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Drug: Estradiol
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Total 6427 results found since Jan 2013.
High estradiol reduces adult neurogenesis but strengthens functional connectivity within the hippocampus during spatial pattern separation in adult female rats
Horm Behav. 2023 Aug 9;155:105409. doi: 10.1016/j.yhbeh.2023.105409. Online ahead of print.ABSTRACTAdult neurogenesis in the dentate gyrus plays an important role for pattern separation, the process of separating similar inputs and forming distinct neural representations. Estradiol modulates neurogenesis and hippocampus function, but to date no examination of estradiol's effects on pattern separation have been conducted. Here, we examined estrogenic regulation of adult neurogenesis and functional connectivity in the hippocampus after the spatial pattern separation task in female rats. Ovariectomized Sprague-Dawley rats rec...
Source: Hormones and Behavior - August 11, 2023 Category: Endocrinology Authors: Shunya Yagi Stephanie E Lieblich Liisa A M Galea Source Type: research
Hormone replacement therapy for postmenopausal atherosclerosis is offset by late age iron deposition
This study suggests that immediate HRT after menopause, along with appropriate iron chelation, might provide benefits from AS.PMID:37561022 | PMC:PMC10414966 | DOI:10.7554/eLife.80494
Source: Atherosclerosis - August 10, 2023 Category: Cardiology Authors: Tianze Xu Jing Cai Lei Wang Li Xu Hongting Zhao Fudi Wang Esther G Meyron-Holtz Fanis Missirlis Tong Qiao Kuanyu Li Source Type: research
Cyhexatin causes developmental toxic effects by disrupting endocrine system and inducing behavioral inhibition, apoptosis and DNA hypomethylation in zebrafish (Danio rerio) larvae
In this study, zebrafish embryos were firstly exposed to CYT (0.06, 0.12, and 0.20 ng/mL, referred to as CYTL, CYTM, and CYTH, respectively) from 2 hpf (hours post fertilization) to 30 dpf (days post fertilization). No developmental toxicity was observed in the CYTL and CYTM groups, except for induced deformed phenotypes in the CYTM group at 120 hpf. However, exposure to CYTH resulted in significant reductions in spontaneous movement (24 hpf), heart rate (48 hpf), hatching rate (48 and 72 hpf), body weight (30 dpf), whole body length (30 dpf), and locomotion (30 dpf). Additionally, CYTH exposure induced morphological malfo...
Source: Chemosphere - August 10, 2023 Category: Chemistry Authors: Fang Jiao Yang Zhao Samwel Mchele Limbu Lingfu Kong Daitao Zhang Xianghe Liu Sha Yang Wenjun Gui Hua Rong Source Type: research
Sequence identification and expression characterization of leptin in the spotted scat, Scatophagus argus
Comp Biochem Physiol B Biochem Mol Biol. 2023 Aug 8:110882. doi: 10.1016/j.cbpb.2023.110882. Online ahead of print.ABSTRACTScatophagus argus is an important marine culture fish in South and South-East Asia, including Southeast coastal areas of China. Artificial propagation technology for S. argus is not optimum; thus further studies on its reproduction biology are required. Although previous studies have shown that leptin (Lep) can regulate fish reproduction, the role of lep genes in S. argus is unknown. Herein, in silico analysis showed that S. argus has two lep genes (lepa and lepb). Protein 3D-structure prediction showe...
Source: Comparative biochemistry and physiology. Part B, Biochemistry and molecular biology. - August 10, 2023 Category: Biochemistry Authors: Wan-Xin Li Li-Ting Cai Yan-Ping Huang Yuan-Qing Huang Shu-Hui Pan Zhi-Long Liu Charles Brighton Ndandala Gang Shi Si-Ping Deng Hong-Juan Shi Guang-Li Li Dong-Neng Jiang Source Type: research
