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Total 23548 results found since Jan 2013.
Climbazole causes cell apoptosis and lipidosis in the liver of grass carp
In this study, grass carp (Ctenopharyngodon idella) and liver cell lines (L8824 cells) were treated with climbazole at concentrations ranging from 0.2 to 20 μg/L for 42 days in vivo and 24 h in vitro to evaluate the effects on the liver, respectively. Pathological, biochemical, and gene transcription and expression analyses were conducted to examine the hepatotoxicity. Our results showed that climbazole significantly decreased the hepatosomatic index, caused cell apoptosis in vivo and in vitro, and finally accumulated lipids in the liver. Beside, climbazole increased ROS levels, reduced Nrf2 and Keap1 mRNA and protein lev...
Source: Aquatic Toxicology - September 18, 2023 Category: Toxicology Authors: Zhi-Jie Lu Wen-Jun Shi Fang-Zhou Gao Dong-Dong Ma Jin-Ge Zhang Si-Ying Li Xiao-Bing Long Qian-Qian Zhang Guang-Guo Ying Source Type: research
Mitochondrial dysfunction and oxidative stress contribute to cross-generational toxicity of benzo(a)pyrene in Danio rerio
This study evaluated the role of mitochondria, which are maternally inherited, in the cross-generational toxicity of benzo(a)pyrene (BaP), a model PAH and known mitochondrial toxicant. Mature female zebrafish (F0) were fed diets containing 0, 12.5, 125, or 1250 μg BaP/g at a feed rate of 1% body weight twice/day for 21 days. These females were bred with unexposed males, and the embryos (F1) were collected for subsequent analyses. Maternally-exposed embryos exhibited altered mitochondrial function and metabolic partitioning (i.e. the portion of respiration attributable to different cellular processes), as evidenced by in v...
Source: Aquatic Toxicology - September 18, 2023 Category: Toxicology Authors: Jordan S Kozal Nishad Jayasundara Andrey Massarsky Casey D Lindberg Anthony N Oliveri Ellen M Cooper Edward D Levin Joel N Meyer Richard T Di Giulio Source Type: research
LINC00668 promoted non-small lung cancer progression by miR-518c-3p/TRIP4 axis
CONCLUSIONS: LINC00668 acted as an oncogene in NSCLC progression through miR-518c-3p/TRIP4 axis. Our study disclosed a new mechanism of LINC00668 functioned in NSCLC and may give a deeper insight of the targeted therapy of NSCLC in the future.PMID:37718780 | DOI:10.3233/CBM-230154
Source: Cancer Biomarkers : Section A of Disease Markers - September 18, 2023 Category: Cancer & Oncology Authors: Zhibin Lu Zhichao Xiao Qi Wang Chunfeng Pan Yang Xia Weibing Wu Liang Chen Source Type: research
Ultrasound improves the low-sodium salt curing of sea bass: Insights into the effects of ultrasound on texture, microstructure, and flavor characteristics
Ultrason Sonochem. 2023 Sep 11;100:106597. doi: 10.1016/j.ultsonch.2023.106597. Online ahead of print.ABSTRACTThe purpose of this study was to evaluate the effects of ultrasonic pretreatment on the quality of cured sea bass. Compared to static marination, ultrasonication significantly increased the rate of NaCl transfer, reduced the hardness and chewiness of fish, and improved water retention. Microstructural observations revealed that the sea bass muscle fibers were severely fragmented, with their borders becoming increasingly blurred with increasing ultrasonic intensity. In addition, ultrasound-assisted marination signif...
Source: Ultrasonics Sonochemistry - September 18, 2023 Category: Chemistry Authors: Hengli Bai Laihao Li Yanyan Wu Shengjun Chen Yongqiang Zhao Qiuxing Cai Yueqi Wang Source Type: research
Genome-wide identification, evolution and expression of TGF- β signaling pathway members in mandarin fish (Siniperca chuatsi)
Int J Biol Macromol. 2023 Sep 16:126949. doi: 10.1016/j.ijbiomac.2023.126949. Online ahead of print.ABSTRACTMembers of the transforming growth factor β (TGF-β) signaling pathway regulate diverse cellular biological processes in embryonic and tissue development. We took mandarin fish (Siniperca chuatsi) as the research object to identify all members of the TGF-β signaling pathway, measure their expression pattern in the key period post hatching, and further explore their possible role in the process of sex regulation. Herein, we identified eighty-three TGF-β signaling pathway members and located them on chromosomes base...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Shiyan Liu Chong Han Jingjun Huang Meihui Li Jiayu Yang Guifeng Li Haoran Lin Shuisheng Li Yong Zhang Source Type: research
Ultrasound improves the low-sodium salt curing of sea bass: Insights into the effects of ultrasound on texture, microstructure, and flavor characteristics
Ultrason Sonochem. 2023 Sep 11;100:106597. doi: 10.1016/j.ultsonch.2023.106597. Online ahead of print.ABSTRACTThe purpose of this study was to evaluate the effects of ultrasonic pretreatment on the quality of cured sea bass. Compared to static marination, ultrasonication significantly increased the rate of NaCl transfer, reduced the hardness and chewiness of fish, and improved water retention. Microstructural observations revealed that the sea bass muscle fibers were severely fragmented, with their borders becoming increasingly blurred with increasing ultrasonic intensity. In addition, ultrasound-assisted marination signif...
Source: Ultrasonics Sonochemistry - September 18, 2023 Category: Chemistry Authors: Hengli Bai Laihao Li Yanyan Wu Shengjun Chen Yongqiang Zhao Qiuxing Cai Yueqi Wang Source Type: research
miR135a administration ameliorates brain ischemic damage by preventing TRPM7 activation during brain ischemia
CONCLUSIONS: The early prevention of TRPM7 activation is protective during brain ischemia.PMID:37718696 | DOI:10.1111/cns.14448
Source: CNS Neuroscience and Therapeutics - September 18, 2023 Category: Neuroscience Authors: P Cepparulo P Brancaccio R Sirabella S Anzilotti N Guida G Laudati V Valsecchi A Vinciguerra V Viscardi L D'Esposito L Formisano L Annunziato G Pignataro O Cuomo Source Type: research
Biomass-based indole derived fluorescence sensor composited with cellulose paper: Detection of picric acid in food and environment samples
Int J Biol Macromol. 2023 Sep 16:126963. doi: 10.1016/j.ijbiomac.2023.126963. Online ahead of print.ABSTRACTPicric acid (PA) is highly water-soluble, the fact makes it stand out as the most hazardous environment pollutant. Therefore, accurate determination of PA is of great significance for human health and environmental protection. Herein, a novel indole-based fluorescent sensor (H1) with good water solubility and fluorescence stability was reported. H1 exhibited 'turn-off' fluorescence response for PA with fast reaction rate (<30 s), unique specificity and excellent selectivity and high sensitivity (limit of detection...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Yingying Zhang Xiaoci Cui Xin Wang Xiuyuan Feng Weixia Cheng Ranhua Xiong Chaobo Huang Source Type: research
Nanopeptide CI20 remarkably enhances growth performance and disease resistances by improving the mucosal structure, antioxidant capacity, and immunity in mandarin fish (Siniperca chuatsi)
In this study, the nanopeptide CI20, which was created by conjugating antimicrobial peptide gcIFN-20H and CMCS, were evaluated the feeding effect in mandarin fish (Siniperca chuatsi). Compared with the control group, 150 mg/kg C-I20-fed fish showed the second highest growth performance with no significant changes in body composition. C-I20-fed fish showed more goblet cells and thicker mucin after feeding. The 150 mg/kg CI20 diet boosted the antioxidant capacity, immunity, and digestive enzymes. After Aeromonas hydrophila and infection spleen and kidney necrosis virus infection, the survival rates in the 150 mg/kg CI20 grou...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Xingchen Huo Jiao Chang Qiwei Zhang Weicheng Wang Pengxu Wang Fengxia Zhao Shan He Chunrong Yang Xiaoling Liu Xufang Liang Yongan Zhang Jianguo Su Source Type: research
Genome-wide identification, evolution and expression of TGF- β signaling pathway members in mandarin fish (Siniperca chuatsi)
Int J Biol Macromol. 2023 Sep 16:126949. doi: 10.1016/j.ijbiomac.2023.126949. Online ahead of print.ABSTRACTMembers of the transforming growth factor β (TGF-β) signaling pathway regulate diverse cellular biological processes in embryonic and tissue development. We took mandarin fish (Siniperca chuatsi) as the research object to identify all members of the TGF-β signaling pathway, measure their expression pattern in the key period post hatching, and further explore their possible role in the process of sex regulation. Herein, we identified eighty-three TGF-β signaling pathway members and located them on chromosomes base...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Shiyan Liu Chong Han Jingjun Huang Meihui Li Jiayu Yang Guifeng Li Haoran Lin Shuisheng Li Yong Zhang Source Type: research
Discretionary foods and drinks in Norwegian children and adolescents' diet: Data from the national dietary survey Ungkost 3
CONCLUSIONS: Almost all 4th and 8th graders in Norway consumed discretionary foods and drinks and these products contributed to a substantial proportion of the total energy intake and limited amounts of nutrients. Those children and adolescents consuming the least discretionary foods and drinks had a higher intake of whole grains, fish and seafood, indicating healthier and more sustainable food habits.PMID:37721223 | DOI:10.1017/S1368980023001982
Source: Public Health Nutrition - September 18, 2023 Category: International Medicine & Public Health Authors: Mari Mohn Paulsen Jannicke Borch Myhre Torunn Holm Totland Lene Frost Andersen Source Type: research
miR135a administration ameliorates brain ischemic damage by preventing TRPM7 activation during brain ischemia
CONCLUSIONS: The early prevention of TRPM7 activation is protective during brain ischemia.PMID:37718696 | DOI:10.1111/cns.14448
Source: CNS Neuroscience and Therapeutics - September 18, 2023 Category: Neuroscience Authors: P Cepparulo P Brancaccio R Sirabella S Anzilotti N Guida G Laudati V Valsecchi A Vinciguerra V Viscardi L D'Esposito L Formisano L Annunziato G Pignataro O Cuomo Source Type: research
LINC00668 promoted non-small lung cancer progression by miR-518c-3p/TRIP4 axis
CONCLUSIONS: LINC00668 acted as an oncogene in NSCLC progression through miR-518c-3p/TRIP4 axis. Our study disclosed a new mechanism of LINC00668 functioned in NSCLC and may give a deeper insight of the targeted therapy of NSCLC in the future.PMID:37718780 | DOI:10.3233/CBM-230154
Source: Cancer Biomarkers : Section A of Disease Markers - September 18, 2023 Category: Cancer & Oncology Authors: Zhibin Lu Zhichao Xiao Qi Wang Chunfeng Pan Yang Xia Weibing Wu Liang Chen Source Type: research
Climbazole causes cell apoptosis and lipidosis in the liver of grass carp
In this study, grass carp (Ctenopharyngodon idella) and liver cell lines (L8824 cells) were treated with climbazole at concentrations ranging from 0.2 to 20 μg/L for 42 days in vivo and 24 h in vitro to evaluate the effects on the liver, respectively. Pathological, biochemical, and gene transcription and expression analyses were conducted to examine the hepatotoxicity. Our results showed that climbazole significantly decreased the hepatosomatic index, caused cell apoptosis in vivo and in vitro, and finally accumulated lipids in the liver. Beside, climbazole increased ROS levels, reduced Nrf2 and Keap1 mRNA and protein lev...
Source: Aquatic Toxicology - September 18, 2023 Category: Toxicology Authors: Zhi-Jie Lu Wen-Jun Shi Fang-Zhou Gao Dong-Dong Ma Jin-Ge Zhang Si-Ying Li Xiao-Bing Long Qian-Qian Zhang Guang-Guo Ying Source Type: research
Mitochondrial dysfunction and oxidative stress contribute to cross-generational toxicity of benzo(a)pyrene in Danio rerio
This study evaluated the role of mitochondria, which are maternally inherited, in the cross-generational toxicity of benzo(a)pyrene (BaP), a model PAH and known mitochondrial toxicant. Mature female zebrafish (F0) were fed diets containing 0, 12.5, 125, or 1250 μg BaP/g at a feed rate of 1% body weight twice/day for 21 days. These females were bred with unexposed males, and the embryos (F1) were collected for subsequent analyses. Maternally-exposed embryos exhibited altered mitochondrial function and metabolic partitioning (i.e. the portion of respiration attributable to different cellular processes), as evidenced by in v...
Source: Aquatic Toxicology - September 18, 2023 Category: Toxicology Authors: Jordan S Kozal Nishad Jayasundara Andrey Massarsky Casey D Lindberg Anthony N Oliveri Ellen M Cooper Edward D Levin Joel N Meyer Richard T Di Giulio Source Type: research
