Food and Drug Administration (FDA) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus Infection in Domestic Dairy Cattle and Cats, United States, 2024
We report highly pathogenic avian influenza A(H5N1) virus in dairy cattle and cats in Kansas and Texas, United States, which reflects the continued spread of clade 2.3.4.4b viruses that entered the country in late 2021. Infected cattle experienced nonspecific illness, reduced feed intake and rumination, and an abrupt drop in milk production, but fatal systemic influenza infection developed in domestic cats fed raw (unpasteurized) colostrum and milk from affected cows. Cow-to-cow transmission appears to have occurred because infections were observed in cattle on Michigan, Idaho, and Ohio farms where avian influenza virus-in...
Source: Emerging Infectious Diseases - April 29, 2024 Category: Infectious Diseases Authors: Eric R Burrough Drew R Magstadt Barbara Petersen Simon J Timmermans Phillip C Gauger Jianqiang Zhang Chris Siepker Marta Mainenti Ganwu Li Alexis C Thompson Patrick J Gorden Paul J Plummer Rodger Main Source Type: research

Hematopoietic Stem Cell Transplantation in Sickle Cell Disease: A Multidimentional Review
Cell Transplant. 2024 Jan-Dec;33:9636897241246351. doi: 10.1177/09636897241246351.ABSTRACTWhile exagamglogene autotemcel (Casgevy) and lovotibeglogene autotemcel (Lyfgenia) have been approved by the US Food and Drug Administration (FDA) as the first cell-based gene therapies for the treatment of patients 12 years of age and older with sickle cell disease (SCD), this treatment is not universally accessible. Allogeneic hematopoietic stem cell transplant (HSCT) has the potential to eradicate the symptoms of patients with SCD, but a significant obstacle in HSCT for SCD is the availability of suitable donors, particularly human...
Source: Cell Transplantation - April 29, 2024 Category: Cytology Authors: Tahereh Rostami Soroush Rad Mohammad Reza Rostami Seied Amirhossein Mirhosseini Hediyeh Alemi Naghmeh Khavandgar Ghasem Janbabai Azadeh Kiumarsi Amir Kasaeian Seied Asadollah Mousavi Source Type: research

Transfusion management and hemoglobin-based oxygen carrier treatment in a patient with anti-Rh17 antibody
DISCUSSION: Overall difficulties in this case included the challenge of finding compatible units, dilemma of transfusing incompatible units in a patient with severe anemia and obtaining alternatives to blood products. This case report demonstrates the successful use of HBOC-21 in treating life-threatening anemia.PMID:38682958 | DOI:10.1111/trf.17855 (Source: Transfusion)
Source: Transfusion - April 29, 2024 Category: Hematology Authors: Noah Mehr Christine Fuja Cody Simon Timothy Carll Rahaf Alkhateb Sulin Wu Anand A Patel Fatima Aldarweesh Source Type: research

Molecules, Vol. 29, Pages 2050: Application of Deferoxamine in Tissue Regeneration Attributed to Promoted Angiogenesis
Ran Zhang Deferoxamine, an iron chelator used to treat diseases caused by excess iron, has had a Food and Drug Administration-approved status for many years. A large number of studies have confirmed that deferoxamine can reduce inflammatory response and promote angiogenesis. Blood vessels play a crucial role in sustaining vital life by facilitating the delivery of immune cells, oxygen, and nutrients, as well as eliminating waste products generated during cellular metabolism. Dysfunction in blood vessels may contribute significantly to the development of life-threatening diseases. Anti-angiogenesis therapy and pro-ang...
Source: Molecules - April 29, 2024 Category: Chemistry Authors: Haijun Shen Yane Ma Yi Qiao Chun Zhang Jialing Chen Ran Zhang Tags: Review Source Type: research

At-Home Diagnostics Solutions for Chlamydia and Gonorrhea
This Viewpoint discusses the US Food and Drug Administration ’s authorization of marketing an at-home testing system for chlamydia and gonorrhea as a good first step in boosting access to screening and treatment and in reducing infection rates. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 29, 2024 Category: General Medicine Source Type: research

Medical Management of Inflammatory Bowel Disease
This article highlights several key trials and discusses modern treatment paradigms for both UC and CD based on disease severity.PMID:38677828 | DOI:10.1016/j.suc.2023.12.005 (Source: The Surgical Clinics of North America)
Source: The Surgical Clinics of North America - April 27, 2024 Category: Surgery Authors: Shahrose Rahman Ranish K Patel Elisa Boden Vassiliki Liana Tsikitis Source Type: research

When Patient Diversity Informs Formulation: Reimagining Treatment for Seborrheic Dermatitis
AbstractSeborrheic dermatitis (SD) impacts a diverse demographic, with treatment effectiveness and suitability varying across hair types and cultural practices. Available shampoo treatments contain surfactants that compromise hair moisture and integrity as well as requiring frequent use, which may not align with the routines of various hair types and cultural hair care practices. Most available topical foams and gels contain high concentrations of drying alcohols that damage hair color and moisture. Newly US Food and Drug Administration (FDA)-approved roflumilast 0.3% foam presents a significant advancement in the treatmen...
Source: Dermatology and Therapy - April 27, 2024 Category: Dermatology Source Type: research