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Cancer: Liver Cancer

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Total 30263 results found since Jan 2013.

A model incorporating clinicopathologic and liver imaging reporting and data system-based magnetic resonance imaging features to identify hepatocellular carcinoma in LR-M observations
CONCLUSION: The combined model incorporating clinicopathologic and MRI features demonstrated a satisfactory prediction result for LR-M HCC.PMID:37665140 | DOI:10.4274/dir.2023.232215
Source: Diagnostic and Interventional Radiology - September 4, 2023 Category: Radiology Authors: Xin-Xing Hu Dong Bai Zhen-Lei Wang Yi Zhang Jue Zhao Mei-Ling Li Jia Yang Lei Zhang Source Type: research

Combination transarterial chemoembolization and microwave ablation vs. microwave ablation monotherapy for hepatocellular carcinomas greater than 3 cm: a comparative study
CONCLUSION: The combination therapy provided significantly longer upfront LTP-free survival in HCCs >3 cm when compared with the MWA treatment alone, albeit with similar local tumor control and overall survival rates when accounting for additional locoregional therapies.PMID:37665139 | DOI:10.4274/dir.2023.232159
Source: Diagnostic and Interventional Radiology - September 4, 2023 Category: Radiology Authors: Jason Chiang Pradeep S Rajendran Frank Hao James Sayre Steven S Raman David S K Lu Justin P McWilliams Source Type: research

A model incorporating clinicopathologic and liver imaging reporting and data system-based magnetic resonance imaging features to identify hepatocellular carcinoma in LR-M observations
CONCLUSION: The combined model incorporating clinicopathologic and MRI features demonstrated a satisfactory prediction result for LR-M HCC.PMID:37665140 | DOI:10.4274/dir.2023.232215
Source: Diagnostic and Interventional Radiology : The Turkish Society of Radiology - September 4, 2023 Category: Radiology Authors: Xin-Xing Hu Dong Bai Zhen-Lei Wang Yi Zhang Jue Zhao Mei-Ling Li Jia Yang Lei Zhang Source Type: research

Combination transarterial chemoembolization and microwave ablation vs. microwave ablation monotherapy for hepatocellular carcinomas greater than 3 cm: a comparative study
CONCLUSION: The combination therapy provided significantly longer upfront LTP-free survival in HCCs >3 cm when compared with the MWA treatment alone, albeit with similar local tumor control and overall survival rates when accounting for additional locoregional therapies.PMID:37665139 | DOI:10.4274/dir.2023.232159
Source: Diagnostic and Interventional Radiology : The Turkish Society of Radiology - September 4, 2023 Category: Radiology Authors: Jason Chiang Pradeep S Rajendran Frank Hao James Sayre Steven S Raman David S K Lu Justin P McWilliams Source Type: research

Transcription Factor JunB Suppresses Hepatitis C Virus Replication
Kobe J Med Sci. 2023 Aug 31;69(3):E86-E95.ABSTRACTWe previously reported that hepatitis C virus (HCV) infection activates the reactive oxygen species (ROS)/c-Jun N-terminal kinase (JNK) signaling pathway. Activation of JNK contributes to the development of liver diseases, including metabolic disorders, steatosis, liver cirrhosis and hepatocellular carcinoma. JNK is known to have numerous target genes, including JunB, a member of activator protein-1 transcription factor family. However, the roles of JunB in the HCV life cycle and HCV-associated pathogenesis remain unclear. To clarify a physiological role of JunB in HCV infe...
Source: Kobe J Med Sci - September 4, 2023 Category: General Medicine Authors: Adi Ariffianto Lin Deng Saki Harada Yujiao Liang Chieko Matsui Takayuki Abe Ikuo Shoji Source Type: research

Dysregulated microRNAs as a biomarker for diagnosis and prognosis of hepatitis B virus-associated hepatocellular carcinoma
World J Gastroenterol. 2023 Aug 21;29(31):4706-4735. doi: 10.3748/wjg.v29.i31.4706.ABSTRACTHepatocellular carcinoma (HCC) is a malignancy with a high incidence and fatality rate worldwide. Hepatitis B virus (HBV) infection is one of the most important risk factors for its occurrence and development. Early detection of HBV-associated HCC (HBV-HCC) can improve clinical decision-making and patient outcomes. Biomarkers are extremely helpful, not only for early diagnosis, but also for the development of therapeutics. MicroRNAs (miRNAs), a subset of non-coding RNAs approximately 22 nucleotides in length, have increasingly attrac...
Source: World Journal of Gastroenterology : WJG - September 4, 2023 Category: Gastroenterology Authors: Ming-He Zhang Yu-Feng Yuan Li-Juan Liu Yu-Xin Wei Wan-Yue Yin Lan-Zhuo-Yin Zheng Ying-Ying Tang Zhao Lv Fan Zhu Source Type: research

Gamma-glutamyl transferase levels in the prediction of the outcomes of hepatocellular carcinoma after surgical resection
J Formos Med Assoc. 2023 Sep 1:S0929-6646(23)00341-8. doi: 10.1016/j.jfma.2023.08.026. Online ahead of print.NO ABSTRACTPMID:37661528 | DOI:10.1016/j.jfma.2023.08.026
Source: J Formos Med Assoc - September 4, 2023 Category: General Medicine Authors: Tung-Hung Su Jia-Horng Kao Source Type: research

Performance and effectiveness of hepatocellular carcinoma screening in individuals with HBsAg seropositivity in China: a multicenter prospective study
Nat Cancer. 2023 Sep 4. doi: 10.1038/s43018-023-00618-8. Online ahead of print.ABSTRACTCurrent guidelines recommend hepatocellular carcinoma (HCC) surveillance for at-risk individuals, including individuals with hepatitis B virus infection. However, the performance and survival benefits of annual screening have not been evaluated through multicenter prospective studies in a Chinese population. Between 2017 and 2021, we included 14,426 participants with hepatitis B surface antigen seropositivity in an annual HCC screening study in China using a multicenter prospective design with ultrasonography and serum alpha-fetoprotein....
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Hongmei Zeng Maomao Cao Changfa Xia Dongmei Wang Kun Chen Zheng Zhu Ruiying Fu Shaokai Zhang Jinyi Zhou Huadong Wang Xianyun Qi Shuguang Dai Yong Chen Zhong Sun Hao Ding Qingwen Li Hui Zhao Xuehong Zhang Jakub Morze John S Ji Feng Sun Xueqin Yu Wanqing Ch Source Type: research

Objective response and progression free survival contribute to prolong overall survival in atezolizumab plus bevacizumab treatment for unresectable hepatocellular carcinoma
CONCLUSION: The presence of anti-tumor response with tumor shrinkage during Atez/Bev treatment contributes to good OS through its durable response. Atez/Bev treatment could be considered as first-line treatment for unresectable HCC. However, there is a need for optimal biomarkers for good-anti-tumor response.PMID:37666216 | DOI:10.1159/000533952
Source: Oncology - September 4, 2023 Category: Cancer & Oncology Authors: Kazuto Tajiri Kenichiro Tsukada Yoshiharu Tokimitsu Yuchi Motofuji Kengo Kawai Nozomu Muraishi Aiko Murayama Yuka Hayashi Yukihiro Shimizu Ichiro Yasuda Source Type: research

Gamma-glutamyl transferase levels in the prediction of the outcomes of hepatocellular carcinoma after surgical resection
J Formos Med Assoc. 2023 Sep 1:S0929-6646(23)00341-8. doi: 10.1016/j.jfma.2023.08.026. Online ahead of print.NO ABSTRACTPMID:37661528 | DOI:10.1016/j.jfma.2023.08.026
Source: J Formos Med Assoc - September 4, 2023 Category: General Medicine Authors: Tung-Hung Su Jia-Horng Kao Source Type: research

Transcription Factor JunB Suppresses Hepatitis C Virus Replication
Kobe J Med Sci. 2023 Aug 31;69(3):E86-E95.ABSTRACTWe previously reported that hepatitis C virus (HCV) infection activates the reactive oxygen species (ROS)/c-Jun N-terminal kinase (JNK) signaling pathway. Activation of JNK contributes to the development of liver diseases, including metabolic disorders, steatosis, liver cirrhosis and hepatocellular carcinoma. JNK is known to have numerous target genes, including JunB, a member of activator protein-1 transcription factor family. However, the roles of JunB in the HCV life cycle and HCV-associated pathogenesis remain unclear. To clarify a physiological role of JunB in HCV infe...
Source: Kobe J Med Sci - September 4, 2023 Category: General Medicine Authors: Adi Ariffianto Lin Deng Saki Harada Yujiao Liang Chieko Matsui Takayuki Abe Ikuo Shoji Source Type: research

Dysregulated microRNAs as a biomarker for diagnosis and prognosis of hepatitis B virus-associated hepatocellular carcinoma
World J Gastroenterol. 2023 Aug 21;29(31):4706-4735. doi: 10.3748/wjg.v29.i31.4706.ABSTRACTHepatocellular carcinoma (HCC) is a malignancy with a high incidence and fatality rate worldwide. Hepatitis B virus (HBV) infection is one of the most important risk factors for its occurrence and development. Early detection of HBV-associated HCC (HBV-HCC) can improve clinical decision-making and patient outcomes. Biomarkers are extremely helpful, not only for early diagnosis, but also for the development of therapeutics. MicroRNAs (miRNAs), a subset of non-coding RNAs approximately 22 nucleotides in length, have increasingly attrac...
Source: World Journal of Gastroenterology : WJG - September 4, 2023 Category: Gastroenterology Authors: Ming-He Zhang Yu-Feng Yuan Li-Juan Liu Yu-Xin Wei Wan-Yue Yin Lan-Zhuo-Yin Zheng Ying-Ying Tang Zhao Lv Fan Zhu Source Type: research

Two new 2-arylbenzo < em > b < /em > furans from < em > Itea indochinensis < /em > and their anti-hepatocellular carcinoma and anti-oxidant effects
Nat Prod Res. 2023 Sep 4:1-9. doi: 10.1080/14786419.2023.2252975. Online ahead of print.ABSTRACTTwo new 2-arylbenzo[b]furans (1-2) and ten known compounds (3-12) were identified from the 95% EtOH extract of the branches and leaves of Itea indochinensis for the first time. Their structures were determined mainly based on extensive analyses of UV, IR, 1D/2D NMR and HRMS spectra. The results of MTT assays demonstrated the anti-tumor potential of compound 1 with good selectivity, which displayed moderate inhibitory effects on proliferation of SK-hep-1 cells with IC50 value of 22.3 μM, while weak inhibitory effect on prolifera...
Source: Natural Product Research - September 4, 2023 Category: Biochemistry Authors: Fang-Fang Xu Jin-Zhen Jian Yi-Jv Li Zhi-Wei Wang Guo-Yong Luo Wu-De Yang Source Type: research