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Vaccination: AIDS Vaccine
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Total 1157 results found since Jan 2013.
Sexual and reproductive health needs of young women living with perinatally acquired HIV
CONCLUSION: High rates of unplanned pregnancy, STIs and cervical abnormalities highlight the continuing SRH needs of YWLPaHIV and requirement for open access to integrated HIV/SRH services despite pandemic restrictions.PMID:37279784 | DOI:10.1177/09564624231179768
Source: Herpes - June 6, 2023 Category: Infectious Diseases Authors: Veronica R Nott George A Hazell Sara Ayres Natalie Kirkhope Sarah Fidler Caroline Foster Source Type: research
In Silico Tool for Identification, Designing, and Searching of IL13-Inducing Peptides in Antigens
Methods Mol Biol. 2023;2673:329-338. doi: 10.1007/978-1-0716-3239-0_23.ABSTRACTInterleukins are a distinctive class of molecules exhibiting various immune signaling functions. Immunoregulatory cytokine, Interleukin 13 (IL13), is primarily synthesized by activated T-helper 2 cells, mast cells, and basophils. IL13, is known to stimulate many allergic and autoimmune diseases, such as asthma, rheumatoid arthritis, systemic sclerosis, ulcerative colitis, airway hyperresponsiveness, glycoprotein hypersecretion, and goblet cell hyperplasia. In addition to such disorders, IL13 also leads to carcinogenesis by inhibiting tumor immun...
Source: Mol Biol Cell - May 31, 2023 Category: Molecular Biology Authors: Shipra Jain Anjali Dhall Sumeet Patiyal Gajendra P S Raghava Source Type: research
Production of monoclonal antibodies for therapeutic purposes: A review
Int Immunopharmacol. 2023 May 25;120:110376. doi: 10.1016/j.intimp.2023.110376. Online ahead of print.ABSTRACTMonoclonal antibodies (mAbs) have been used in the development of immunotherapies that target a variety of diseases, such as cancer, autoimmune diseases, and even viral infections; they play a key role in immunization and are expected after vaccination. However, some conditions do not promote the development of neutralizing antibodies. Production and use of mAbs, generated in biofactories, represent vast potential as aids in immunological responses when the organism cannot produce them on their own, these convey un...
Source: International Immunopharmacology - May 27, 2023 Category: Allergy & Immunology Authors: Waller-Pulido Alejandra Jim énez-Pérez Miriam Irene Gonzalez-Sanchez Fabio Antonio Rojo-Gutierrez Rocio Patricia Torres-Anguiano Elizabeth Aleman-Aguilar Juan Pablo Garcia-Varela Rebeca Source Type: research
Conserved multiepitope vaccine constructs: A potent HIV-1 therapeutic vaccine in clinical trials
In this study, we used the PubMed and ClinicalTrial.gov databases to review the rationale of designing curative HIV-1 vaccine immunogens based on the conserved favorable site of the virus. Most of these studies evaluate the efficacy of vaccine candidates in combination with other therapeutics and/or with new formulations and immunization protocols. This review briefly describes the design of conserved multiepitope constructs and outlines the results of these vaccine candidates in the recent clinical pipeline.PMID:37156468 | DOI:10.1016/j.bjid.2023.102774
Source: Braz J Infect Dis - May 8, 2023 Category: Infectious Diseases Authors: Elahe Akbari Masoud Seyedinkhorasani Azam Bolhassani Source Type: research
Effects of public health emergencies of international concern on disease control: a systematic review
CONCLUSIONS: Socioeconomic inequity is a determinant of the effects of public health emergencies of international concern within affected populations. The diversion of resources and attention from health authorities disproportionately affects vulnerable populations and can lead, over time, to a weakening of health systems. The analysis of the effects of public health emergencies is important for the development of new protocols that can better respond to future crises.PMID:37089787 | PMC:PMC10120386 | DOI:10.26633/RPSP.2023.74
Source: Pan American Journal of Public Health - April 24, 2023 Category: International Medicine & Public Health Authors: Giovanna Rotondo de Ara újo Pedro A S V de Castro Isabela R Ávila Juliana Maria T Bezerra David S Barbosa Source Type: research
Response to HIV-1 gp160-carrying recombinant virus HSV-1 and HIV-1 VLP combined vaccine in BALB/c mice
Front Microbiol. 2023 Mar 17;14:1136664. doi: 10.3389/fmicb.2023.1136664. eCollection 2023.ABSTRACTHuman immunodeficiency virus (HIV) induced AIDS causes a large number of infections and deaths worldwide every year, still no vaccines are available to prevent infection. Recombinant herpes simplex virus type 1 (HSV-1) vector-based vaccines coding the target proteins of other pathogens have been widely used for disease control. Here, a recombinant virus with HIV-1 gp160 gene integration into the internal reverse (IR) region-deleted HSV-1 vector (HSV-BAC), was obtained by bacterial artificial chromosome (BAC) technology, and i...
Source: Herpes - April 3, 2023 Category: Infectious Diseases Authors: Beibei Zhang Hongyan Mao Hongjuan Zhu Jingxia Guo Paul Zhou Zhenghai Ma Source Type: research
Role of Low-Risk HPV PCR Monoinfection in Screening for HSIL and Anal Cancer in Men Who Have Sex with Men Living with HIV
Int J Mol Sci. 2023 Mar 15;24(6):5642. doi: 10.3390/ijms24065642.ABSTRACTTo determine the value of low-risk human papillomavirus (HPV) PCR to screen for "high-grade anal squamous intraepithelial lesion and anal cancer" (HSIL-plus), rate of patients with low-grade anal squamous intraepithelial lesion (LSIL) progressing to HSIL-plus, and progression-related factors. Prospective, longitudinal study of consecutive MSM-LHIV attended between May 2010 and December 2021 and followed for 43 months (IQR: 12-76). HIV-related variables were gathered at baseline, performing anal cytology for HPV detection/genotyping, thin-layer cytolog...
Source: Anal Sci - March 29, 2023 Category: Chemistry Authors: Carmen Mar ía García-Martínez Inmaculada Calle-G ómez Javier L ópez-Hidalgo Patricia G ómez-Ronquillo Mohamed Omar-Mohamed Balgahata Carmen Hidalgo-Tenorio Source Type: research
Health care provider knowledge around shared clinical decision-making regarding HPV vaccination of adults aged 27-45 years in the United States
CONCLUSIONS: Findings suggest that there are physician knowledge gaps related to SCDM for HPV vaccination. To improve access to HPV vaccination for people most likely to benefit, increasing availability and use of decision aids to support SCDM discussions might help healthcare providers and patients jointly make the most informed decisions about HPV vaccination.PMID:36990828 | DOI:10.1016/j.vaccine.2023.02.051
Source: Vaccine - March 29, 2023 Category: Allergy & Immunology Authors: Courtney A Gidengil Andrew M Parker Lauri E Markowitz Amber M Gedlinske Natoshia M Askelson Christine A Petersen Elissa Meites Megan C Lindley Aaron M Scherer Source Type: research
Role of Low-Risk HPV PCR Monoinfection in Screening for HSIL and Anal Cancer in Men Who Have Sex with Men Living with HIV
Int J Mol Sci. 2023 Mar 15;24(6):5642. doi: 10.3390/ijms24065642.ABSTRACTTo determine the value of low-risk human papillomavirus (HPV) PCR to screen for "high-grade anal squamous intraepithelial lesion and anal cancer" (HSIL-plus), rate of patients with low-grade anal squamous intraepithelial lesion (LSIL) progressing to HSIL-plus, and progression-related factors. Prospective, longitudinal study of consecutive MSM-LHIV attended between May 2010 and December 2021 and followed for 43 months (IQR: 12-76). HIV-related variables were gathered at baseline, performing anal cytology for HPV detection/genotyping, thin-layer cytolog...
Source: Anal Sci - March 29, 2023 Category: Chemistry Authors: Carmen Mar ía García-Martínez Inmaculada Calle-G ómez Javier L ópez-Hidalgo Patricia G ómez-Ronquillo Mohamed Omar-Mohamed Balgahata Carmen Hidalgo-Tenorio Source Type: research
