Safety and immunogenicity of a pichia pastoris-expressed bivalent human papillomavirus (types 16 and 18) L1 virus-like particle vaccine in healthy Chinese women aged 9-45  years: A randomized, double-blind, placebo-controlled phase 1 clinical trial

CONCLUSION: The pichia pastoris-expressed bivalent HPV vaccine was safe and immunogenic in Chinese females aged 9-45 years. The low dosage (0.5 mL) was selected for further immunogenicity and efficacy study.PMID:37061370 | DOI:10.1016/j.vaccine.2023.04.009

Source: Vaccine - April 15, 2023 Category: Allergy & Immunology Authors: Juan Li Li-Wei Shi Bang-Wei Yu Li-Rong Huang Ling-Yun Zhou Li Shi Zhi-Wei Jiang Jie-Lai Xia Xuan-Yi Wang Rong-Cheng Li Lin Yuan Yan-Ping Li Chang-Gui Li Source Type: research