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A data driven approach to multiple stressor impact assessment for a marine protected area
This article is protected by copyright. All rights reserved.PMID:37668099 | DOI:10.1111/cobi.14177
Source: Conservation Biology - September 5, 2023 Category: Biology Authors: Laura L Griffiths Joel Williams Christina A Buelow Vivitskaia J Tulloch Mischa P Turschwell Max D Campbell David Harasti Rod M Connolly Christopher J Brown Source Type: research
Fortification of condiments and seasonings with iron for preventing anaemia and improving health
CONCLUSIONS: We are uncertain whether consuming iron-fortified condiments/seasonings reduces anaemia, improves haemoglobin concentration, or improves ferritin concentration. It may reduce ID. Findings about ferritin should be interpreted with caution since its concentrations increase during inflammation. Consuming condiments/seasonings fortified with iron plus other micronutrients may reduce anaemia, and we are uncertain whether this will improve haemoglobin concentration or ferritin concentration. More studies are needed to determine the true effect of iron-fortified condiments/seasonings on preventing anaemia and improvi...
Source: Cochrane Database of Systematic Reviews - September 4, 2023 Category: General Medicine Authors: Chowdhury Sb Jalal Luz Maria De-Regil Vanessa Pike Prasanna Mithra Source Type: research
Transcriptional regulation of the Japanese flounder Cu,Zn-SOD (Jfsod1) gene in RAW264.7 cells during oxidative stress caused by causative bacteria of edwardsiellosis
In this study, NUF251 stimulated intracellular superoxide radical production in mouse macrophage RAW264.7 cells, which was reduced by N-acetylcysteine. This result suggests that NUF251 infection causes oxidative stress. To evaluate the regulatory mechanism of Jfsod1 at transcriptional levels under oxidative stress induced by NUF251 infection, we cloned and determined the nucleotide sequence (1124 bp) of the 5'-flanking region of the Jfsod1 gene. The sequence analysis demonstrated that the binding sites for the transcription factors C/EBPα and NF-IL6 involved in the transcriptional regulation of the mammalian sod1 gene exi...
Source: Biochimie - September 4, 2023 Category: Biochemistry Authors: Xiao-Mi Sun Asami Yoshida Takuya Ishii Yan-Rong Jiang Yi-Li Gao Mikinori Ueno Katsuya Hirasaka Kiyoshi Osatomi Source Type: research
A review on neurodegeneration in the fast-ageing killifish, the first animal model to study the natural occurrence of neuronal cell loss
Ageing Res Rev. 2023 Sep 2:102065. doi: 10.1016/j.arr.2023.102065. Online ahead of print.ABSTRACTThanks to medical and technological improvements, our world population has become ever-greying. In consequence, the incidence and prevalence of age-related central nervous system neuropathies, such as Alzheimer's (AD) and Parkinson's disease (PD), are increasing tremendously. Despite many research efforts, the precise aetiology of these age-related neurodegenerative disorders remains elusive, highlighting the urgent need for more effective treatments. Current preclinical research mainly uses animal models that do not fully reca...
Source: Cell Research - September 4, 2023 Category: Cytology Authors: Steven Bergmans Laura Raes Lieve Moons Lies De Groef Source Type: research
Effects of methomyl on the intestinal microbiome and hepatic transcriptome of tilapia, and the modifying effects of mint co-culture
In this study, we investigated the impact of MET on the antioxidant system of Oreochromis niloticus in presence of mint as a floating bed. Results revealed that the superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase, and glutathione S-transferase significantly decreased and the GSH content significantly increased in the intestine. The hepatic peroxisome proliferator-activated receptor (PPAR) signalling pathway, carbon metabolism, renal phosphoinositide 3-kinase (PI3K)-Akt, mitogen-activated protein kinase (MAPK) signalling pathway, and phagosomes were significantly affected. Upon long-term exposure, circadi...
Source: Aquatic Toxicology - September 4, 2023 Category: Toxicology Authors: Yao Zheng Benkhelifa Fateh Gangchun Xu Source Type: research
A review on neurodegeneration in the fast-ageing killifish, the first animal model to study the natural occurrence of neuronal cell loss
Ageing Res Rev. 2023 Sep 2:102065. doi: 10.1016/j.arr.2023.102065. Online ahead of print.ABSTRACTThanks to medical and technological improvements, our world population has become ever-greying. In consequence, the incidence and prevalence of age-related central nervous system neuropathies, such as Alzheimer's (AD) and Parkinson's disease (PD), are increasing tremendously. Despite many research efforts, the precise aetiology of these age-related neurodegenerative disorders remains elusive, highlighting the urgent need for more effective treatments. Current preclinical research mainly uses animal models that do not fully reca...
Source: Ageing Research Reviews - September 4, 2023 Category: Genetics & Stem Cells Authors: Steven Bergmans Laura Raes Lieve Moons Lies De Groef Source Type: research
Transcriptional regulation of the Japanese flounder Cu,Zn-SOD (Jfsod1) gene in RAW264.7 cells during oxidative stress caused by causative bacteria of edwardsiellosis
In this study, NUF251 stimulated intracellular superoxide radical production in mouse macrophage RAW264.7 cells, which was reduced by N-acetylcysteine. This result suggests that NUF251 infection causes oxidative stress. To evaluate the regulatory mechanism of Jfsod1 at transcriptional levels under oxidative stress induced by NUF251 infection, we cloned and determined the nucleotide sequence (1124 bp) of the 5'-flanking region of the Jfsod1 gene. The sequence analysis demonstrated that the binding sites for the transcription factors C/EBPα and NF-IL6 involved in the transcriptional regulation of the mammalian sod1 gene exi...
Source: Biochimie - September 4, 2023 Category: Biochemistry Authors: Xiao-Mi Sun Asami Yoshida Takuya Ishii Yan-Rong Jiang Yi-Li Gao Mikinori Ueno Katsuya Hirasaka Kiyoshi Osatomi Source Type: research
A review on neurodegeneration in the fast-ageing killifish, the first animal model to study the natural occurrence of neuronal cell loss
Ageing Res Rev. 2023 Sep 2:102065. doi: 10.1016/j.arr.2023.102065. Online ahead of print.ABSTRACTThanks to medical and technological improvements, our world population has become ever-greying. In consequence, the incidence and prevalence of age-related central nervous system neuropathies, such as Alzheimer's (AD) and Parkinson's disease (PD), are increasing tremendously. Despite many research efforts, the precise aetiology of these age-related neurodegenerative disorders remains elusive, highlighting the urgent need for more effective treatments. Current preclinical research mainly uses animal models that do not fully reca...
Source: Ageing Research Reviews - September 4, 2023 Category: Genetics & Stem Cells Authors: Steven Bergmans Laura Raes Lieve Moons Lies De Groef Source Type: research
LncRNA-LINC00472 suppresses the malignant progression of non-small cell lung cancer via modulation of the miRNA-1275/Homeobox A2 axis
CONCLUSIONS: The LINC00472 functioned as a competing endogenous RNA to modulate HOXA2 level by sponging miR-1275 in NSCLC. Simultaneously, the LINC00472/miR-1275/HOXA2 axis may be a possible therapeutic target and biomarker for NSCLC.PMID:37665081 | DOI:10.17219/acem/168431
Source: Clinical Lung Cancer - September 4, 2023 Category: Cancer & Oncology Authors: Meichen Jiang Xiangli Ye Dongliang Shi Qili Lin Feijian Huang Yong Li Source Type: research
Fortification of condiments and seasonings with iron for preventing anaemia and improving health
CONCLUSIONS: We are uncertain whether consuming iron-fortified condiments/seasonings reduces anaemia, improves haemoglobin concentration, or improves ferritin concentration. It may reduce ID. Findings about ferritin should be interpreted with caution since its concentrations increase during inflammation. Consuming condiments/seasonings fortified with iron plus other micronutrients may reduce anaemia, and we are uncertain whether this will improve haemoglobin concentration or ferritin concentration. More studies are needed to determine the true effect of iron-fortified condiments/seasonings on preventing anaemia and improvi...
Source: Cochrane Database of Systematic Reviews - September 4, 2023 Category: General Medicine Authors: Chowdhury Sb Jalal Luz Maria De-Regil Vanessa Pike Prasanna Mithra Source Type: research
Effects of methomyl on the intestinal microbiome and hepatic transcriptome of tilapia, and the modifying effects of mint co-culture
In this study, we investigated the impact of MET on the antioxidant system of Oreochromis niloticus in presence of mint as a floating bed. Results revealed that the superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase, and glutathione S-transferase significantly decreased and the GSH content significantly increased in the intestine. The hepatic peroxisome proliferator-activated receptor (PPAR) signalling pathway, carbon metabolism, renal phosphoinositide 3-kinase (PI3K)-Akt, mitogen-activated protein kinase (MAPK) signalling pathway, and phagosomes were significantly affected. Upon long-term exposure, circadi...
Source: Aquatic Toxicology - September 4, 2023 Category: Toxicology Authors: Yao Zheng Benkhelifa Fateh Gangchun Xu Source Type: research
A review on neurodegeneration in the fast-ageing killifish, the first animal model to study the natural occurrence of neuronal cell loss
Ageing Res Rev. 2023 Sep 2:102065. doi: 10.1016/j.arr.2023.102065. Online ahead of print.ABSTRACTThanks to medical and technological improvements, our world population has become ever-greying. In consequence, the incidence and prevalence of age-related central nervous system neuropathies, such as Alzheimer's (AD) and Parkinson's disease (PD), are increasing tremendously. Despite many research efforts, the precise aetiology of these age-related neurodegenerative disorders remains elusive, highlighting the urgent need for more effective treatments. Current preclinical research mainly uses animal models that do not fully reca...
Source: Ageing Research Reviews - September 4, 2023 Category: Genetics & Stem Cells Authors: Steven Bergmans Laura Raes Lieve Moons Lies De Groef Source Type: research
Development of an indirect ELISA for detection of the adaptive immune response of black carp (Mylopharyngodon piceus)
J Immunol Methods. 2023 Sep 1:113550. doi: 10.1016/j.jim.2023.113550. Online ahead of print.ABSTRACTBlack carp (Mylopharyngodon piceus) is an important fishery resource and the main breeding target in China. Due to the lack of an assay of immunoglobulin M (IgM) antibodies in black carp, there is no effective method to evaluate adaptive immune response, which limits immunological studies and vaccine development. The present study used mAbs (monoclonal antibodies) against serum IgM of grass carp as capture antibodies. The results of Western blot analysis indicated that these antibodies had strong affinity and specificity to ...
Source: Journal of Immunological Methods - September 3, 2023 Category: Allergy & Immunology Authors: Tongtong Wang Shanshan Jin L V Ruoxuan Yuting Meng Guozhong Li Yuxing Han Qiusheng Zhang Source Type: research
Phosphatidylethanolamine alleviates OX-LDL-induced macrophage inflammation by upregulating autophagy and inhibiting NLRP1 inflammasome activation
In conclusion, we elucidated the role of the CD36-NLRP1-caspase-1 signaling pathway in OX-LDL-induced inflammation in fish and revealed for the first time that altering PE abundance in OX-LDL-treated cells could alleviate inflammasome-mediated inflammation by inducing autophagy. Given the relationship between OX-LDL-induced inflammation and atherosclerosis, this study prompts that the use of PE-rich foods promises to be a new strategy for atherosclerosis treatment in vertebrates.PMID:37660837 | DOI:10.1016/j.freeradbiomed.2023.08.031
Source: Atherosclerosis - September 3, 2023 Category: Cardiology Authors: Tingting Hao Wei Fang Dan Xu Qiang Chen Qiangde Liu Kun Cui Xiufei Cao Yueru Li Kangsen Mai Qinghui Ai Source Type: research
