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Cancer: Adenocarcinoma
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Total 24262 results found since Jan 2013.
Presentation of Gastrointestinal Stromal Tumor, Pancreatic Adenocarcinoma, and Gastric Adenocarcinoma in a Woman With No Identifiable Genetic Abnormalities
This report details the first known case of co-occurrence of gastrointestinal stromal tumor (GIST), pancreatic adenocarcinoma, and gastric adenocarcinoma in an individual with no identifiable genetic abnormalities. The patient is a 57-year-old female who presented with abdominal pain. CT scan demonstrated a pancreatic mass, and endoscopic ultrasound demonstrated an additional gastric mass. Biopsy of both masses demonstrated adenocarcinoma; however, the masses were found to have different origins. The patient underwent neoadjuvant chemotherapy with excellent response. She then underwent surgical intervention, which demonstr...
Source: The American Surgeon - September 12, 2023 Category: Surgery Authors: Catherine Read Marybeth Hughes Omar Itani Source Type: research
A novel cuproptosis-related gene prognostic signature in colon adenocarcinoma
This study plans to establish a survival prognosis model for colon adenocarcinoma (COAD) patients based on cuproptosis-related genes (CRGs). We investigated the genetic alterations of CRGs in COAD based on The Cancer Genome Atlas database and validated in the GSE41328 dataset. Our results showed that LIPT1, PDHA1, GLS, and CDKN2A had significantly higher expression in COAD tissues than in normal tissues, while FDX1, DLD, and MTF1 had significantly lower expression in COAD tissues than in normal tissues (|(log2(fold change))| > 2, p < 0.05). DLD (hazard ratio (HR): 0.658; 95% confidence interval (CI): 0.445, 0.974; p ...
Source: Canadian Journal of Physiology and Pharmacology - September 12, 2023 Category: Drugs & Pharmacology Authors: Yongqin Su Kun Zhang Source Type: research
Impact of oophorectomy on survival and improving nutritional status in ovarian metastasis from colorectal adenocarcinoma
CONCLUSIONS: Oophorectomy for ovarian metastasis from colorectal cancers was safely performed. It improved the patients' symptoms and nutritional status and may result in improved prognosis.PMID:37699374 | DOI:10.1159/000533599
Source: Oncology - September 12, 2023 Category: Cancer & Oncology Authors: Yusuke Miyagawa Masato Kitazawa Shigeo Tokumaru Satoshi Nakamura Makoto Koyama Yuta Yamamoto Satoru Miyazaki Nao Hondo Yuji Soejima Source Type: research
Identifying luteolin as a potential drug for treating lung adenocarcinoma with COVID-19 affection based on integration analysis of pharmacology and transcriptome
CONCLUSION: HSP90AA1 was a target gene for further designing effective drugs for LUAD patients. Luteolin was a potential drug for treating patients with both LUAD and COVID-19.PMID:37694790 | DOI:10.2174/0929867331666230908090326
Source: Current Medicinal Chemistry - September 11, 2023 Category: Chemistry Authors: Ping Peng Na Li Ni Zhang Xiangning Fu Shu Peng Yujie Zhao Bo Ai Source Type: research
Potential association of HSPD1 with dysregulations in ribosome biogenesis and immune cell infiltration in lung adenocarcinoma: An integrated bioinformatic approach
CONCLUSIONS: HSPD1 may play a role in the regulation of ribosome biogenesis and B cell-mediated immunity in LUAD. It could serve as a predictive biomarker for prognosis and immunotherapy response in LUAD.PMID:37694354 | DOI:10.3233/CBM-220442
Source: Cancer Biomarkers : Section A of Disease Markers - September 11, 2023 Category: Cancer & Oncology Authors: Siripat Aluksanasuwan Keerakarn Somsuan Jatuporn Ngoenkam Somchai Chutipongtanate Sutatip Pongcharoen Source Type: research
Identification of molecular biomarkers associated with non-small-cell lung carcinoma (NSCLC) using whole-exome sequencing
CONCLUSIONS: Our bioinformatics analysis identified KCNJ18, GPRIN2, TEKT4, HRNR, FOLR3, ESSRA, CTBP2, MPRIP, TBP, and FBXO6 may contribute to progression in NSCLC and could be used as new biomarkers for the treatment. The mechanism by which GPRIN2, KCNJ12, and TEKT4 contribute to tumorigenesis is unclear, but our results suggest they may play an important role in NSCLC and it is worth investigating in future.PMID:37694353 | DOI:10.3233/CBM-220211
Source: Cancer Biomarkers : Section A of Disease Markers - September 11, 2023 Category: Cancer & Oncology Authors: Varsha Singh Amit Katiyar Prabhat Malik Sunil Kumar Anant Mohan Harpreet Singh Deepali Jain Source Type: research
The disappearance of gastric metastasis and liver metastasis in non-small cell lung adenocarcinoma is due to osimertinib
CONCLUSIONS: This is the first report to our knowledge of a patient who presented with gastric and hepatic metastases from lung cancer and achieved complete remission with osimertinib and local radiotherapy, with good quality of life, which also provides a basis for future clinical work and is of great significance.PMID:37695388 | DOI:10.1007/s00432-023-05386-7
Source: Clinical Lung Cancer - September 11, 2023 Category: Cancer & Oncology Authors: Yun Wang Chao Yan Chuantao Zhang Enhao Yu Kai Wang Xiangyong Liu Jie Yu Chunyang Zhou Aijie Yang Source Type: research
Effects of Dichloromethane and N-Butanol Fractions of < em > Nigella sativa < /em > on ACHN and GP-293 Cell Line Morphology, Viability, and Apoptosis
CONCLUSION: Our findings demonstrated that these two fractions of N. sativa induce inhibitory effects on the ACHN cell line morphology and viability. These effects were lower than those induced by the total extract. In addition, the two fractions caused more marked effects in the renal cancer cell line compared with the GP-293 cell line.PMID:37694244 | PMC:PMC10492620 | DOI:10.4103/abr.abr_394_22
Source: Biomed Res - September 11, 2023 Category: Research Authors: Samira Shahraki Sara Hosseinian Elham Shahraki Mehdi Kheirandish Abolfazl Khajavirad Source Type: research
Pancreatic ductal adenocarcinoma with a high expression of alcohol dehydrogenase 1B is associated with less aggressive features and a favorable prognosis
In conclusion, PDAC with high ADH1B expression had less cell proliferation and malignant features, along with higher immune cell infiltration, and had a better prognosis.PMID:37693153 | PMC:PMC10492124
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Kohei Chida Masanori Oshi Arya Mariam Roy Takumi Sato Itaru Endo Kazuaki Takabe Source Type: research
Decoding SEC24 Homolog D, COPII coat complex component accuracy as a signature gene in three human cancers
In this study, we conducted an extensive investigation of SEC24D, aiming to elucidate its potential role and underlying mechanisms across multiple human tumors. Our analysis relied on data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. To validate our findings, we employed RNA sequencing (RNA-seq), targeted bisulfite sequencing (bisulfite-seq) molecular techniques. Our findings revealed elevated mRNA (Messenger RNA) and protein levels of SEC24D in different tumor tissues. However, the up-regulation of SEC24D was significantly correlated with shorter overall survival (OS), metastasis, and v...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Weiwei Du Yang Sun Wentao Ji Tian Luo Dandan Zhang Weihong Guo Jianping Liang Yanhua Lv Mengwei Dong Kaixin Li Source Type: research
hsa_circ_0000519 promotes the progression of lung adenocarcinoma through the hsa-miR-1296-5p/DARS axis
In conclusion, hsa_circ_0000519 promotes LUAD progression through the hsa-miR-1296-5p/DARS axis and may be expected as a novel biomarker and therapeutic for LUAD.PMID:37693148 | PMC:PMC10492121
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Guangxu Tu Weilin Peng Xiong Peng Zhenyu Zhao Shuai Shi Qidong Cai Boxue He Wei Yin Shaoliang Peng Li Wang Fenglei Yu Xiang Wang Source Type: research
Pancreatic cancer cell-derived semaphorin 3A promotes neuron recruitment to accelerate tumor growth and dissemination
Am J Cancer Res. 2023 Aug 15;13(8):3417-3432. eCollection 2023.ABSTRACTPerineural invasion and neurogenesis are frequently observed in pancreatic ductal adenocarcinoma (PDAC), and they are associated with a poor prognosis. Axon guidance factor semaphorin 3A (SEMA3A) is upregulated in PDAC. However, it remains unclear whether cancer-derived SEMA3A influences nerve innervation and pancreatic tumorigenesis. In silico analyses were performed using PROGgene and NetworkAnalyst to clarify the importance of SEMA3A and its receptors, plexin A1 (PLXNA1) and neuropilin 2 (NRP2), in pancreatic cancer. In vitro assays, including migrat...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Yu-Hsuan Hung Ya-Chin Hou Shih-Han Hsu Li-Yun Wang Ya-Li Tsai Yan-Shen Shan Yung-Yeh Su Wen-Chun Hung Li-Tzong Chen Source Type: research
Clinical outcome analysis of non-small cell lung cancer patients with brain metastasis receiving metastatic brain tumor resection surgery: a multicenter observational study
Am J Cancer Res. 2023 Aug 15;13(8):3607-3617. eCollection 2023.ABSTRACTBrain metastasis is most common in primary non-small cell lung cancer (NSCLC), and some patients require neurosurgical resection for intracranial disease control. Because advances in systemic therapies for metastatic NSCLC have been developed in the past decade, we aimed to analyze and determine clinical factors associated with the postresection survival of NSCLC patients with brain metastasis who underwent neurosurgery followed by systemic therapy. Between January 2017 and December 2021, data for 93 NSCLC patients with brain metastasis treated with neu...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Ping-Chih Hsu Li-Chung Chiu Ko-Ting Chen Chun-Chieh Wang Chen-Te Wu Chiao-En Wu Ho-Wen Ko Scott Chih-Hsi Kuo Yu-Ching Lin Chin-Chou Wang Cheng-Ta Yang Source Type: research
Bioinformatics, RNA sequencing, and targeted bisulfite sequencing analyses identify the role of PROM2 as a diagnostic and prognostic biomarker
CONCLUSION: Via this study, we effectively revealed PROM2 overexpression as a potential diagnostic and prognostic biomarker of survival in BRCA, LUAD, and UCEC.PMID:37692961 | PMC:PMC10492044
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Arsalan Ahmed Uqaili Gulzar Usman Urooj Bhatti Hilal Nasir Rabeea Zia Muhammad Aitzaz Akram Fahim Ali Jawad Afshan Farid Mohamed Ragab AbdelGawwad Saeedah Musaed Almutairi Mohamed S Elshikh Sajid Hussain Rabab Ahmed Rasheed Source Type: research
