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Cancer: Gastric (Stomach) Cancer
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Total 20058 results found since Jan 2013.
Construction of an autophagy-related eleven long noncoding RNA signature to predict the outcomes, immune cell infiltration, and immunotherapy response in patients with gastric cancer
This study aims to establish an autophagy-related LncRNA (ARL) signature (ARLSig) and explore its immunogenomic implications in patients with GC. The RNA sequencing and clinical data of patients with GC from The Cancer Genome Atlas database, and autophagy genes from the Human Autophagy Database were extracted. The co-expression and Cox regression analyses were performed to establish a prognostic ARLSig. Further, the differences in clinicopathology, immune microenvironment, immune function, and response to immunotherapy between the risk groups were explored by several algorithms. A prognostic risk model consisting of 11 ARL...
Source: J Physiol Pharmacol - September 3, 2023 Category: Drugs & Pharmacology Authors: G C Mu Y J Luo J Q Chen Source Type: research
Overexpression of Integrin alpha V (ITGAV) in gastric cancer and its prognostic significance
Asian J Surg. 2023 Aug 31:S1015-9584(23)01352-0. doi: 10.1016/j.asjsur.2023.08.171. Online ahead of print.NO ABSTRACTPMID:37659950 | DOI:10.1016/j.asjsur.2023.08.171
Source: Asian Journal of Surgery - September 2, 2023 Category: Surgery Authors: Wen Zhang Yi Chen Zhenguo Qiao Yan Liu Source Type: research
A state-of-art of underlying molecular mechanisms and pharmacological interventions/nanotherapeutics for cisplatin resistance in gastric cancer
Biomed Pharmacother. 2023 Aug 31;166:115337. doi: 10.1016/j.biopha.2023.115337. Online ahead of print.ABSTRACTThe fourth common reason of death among patients is gastric cancer (GC) and it is a dominant tumor type in Ease Asia. One of the problems in GC therapy is chemoresistance. Cisplatin (CP) is a platinum compound that causes DNA damage in reducing tumor progression and viability of cancer cells. However, due to hyperactivation of drug efflux pumps, dysregulation of genes and interactions in tumor microenvironment, tumor cells can develop resistance to CP chemotherapy. The current review focuses on the CP resistance em...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 2, 2023 Category: Drugs & Pharmacology Authors: Jitendra Gupta Abdulrahman T Ahmed Nahla A Tayyib Rahman S Zabibah Qakhramon Shomurodov Mostafai N Kadheim Fahad Alsaikhan Pushpamala Ramaiah Lathamangeswari Chinnasamy Saeed Samarghandian Source Type: research
Neoadjuvant Gastric Score: How Response to Neoadjuvant Chemotherapy Affects Overall Survival and Adjuvant Benefit
CONCLUSION: NAR score may be repurposed to generate a prognostic tool in gastric adenocarcinoma to predict 5-year OS and has the potential to guide decision-making regarding allocation of adjuvant therapy. Further studies should prospectively validate these findings to confirm clinical utility.PMID:37659978 | DOI:10.1245/s10434-023-14259-9
Source: Ann Oncol - September 2, 2023 Category: Cancer & Oncology Authors: Chase J Wehrle Caleb N Seavey Jenny Chang Katherine Stackhouse Kimberly Woo Toms Augustin Daniel Joyce Robert Simon R Matthew Walsh Samer A Naffouje Source Type: research
Overexpression of Integrin alpha V (ITGAV) in gastric cancer and its prognostic significance
Asian J Surg. 2023 Aug 31:S1015-9584(23)01352-0. doi: 10.1016/j.asjsur.2023.08.171. Online ahead of print.NO ABSTRACTPMID:37659950 | DOI:10.1016/j.asjsur.2023.08.171
Source: Asian Journal of Surgery - September 2, 2023 Category: Surgery Authors: Wen Zhang Yi Chen Zhenguo Qiao Yan Liu Source Type: research
A state-of-art of underlying molecular mechanisms and pharmacological interventions/nanotherapeutics for cisplatin resistance in gastric cancer
Biomed Pharmacother. 2023 Aug 31;166:115337. doi: 10.1016/j.biopha.2023.115337. Online ahead of print.ABSTRACTThe fourth common reason of death among patients is gastric cancer (GC) and it is a dominant tumor type in Ease Asia. One of the problems in GC therapy is chemoresistance. Cisplatin (CP) is a platinum compound that causes DNA damage in reducing tumor progression and viability of cancer cells. However, due to hyperactivation of drug efflux pumps, dysregulation of genes and interactions in tumor microenvironment, tumor cells can develop resistance to CP chemotherapy. The current review focuses on the CP resistance em...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 2, 2023 Category: Drugs & Pharmacology Authors: Jitendra Gupta Abdulrahman T Ahmed Nahla A Tayyib Rahman S Zabibah Qakhramon Shomurodov Mostafai N Kadheim Fahad Alsaikhan Pushpamala Ramaiah Lathamangeswari Chinnasamy Saeed Samarghandian Source Type: research
Control of the flagellation pattern in < em > Helicobacter pylori < /em > by FlhF and FlhG
J Bacteriol. 2023 Sep 1:e0011023. doi: 10.1128/jb.00110-23. Online ahead of print.ABSTRACTFlhF and FlhG control the location and number of flagella, respectively, in many polar-flagellated bacteria. The roles of FlhF and FlhG are not well characterized in bacteria that have multiple polar flagella, such as Helicobacter pylori. Deleting flhG in H. pylori shifted the flagellation pattern where most cells had approximately four flagella to a wider and more even distribution in flagellar number. As reported in other bacteria, deleting flhF in H. pylori resulted in reduced motility, hypoflagellation, and the improper localizati...
Source: Cancer Control - September 1, 2023 Category: Cancer & Oncology Authors: Katherine H Gibson Jack M Botting Natalie Al-Otaibi Kriti Maitre Julien Bergeron Vincent J Starai Timothy R Hoover Source Type: research
Can We StoP Worrying about Long-term PPIs and Gastric Cancer Risk?
Cancer Epidemiol Biomarkers Prev. 2023 Sep 1;32(9):1127-1129. doi: 10.1158/1055-9965.EPI-23-0809.ABSTRACTProton pump inhibitors (PPI) are a cornerstone of management for many digestive diseases. While chronic PPI use induces physiologic changes including gastric acid suppression and hypergastrinemia, existing data are conflicting on whether this impacts the risk of gastric cancer among PPI users. Sassano and colleagues utilized pooled case-control data from five studies in the Stomach cancer Pooling (StoP) Project to investigate the association between PPI use and histologically confirmed gastric cancer. Short-term PPI use...
Source: Cancer Control - September 1, 2023 Category: Cancer & Oncology Authors: Courtney M Richman David A Leiman Source Type: research
Economic burden of cancer attributable to modifiable risk factors in Japan
This study aimed to estimate the economic burden of cancer attributable to major lifestyle and environmental risk factors in Japan in 2015. We evaluated the economic cost of cancer attributable to modifiable risk factors from a societal perspective. We obtained the direct medical costs for 2015 from the National Database of Health Insurance Claims and Specific Health Checkups of Japan, and estimated the indirect costs of premature mortality and of morbidity due to cancer using the relevant national surveys in Japan. Finally, we estimated the economic cost of cancer associated with lifestyle and environmental risk factors. ...
Source: Cancer Control - September 1, 2023 Category: Cancer & Oncology Authors: Eiko Saito Shiori Tanaka Sarah Krull Abe Mayo Hirayabashi Junko Ishihara Kota Katanoda Yingsong Lin Chisato Nagata Norie Sawada Ribeka Takachi Atsushi Goto Junko Tanaka Kayo Ueda Megumi Hori Tomohiro Matsuda Manami Inoue Source Type: research
Homeobox-D 1 and FTO form a transcriptional-epigenetic feedback loop to promote head and neck cancer proliferation
In this study, we demonstrate that the TF homeobox-D1 (HOXD1) and the m6A demethylase fat mass and obesity-associated protein (FTO) form a positive feedback loop to promote cell proliferation and survival in HNSC. Clinically, HOXD1 expression is dysregulated in multiple cancer types and is associated with worse prognosis in patients with HNSC, stomach adenocarcinoma, uterine corpus endometrial carcinoma, and pheochromocytoma and paraganglioma. Mechanistically, FTO is overexpressed in HNSC tumor samples and positively regulates HOXD1 expression in an m6A-dependent manner. Functionally, deficiency of HOXD1 relieved the resis...
Source: Cell Biology International - September 1, 2023 Category: Cytology Authors: Chunyan Zhang Linsen Xie Zhen Lin Source Type: research
