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Cancer: Liver Cancer
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Total 30263 results found since Jan 2013.
Liver Transplantation for Hepatocellular Carcinoma in Patients with Inherited Metabolic Liver Diseases: A Single-Center Analysis
CONCLUSION: Liver transplant for these categories of patients is associated with good disease-free and overall survival, even in the presence of some seemingly poor prognostic features.PMID:37681267 | DOI:10.5152/tjg.2023.22679
Source: The Turkish Journal of Gastroenterology - September 8, 2023 Category: Gastroenterology Authors: İbrahim Umar Garzali Abdirahman Sakulen Hargura Volkan İnce Fatma İlknur Varol Brian I Carr Sezai Y ılmaz Source Type: research
FDA Approval Summary: Tremelimumab in combination with durvalumab for the treatment of patients with unresectable hepatocellular carcinoma
Clin Cancer Res. 2023 Sep 7. doi: 10.1158/1078-0432.CCR-23-2124. Online ahead of print.ABSTRACTOn October 21, 2022, the FDA approved tremelimumab (Imjudo) in combination with durvalumab for adult patients with unresectable hepatocellular carcinoma (uHC). The approval was based on the results from the HIMALAYA study, in which patients with uHC who were naïve to previous systemic treatment were randomized to receive one of three study arms: tremelimumab in combination with durvalumab (n=393), durvalumab (n=389), or sorafenib (n=389). The primary objective of improvement in overall survival (OS) for tremelimumab in combinati...
Source: Clinical Cancer Research - September 7, 2023 Category: Cancer & Oncology Authors: Timil H Patel Jamie R Brewer Jiaxin Fan Joyce Cheng Yuan Li Shen Yue Xiang Hong Zhao Steven J Lemery Richard Pazdur Paul G Kluetz Lola A Fashoyin-Aje Source Type: research
Comparison of RETREAT and CCFSS Scoring Systems for Risk Estimation of Hepatocellular Carcinoma Recurrence After Radical Resection
CONCLUSION: The RETREAT score demonstrates higher efficacy compared to the CCFSS score in predicting postoperative recurrence in hepatocellular carcinoma (HCC) patients and can serve as a valuable tool for the prognostic evaluation of HCC patients who undergo radical resection. The RETREAT score's superiority can be attributed to its higher area under the curve (AUC) and improved sensitivity and specificity, which allow for better discrimination between positive and negative cases. This enhanced accuracy enables clinicians to make more informed decisions towards post-surgical management and treatment strategies, ultimately...
Source: Alternative Therapies in Health and Medicine - September 7, 2023 Category: Complementary Medicine Authors: Sheng Zhang Xuan Zhang Cong Mo Yunfan Luo Source Type: research
Stimuli-Responsive Hydrogel Microcapsules Harnessing the COVID-19 Immune Response for Cancer Therapeutics
We present the development of stimuli-responsive microcapsules, loaded with a viral immunogenetic agent, harnessing the immune response against the Coronavirus Disease 2019, COVID-19, to selectively attack liver cancer cells (hepatoma) or recognize breast cancer or hepatoma, by expression of green fluorescence protein, GFP. The pH-responsive microcapsules, modified with DNA-tetrahedra nanostructures, increased hepatoma permeation by 50%. Incorporation of a GFP-encoding lentivirus vector inside the tumor-targeting pH-stimulated miRNA-triggered and Alpha-fetoprotein-dictated microcapsules enables the demonstration of neoplas...
Source: Angewandte Chemie - September 7, 2023 Category: Chemistry Authors: Amit Fischer Avner Ehrlich Yevgeni Plotkin Yu Ouyang Klil Asulin Ioannidis Konstantinos Chunhai Fan Yaakov Nahmias Itamar Willner Source Type: research
YY1-regulated lncRNA SOCS2-AS1 suppresses HCC cell stemness and progression via miR-454-3p/CPEB1
CONCLUSIONS: YY1-regulated lncRNA SOCS2-AS1 suppresses HCC cell stemness and progression via miR-454-3p/CPEB1.PMID:37677983 | DOI:10.1016/j.bbrc.2023.08.056
Source: Biochemical and Biophysical Research communications - September 7, 2023 Category: Biochemistry Authors: Feng Zhong Yuanxi Wang Source Type: research
A TiN-based nanophotosensitizer for enhanced photothermal therapy with the aid of ultrasound
CONCLUSION: The research has established NBs@C3F8-TiN as a suitable ultrasound photothermal agent due to its appropriate size and efficient photothermal efficacy for visual photothermal therapy for HCC.PMID:37677981 | DOI:10.1016/j.bbrc.2023.09.003
Source: Biochemical and Biophysical Research communications - September 7, 2023 Category: Biochemistry Authors: Nan Li Yunfeng Sun Jiabao Ouyang Yuna Che Chen Chen Wen Li Changjun Wu Source Type: research
YY1-regulated lncRNA SOCS2-AS1 suppresses HCC cell stemness and progression via miR-454-3p/CPEB1
CONCLUSIONS: YY1-regulated lncRNA SOCS2-AS1 suppresses HCC cell stemness and progression via miR-454-3p/CPEB1.PMID:37677983 | DOI:10.1016/j.bbrc.2023.08.056
Source: Biochemical and Biophysical Research communications - September 7, 2023 Category: Biochemistry Authors: Feng Zhong Yuanxi Wang Source Type: research
A TiN-based nanophotosensitizer for enhanced photothermal therapy with the aid of ultrasound
CONCLUSION: The research has established NBs@C3F8-TiN as a suitable ultrasound photothermal agent due to its appropriate size and efficient photothermal efficacy for visual photothermal therapy for HCC.PMID:37677981 | DOI:10.1016/j.bbrc.2023.09.003
Source: Biochemical and Biophysical Research communications - September 7, 2023 Category: Biochemistry Authors: Nan Li Yunfeng Sun Jiabao Ouyang Yuna Che Chen Chen Wen Li Changjun Wu Source Type: research
Treatment Disparities Partially Mediate Socioeconomic- and Race/Ethnicity-Based Survival Disparities in Stage I-II Hepatocellular Carcinoma
CONCLUSIONS: SES-based disparities in use of procedural interventions mediate a large proportion of survival disparities, particularly among Black and Hispanic patients. Initiatives aimed at attenuating these treatment disparities should be pursued.PMID:37679537 | DOI:10.1245/s10434-023-14132-9
Source: Ann Oncol - September 7, 2023 Category: Cancer & Oncology Authors: Douglas S Swords Timothy E Newhook Ching-Wei D Tzeng Nader N Massarweh Yun Shin Chun Sunyoung Lee Ahmed O Kaseb Mark Ghobrial Jean-Nicolas Vauthey Hop S Tran Cao Source Type: research
Effects of iodine-125 seed brachytherapy on patients with heterochronous pulmonary metastasis from hepatocellular carcinoma: A propensity score matching study
CONCLUSION: ISB improves local control and OS rates of HPM secondary to HCC; thus, it is an effective and feasible option for patients with HPM secondary to HCC.PMID:37675723 | DOI:10.4103/jcrt.jcrt_519_22
Source: Cancer Control - September 7, 2023 Category: Cancer & Oncology Authors: Chongshuang Yang Chuang He Songtao Yu Jing Yuan Yunhua Xiao Xuequan Huang Source Type: research
Blueprint to hepatitis B elimination in China: A modelling analysis of clinical strategies
CONCLUSIONS: Eliminating HBV will require interventional strategies to improve diagnostic, linkage-to-care, and treatment coverages. Developing novel therapies will be crucial in further reducing HBV-related mortality and removing HBV as a public health threat.IMPACT AND IMPLICATIONS: This study explores the key developments and optimal intervention strategies needed to achieve WHO hepatitis B elimination targets by 2030 in China. It highlights that China can realise the HBV elimination targets in the incidence by 2025, and by upscaling diagnostic, linkage-to-care, and treatment coverages, up to 2 million lives could poten...
Source: Cancer Control - September 7, 2023 Category: Cancer & Oncology Authors: Rui Li Mingwang Shen Jason J Ong Fuqiang Cui Wenyi Hu Polin Chan Zhuoru Zou Shu Su Hangting Liu Lei Zhang Wai-Kay Seto William C W Wong Source Type: research
YY1-regulated lncRNA SOCS2-AS1 suppresses HCC cell stemness and progression via miR-454-3p/CPEB1
CONCLUSIONS: YY1-regulated lncRNA SOCS2-AS1 suppresses HCC cell stemness and progression via miR-454-3p/CPEB1.PMID:37677983 | DOI:10.1016/j.bbrc.2023.08.056
Source: Cell Research - September 7, 2023 Category: Cytology Authors: Feng Zhong Yuanxi Wang Source Type: research
A TiN-based nanophotosensitizer for enhanced photothermal therapy with the aid of ultrasound
CONCLUSION: The research has established NBs@C3F8-TiN as a suitable ultrasound photothermal agent due to its appropriate size and efficient photothermal efficacy for visual photothermal therapy for HCC.PMID:37677981 | DOI:10.1016/j.bbrc.2023.09.003
Source: Cell Research - September 7, 2023 Category: Cytology Authors: Nan Li Yunfeng Sun Jiabao Ouyang Yuna Che Chen Chen Wen Li Changjun Wu Source Type: research
