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Cancer: Gastric (Stomach) Cancer

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Reduced risk of de novo Barrett esophagus after bariatric surgery: a national database study
CONCLUSION: Patients who underwent bariatric surgery (RYGB or SG) had a lower risk of being diagnosed with BE compared with screening colonoscopy controls who did not receive bariatric surgery. This effect appears to be largely mediated by reduction in weight and BMI.PMID:37722939 | DOI:10.1016/j.soard.2023.08.009
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - September 18, 2023 Category: Surgery Authors: Alexander Hurtado Apoorva K Chandar Jaime Abraham Perez Regina Casselberry Scott A Martin Kayla DeLano Mujjahid Abbas Amitabh Chak Source Type: research

Effects of methylation and imprinting expression of Insulin-like growth factor 2 gene in gastric cancer
CONCLUSION: Our data suggest that IGF2 is involved in the occurrence and development of gastric cancer. Targeting IGF2 may be a potential therapeutic target for gastric cancer.PMID:37718779 | DOI:10.3233/CBM-230105
Source: Cancer Biomarkers : Section A of Disease Markers - September 18, 2023 Category: Cancer & Oncology Authors: Jiting Sun Jun Shu Duo Shi Wen Liu Yan Zhang Bing Luo Source Type: research

Corrigendum to: "Dihydroartemisinin inhibits the growth and invasion of gastric cancer cells by regulating cyclin D1-CDK4-Rb signaling" Pathol. Res. Pract. 216 (2020) 152795
Pathol Res Pract. 2023 Sep 16:154824. doi: 10.1016/j.prp.2023.154824. Online ahead of print.NO ABSTRACTPMID:37722992 | DOI:10.1016/j.prp.2023.154824
Source: Pathology, Research and Practice - September 18, 2023 Category: Pathology Authors: Hui-Ning Fan Mei-Ying Zhu Shi-Qiao Peng Jin-Shui Zhu Jing Zhang Guo-Qiang Qu Source Type: research

Impact on quality of life with affirmative feedback on weight loss after gastrectomy
This study investigated the feasibility of improving post-gastrectomy satisfaction/quality of life (QoL) of gastric cancer survivors by readjusting their expectations through patient interviews. Weight loss after gastric cancer surgery is common, and a change in the departmental policy helped in providing cancer survivors with an alternative interpretation of lost weight. Under the new policy, a group of patients who were preoperatively overweight or obese were provided with affirmative feedback, despite their postoperative weight loss. The European Organization for Research and Treatment of Cancer QoL Questionnaire-C30 an...
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Seung Soo Lee Ho Young Chung Oh Kyoung Kwon Source Type: research

Reduced risk of de novo Barrett esophagus after bariatric surgery: a national database study
CONCLUSION: Patients who underwent bariatric surgery (RYGB or SG) had a lower risk of being diagnosed with BE compared with screening colonoscopy controls who did not receive bariatric surgery. This effect appears to be largely mediated by reduction in weight and BMI.PMID:37722939 | DOI:10.1016/j.soard.2023.08.009
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - September 18, 2023 Category: Surgery Authors: Alexander Hurtado Apoorva K Chandar Jaime Abraham Perez Regina Casselberry Scott A Martin Kayla DeLano Mujjahid Abbas Amitabh Chak Source Type: research

Effects of methylation and imprinting expression of Insulin-like growth factor 2 gene in gastric cancer
CONCLUSION: Our data suggest that IGF2 is involved in the occurrence and development of gastric cancer. Targeting IGF2 may be a potential therapeutic target for gastric cancer.PMID:37718779 | DOI:10.3233/CBM-230105
Source: Cancer Biomarkers : Section A of Disease Markers - September 18, 2023 Category: Cancer & Oncology Authors: Jiting Sun Jun Shu Duo Shi Wen Liu Yan Zhang Bing Luo Source Type: research

Crocin Combined With Cisplatin Regulates Proliferation, Apoptosis And Emt Of Gastric Cancer Cells Via The Fgfr3/Mapk/Erk Pathway In Vitro And In Vivo
CONCLUSION: Our results showed that up-regulation of FGFR3 reversed the inhibitory effect of crocin+DDP on the MAPK/ERK signaling pathway. Still, this effect could be counteracted by PD184352, which simultaneously regulated the proliferation, apoptosis, and EMT of AGS cells. In conclusion, crocin, combined with DDP, inhibits proliferation, apoptosis, and EMT of GC through the FRFR3/MAPK/ERK pathway.PMID:37718528 | DOI:10.2174/1568009624666230915111239
Source: Current Cancer Drug Targets - September 18, 2023 Category: Cancer & Oncology Authors: Yan Li Qi-Jing Guo Rong Chen LingLin Zhao Xianshu Cui Yingfang Deng Yu-Shuang Luo Source Type: research

Effects of methylation and imprinting expression of Insulin-like growth factor 2 gene in gastric cancer
CONCLUSION: Our data suggest that IGF2 is involved in the occurrence and development of gastric cancer. Targeting IGF2 may be a potential therapeutic target for gastric cancer.PMID:37718779 | DOI:10.3233/CBM-230105
Source: Cancer Biomarkers : Section A of Disease Markers - September 18, 2023 Category: Cancer & Oncology Authors: Jiting Sun Jun Shu Duo Shi Wen Liu Yan Zhang Bing Luo Source Type: research

Combined Use of Tumor Markers in Gastric Cancer: A Novel Method with Promising Prognostic Accuracy and Practicality
CONCLUSION: The combined use of tumor markers significantly improved the prognostic value compared with using a single tumor marker. The survival prediction model including the combined tumor markers was accurate and effective.PMID:37718336 | DOI:10.1245/s10434-023-14194-9
Source: Ann Oncol - September 17, 2023 Category: Cancer & Oncology Authors: Ruopeng Zhang Xiaojiang Chen Guoming Chen Zhoukai Zhao Yicheng Wei Feiyang Zhang Jun Lin Runcong Nie Yingbo Chen Source Type: research

The relationship between tissue differentiation-inducing non-protein coding RNA expression and tumor size in patients with breast cancer
This study aimed to evaluate the expression level of Tissue Differentiation-Inducing Non-Protein Coding RNA (TINCR) in adjacent tumor and non-tumor tissues of 60 women with invasive ductal breast cancer. The relationship between TINCR expression and the clinical characteristics of patients has also been studied. For this purpose, total RNA was isolated from breast cancer patients' adjacent tumor and non-tumor tissue. RT Prime Script reagent was then used to convert total RNA to cDNA. The qRT-PCR quantified the TINCR expression level and analyzed the results by paired t-test. In addition, ROC curve analysis was used to eval...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Shen Tan Aimin Cui Nan Bai Zicui Zhang Source Type: research

B7-H3 and CD47 co-expression in gastric cancer is a predictor of poor prognosis and potential targets for future dual-targeting immunotherapy
CONCLUSION: Our findings demonstrated a correlation between B7-H3 expression and CD47 expression in GC patient tissues. Co-expression of B7-H3 and CD47 can serve as an indicator of poor prognosis in GC patients. In GC tumor tissue, but not adjacent tissue, B7-H3 and CD47 expression was accompanied with macrophage infiltration.PMID:37715830 | DOI:10.1007/s00432-023-05408-4
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Siji Chen Shenghua Zhan Sisi Ding Qiange Zhang Hanqin Xuan Xueguang Zhang Lei Cao Source Type: research

A web-based prediction model for long-term cancer-specific survival of middle-aged patients with early-stage gastric cancer: a multi-institutional retrospective study
CONCLUSION: This study developed and validated a new nomogram to predict CSS in middle-aged patients with EGC. The prediction model has unique and practical value and can help doctors carry out individualized treatment and judge prognosis.PMID:37712958 | DOI:10.1007/s00432-023-05405-7
Source: Pain Physician - September 15, 2023 Category: Anesthesiology Authors: Simeng Zhang Longbo Zheng Yuxia Zhang Yuan Gao Lei Liu Zinian Jiang Liang Wang Zheng Ma Jinhui Wu Jiansheng Chen Yun Lu Dongsheng Wang Source Type: research

Control of < em > Helicobacter pylori < /em > with engineered probiotics secreting selective guided antimicrobial peptides
Microbiol Spectr. 2023 Sep 15:e0201423. doi: 10.1128/spectrum.02014-23. Online ahead of print.ABSTRACTHelicobacter pylori is the primary cause of 78% of gastric cancer cases, providing an opportunity to prevent cancer by controlling a single bacterial pathogen within the complex gastric microbiota. We developed highly selective antimicrobial agents against H. pylori by fusing an H. pylori-binding guide peptide (MM1) to broad-spectrum antimicrobial peptides. The common dairy probiotic Lactococcus lactis was then engineered to secrete these guided antimicrobial peptides (gAMPs). When co-cultured in vitro with H. pylori, the ...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Ankan Choudhury Patrick S Ortiz Mikaeel Young Md Toslim Mahmud Ryan T Stoffel K Leigh Greathouse Christopher M Kearney Source Type: research