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Retrospective study on long-term effects of hormone replacement therapy (HRT) and iron chelation therapy on glucose homeostasis and insulin secretion in female ß- thalassemia major (β-TM) patients with acquired hypogonadotropic- hypogonadism (AHH)
CONCLUSION: Deterioration of glycemia (dysglycemia) occurred in 45.4% (5/11) of thalassemic females on long-term HRT. Additional studies are needed to elucidate the validity of our preliminary observations.PMID:37539597 | DOI:10.23750/abm.v94i4.14631
Source: Acta Bio-Medica : Atenei Parmensis - August 4, 2023 Category: General Medicine Authors: Vincenzo De Sanctis Shahina Daar Ashraf Soliman Ploutarchos Tzoulis Salvatore Di Maio Christos Kattamis Source Type: research
CETP expression ameliorates endothelial function in female mice through estrogen receptor- α and endothelial nitric oxide synthase pathway
Am J Physiol Heart Circ Physiol. 2023 Aug 4. doi: 10.1152/ajpheart.00365.2023. Online ahead of print.ABSTRACTEndothelial dysfunction is an early manifestation of atherosclerosis. The cholesteryl ester transfer protein (CETP) has been considered pro-atherogenic by reducing plasma HDL levels. However, CETP may exhibit cell- or tissue-specific effects. We have previously reported that male mice expressing the human CETP gene show impaired endothelium-mediated vascular relaxation associated with oxidative stress. Although sexual dimorphisms on the metabolic role of CETP has been proposed, possible sex differences in the vascul...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 4, 2023 Category: Physiology Authors: Carolina M Lazaro Jamaira A Victorio Ana Paula Davel Helena C F Oliveira Source Type: research
Synergistic regulation of uterine radial artery adaptation to pregnancy by paracrine and haemodynamic factors
Am J Physiol Heart Circ Physiol. 2023 Aug 4. doi: 10.1152/ajpheart.00205.2023. Online ahead of print.ABSTRACTFetal growth throughout pregnancy relies on delivery of an increasing volume of maternal blood to the placenta. To facilitate this, the uterine vascular network adapts structurally and functionally, resulting in wider blood vessels with decreased flow-mediated reactivity. Impaired remodeling of the rate-limiting uterine radial arteries has been associated with fetal growth restriction. However, the mechanisms underlying normal or pathological radial artery remodeling are poorly understood. Here, we used pressure myo...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 4, 2023 Category: Physiology Authors: Hanna H Allerkamp Stephanie C Leighton Teagan Pole Alys R Clark Joanna L James Source Type: research
CETP expression ameliorates endothelial function in female mice through estrogen receptor- α and endothelial nitric oxide synthase pathway
Am J Physiol Heart Circ Physiol. 2023 Aug 4. doi: 10.1152/ajpheart.00365.2023. Online ahead of print.ABSTRACTEndothelial dysfunction is an early manifestation of atherosclerosis. The cholesteryl ester transfer protein (CETP) has been considered pro-atherogenic by reducing plasma HDL levels. However, CETP may exhibit cell- or tissue-specific effects. We have previously reported that male mice expressing the human CETP gene show impaired endothelium-mediated vascular relaxation associated with oxidative stress. Although sexual dimorphisms on the metabolic role of CETP has been proposed, possible sex differences in the vascul...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 4, 2023 Category: Physiology Authors: Carolina M Lazaro Jamaira A Victorio Ana Paula Davel Helena C F Oliveira Source Type: research
Synergistic regulation of uterine radial artery adaptation to pregnancy by paracrine and haemodynamic factors
Am J Physiol Heart Circ Physiol. 2023 Aug 4. doi: 10.1152/ajpheart.00205.2023. Online ahead of print.ABSTRACTFetal growth throughout pregnancy relies on delivery of an increasing volume of maternal blood to the placenta. To facilitate this, the uterine vascular network adapts structurally and functionally, resulting in wider blood vessels with decreased flow-mediated reactivity. Impaired remodeling of the rate-limiting uterine radial arteries has been associated with fetal growth restriction. However, the mechanisms underlying normal or pathological radial artery remodeling are poorly understood. Here, we used pressure myo...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 4, 2023 Category: Physiology Authors: Hanna H Allerkamp Stephanie C Leighton Teagan Pole Alys R Clark Joanna L James Source Type: research
Retrospective study on long-term effects of hormone replacement therapy (HRT) and iron chelation therapy on glucose homeostasis and insulin secretion in female ß- thalassemia major (β-TM) patients with acquired hypogonadotropic- hypogonadism (AHH)
CONCLUSION: Deterioration of glycemia (dysglycemia) occurred in 45.4% (5/11) of thalassemic females on long-term HRT. Additional studies are needed to elucidate the validity of our preliminary observations.PMID:37539597 | DOI:10.23750/abm.v94i4.14631
Source: Acta Bio-Medica : Atenei Parmensis - August 4, 2023 Category: General Medicine Authors: Vincenzo De Sanctis Shahina Daar Ashraf Soliman Ploutarchos Tzoulis Salvatore Di Maio Christos Kattamis Source Type: research
CETP expression ameliorates endothelial function in female mice through estrogen receptor- α and endothelial nitric oxide synthase pathway
Am J Physiol Heart Circ Physiol. 2023 Aug 4. doi: 10.1152/ajpheart.00365.2023. Online ahead of print.ABSTRACTEndothelial dysfunction is an early manifestation of atherosclerosis. The cholesteryl ester transfer protein (CETP) has been considered pro-atherogenic by reducing plasma HDL levels. However, CETP may exhibit cell- or tissue-specific effects. We have previously reported that male mice expressing the human CETP gene show impaired endothelium-mediated vascular relaxation associated with oxidative stress. Although sexual dimorphisms on the metabolic role of CETP has been proposed, possible sex differences in the vascul...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 4, 2023 Category: Physiology Authors: Carolina M Lazaro Jamaira A Victorio Ana Paula Davel Helena C F Oliveira Source Type: research
Synergistic regulation of uterine radial artery adaptation to pregnancy by paracrine and haemodynamic factors
Am J Physiol Heart Circ Physiol. 2023 Aug 4. doi: 10.1152/ajpheart.00205.2023. Online ahead of print.ABSTRACTFetal growth throughout pregnancy relies on delivery of an increasing volume of maternal blood to the placenta. To facilitate this, the uterine vascular network adapts structurally and functionally, resulting in wider blood vessels with decreased flow-mediated reactivity. Impaired remodeling of the rate-limiting uterine radial arteries has been associated with fetal growth restriction. However, the mechanisms underlying normal or pathological radial artery remodeling are poorly understood. Here, we used pressure myo...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 4, 2023 Category: Physiology Authors: Hanna H Allerkamp Stephanie C Leighton Teagan Pole Alys R Clark Joanna L James Source Type: research
CETP expression ameliorates endothelial function in female mice through estrogen receptor- α and endothelial nitric oxide synthase pathway
Am J Physiol Heart Circ Physiol. 2023 Aug 4. doi: 10.1152/ajpheart.00365.2023. Online ahead of print.ABSTRACTEndothelial dysfunction is an early manifestation of atherosclerosis. The cholesteryl ester transfer protein (CETP) has been considered pro-atherogenic by reducing plasma HDL levels. However, CETP may exhibit cell- or tissue-specific effects. We have previously reported that male mice expressing the human CETP gene show impaired endothelium-mediated vascular relaxation associated with oxidative stress. Although sexual dimorphisms on the metabolic role of CETP has been proposed, possible sex differences in the vascul...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 4, 2023 Category: Physiology Authors: Carolina M Lazaro Jamaira A Victorio Ana Paula Davel Helena C F Oliveira Source Type: research
Synergistic regulation of uterine radial artery adaptation to pregnancy by paracrine and haemodynamic factors
Am J Physiol Heart Circ Physiol. 2023 Aug 4. doi: 10.1152/ajpheart.00205.2023. Online ahead of print.ABSTRACTFetal growth throughout pregnancy relies on delivery of an increasing volume of maternal blood to the placenta. To facilitate this, the uterine vascular network adapts structurally and functionally, resulting in wider blood vessels with decreased flow-mediated reactivity. Impaired remodeling of the rate-limiting uterine radial arteries has been associated with fetal growth restriction. However, the mechanisms underlying normal or pathological radial artery remodeling are poorly understood. Here, we used pressure myo...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 4, 2023 Category: Physiology Authors: Hanna H Allerkamp Stephanie C Leighton Teagan Pole Alys R Clark Joanna L James Source Type: research
