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Vaccination: Cervical Cancer Vaccine
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Total 2139 results found since Jan 2013.
Phase II Trial of MEDI0457 and Durvalumab for Patients With Recurrent/Metastatic Human Papillomavirus-Associated Cancers
CONCLUSIONS: The combination of MEDI0457 and durvalumab demonstrated acceptable safety and tolerability in patients with advanced HPV-16/18 cancers. The low ORR among patients with cervical cancer led to study discontinuation despite a clinically meaningful disease control rate.PMID:37104874 | DOI:10.1093/oncolo/oyad085
Source: Cancer Control - April 27, 2023 Category: Cancer & Oncology Authors: Van K Morris Amir Jazaeri Shannon N Westin Curtis Pettaway Solly George Ryan W Huey Michaela Grinsfelder Aaron Shafer Benny Johnson David Vining Ming Guo Bryan Fellman Michael Frumovitz Source Type: research
Future perspectives of emerging novel drug targets and immunotherapies to control drug addiction
This article's main highlight is discussing the drug targets of SUDs and their associated mechanisms. Importantly, we have also discussed the scope of prophylactic measures to eliminate drug dependence.PMID:37099943 | DOI:10.1016/j.intimp.2023.110210
Source: International Immunopharmacology - April 26, 2023 Category: Allergy & Immunology Authors: Jonaid Ahmad Malik Javed N Agrewala Source Type: research
Attitudes towards HPV and COVID school-entry policies among adults living in Puerto Rico
This study compared attitudes toward HPV and COVID vaccines with respect to school-entry policies among adults living in PR. A convenience sample of 222 adults (≥21 years old) completed an online survey from November 2021 to January 2022. Participants answered questions about HPV and COVID vaccines, attitudes toward vaccination policies for school-entry, and perceptions of sources of information. We assessed the magnitude of association between the agreement of school-entry policies for COVID and HPV vaccination by estimating the prevalence ratio (PRadjusted) with 95% Confidence Intervals (95% CI). The most trusted sourc...
Source: Cancer Control - April 24, 2023 Category: Cancer & Oncology Authors: Jessica N Rivera-Rivera Olga L D íaz-Miranda Diana T Medina-Laabes Erick Su árez Ana P Ortiz Vivian Col ón-López Source Type: research
Public School Adolescents Had Increased Odds of Being Willing to Uptake HPV Vaccinations Owing to Sociodemographic and Healthcare Access Features in Bahir Dar City, Ethiopia
CONCLUSION: Adolescent girls in public primary schools were more likely to uptake HPV vaccination than those in private provided that income status and socioeconomic factors became less important. Willingness to uptake HPV vaccination was found to be low as compared to the WHO target for Ethiopian context and was influenced by maternal education status, perceived barriers, cues to action, and self-efficacy. As a result, greater emphasis should be placed on implementing a school-based and maternal educational program on cervical cancer prevention and control focusing on the behavioral contexts.PMID:37090189 | PMC:PMC1011553...
Source: Biomed Res - April 24, 2023 Category: Research Authors: Birhanu Feleke Shitu Desta Debalkie Atnafu Yeshambel Agumas Source Type: research
Etiology, diagnosis, treatment, and prevention of human papilloma virus-associated oropharyngeal squamous cell carcinoma
Int J Clin Oncol. 2023 Apr 24. doi: 10.1007/s10147-023-02336-8. Online ahead of print.ABSTRACTClassical oropharyngeal squamous cell carcinoma (OPSCC) caused by alcohol consumption and smoking and HPV-associated OPSCC caused by human papillomavirus (HPV) infection have different etiologies, incidences, and prognoses. Therefore, the 8th American Joint committee on Cancer (AJCC) and Union for International Cancer Control (UICC) TNM classifications propose distinguishing HPV-associated OPSCC from classical OPSCC and classifying it as an independent disease. Therefore, this review provides an overview of HPV-associated OPSCC fr...
Source: Cancer Control - April 24, 2023 Category: Cancer & Oncology Authors: Hirotaka Shinomiya Ken-Ichi Nibu Source Type: research
Therapeutic efficacy of a VSV-GP-based human papilloma virus vaccine in a murine cancer model
In this study, we generated a live attenuated cancer vaccine based on the chimeric vesicular stomatitis virus VSV-GP, which has previously proven to be a potent vaccine vector and oncolytic virus. Genes at an earlier position in the genome more to the 3' end are expressed stronger compared to genes located further downstream. By inserting an HPV16-derived antigen cassette consisting of E2, E6 and E7 into VSV-GP either at first (HPVp1) or fifth (HPVp5) position in VSV-GP's genome we aimed to analyze the effect of vaccine antigen position and consequently expression level on viral fitness, immunogenicity, and anti-tumoral ef...
Source: Mol Biol Cell - April 22, 2023 Category: Molecular Biology Authors: Lydia Riepler Laura-Sophie Frommelt Sarah Wilmschen-Tober Wilbert Mbuya Kathrin Held Andr é Volland Dorothee von Laer Christof Geldmacher Janine Kimpel Source Type: research
Cervical human papillomavirus prevalence according to socioeconomic and demographic characteristics in a large Danish screening population
CONCLUSIONS: We found slightly higher hrHPV prevalences in women with basic education, low income and unemployment. The differences largely disappeared when taking into account marital status as a potential proxy for sexual behaviour. Our findings support a need for targeted information on safe sexual practices and promoting socioeconomic equality in HPV vaccination and cervical cancer screening participation.PMID:37078420 | DOI:10.1177/14034948231168297
Source: Scandinavian Journal of Public Health - April 20, 2023 Category: International Medicine & Public Health Authors: Freja L Ærke Sand Louise T Thomsen Dorthe Oernskov Christian Munk Marianne Waldstroem Susanne K Kjaer Source Type: research
Risk Factors and Trends for HPV-Associated Subsequent Malignant Neoplasms among Adolescent and Young Adult Cancer Survivors
CONCLUSIONS: HPV-SMN in AYA survivors are driven by oropharyngeal cancers despite temporal declines in oropharyngeal-SMN. Hispanic survivors are at risk for cervical-SMN relative to the general population.IMPACT: Encouraging HPV vaccination and cervical and oral cancer screenings may reduce HPV-SMN burden among AYA survivors.PMID:37071501 | DOI:10.1158/1055-9965.EPI-22-0826
Source: Cancer Control - April 18, 2023 Category: Cancer & Oncology Authors: Judy Y Ou Natalie Bennion Kellee Parker Douglas Fair Heidi A Hanson Deanna Kepka Echo L Warner Joemy M Ramsay Heydon K Kaddas Anne C Kirchhoff Source Type: research
Knowledge and attitudes towards cervical cancer prevention among women in Khartoum state, Sudan
CONCLUSION: This study revealed that the participant's knowledge and attitudes levels are mainly driven by their occupation, educational level, family income, and marital status altogether. This underscores the need for a countrywide community engagement campaign through health education and raising awareness sessions, and massive social media to sensitize the community and healthcare providers about the risk of cervical cancer and the available prevention and control measures.PMID:37070544 | DOI:10.1177/17455057231166286
Source: Cancer Control - April 18, 2023 Category: Cancer & Oncology Authors: Emmanuel Edwar Siddig Ayman Ahmed Eiman Siddig Ahmed Mona Ali Mohammed Ezzan Kunna Sarah M El-Sadig Yousif Ali Rana Alamin Hassan Eman Taha Ali Nouh Saad Mohamed Source Type: research
Safety and immunogenicity of a pichia pastoris-expressed bivalent human papillomavirus (types 16 and 18) L1 virus-like particle vaccine in healthy Chinese women aged 9-45 years: A randomized, double-blind, placebo-controlled phase 1 clinical trial
CONCLUSION: The pichia pastoris-expressed bivalent HPV vaccine was safe and immunogenic in Chinese females aged 9-45 years. The low dosage (0.5 mL) was selected for further immunogenicity and efficacy study.PMID:37061370 | DOI:10.1016/j.vaccine.2023.04.009
Source: Vaccine - April 15, 2023 Category: Allergy & Immunology Authors: Juan Li Li-Wei Shi Bang-Wei Yu Li-Rong Huang Ling-Yun Zhou Li Shi Zhi-Wei Jiang Jie-Lai Xia Xuan-Yi Wang Rong-Cheng Li Lin Yuan Yan-Ping Li Chang-Gui Li Source Type: research
