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Next generation 3D-printed intravaginal ring for prevention of HIV and unintended pregnancy
Biomaterials. 2023 Aug 3;301:122260. doi: 10.1016/j.biomaterials.2023.122260. Online ahead of print.ABSTRACTGlobally, there are 20 million adolescent girls and young women living with HIV who have limited access to long-acting, effective, women-controlled preventative methods. Additionally, although there are many contraceptive methods available, globally, half of all pregnancies remain unintended. Here we report the first 3D-printed multipurpose prevention technology (MPT) intravaginal ring (IVR) for HIV prevention and contraception. We utilized continuous liquid interface production (CLIP™) to fabricate MPT IVRs in a b...
Source: Biomaterials - August 7, 2023 Category: Materials Science Authors: Isabella C Young Priya Srinivasan Roopali Shrivastava Rima Janusziewicz Allison Thorson Mackenzie L Cottrell Rani S Sellers Craig Sykes Amanda Schauer Dawn Little Kristen Kelley Angela D M Kashuba David Katz Richard B Pyles J Gerardo Garc ía-Lerma Kathle Source Type: research
Fight Aging! Newsletter, August 7th 2023
In conclusion, here, we demonstrate a novel mechanism for ESC-EVs to protect cells from senescence. However, whether ESC-EVs rejuvenate aged mice via miR-15b-5p and miR-290a-5p remains unknown. Next, we plan to use miR-15b-5p and miR-290a-5p antagonists while treating aged mice with ESC-EVs to further investigate the mechanism by which ESC-EVs resist aging in vivo.
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Fatty Acid Metabolism as a Commonality in Different Approaches to Slowing Aging
https://www.fightaging.org/archives/2023/08/fatty-acid-metabolism-as-a-commonality-in-different-approaches-to-slowing-aging/
It seems...
Source: Fight Aging! - August 6, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Comparative studies on ovary and serum hormone levels in silver and blue foxes and their hybrids
Anim Reprod Sci. 2023 Aug 2;256:107316. doi: 10.1016/j.anireprosci.2023.107316. Online ahead of print.ABSTRACTThe silver and blue fox appear closely related despite their belonging to different genera, and the male and female fox hybrids are completely sterile in mating inter se or back to either of the parental groups. In the present study, we compared ovarian morphology and serum hormone concentrations among silver foxes, blue foxes, HSBs (silver fox male × blue fox female hybrids) and HBSs (blue fox male × silver fox female hybrids) during the pre-breeding and the breeding period. We found that either the fertile blue...
Source: Animal Reproduction Science - August 5, 2023 Category: Zoology Authors: Yang Tong'ao Guo Ruonan Wang Yuanyuan Liu Hongli Zhang Haihua Yang Yahan Source Type: research
Interaction of gonadal hormones, dopaminergic system, and epigenetic regulation in the generation of sex differences in substance use disorders: a systematic review
Front Neuroendocrinol. 2023 Aug 3:101085. doi: 10.1016/j.yfrne.2023.101085. Online ahead of print.ABSTRACTSubstance use disorder (SUD) is a chronic condition characterized by pathological drug-taking and seeking behaviors. remarkably different between males and females, suggesting that drug addiction is a sexually differentiated disorder. The neurobiological bases of sex differences in SUD include sex-specific reward system activation, influenced by interactions between gonadal hormone level changes, dopaminergic reward circuits, and epigenetic modifications of key reward system genes. This systematic review, adhering to P...
Source: Frontiers in Neuroendocrinology - August 5, 2023 Category: Endocrinology Authors: Raquel Santos-Toscano Maria Angeles Arevalo Luis Miguel Garcia-Segura Daniela Grassi Natalia Lagunas Source Type: research
Comparative studies on ovary and serum hormone levels in silver and blue foxes and their hybrids
Anim Reprod Sci. 2023 Aug 2;256:107316. doi: 10.1016/j.anireprosci.2023.107316. Online ahead of print.ABSTRACTThe silver and blue fox appear closely related despite their belonging to different genera, and the male and female fox hybrids are completely sterile in mating inter se or back to either of the parental groups. In the present study, we compared ovarian morphology and serum hormone concentrations among silver foxes, blue foxes, HSBs (silver fox male × blue fox female hybrids) and HBSs (blue fox male × silver fox female hybrids) during the pre-breeding and the breeding period. We found that either the fertile blue...
Source: Animal Reproduction Science - August 5, 2023 Category: Zoology Authors: Yang Tong'ao Guo Ruonan Wang Yuanyuan Liu Hongli Zhang Haihua Yang Yahan Source Type: research
Interaction of gonadal hormones, dopaminergic system, and epigenetic regulation in the generation of sex differences in substance use disorders: a systematic review
Front Neuroendocrinol. 2023 Aug 3:101085. doi: 10.1016/j.yfrne.2023.101085. Online ahead of print.ABSTRACTSubstance use disorder (SUD) is a chronic condition characterized by pathological drug-taking and seeking behaviors. remarkably different between males and females, suggesting that drug addiction is a sexually differentiated disorder. The neurobiological bases of sex differences in SUD include sex-specific reward system activation, influenced by interactions between gonadal hormone level changes, dopaminergic reward circuits, and epigenetic modifications of key reward system genes. This systematic review, adhering to P...
Source: Frontiers in Neuroendocrinology - August 5, 2023 Category: Endocrinology Authors: Raquel Santos-Toscano Maria Angeles Arevalo Luis Miguel Garcia-Segura Daniela Grassi Natalia Lagunas Source Type: research
Comparative studies on ovary and serum hormone levels in silver and blue foxes and their hybrids
Anim Reprod Sci. 2023 Aug 2;256:107316. doi: 10.1016/j.anireprosci.2023.107316. Online ahead of print.ABSTRACTThe silver and blue fox appear closely related despite their belonging to different genera, and the male and female fox hybrids are completely sterile in mating inter se or back to either of the parental groups. In the present study, we compared ovarian morphology and serum hormone concentrations among silver foxes, blue foxes, HSBs (silver fox male × blue fox female hybrids) and HBSs (blue fox male × silver fox female hybrids) during the pre-breeding and the breeding period. We found that either the fertile blue...
Source: Animal Reproduction Science - August 5, 2023 Category: Zoology Authors: Yang Tong'ao Guo Ruonan Wang Yuanyuan Liu Hongli Zhang Haihua Yang Yahan Source Type: research
Retrospective study on long-term effects of hormone replacement therapy (HRT) and iron chelation therapy on glucose homeostasis and insulin secretion in female ß- thalassemia major (β-TM) patients with acquired hypogonadotropic- hypogonadism (AHH)
CONCLUSION: Deterioration of glycemia (dysglycemia) occurred in 45.4% (5/11) of thalassemic females on long-term HRT. Additional studies are needed to elucidate the validity of our preliminary observations.PMID:37539597 | DOI:10.23750/abm.v94i4.14631
Source: Acta Bio-Medica : Atenei Parmensis - August 4, 2023 Category: General Medicine Authors: Vincenzo De Sanctis Shahina Daar Ashraf Soliman Ploutarchos Tzoulis Salvatore Di Maio Christos Kattamis Source Type: research
