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Nutrition: Calcium
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Insights into the mediation of Ca < sup > 2+ < /sup > signaling in the promoting effects of LETX-VI on the synthesis and release of dopamine
J Cell Commun Signal. 2023 Sep 13. doi: 10.1007/s12079-023-00783-6. Online ahead of print.ABSTRACTLatroeggtoxin-VI (LETX-VI) is an active protein and was previously demonstrated to have effects on the synthesis and release of dopamine. Hererin, the involvement of Ca2+ signaling in the effects of LETX-VI on dopamine was systematically investigated, using PC12 cells as a neuron model. LETX-VI was shown to promote dopamine release from PC12 cells both in the presence and absence of extracellular Ca2+; however the presence of extracellular Ca2+ was favorable for enhancing the promoting effects of LETX-VI on dopamine, because L...
Source: Journal of Cell Communication and Signaling - September 13, 2023 Category: Molecular Biology Authors: Zhixiang Lei Haiyan Wang Yiwen Zhai Minglu Sun Si Chen Panfeng Yin Xianchun Wang Source Type: research
Contribution of school meals to the recommended nutrient and energy intake of children enrolled in the National Homegrown School Feeding Program in Zaria, Nigeria
CONCLUSION: The meals served through the NHSFP contributed at least 33% of the RNI for energy, protein, iron, calcium, sodium, vitamin A, and zinc. However, they could not meet the 33% of the RNI for carbohydrates, fiber, potassium, and vitamin C. Increasing the portion sizes and the diversity of the meals can address the suboptimal contribution of the meals to the RNI for carbohydrates, fiber, potassium, and vitamin C.PMID:37704525 | DOI:10.1016/j.arcped.2023.07.004
Source: Archives de Pediatrie - September 13, 2023 Category: Pediatrics Authors: Halliru Zailani Olumuyiwa Adeyemi Owolabi Abdullahi Balarabe Sallau Source Type: research
Effect of propolis on membrane bound enzymes linked with breast cancer
Bioinformation. 2022 Dec 31;18(12):1192-1195. doi: 10.6026/973206300181192. eCollection 2022.ABSTRACTAccording to estimates from the World Health Organization [WHO], in 2020, 685000 people worldwide died and 2.3 million women were diagnosed with breast cancer. Breast cancer will be the most common cancer in the world by the end of 2020, when 7.8 million women will still be living who had received a diagnosis within the previous five years. The current study was formulated to note the effects of ethanolic extract of Propolis and Withaferin-A on Breast tumor initiation by benzo(a)pyrene [B(a)p], and its effects on ATPase enz...
Source: Bioinformation - September 13, 2023 Category: Bioinformatics Authors: Sadhasivan Meghalatha Thazhathuputhenpurayil Muninathan Natarajan Source Type: research
SMOC2 promoted vascular smooth muscle cell proliferation, migration, and extracellular matrix degradation by activating BMP/TGF- β1 signaling pathway
J Clin Biochem Nutr. 2023 Sep;73(2):116-123. doi: 10.3164/jcbn.22-100. Epub 2023 Jul 5.ABSTRACTA widespread degenerative condition of the aorta, abdominal aortic aneurysm (AAA), severely endangers the health of middle-aged and elderly people. SPARC related modular calcium binding2 (SMOC2) is upregulated in the carotid arteries of rats with atherosclerotic lesions, but its function in AAA is still unknown. Therefore, the aim of this research was to evaluate the function of SMOC2 in AAA. The results showed that in the AAA tissues, SMOC2 expression was upregulated compared with healthy controls. Overexpression of SMOC2 promot...
Source: Clinical Biochemistry - September 13, 2023 Category: Biochemistry Authors: Xiaowei Wang Meng Wang Zhongxiao Zhou Xin Zou Guoxin Song Qingsong Zhang Haimeng Zhou Source Type: research
Interaction of quercetin and its derivatives with Ca2+-ATPase from sarcoplasmic reticulum: Kinetic and molecular modeling studies
Gen Physiol Biophys. 2023 Sep;42(5):457-468. doi: 10.4149/gpb_2023020.ABSTRACTSarcoplasmic reticulum Ca2+-ATPases (SERCAs) regulate cellular calcium homeostasis and are targeted for age-related diseases. Among 14 SERCA mRNA splice variants, SERCA1a is specific to adult fast-twitch skeletal muscle. Quercetin derivatives (monochloropivaloylquercetin (CPQ), IC50 = 195.7 µM; 2-chloro-1,4-naphthoquinonequercetin (CHNQ), IC50 = 60.3 µM) were studied for their impact on SERCA1a using molecular modeling and enzyme kinetics. While there were some similarities in kinetic parameters and molecular modeling, the compounds exhibited d...
Source: General Physiology and Biophysics - September 13, 2023 Category: Physiology Authors: Petronela Rezbarikova Jana Viskupicova Magdalena Majekova Lubica Horakova Source Type: research
Mitochondrial Calcium Uniporter (MCU) that Modulates Mitochondrial Calcium Uptake and Facilitates Endometrial Cancer Progression through Interaction with VDAC1
CONCLUSION: This investigation demonstrated that MCU-induced mitochondrial calcium uptake plays a critical role in endometrial tumorigenesis through interaction with VDAC1.PMID:37702230 | DOI:10.2174/1568009624666230912095526
Source: Current Cancer Drug Targets - September 13, 2023 Category: Cancer & Oncology Authors: Hongyan Xiao Lijun Ma Jie Ding Honghong Wang Xiaofang Bi Fengmei Tan Wenhua Piao Source Type: research
Model-Informed Dosing Regimen of Ticagrelor in Chinese Patients with Acute Coronary Syndrome
Clin Pharmacol Ther. 2023 Sep 13. doi: 10.1002/cpt.3048. Online ahead of print.ABSTRACTThe exposure to ticagrelor is higher in the East Asian population compared to the Caucasian population, thus, East Asians have an increased risk of bleeding. We developed a population pharmacokinetic model of ticagrelor based on a randomized 3 × 3 crossover study in healthy subjects. The area under concentration-time curve (AUC) of Chinese patients with acute coronary syndrome was simulated based on this model. Following this, eight machine learning methods were used to construct bleeding risk models. Variables included in the final ble...
Source: Clinical Pharmacology and Therapeutics - September 13, 2023 Category: Drugs & Pharmacology Authors: Yaxin Liu Yun Kuang Min Hai Cheng Cui Dongyang Liu Guoping Yang Source Type: research
Contribution of school meals to the recommended nutrient and energy intake of children enrolled in the National Homegrown School Feeding Program in Zaria, Nigeria
CONCLUSION: The meals served through the NHSFP contributed at least 33% of the RNI for energy, protein, iron, calcium, sodium, vitamin A, and zinc. However, they could not meet the 33% of the RNI for carbohydrates, fiber, potassium, and vitamin C. Increasing the portion sizes and the diversity of the meals can address the suboptimal contribution of the meals to the RNI for carbohydrates, fiber, potassium, and vitamin C.PMID:37704525 | DOI:10.1016/j.arcped.2023.07.004
Source: Archives de Pediatrie - September 13, 2023 Category: Pediatrics Authors: Halliru Zailani Olumuyiwa Adeyemi Owolabi Abdullahi Balarabe Sallau Source Type: research
Insights into the mediation of Ca < sup > 2+ < /sup > signaling in the promoting effects of LETX-VI on the synthesis and release of dopamine
J Cell Commun Signal. 2023 Sep 13. doi: 10.1007/s12079-023-00783-6. Online ahead of print.ABSTRACTLatroeggtoxin-VI (LETX-VI) is an active protein and was previously demonstrated to have effects on the synthesis and release of dopamine. Hererin, the involvement of Ca2+ signaling in the effects of LETX-VI on dopamine was systematically investigated, using PC12 cells as a neuron model. LETX-VI was shown to promote dopamine release from PC12 cells both in the presence and absence of extracellular Ca2+; however the presence of extracellular Ca2+ was favorable for enhancing the promoting effects of LETX-VI on dopamine, because L...
Source: Journal of Cell Communication and Signaling - September 13, 2023 Category: Molecular Biology Authors: Zhixiang Lei Haiyan Wang Yiwen Zhai Minglu Sun Si Chen Panfeng Yin Xianchun Wang Source Type: research
Mitochondrial Calcium Uniporter (MCU) that Modulates Mitochondrial Calcium Uptake and Facilitates Endometrial Cancer Progression through Interaction with VDAC1
CONCLUSION: This investigation demonstrated that MCU-induced mitochondrial calcium uptake plays a critical role in endometrial tumorigenesis through interaction with VDAC1.PMID:37702230 | DOI:10.2174/1568009624666230912095526
Source: Current Cancer Drug Targets - September 13, 2023 Category: Cancer & Oncology Authors: Hongyan Xiao Lijun Ma Jie Ding Honghong Wang Xiaofang Bi Fengmei Tan Wenhua Piao Source Type: research
Deubiquitinase USP19 modulates apoptotic calcium release and endoplasmic reticulum stress by deubiquitinating BAG6 in triple negative breast cancer
CONCLUSIONS: Our study reveals that USP19 elevates the intracellular Ca2+ concentration to alter ER stress via regulation of BAG6 and BCL2 stability and may be a viable therapeutic target for TNBC therapy.PMID:37700495 | PMC:PMC10497826 | DOI:10.1002/ctm2.1398
Source: Clinical Genitourinary Cancer - September 13, 2023 Category: Cancer & Oncology Authors: Xiaoqiang Zhang Xuyu Chen Fangze Qian Yanhui Zhu Gao He Junzhe Yang Xian Wu Hongfei Zhang Xiafei Yu Xiaoan Liu Source Type: research
Model-Informed Dosing Regimen of Ticagrelor in Chinese Patients with Acute Coronary Syndrome
Clin Pharmacol Ther. 2023 Sep 13. doi: 10.1002/cpt.3048. Online ahead of print.ABSTRACTThe exposure to ticagrelor is higher in the East Asian population compared to the Caucasian population, thus, East Asians have an increased risk of bleeding. We developed a population pharmacokinetic model of ticagrelor based on a randomized 3 × 3 crossover study in healthy subjects. The area under concentration-time curve (AUC) of Chinese patients with acute coronary syndrome was simulated based on this model. Following this, eight machine learning methods were used to construct bleeding risk models. Variables included in the final ble...
Source: Clinical Pharmacology and Therapeutics - September 13, 2023 Category: Drugs & Pharmacology Authors: Yaxin Liu Yun Kuang Min Hai Cheng Cui Dongyang Liu Guoping Yang Source Type: research
ABO blood type correlates with risk and protective factors for chronic suppurative otitis media
CONCLUSIONS AND SIGNIFICANCE: Our study identified the risk and protective factors for CSOM among different blood types. The findings might provide new insights into taking precautions against CSOM in people of different blood types.PMID:37702578 | DOI:10.1080/00016489.2023.2252031
Source: Acta Oto-Laryngologica - September 13, 2023 Category: ENT & OMF Authors: Junli Wang Bin Chen Ying Gao Juan Hu Zichen Chen Yan Zhang Source Type: research
Effect of propolis on membrane bound enzymes linked with breast cancer
Bioinformation. 2022 Dec 31;18(12):1192-1195. doi: 10.6026/973206300181192. eCollection 2022.ABSTRACTAccording to estimates from the World Health Organization [WHO], in 2020, 685000 people worldwide died and 2.3 million women were diagnosed with breast cancer. Breast cancer will be the most common cancer in the world by the end of 2020, when 7.8 million women will still be living who had received a diagnosis within the previous five years. The current study was formulated to note the effects of ethanolic extract of Propolis and Withaferin-A on Breast tumor initiation by benzo(a)pyrene [B(a)p], and its effects on ATPase enz...
Source: Bioinformation - September 13, 2023 Category: Bioinformatics Authors: Sadhasivan Meghalatha Thazhathuputhenpurayil Muninathan Natarajan Source Type: research
