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Total 19019 results found since Jan 2013.
Integration of systematic review, lipidomics with experiment verification reveals abnormal sphingolipids facilitate diabetes retinopathy by inducing oxidative stress on RMECs
CONCLUSIONS: Integrated systematic review, lipidomics and experiment verification reveal that abnormal sphingolipid metabolism facilitates DR by inducing oxidative stress on RMECs. Our study could provide the experimental basis for finding potential biomarkers for the diagnosis and treatment of DR.PMID:37659619 | DOI:10.1016/j.bbalip.2023.159382
Source: Mol Biol Cell - September 2, 2023 Category: Molecular Biology Authors: Zhenshuang Yuan Yue Tian Cong Zhang Mingshuang Wang Jiaqi Xie Can Wang Jianmei Huang Source Type: research
A simple, rapid fluorescent reporter-based method for detection of ectopic cre recombinase expression in presumed retinal cell type-targeted mouse lines
Exp Eye Res. 2023 Aug 31:109637. doi: 10.1016/j.exer.2023.109637. Online ahead of print.ABSTRACTAlthough cell type-specific Cre recombinase-expressing mouse lines are commonly used to generate conditional knockout of genes of interest, germline recombination and ectopic "leakiness" in Cre recombinase expression in non-specific cell types has been observed in several neuronal and glial-specific Cre lines. This often leads to inadvertent loss of conditional mouse lines, requiring rederivation. It is therefore imperative to be able to monitor and validate cell type-specific Cre recombinase-mediated gene editing. Herein, we de...
Source: Cell Research - September 2, 2023 Category: Cytology Authors: Sriganesh Ramachandra Rao Steven J Fliesler Source Type: research
Integration of systematic review, lipidomics with experiment verification reveals abnormal sphingolipids facilitate diabetes retinopathy by inducing oxidative stress on RMECs
CONCLUSIONS: Integrated systematic review, lipidomics and experiment verification reveal that abnormal sphingolipid metabolism facilitates DR by inducing oxidative stress on RMECs. Our study could provide the experimental basis for finding potential biomarkers for the diagnosis and treatment of DR.PMID:37659619 | DOI:10.1016/j.bbalip.2023.159382
Source: Biochimica et Biophysica Acta - September 2, 2023 Category: Biochemistry Authors: Zhenshuang Yuan Yue Tian Cong Zhang Mingshuang Wang Jiaqi Xie Can Wang Jianmei Huang Source Type: research
Nintedanib inhibits normal human vitreous-induced epithelial-mesenchymal transition in human retinal pigment epithelial cells
CONCLUSIONS: By elucidating the anti-EMT effects of nintedanib in HV-induced RPE cells, our study highlights the potential of this oral triple tyrosine kinase inhibitor in the treatment of PVR. These findings contribute to the growing body of research aimed at developing novel strategies to prevent and manage PVR, ultimately improving the success rates of retinal detachment repair.PMID:37659204 | DOI:10.1016/j.biopha.2023.115403
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 2, 2023 Category: Drugs & Pharmacology Authors: Yiwei Yin Shikun Liu Hanhan Liu Wenyi Wu Source Type: research
A simple, rapid fluorescent reporter-based method for detection of ectopic cre recombinase expression in presumed retinal cell type-targeted mouse lines
Exp Eye Res. 2023 Aug 31:109637. doi: 10.1016/j.exer.2023.109637. Online ahead of print.ABSTRACTAlthough cell type-specific Cre recombinase-expressing mouse lines are commonly used to generate conditional knockout of genes of interest, germline recombination and ectopic "leakiness" in Cre recombinase expression in non-specific cell types has been observed in several neuronal and glial-specific Cre lines. This often leads to inadvertent loss of conditional mouse lines, requiring rederivation. It is therefore imperative to be able to monitor and validate cell type-specific Cre recombinase-mediated gene editing. Herein, we de...
Source: Experimental Eye Research - September 2, 2023 Category: Opthalmology Authors: Sriganesh Ramachandra Rao Steven J Fliesler Source Type: research
4D-DIA quantitative proteomics revealed the core mechanism of diabetic retinopathy after berberine treatment
CONCLUSION: The present findings confirmed the role of BBR in DR treatment and explained associated molecular network mechanism, in which, CA1 could be considered as a crucial candidate in the protection of RPEs with berberine treatment.PMID:37659689 | DOI:10.1016/j.ejphar.2023.175947
Source: European Journal of Pharmacology - September 2, 2023 Category: Drugs & Pharmacology Authors: Li Na Min Xu Ji-Lin Chen Guo-Jiao Chen Jie Sun Qiang Zhang Jun-Qi Li Xi-Liang Guo Zhong-Fu Zuo Xue-Zheng Liu Ting-Hua Wang Source Type: research
Integration of systematic review, lipidomics with experiment verification reveals abnormal sphingolipids facilitate diabetes retinopathy by inducing oxidative stress on RMECs
CONCLUSIONS: Integrated systematic review, lipidomics and experiment verification reveal that abnormal sphingolipid metabolism facilitates DR by inducing oxidative stress on RMECs. Our study could provide the experimental basis for finding potential biomarkers for the diagnosis and treatment of DR.PMID:37659619 | DOI:10.1016/j.bbalip.2023.159382
Source: Biochimica et Biophysica Acta - September 2, 2023 Category: Biochemistry Authors: Zhenshuang Yuan Yue Tian Cong Zhang Mingshuang Wang Jiaqi Xie Can Wang Jianmei Huang Source Type: research
Engineered peptide-drug conjugate provides sustained protection of retinal ganglion cells with topical administration in rats
J Control Release. 2023 Aug 30:S0168-3659(23)00558-8. doi: 10.1016/j.jconrel.2023.08.058. Online ahead of print.ABSTRACTEffective eye drop delivery systems for treating diseases of the posterior segment have yet to be clinically validated. Further, adherence to eye drop regimens is often problematic due to the difficulty and inconvenience of repetitive dosing. Here, we describe a strategy for topically dosing a peptide-drug conjugate to achieve effective and sustained therapeutic sunitinib concentrations to protect retinal ganglion cells (RGCs) in a rat model of optic nerve injury. We combined two promising delivery techno...
Source: Cancer Control - September 1, 2023 Category: Cancer & Oncology Authors: Henry T Hsueh Renee Ti Chou Usha Rai Patricia Kolodziejski Wathsala Liyanage Jahnavi Pejavar Ann Mozzer Charlotte Davison Matthew B Appell Yoo Chun Kim Kirby T Leo HyeYoung Kwon Maanasa Sista Nicole M Anders Avelina Hemingway Sri Vishnu Kiran Rompicharla Source Type: research
Quantitative intravitreal pharmacokinetics in mouse as a step towards inter-species translation
In this study, we applied non-invasive in vivo fluorophotometry to study pharmacokinetics of intravitreal fluorescein sodium (molecular weight 0.38 kDa) and fluorescein isothiocyanate-dextran (FD-150; molecular weight 150 kDa) in mice. Intravitreal half-lives of fluorescein and FD-150 in mouse eyes were 0.53 ± 0.06 h and 2.61 ± 0.86 h, respectively. These values are 8-230 times shorter than the elimination half-lives of similar compounds in the human vitreous. The apparent volumes of distribution in the mouse vitreous were close to the anatomical volume of the mouse vitreous (FD-150, 5.1 μl; fluorescein, 9.6 μl). Dose ...
Source: Experimental Eye Research - September 1, 2023 Category: Opthalmology Authors: Jooseppi Puranen Veli-Pekka Ranta Marika Ruponen Arto Urtti Amir Sadeghi Source Type: research
Twenty-four hour diurnal variation in retinal oxygen saturation
In conclusion, retinal oxygenation saturation undergoes diurnal variations over 24 h. These findings contribute to a better understanding of intrinsic and extrinsic factors influencing oxygenation of the area surrounding the fovea.PMID:37657366 | DOI:10.1016/j.visres.2023.108314
Source: Vision Research - September 1, 2023 Category: Opthalmology Authors: Rachel C Williams Wendy W Harrison Andrew Carkeet Lisa A Ostrin Source Type: research
Fundus autofluorescence of retinal atrophy progression between fundus flavimaculatus and extensive macular atrophy with pseudo-drusen
CONCLUSION: The progression of the atrophy in eyes with Extensive Macular Atrophy with Pseudo-drusen (EMAP) is significantly more rapid than in eyes with Fundus Flavimaculatus (FFM).PMID:37649340 | DOI:10.1177/11206721231199635
Source: European Journal of Ophthalmology - August 31, 2023 Category: Opthalmology Authors: Mark Rabinovich Carl-Joe Mehanna Juan Manuel Lopez Eric H Souied Source Type: research
The contribution of indocyanine green angiography in a case of unilateral retinal pigment epithelium dysgenesis
CONCLUSION: URPED is an extremely rare clinical entity with only a few cases reported. In this case the almost pathognomonic differential features of URPED were best appreciated with ICGA imaging. To our knowledge, this is the first reported case of URPED with these abnormal findings on ICGA meaning it could be part of the spectrum of the disease.PMID:37649336 | DOI:10.1177/11206721231199337
Source: European Journal of Ophthalmology - August 31, 2023 Category: Opthalmology Authors: Enrique Cervera-Taulet Javier Montero-Hern ández Clara Monferrer Adsuara Jose S Pulido Source Type: research
