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Therapy: Immunotherapy
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Circadian Regulation of Drug Responses: Toward Sex-Specific and Personalized Chronotherapy
Annu Rev Pharmacol Toxicol. 2023 Sep 18. doi: 10.1146/annurev-pharmtox-051920-095416. Online ahead of print.ABSTRACTToday's challenge for precision medicine involves the integration of the impact of molecular clocks on drug pharmacokinetics, toxicity, and efficacy, toward personalized chronotherapy. Meaningful improvements of tolerability and/or efficacy of medications through proper administration timing have been confirmed over the past decade for immunotherapy and chemotherapy against cancer, as well as for commonly used pharmacological agents in cardiovascular, metabolic, inflammatory, and neurological conditions. Expe...
Source: Annual Review of Pharmacology and Toxicology - September 18, 2023 Category: Drugs & Pharmacology Authors: Francis A L évi Alper Okyar Eva Hadadi Pasquale F Innominato Annabelle Ballesta Source Type: research
Comparative analysis of the severity and progression of cutaneous leishmaniasis caused by Leishmania tropica in untreated and glucantime-treated patients
In this study, we investigated immunological phenotypes for three groups: glucantime treated (n=30) and untreated (n=30) CL patients infected with Leishmania tropica (L. tropica), and healthy controls (n=20). T-lymphocytes (CD4+ and CD8+), and B lymphocytes (CD14+ and CD19+) were isolated using antibody-conjugated microbeads and magnetic field isolation to achieve high purity. A higher significant difference was observed between T-lymphocytes (CD4+ and CD8+), and B-lymphocytes (CD14+ and CD19+) cells in CL-infected groups before and after treatment (p<0.0001). When compared, there was also a significant difference among...
Source: Acta Tropica - September 17, 2023 Category: Infectious Diseases Authors: Shumaila Naz Aiman Aroosh Naeem Raza Arshad Islam Anam Fatima Yusuf Ozbel Seray Toz Obaid Hayat Shahid Waseem Source Type: research
F77 antigen is a promising target for adoptive T cell therapy of prostate cancer
This study entails the generation and evaluation of a second-generation CAR against a carbohydrate antigen on malignant prostate cancer cells. Using a single chain fragment variable (scFv) from an F77-specific mouse monoclonal antibody, we created second-generation CARs with CD28 and CD137 (4-1BB) costimulatory signals. F77 expressing lentiviral CAR T cells produce cytokines and kill tumor cells in a F77 expression-dependent manner. These F77-specific CAR T cells eradicate prostate tumors in a human xenograft model employing PC3 cells. These findings validate F77 as a promising immunotherapeutic target for prostate cancer ...
Source: Biochemical and Biophysical Research communications - September 17, 2023 Category: Biochemistry Authors: Payal Grover Selene Nunez-Cruz John Leferovich Tyra Wentz Atrish Bagchi Michael C Milone Mark I Greene Source Type: research
Targeting STING in cancer: Challenges and emerging opportunities
Biochim Biophys Acta Rev Cancer. 2023 Sep 15:188983. doi: 10.1016/j.bbcan.2023.188983. Online ahead of print.ABSTRACTThe cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway is a key pathway through which the host regulates immune responses by recognizing cytoplasmic double-stranded DNA of abnormal origin, and it plays an important role in tumor growth as well as metastasis, with relevant molecular details constantly being explored and updated. The significant immunomodulatory effects make STING an attractive target for cancer immunotherapy, and STING agonists have been receiving great at...
Source: Biochimica et Biophysica Acta - September 17, 2023 Category: Biochemistry Authors: Kexin Zhao Jiaojiao Huang Yue Zhao Shengjun Wang Juan Xu Kai Yin Source Type: research
F77 antigen is a promising target for adoptive T cell therapy of prostate cancer
This study entails the generation and evaluation of a second-generation CAR against a carbohydrate antigen on malignant prostate cancer cells. Using a single chain fragment variable (scFv) from an F77-specific mouse monoclonal antibody, we created second-generation CARs with CD28 and CD137 (4-1BB) costimulatory signals. F77 expressing lentiviral CAR T cells produce cytokines and kill tumor cells in a F77 expression-dependent manner. These F77-specific CAR T cells eradicate prostate tumors in a human xenograft model employing PC3 cells. These findings validate F77 as a promising immunotherapeutic target for prostate cancer ...
Source: Cell Research - September 17, 2023 Category: Cytology Authors: Payal Grover Selene Nunez-Cruz John Leferovich Tyra Wentz Atrish Bagchi Michael C Milone Mark I Greene Source Type: research
Comparative analysis of the severity and progression of cutaneous leishmaniasis caused by Leishmania tropica in untreated and glucantime-treated patients
In this study, we investigated immunological phenotypes for three groups: glucantime treated (n=30) and untreated (n=30) CL patients infected with Leishmania tropica (L. tropica), and healthy controls (n=20). T-lymphocytes (CD4+ and CD8+), and B lymphocytes (CD14+ and CD19+) were isolated using antibody-conjugated microbeads and magnetic field isolation to achieve high purity. A higher significant difference was observed between T-lymphocytes (CD4+ and CD8+), and B-lymphocytes (CD14+ and CD19+) cells in CL-infected groups before and after treatment (p<0.0001). When compared, there was also a significant difference among...
Source: Acta Tropica - September 17, 2023 Category: Infectious Diseases Authors: Shumaila Naz Aiman Aroosh Naeem Raza Arshad Islam Anam Fatima Yusuf Ozbel Seray Toz Obaid Hayat Shahid Waseem Source Type: research
Targeting STING in cancer: Challenges and emerging opportunities
Biochim Biophys Acta Rev Cancer. 2023 Sep 15:188983. doi: 10.1016/j.bbcan.2023.188983. Online ahead of print.ABSTRACTThe cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway is a key pathway through which the host regulates immune responses by recognizing cytoplasmic double-stranded DNA of abnormal origin, and it plays an important role in tumor growth as well as metastasis, with relevant molecular details constantly being explored and updated. The significant immunomodulatory effects make STING an attractive target for cancer immunotherapy, and STING agonists have been receiving great at...
Source: Biochimica et Biophysica Acta - September 17, 2023 Category: Biochemistry Authors: Kexin Zhao Jiaojiao Huang Yue Zhao Shengjun Wang Juan Xu Kai Yin Source Type: research
Molecular Subtypes Based on PANoptosis Genes and Characteristics of Immune Infiltration in Cutaneous Melanoma
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):1-8. doi: 10.14715/cmb/2023.69.8.1.ABSTRACTCutaneous melanoma (CM) remains the most life-threatening form of skin cancer. Further risk stratification and search for new prognostic targets for CM are of positive clinical significance. PANoptosis is defined as an inflammatory programmed cell death mediated by the PANoptosome complex and cannot be characterized by pyroptosis, apoptosis or necroptosis alone. Although PANoptosis is closely associated with many diseases including cancer, it has not been reported in CM. Combined with GTEx and TCGA database, we extracted 14 PANopto...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Like Zhong Wenkang Qian Wangang Gong Li Zhu Xu Wang Source Type: research
Imaging immune checkpoint networks in cancer tissues with supermultiplexed SERS nanoprobes
Biomaterials. 2023 Sep 12;302:122327. doi: 10.1016/j.biomaterials.2023.122327. Online ahead of print.ABSTRACTCombined immune checkpoint (ICP) inhibitors maximize immune response rates of patients compared to the single-drug treatment strategy in cancer immunotherapy, and prediction of such optimal combinations requires high-throughput imaging techniques and suitable data analysis. In this work, we report a rational strategy for predicting combined drugs of ICP inhibitors based on supermultiplexed surface-enhanced Raman scattering (SERS) imaging and correlation network analysis. To this end, we first built an ultrasensitive...
Source: Biomaterials - September 16, 2023 Category: Materials Science Authors: Jin Li Fugang Liu Xinyuan Bi Jian Ye Source Type: research
B7-H3 and CD47 co-expression in gastric cancer is a predictor of poor prognosis and potential targets for future dual-targeting immunotherapy
CONCLUSION: Our findings demonstrated a correlation between B7-H3 expression and CD47 expression in GC patient tissues. Co-expression of B7-H3 and CD47 can serve as an indicator of poor prognosis in GC patients. In GC tumor tissue, but not adjacent tissue, B7-H3 and CD47 expression was accompanied with macrophage infiltration.PMID:37715830 | DOI:10.1007/s00432-023-05408-4
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Siji Chen Shenghua Zhan Sisi Ding Qiange Zhang Hanqin Xuan Xueguang Zhang Lei Cao Source Type: research
Cancer cell-intrinsic PD-1: Its role in malignant progression and immunotherapy
Biomed Pharmacother. 2023 Sep 14;167:115514. doi: 10.1016/j.biopha.2023.115514. Online ahead of print.ABSTRACTProgrammed cell death protein-1 (PD-1), also called CD279, is coded by the PDCD1 gene and is constitutively expressed on the surface of immune cells. As a receptor and immune checkpoint, PD-1 can bind to programmed death ligand-1/programmed death ligand-2 (PD-L1/PD-L2) in tumor cells, leading to tumor immune evasion. Anti-PD-1 and anti-PD-L1 are important components in tumor immune therapy. PD-1 is also expressed as an intrinsic variant (iPD-1) in cancer cells where it plays important roles in malignant progression...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Muhua Chen Lei Bie Jieer Ying Source Type: research
Prediction of survival and immunotherapy response by the combined classifier of G protein-coupled receptors and tumor microenvironment in melanoma
CONCLUSIONS: We have developed a GPCR-TME classifier that could predict the OS and immunotherapy response of patients with melanoma highly effectively based on multi-omics analysis.PMID:37716991 | DOI:10.1186/s40001-023-01346-6
Source: Cell Research - September 16, 2023 Category: Cytology Authors: Kangjie Shen Qiangcheng Wang Lu Wang Yang Yang Min Ren Yanlin Li Zixu Gao Shaoluan Zheng Yiteng Ding Jiani Ji Chenlu Wei Tianyi Zhang Yu Zhu Jia Feng Feng Qin Yanwen Yang Chuanyuan Wei Jianying Gu Source Type: research
Molecular Subtypes Based on PANoptosis Genes and Characteristics of Immune Infiltration in Cutaneous Melanoma
Cell Mol Biol (Noisy-le-grand). 2023 Aug 31;69(8):1-8. doi: 10.14715/cmb/2023.69.8.1.ABSTRACTCutaneous melanoma (CM) remains the most life-threatening form of skin cancer. Further risk stratification and search for new prognostic targets for CM are of positive clinical significance. PANoptosis is defined as an inflammatory programmed cell death mediated by the PANoptosome complex and cannot be characterized by pyroptosis, apoptosis or necroptosis alone. Although PANoptosis is closely associated with many diseases including cancer, it has not been reported in CM. Combined with GTEx and TCGA database, we extracted 14 PANopto...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Like Zhong Wenkang Qian Wangang Gong Li Zhu Xu Wang Source Type: research
