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Identification of molecular biomarkers associated with non-small-cell lung carcinoma (NSCLC) using whole-exome sequencing
CONCLUSIONS: Our bioinformatics analysis identified KCNJ18, GPRIN2, TEKT4, HRNR, FOLR3, ESSRA, CTBP2, MPRIP, TBP, and FBXO6 may contribute to progression in NSCLC and could be used as new biomarkers for the treatment. The mechanism by which GPRIN2, KCNJ12, and TEKT4 contribute to tumorigenesis is unclear, but our results suggest they may play an important role in NSCLC and it is worth investigating in future.PMID:37694353 | DOI:10.3233/CBM-220211
Source: Cancer Biomarkers : Section A of Disease Markers - September 11, 2023 Category: Cancer & Oncology Authors: Varsha Singh Amit Katiyar Prabhat Malik Sunil Kumar Anant Mohan Harpreet Singh Deepali Jain Source Type: research
Bioinformatics analysis of CUL2/4A/9 and its function in head and neck squamous cell carcinoma
CONCLUSION: These results suggest that the transcriptional levels of CUL2/4A/9 were upregulated and these genes could affect proliferation and migration of HNSCC cells. Therefore, CUL2/4A/9 could potentially function as novel independent biomarkers in HNSCC patients.PMID:37695034 | DOI:10.5603/EP.a2023.0029
Source: Endokrynologia Polska - September 11, 2023 Category: Endocrinology Authors: Bingqing Xu Ruohuang Wang Jisheng Zhang Lin Wang Xin Cui Fangyu Chai Xiaoyun Du Yan Jiang Source Type: research
Identification of molecular biomarkers associated with non-small-cell lung carcinoma (NSCLC) using whole-exome sequencing
CONCLUSIONS: Our bioinformatics analysis identified KCNJ18, GPRIN2, TEKT4, HRNR, FOLR3, ESSRA, CTBP2, MPRIP, TBP, and FBXO6 may contribute to progression in NSCLC and could be used as new biomarkers for the treatment. The mechanism by which GPRIN2, KCNJ12, and TEKT4 contribute to tumorigenesis is unclear, but our results suggest they may play an important role in NSCLC and it is worth investigating in future.PMID:37694353 | DOI:10.3233/CBM-220211
Source: Cancer Biomarkers : Section A of Disease Markers - September 11, 2023 Category: Cancer & Oncology Authors: Varsha Singh Amit Katiyar Prabhat Malik Sunil Kumar Anant Mohan Harpreet Singh Deepali Jain Source Type: research
Bioinformatics analysis of CUL2/4A/9 and its function in head and neck squamous cell carcinoma
CONCLUSION: These results suggest that the transcriptional levels of CUL2/4A/9 were upregulated and these genes could affect proliferation and migration of HNSCC cells. Therefore, CUL2/4A/9 could potentially function as novel independent biomarkers in HNSCC patients.PMID:37695034 | DOI:10.5603/EP.a2023.0029
Source: Endokrynologia Polska - September 11, 2023 Category: Endocrinology Authors: Bingqing Xu Ruohuang Wang Jisheng Zhang Lin Wang Xin Cui Fangyu Chai Xiaoyun Du Yan Jiang Source Type: research
Clinical practice consensus for the diagnosis and management of melanoma in Taiwan
J Formos Med Assoc. 2023 Sep 8:S0929-6646(23)00290-5. doi: 10.1016/j.jfma.2023.07.016. Online ahead of print.ABSTRACTMelanoma is rare in Taiwan. Asian melanoma is distinct from Western melanoma because acral and mucosal melanoma accounts for the majority of melanoma cases, leading to distinct tumor behaviors and genetic profiling. With consideration of the clinical guidelines in Western countries, Taiwanese experts developed a local clinical practice consensus guideline. This consensus includes diagnosis, staging, and surgical and systemic treatment, based only on clinical evidence, local epidemiology, and available resour...
Source: J Formos Med Assoc - September 10, 2023 Category: General Medicine Authors: Chiao-En Wu Yi-Hua Liao Cheng-Lin Wu Ruoh-Fang Yen Chia-Chi Lin Muh-Hwa Yang Chueh-Chuan Yen Wu-Chou Su Chia-Jui Yen Yi-Fang Chang Ming-Fang Wu Youngsen Yang Chen-Yuan Lin Wen-Chi Yang Hui-Ching Wang Cheng-Yuan Li Yin-Yu Ho Yao-Yu Chang Chieh-Shan Wu Hsiu Source Type: research
High-throughput screening and clinical importance of autophagy-associated genes in basal cell carcinoma
In this study, we aimed to illuminate the role of autophagy-associated signaling signatures during development and progression of basal cell carcinoma. For the study, a total of 72 autophagy-related genes were screened using a high-throughput qPCR approach integrating Fluidigm 96.96 Dynamic Array™ integrated fluidic circuits (IFC) and BioMark™ HD Real-Time PCR system, which enabled efficient and precise analysis of gene expression patterns. Results were analyzed using Fluidigm's Real-Time PCR Analysis software and 2-ΔΔCt formula was used for the calculation of expression changes. Notably, expression levels of INS, TM...
Source: Pathology, Research and Practice - September 10, 2023 Category: Pathology Authors: Saffet Ulutas Mehmet Mutaf Mustafa Nihat Koc Tarik Oztuzcu Mustafa Ulasli Serdar Oztuzcu Source Type: research
Pulmonary metastatic desmoplastic melanoma mimicking schwannoma: A case report
Asian J Surg. 2023 Sep 8:S1015-9584(23)01401-X. doi: 10.1016/j.asjsur.2023.08.232. Online ahead of print.NO ABSTRACTPMID:37690898 | DOI:10.1016/j.asjsur.2023.08.232
Source: Asian Journal of Surgery - September 10, 2023 Category: Surgery Authors: Yuchun Ding Tangbo Zhang Liang Wang Source Type: research
High-throughput screening and clinical importance of autophagy-associated genes in basal cell carcinoma
In this study, we aimed to illuminate the role of autophagy-associated signaling signatures during development and progression of basal cell carcinoma. For the study, a total of 72 autophagy-related genes were screened using a high-throughput qPCR approach integrating Fluidigm 96.96 Dynamic Array™ integrated fluidic circuits (IFC) and BioMark™ HD Real-Time PCR system, which enabled efficient and precise analysis of gene expression patterns. Results were analyzed using Fluidigm's Real-Time PCR Analysis software and 2-ΔΔCt formula was used for the calculation of expression changes. Notably, expression levels of INS, TM...
Source: Pathology, Research and Practice - September 10, 2023 Category: Pathology Authors: Saffet Ulutas Mehmet Mutaf Mustafa Nihat Koc Tarik Oztuzcu Mustafa Ulasli Serdar Oztuzcu Source Type: research
Clinical practice consensus for the diagnosis and management of melanoma in Taiwan
J Formos Med Assoc. 2023 Sep 8:S0929-6646(23)00290-5. doi: 10.1016/j.jfma.2023.07.016. Online ahead of print.ABSTRACTMelanoma is rare in Taiwan. Asian melanoma is distinct from Western melanoma because acral and mucosal melanoma accounts for the majority of melanoma cases, leading to distinct tumor behaviors and genetic profiling. With consideration of the clinical guidelines in Western countries, Taiwanese experts developed a local clinical practice consensus guideline. This consensus includes diagnosis, staging, and surgical and systemic treatment, based only on clinical evidence, local epidemiology, and available resour...
Source: J Formos Med Assoc - September 10, 2023 Category: General Medicine Authors: Chiao-En Wu Yi-Hua Liao Cheng-Lin Wu Ruoh-Fang Yen Chia-Chi Lin Muh-Hwa Yang Chueh-Chuan Yen Wu-Chou Su Chia-Jui Yen Yi-Fang Chang Ming-Fang Wu Youngsen Yang Chen-Yuan Lin Wen-Chi Yang Hui-Ching Wang Cheng-Yuan Li Yin-Yu Ho Yao-Yu Chang Chieh-Shan Wu Hsiu Source Type: research
Second primary malignancies in patients with lymphoma in Denmark after high-dose chemotherapy and autologous haematopoietic stem-cell transplantation: a population-based, retrospective cohort study
Lancet Haematol. 2023 Sep 6:S2352-3026(23)00212-0. doi: 10.1016/S2352-3026(23)00212-0. Online ahead of print.ABSTRACTBACKGROUND: Second primary malignancies (SPMs) are known complications after chemotherapy, but the risk is not well characterised for patients with lymphoma treated with high-dose chemotherapy and autologous haematopoietic stem-cell transplantation (HSCT). We aimed to investigate the rate of SPMs in this population relative to matched control individuals from the general population.METHODS: In this retrospective, population-based cohort study, patients aged 18 years or older with an aggressive lymphoma who r...
Source: Cancer Control - September 9, 2023 Category: Cancer & Oncology Authors: Trine Trab Joachim Baech Lasse Hjort Jakobsen Simon Husby Marianne Tang Severinsen Sandra Eloranta Jette S G ørløv Judit M J ørgensen Sif Gudbrandsdottir Thomas Stauffer Larsen Peter Brown Kirsten Gr ønbæk Karin E Smedby Tarec C El-Galaly Source Type: research
Machine-Learning-Aided Prediction of Brain Metastases Development in Non-Small-Cell Lung Cancers
CONCLUSION: Analysis of the importance of input features suggests that the models are learning the relevant relationships between clinical features/development of BM. A higher number of samples is to be prioritized to improve performance. Employed prospectively at initial diagnosis, such models can help select high-risk subgroups for surveillance brain MRI.PMID:37689579 | DOI:10.1016/j.cllc.2023.08.002
Source: Clinical Lung Cancer - September 9, 2023 Category: Cancer & Oncology Authors: Giovanni Vison à Lisa M Spiller Sophia Hahn Elke Hattingen Thomas J Vogl Gabriele Schweikert Katrin Bankov Melanie Demes Henning Reis Peter Wild Pia S Zeiner Fabian Acker Martin Sebastian Katharina J Wenger Source Type: research
Exploring the Biomedical Applications of Biosynthesized Silver Nanoparticles Using < em > Perilla frutescens < /em > Flavonoid Extract: Antibacterial, Antioxidant, and Cell Toxicity Properties against Colon Cancer Cells
In this study, we also explained the plausible mechanisms of the biosynthesis, anticancer, and antibacterial effects of PFFE-AgNPs. Overall, these findings suggest that PFFE-AgNPs have potential as a multi-functional nanomaterial for biomedical applications, particularly in cancer therapy and infection control. However, it is important to note that further research is needed to determine the safety and efficacy of these nanoparticles in vivo, as well as to explore their potential in other areas of medicine.PMID:37687260 | DOI:10.3390/molecules28176431
Source: Cancer Control - September 9, 2023 Category: Cancer & Oncology Authors: Tianyu Hou Yurong Guo Wanyu Han Yang Zhou Vasudeva Reddy Netala Huizhen Li He Li Zhijun Zhang Source Type: research
