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Total 8585 results found since Jan 2013.
Sex-specific lung inflammation and mitochondrial damage in a model of electronic cigarette exposure in asthma
Am J Physiol Lung Cell Mol Physiol. 2023 Sep 12. doi: 10.1152/ajplung.00033.2023. Online ahead of print.ABSTRACTThe prevalence of electronic cigarette (EC) use among adult asthmatics has continued to increase over time, in part due to the belief of being less harmful than smoking. However, the extent of their toxicity and the involved mechanisms contributing to the deleterious impact of EC exposure on patients with pre-existing asthma have not been delineated. In the present project, we tested the hypothesis that EC use contributes to respiratory damage and worsening inflammation in the lungs of asthmatics. To define the c...
Source: Am J Physiol Lung Ce... - September 12, 2023 Category: Respiratory Medicine Authors: Min-Ae Song Ji Young Kim Matthew W Gorr Roy A Miller Manjula Karpurapu Jackie Nguyen Devki Patel Kellie J Archer Navjot Pabla Peter G Shields Loren E Wold John W Christman Sangwoon Chung Source Type: research
The influence of various endocrine disruptors on the reproductive system
This article presents the current state of knowledge of the effect of EDCs and additional factors such as smoking, alcohol consumption, and cannabis on the gonads. The article is an overview of the impact of EDCs and their mechanism of action, with particular emphasis on gonads, based on databases such as PubMed, EMBASE and Google Scholar, and Web of Science available until May 2022. The impact of human exposure to bisphenol A (BPA) is not fully understood, but it has been shown that phthalates show a negative correlation in anti-androgenic activity in the case of men and women for the anti-Müllerian hormone (AMH). Smokin...
Source: Endokrynologia Polska - September 11, 2023 Category: Endocrinology Authors: Agata Czarnywojtek Magdalena Borowska Kamil Dyrka Jakub Moskal Jeremi Ko ściński Iwona Krela-Ka źmierczak Agnieszka Marta Lewandowska Boushra Abou Hjeily Pawe ł Gut Karolina Hoffmann Stefaan Van Gool Nadia Sawicka-Gutaj Marek Rucha ła Source Type: research
Pharmacological and electronic cigarette interventions for smoking cessation in adults: component network meta-analyses
CONCLUSIONS: The most effective interventions were nicotine e-cigarettes, varenicline and cytisine (all high certainty), as well as combination NRT (additive effect, certainty not rated). There was also high-certainty evidence for the effectiveness of nicotine patch, fast-acting NRT and bupropion. Less certain evidence of benefit was present for nortriptyline (moderate certainty), non-nicotine e-cigarettes and tapering of nicotine dose (both low certainty). There was moderate-certainty evidence that bupropion may slightly increase the frequency of SAEs, although there was also the possibility of no increased risk. There wa...
Source: Cochrane Database of Systematic Reviews - September 11, 2023 Category: General Medicine Authors: Nicola Lindson Annika Theodoulou Jos é M Ordóñez-Mena Thomas R Fanshawe Alex J Sutton Jonathan Livingstone-Banks Anisa Hajizadeh Sufen Zhu Paul Aveyard Suzanne C Freeman Sanjay Agrawal Jamie Hartmann-Boyce Source Type: research
The influence of various endocrine disruptors on the reproductive system
This article presents the current state of knowledge of the effect of EDCs and additional factors such as smoking, alcohol consumption, and cannabis on the gonads. The article is an overview of the impact of EDCs and their mechanism of action, with particular emphasis on gonads, based on databases such as PubMed, EMBASE and Google Scholar, and Web of Science available until May 2022. The impact of human exposure to bisphenol A (BPA) is not fully understood, but it has been shown that phthalates show a negative correlation in anti-androgenic activity in the case of men and women for the anti-Müllerian hormone (AMH). Smokin...
Source: Endokrynologia Polska - September 11, 2023 Category: Endocrinology Authors: Agata Czarnywojtek Magdalena Borowska Kamil Dyrka Jakub Moskal Jeremi Ko ściński Iwona Krela-Ka źmierczak Agnieszka Marta Lewandowska Boushra Abou Hjeily Pawe ł Gut Karolina Hoffmann Stefaan Van Gool Nadia Sawicka-Gutaj Marek Rucha ła Source Type: research
LINC01638 Sustains Human Mesenchymal Stem Cell Self-Renewal and Competency for Osteogenic Cell Fate
Res Sq. 2023 Aug 28:rs.3.rs-3210911. doi: 10.21203/rs.3.rs-3210911/v1. Preprint.ABSTRACTThe skeleton forms from multipotent human mesenchymal stem cells (hMSCs) competent to commit to specific lineages. Long noncoding RNAs (lncRNAs) have been identified as key epigenetic regulators of tissue development. However, regulation of osteogenesis by lncRNAs as mediators of commitment to the bone phenotype is largely unexplored. We focused on LINC01638, which is highly expressed in hMSCs and has been studied in cancers, but not in regulating osteogenesis. We demonstrated that LINC01638 promotes initiation of the osteoblast phenoty...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Jonathan Gordon Coralee E Tye Bodhisatwa Banerjee Prachi N Ghule Andre J Wijnen Fleur S Kabala Natalie A Page Michelle M Falcone Janet L Stein Gary S Stein Jane B Lian Source Type: research
Opioid and benzodiazepine misuse in the United States: The impact of socio-demographic characteristics
CONCLUSION AND SCIENTIFIC SIGNIFICANCE: A large portion of US adults are misusing opioids, benzodiazepines, and both drugs. Specifically, bisexual individuals experience higher odds of opioid misuse, benzodiazepine misuse and misuse of both drugs compared with heterosexuals, while males are experiencing lower odds of benzodiazepine misuse compared with females. Individuals aged 26-49 experience the highest odds of opioid misuse, though misuse of both drugs was higher among the 18-25 age group. Findings underscore the use of targeted preventive measures to reduce misuse of these drugs among at-risk populations identified in...
Source: American Journal on Addictions - September 10, 2023 Category: Addiction Authors: Mohammad Rifat Haider Jayani Jayawardhana Source Type: research
Preliminary study on the E-liquid and aerosol on the neurobehavior of C. elegans
This study can provide new ideas for future studies on the neurotoxic effects and safety assessment of the E-cigarettes, and provide theoretical reference for the study on the injury mechanism of E-cigarettes.PMID:37690220 | DOI:10.1016/j.envint.2023.108180
Source: Environment International - September 10, 2023 Category: Environmental Health Authors: Yanting Pang Menghan Li Fuxian Li Jialin Lei Ting Zhang Source Type: research
Opioid and benzodiazepine misuse in the United States: The impact of socio-demographic characteristics
CONCLUSION AND SCIENTIFIC SIGNIFICANCE: A large portion of US adults are misusing opioids, benzodiazepines, and both drugs. Specifically, bisexual individuals experience higher odds of opioid misuse, benzodiazepine misuse and misuse of both drugs compared with heterosexuals, while males are experiencing lower odds of benzodiazepine misuse compared with females. Individuals aged 26-49 experience the highest odds of opioid misuse, though misuse of both drugs was higher among the 18-25 age group. Findings underscore the use of targeted preventive measures to reduce misuse of these drugs among at-risk populations identified in...
Source: The American Journal on Addictions - September 10, 2023 Category: Addiction Authors: Mohammad Rifat Haider Jayani Jayawardhana Source Type: research
