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Hormetic dose responses induced by nickel oxide nanoparticles (NiONPs) on growth, biochemical, and antioxidant defense systems of Dracocephalum kotschyi
Environ Sci Pollut Res Int. 2023 Aug 25. doi: 10.1007/s11356-023-29359-y. Online ahead of print.ABSTRACTThe application of nickel oxide nanoparticles (NiONPs) in various fields leads to their release into soil and water and, consequently, interaction with plants. Unlike its bulk counterpart, the phytotoxic potential of NiONPs is relatively less studied, particularly in a hormesis framework. Hormesis is an interesting phenomenon characterized by low-dose stimulation and high-dose inhibition. Therefore, this study demonstrates the stimulatory and inhibitory effects of NiONPs on Dracocephalum kotschyi Boiss as a medicinal pla...
Source: Environmental Science and Pollution Research International - August 25, 2023 Category: Environmental Health Authors: Azam Chahardoli Source Type: research
Proteomics Analysis of Polyphyllin D-Treated Triple-Negative Breast Cancer Cells Reveal the Anticancer Mechanisms of Polyphyllin D
In conclusion, a comprehensive proteomics study was performed on PD-treated or untreated TNBC cells, revealing the anticancer mechanisms of PD.PMID:37624509 | DOI:10.1007/s12010-023-04679-4
Source: Applied Biochemistry and Biotechnology - August 25, 2023 Category: Biochemistry Authors: Chuanchao Wei Anwei Mao Yongzhi Liu Qing Zhang Gaofeng Pan Weiyan Liu Jiazhe Liu Source Type: research
Nano-platform Strategies of Herbal Components for the management of Rheumatoid Arthritis: A Review on the Battle for Next-Generation Formulations
CONCLUSION: In conclusion, there are many anti-arthritic herbal and synthetic medicine available in the market that are currently used in the treatment of RA. However, chronic use of these medications may result in a variety of side effects. Because therapy for RA is frequently necessary for the rest of ones life. The use of natural products may be a better option for RA management. These phytoconstituents, however, have several disadvantages, including limited bioavailability, low stability, and the need for a greater dosage. These problems can be rectified by using nano-technology.PMID:37622715 | DOI:10.2174/1567201821666230825102748
Source: Current Drug Delivery - August 25, 2023 Category: Drugs & Pharmacology Authors: Jyoti Prabha Mohit Kumar Devesh Kumar Shruti Chopra Amit Bhatia Source Type: research
Ginsenosides in endometrium-related diseases: Emerging roles and mechanisms
Biomed Pharmacother. 2023 Aug 23;166:115340. doi: 10.1016/j.biopha.2023.115340. Online ahead of print.ABSTRACTGinsenosides, agents extracted from an important herb (ginseng), are expected to provide new therapies for endometrium-related diseases. Based on the molecular types of ginsenosides, we reviewed the main pharmacological effects of ginsenosides against endometrium-related diseases (e.g., endometrial cancers, endometriosis, and endometritis). The mechanism of action of ginsenosides involves inducing apoptosis of endometrium-related cells, promoting autophagy of endometrium-related cells, regulating epithelial-mesench...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 25, 2023 Category: Drugs & Pharmacology Authors: Yang-Yang Zhang Mao-Zhi Li Hui-Hui Shen Ayitila Abudukeyoumu Feng Xie Jiang-Feng Ye Feng-Yuan Xu Jian-Song Sun Ming-Qing Li Source Type: research
AR/PCC herb pair inhibits osteoblast pyroptosis to alleviate diabetes-related osteoporosis by activating Nrf2/Keap1 pathway
J Cell Mol Med. 2023 Aug 24. doi: 10.1111/jcmm.17928. Online ahead of print.ABSTRACTOsteoporosis is a prevalent complication of diabetes, characterized by systemic metabolic impairment of bone mass and microarchitecture, particularly in the spine. Anemarrhenae Rhizoma/Phellodendri Chinensis Cortex (AR/PCC) herb pair has been extensively employed in Traditional Chinese Medicine to manage diabetes; however, its potential to ameliorate diabetic osteoporosis (DOP) has remained obscure. Herein, we explored the protective efficacy of AR/PCC herb pair against DOP using a streptozotocin (STZ)-induced rat diabetic model. Our data s...
Source: J Cell Mol Med - August 25, 2023 Category: Molecular Biology Authors: Fangda Fu Huan Luo Yu Du Yuying Chen Kun Tian Jin Pan Jian Li Nani Wang Ronghua Bao Hongting Jin Peijian Tong Hongfeng Ruan Chengliang Wu Source Type: research
Ginsenosides in endometrium-related diseases: Emerging roles and mechanisms
Biomed Pharmacother. 2023 Aug 23;166:115340. doi: 10.1016/j.biopha.2023.115340. Online ahead of print.ABSTRACTGinsenosides, agents extracted from an important herb (ginseng), are expected to provide new therapies for endometrium-related diseases. Based on the molecular types of ginsenosides, we reviewed the main pharmacological effects of ginsenosides against endometrium-related diseases (e.g., endometrial cancers, endometriosis, and endometritis). The mechanism of action of ginsenosides involves inducing apoptosis of endometrium-related cells, promoting autophagy of endometrium-related cells, regulating epithelial-mesench...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 25, 2023 Category: Drugs & Pharmacology Authors: Yang-Yang Zhang Mao-Zhi Li Hui-Hui Shen Ayitila Abudukeyoumu Feng Xie Jiang-Feng Ye Feng-Yuan Xu Jian-Song Sun Ming-Qing Li Source Type: research
The chemical composition of the aerial parts essential oil of < em > Stachys ocymastrum < /em > L. Briq. (Lamiaceae) growing in Sicily (Italy)
Nat Prod Res. 2023 Aug 25:1-7. doi: 10.1080/14786419.2023.2250515. Online ahead of print.ABSTRACTThe genus Stachys L. (Lamiaceae) comprises more than 300 species as annual or perennial herbs or small shrubs, spread in temperate regions of Mediterranean, Asia, America, and Southern Africa. Several species have been used in the traditional medicine to treat stress, skin inflammations, gastrointestinal disorders, asthma, and genital tumours. In the present study the chemical composition of the essential oil from aerial parts of Stachys ocymastrum L. Briq., belonging to section Olisia, endemic of the Western Mediterranean and ...
Source: Natural Product Research - August 25, 2023 Category: Biochemistry Authors: Alessandro Vaglica Antonella Porrello Natale Badalamenti Vincenzo Ilardi Maurizio Bruno Source Type: research
< em > Moringa oleifera < /em > : A Review on the Antiproliferative Potential in Breast Cancer Cells
Curr Issues Mol Biol. 2023 Aug 18;45(8):6880-6902. doi: 10.3390/cimb45080434.ABSTRACTThe global burden of female breast cancer and associated deaths has become a major concern. Many chemotherapeutic agents, such as doxorubicin, have been shown to have adverse side effects. The development of multi-drug resistance is a common occurrence, contributing to chemotherapeutic failure. The resistance of breast cancer cells to drug treatment leads to a decline in the treatment efficacy and an increase in cancer recurrence. Therefore, action is required to produce alternative drug therapies, such as herbal drugs. Herbal drugs have b...
Source: Current Issues in Molecular Biology - August 25, 2023 Category: Molecular Biology Authors: Malebogo M Moremane Beynon Abrahams Charlette Tiloke Source Type: research
AR/PCC herb pair inhibits osteoblast pyroptosis to alleviate diabetes-related osteoporosis by activating Nrf2/Keap1 pathway
J Cell Mol Med. 2023 Aug 24. doi: 10.1111/jcmm.17928. Online ahead of print.ABSTRACTOsteoporosis is a prevalent complication of diabetes, characterized by systemic metabolic impairment of bone mass and microarchitecture, particularly in the spine. Anemarrhenae Rhizoma/Phellodendri Chinensis Cortex (AR/PCC) herb pair has been extensively employed in Traditional Chinese Medicine to manage diabetes; however, its potential to ameliorate diabetic osteoporosis (DOP) has remained obscure. Herein, we explored the protective efficacy of AR/PCC herb pair against DOP using a streptozotocin (STZ)-induced rat diabetic model. Our data s...
Source: Molecular Medicine - August 25, 2023 Category: Molecular Biology Authors: Fangda Fu Huan Luo Yu Du Yuying Chen Kun Tian Jin Pan Jian Li Nani Wang Ronghua Bao Hongting Jin Peijian Tong Hongfeng Ruan Chengliang Wu Source Type: research
Hormetic dose responses induced by nickel oxide nanoparticles (NiONPs) on growth, biochemical, and antioxidant defense systems of Dracocephalum kotschyi
Environ Sci Pollut Res Int. 2023 Aug 25. doi: 10.1007/s11356-023-29359-y. Online ahead of print.ABSTRACTThe application of nickel oxide nanoparticles (NiONPs) in various fields leads to their release into soil and water and, consequently, interaction with plants. Unlike its bulk counterpart, the phytotoxic potential of NiONPs is relatively less studied, particularly in a hormesis framework. Hormesis is an interesting phenomenon characterized by low-dose stimulation and high-dose inhibition. Therefore, this study demonstrates the stimulatory and inhibitory effects of NiONPs on Dracocephalum kotschyi Boiss as a medicinal pla...
Source: Environmental Science and Pollution Research International - August 25, 2023 Category: Environmental Health Authors: Azam Chahardoli Source Type: research
AR/PCC herb pair inhibits osteoblast pyroptosis to alleviate diabetes-related osteoporosis by activating Nrf2/Keap1 pathway
J Cell Mol Med. 2023 Aug 24. doi: 10.1111/jcmm.17928. Online ahead of print.ABSTRACTOsteoporosis is a prevalent complication of diabetes, characterized by systemic metabolic impairment of bone mass and microarchitecture, particularly in the spine. Anemarrhenae Rhizoma/Phellodendri Chinensis Cortex (AR/PCC) herb pair has been extensively employed in Traditional Chinese Medicine to manage diabetes; however, its potential to ameliorate diabetic osteoporosis (DOP) has remained obscure. Herein, we explored the protective efficacy of AR/PCC herb pair against DOP using a streptozotocin (STZ)-induced rat diabetic model. Our data s...
Source: J Cell Mol Med - August 25, 2023 Category: Molecular Biology Authors: Fangda Fu Huan Luo Yu Du Yuying Chen Kun Tian Jin Pan Jian Li Nani Wang Ronghua Bao Hongting Jin Peijian Tong Hongfeng Ruan Chengliang Wu Source Type: research
The chemical composition of the aerial parts essential oil of < em > Stachys ocymastrum < /em > L. Briq. (Lamiaceae) growing in Sicily (Italy)
Nat Prod Res. 2023 Aug 25:1-7. doi: 10.1080/14786419.2023.2250515. Online ahead of print.ABSTRACTThe genus Stachys L. (Lamiaceae) comprises more than 300 species as annual or perennial herbs or small shrubs, spread in temperate regions of Mediterranean, Asia, America, and Southern Africa. Several species have been used in the traditional medicine to treat stress, skin inflammations, gastrointestinal disorders, asthma, and genital tumours. In the present study the chemical composition of the essential oil from aerial parts of Stachys ocymastrum L. Briq., belonging to section Olisia, endemic of the Western Mediterranean and ...
Source: Natural Product Research - August 25, 2023 Category: Biochemistry Authors: Alessandro Vaglica Antonella Porrello Natale Badalamenti Vincenzo Ilardi Maurizio Bruno Source Type: research
< em > Moringa oleifera < /em > : A Review on the Antiproliferative Potential in Breast Cancer Cells
Curr Issues Mol Biol. 2023 Aug 18;45(8):6880-6902. doi: 10.3390/cimb45080434.ABSTRACTThe global burden of female breast cancer and associated deaths has become a major concern. Many chemotherapeutic agents, such as doxorubicin, have been shown to have adverse side effects. The development of multi-drug resistance is a common occurrence, contributing to chemotherapeutic failure. The resistance of breast cancer cells to drug treatment leads to a decline in the treatment efficacy and an increase in cancer recurrence. Therefore, action is required to produce alternative drug therapies, such as herbal drugs. Herbal drugs have b...
Source: Current Issues in Molecular Biology - August 25, 2023 Category: Molecular Biology Authors: Malebogo M Moremane Beynon Abrahams Charlette Tiloke Source Type: research
The Effect of the Mixed Extract of < em > Kalopanax pictus < /em > Nakai and < em > Achyranthes japonica < /em > Nakai on the Improvement of Degenerative Osteoarthritis through Inflammation Inhibition in the Monosodium Iodoacetate-Induced Mouse Model
The objective of this study is to confirm the potential of a mixture extract of Kalopanax pictus Nakai and Achyranthes japonica Nakai as a functional raw material for improving osteoarthritis through anti-inflammatory effects in macrophages and MIA-induced arthritis experimental animals. In macrophages inflamed by lipopolysaccharide (LPS), treatment of Kalopanax pictus Nakai and Achyranthes japonica Nakai mixture inhibits NF-κB and mitogen-activated protein kinase (MAPK) activities, thereby inhibiting inflammatory cytokine tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6), inflammatory factors PGE2, MMP-2, and...
Source: Current Issues in Molecular Biology - August 25, 2023 Category: Molecular Biology Authors: Hak-Yong Lee Young-Mi Park Hai-Min Hwang Dong-Yeop Shin Han-Na Jeong Jae-Gon Kim Hyo-Yeon Park Dae-Sung Kim Jin-Joo Yoo Myung-Sunny Kim Min-Jung Kim Hye-Jeong Yang Soo-Cheol Choi In-Ah Lee Source Type: research
Nano-platform Strategies of Herbal Components for the management of Rheumatoid Arthritis: A Review on the Battle for Next-Generation Formulations
CONCLUSION: In conclusion, there are many anti-arthritic herbal and synthetic medicine available in the market that are currently used in the treatment of RA. However, chronic use of these medications may result in a variety of side effects. Because therapy for RA is frequently necessary for the rest of ones life. The use of natural products may be a better option for RA management. These phytoconstituents, however, have several disadvantages, including limited bioavailability, low stability, and the need for a greater dosage. These problems can be rectified by using nano-technology.PMID:37622715 | DOI:10.2174/1567201821666230825102748
Source: Current Drug Delivery - August 25, 2023 Category: Drugs & Pharmacology Authors: Jyoti Prabha Mohit Kumar Devesh Kumar Shruti Chopra Amit Bhatia Source Type: research
