sponges living in a semi-enclosed tropical lagoon
This study examined the concentration of metallic trace elements (MTE) in two marine sponges, Rhabdastrella globostellata and Hyrtios erectus, from three sampling zones of the semi-enclosed Bouraké Lagoon (New Caledonia, South West Pacific). MTE in sponge tissues, seawater, and surrounding sediments was measured using inductively coupled plasma with optical emission spectroscopy. The variability in sponge MTE concentrations between species and sampling zones was visually discriminated using a principal component analysis (PCA). Sponges showed Fe, Mn, Cr, Ni, and Zn concentrations 2 to 10 times higher than in the surroundi...
Source: Biometals - September 19, 2023 Category: Biochemistry Authors: Federica Maggioni Pierre-Louis Stenger Yves Letourneur Philippe Jourand Clarisse Majorel Source Type: research
Long-term intake of α-glycerophosphocholine (GPC) suppresses microglial inflammation and blood-brain barrier (BBB) disruption and promotes neurogenesis in senescence-accelerated mice prone 8 (SAMP8)
Biosci Biotechnol Biochem. 2023 Sep 18:zbad135. doi: 10.1093/bbb/zbad135. Online ahead of print.ABSTRACTWe evaluated the effects of long-term glycerophosphocholine (GPC) intake on microglia, the blood-brain barrier (BBB), and neurogenesis in senescence-accelerated mice prone 8 (SAMP8). The GPC intake suppressed microglial activation and BBB disruption and sustained doublecortin (DCX)-positive cells in the hippocampus. The results indicate that GPC intake exerts anti-inflammatory and neuroprotective effects in the brain of aged mice.PMID:37723613 | DOI:10.1093/bbb/zbad135
Source: Bioscience, Biotechnology, and Biochemistry - September 19, 2023 Category: Biochemistry Authors: Mitsuki Umino Mayumi Okuda Takeshi Ohkubo Tsutomu Fujii Kiminori Matsubara Source Type: research
Amino acid metabolism dysregulation associated with inflammation and insulin resistance in HIV-infected individuals with metabolic disorders
In this study, we performed targeted metabolomic analyses on 64 patients with HIV/AIDS and 21 healthy controls. Twenty-four amino acids and selected intermediate metabolites in the serum were quantitatively detected using high-performance liquid chromatography-tandem mass spectrometry, and characteristic changes and metabolic pathways were analyzed in HIV-infected patients with different degrees of abnormal glucose and lipid metabolism. Spearman's partial correlation was used to analyze the association between amino acids, biochemical parameters, and inflammatory cytokines. The results showed that the main metabolic pathwa...
Source: Amino Acids - September 19, 2023 Category: Biochemistry Authors: Jing Zhang Yanfang Chen Mingli Wang Liuting Zhong Linghua Li Zhongwen Yuan Shangrong Zou Source Type: research
Untargeted metabolomics analysis of plasma metabolic characteristics in patients with acne and insulin resistance
This study aimed to identify significantly different metabolites and related metabolic pathways in the serum of acne vulgaris patients with or without insulin resistance. LC-MS/MS was used to analyze serum samples from patients about acne with insulin resistance (n = 51) and acne without insulin resistance (n = 69) to identify significant metabolites and metabolic pathways. In this study, 18 significant differential metabolites were screened for the first time. In the positive-ion mode, the upregulated substances were creatine, sarcosine, D-proline, uracil, Phe-Phe, L-pipecolic acid, and DL-phenylalanine; the downregulated...
Source: Amino Acids - September 19, 2023 Category: Biochemistry Authors: Qingqing He Huiling Shu Yu Peng Yang Xu Li Liu Jie Zhou Juan Zhao Xia Xiong Changqiang Li Source Type: research
Apoptin NLS2 homodimerization strategy for improved antibacterial activity and bio-stability
In conclusion, these results suggest that nuclear localization sequence with a modified dimeric approach could represent a rich source of template for designing future antimicrobial peptides.PMID:37725185 | DOI:10.1007/s00726-023-03321-1
Source: Amino Acids - September 19, 2023 Category: Biochemistry Authors: Anu Kumari Mahavir Singh Ruchi Sharma Tarun Kumar Naresh Jindal Sushila Maan Vinay G Joshi Source Type: research
Serum branched amino acids and the risk of all-cause mortality: a meta-analysis and systematic review
Amino Acids. 2023 Sep 19. doi: 10.1007/s00726-023-03329-7. Online ahead of print.ABSTRACTRecently, the serum levels of branched-chain amino acids (BCAAs) have been considered as an indicator to evaluate health status and predict chronic diseases risk. This systematic review and meta-analysis aimed to assess the relationship between Serum BCAAs and the risk of all-cause mortality. We carried out a comprehensive and systematic search in various important databases, including PubMed, Scopus, and Web of Science databases to find the relevant studies published up to October 2022 with no language, design, or time limitation. We ...
Source: Amino Acids - September 19, 2023 Category: Biochemistry Authors: Farshad Teymoori Hamid Ahmadirad Mitra Kazemi Jahromi Ebrahim Mokhtari Hossein Farhadnejad Milad Mohammadzadeh Mitra Babrpanjeh Tahere Shahrokhtabar Sanaz Jamshidi Parvin Mirmiran Source Type: research
Jinfukang inhibits clustering and invasion of circulating lung tumor cells by regulating the EGFR signaling pathway
Acta Biochim Biophys Sin (Shanghai). 2023 Sep 18. doi: 10.3724/abbs.2023148. Online ahead of print.NO ABSTRACTPMID:37723875 | DOI:10.3724/abbs.2023148
Source: Acta Biochimica et Biophysica Sinica - September 19, 2023 Category: Biochemistry Authors: Yun Yang Lihua Zhu Jiajun Liu Pan Yu Zujun Que Yan Li Hegen Li Jianhui Tian Source Type: research
LncRNA AP000695.2 promotes glycolysis of lung adenocarcinoma via the miR-335-3p/TEAD1 axis
This study aims to verify and explore the mechanism of AP000695.2 in glycolysis of LUAD. Overexpression plasmid and siRNA are used to construct cell models of upregulation and downregulation of AP000695.2, respectively. AP000695.2 is highly expressed in lung cancer cell lines as revealed by qPCR. Western blot analysis, FDG uptake, lactate production assay and ECAR determination results show that high expression of AP000695.2 facilitates glycolysis of LUAD cells. CCK-8, EdU staining, Transwell and wound healing assays show that high expression of AP000695.2 promotes cell growth and migration of LUAD. The relationship betwee...
Source: Acta Biochimica et Biophysica Sinica - September 19, 2023 Category: Biochemistry Authors: Shuoyan Xu Zhiming Cheng Bulin Du Yao Diao Yaming Li Xuena Li Source Type: research
MicroRNA-411-3p motivates methotrexate's cellular uptake and cytotoxicity via targeting Yin-yang 1 in leukemia cells
This study aimed to figure out how microRNA (miR)-411-3p's impacts on methotrexate (MTX)'s cellular uptake and cytotoxicity in acute lymphoblastic leukaemia (ALL) CEM-C1 cells by targeting Yin-yang 1 (YY1). miR-411-3p and YY1 were detected by RT-qPCR or Western blot. Intracellular MTX concentration was measured by enzyme-linked immunosorbent assay. Cell viability and apoptosis were evaluated by CCK-8, clonal formation assay, and flow cytometry. Verification of miR-411-3p and YY1's targeting link was manifested. It came out that miR-411-3p mimic or si-YY1 elevated intracellular MTX, MTX-induced cytotoxicity and apoptosis ra...
Source: Acta Biochim Pol - September 19, 2023 Category: Biochemistry Authors: HuiJing Sun ShuGuang Zhou ZhouSheng Yang MingYu Meng Yan Dai XinYe Li XiaoYu Chen Source Type: research
Paxillin interactome identified by SILAC and label-free approaches coupled to TurboID sheds light on the compositions of focal adhesions in mouse embryonic stem cells
This study illustrates the effectiveness of TurboID in mESCs. Importantly, we found that application of both SILAC and LF methods in combination allowed us to analyze the TurboID proteomics data in an unbiased, stringent and yet comprehensive manner.PMID:37725837 | DOI:10.1016/j.bbrc.2023.09.017
Source: Biochemical and Biophysical Research communications - September 19, 2023 Category: Biochemistry Authors: Qianqian He Siu Kwan Sze Kai Soon Ng Cheng-Gee Koh Source Type: research
Estrogen sulfotransferase SULT1E1 expression levels and regulated factors in malignant tumours
Protein Pept Lett. 2023 Sep 15. doi: 10.2174/0929866530666230915103418. Online ahead of print.ABSTRACTEstrogen plays a key role in the development and progression of many malignant tumours, and the regulation of estrogen levels involves several metabolic pathways. Among these pathways, estrogen sulfotransferase (SULT1E1) is the enzyme with the most affinity for estrogen and is primarily responsible for catalysing the metabolic reaction of estrogen sulphation. Relevant studies have shown significant differences in the expression of SULT1E1 in different malignant tumours, suggesting that SULT1E1 plays a dual role in malignan...
Source: Protein and Peptide Letters - September 19, 2023 Category: Biochemistry Authors: Rui Wang Xia Li Yangyang Li Mengjie Zhao Lida Mi Weiwei Chen Jianxiang Song Source Type: research
