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Therapy: Stem Cell Therapy

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Total 3267 results found since Jan 2013.

Harnessing cell-material interactions to control stem cell secretion for osteoarthritis treatment
Biomaterials. 2023 Mar 13;296:122091. doi: 10.1016/j.biomaterials.2023.122091. Online ahead of print.ABSTRACTOsteoarthritis (OA) is the most common debilitating joint disease, yet there is no curative treatment for OA to date. Delivering mesenchymal stromal cells (MSCs) as therapeutic cells to mitigate the inflammatory symptoms associated with OA is attracting increasing attention. In principle, MSCs could respond to the pro-inflammatory microenvironment of an OA joint by the secretion of anti-inflammatory, anti-apoptotic, immunomodulatory and pro-regenerative factors, therefore limiting pain, as well as the disease develo...
Source: Biomaterials - March 22, 2023 Category: Materials Science Authors: Nathan Lagneau Pierre Tournier Fabien Nativel Yves Maugars J érôme Guicheux Catherine Le Visage Vianney Delplace Source Type: research

Role of Conservative Treatment vs Surgical Treatment for Rotator Cuff Tears: A Narrative Review
AbstractPurpose of ReviewRotator cuff tear is one of the most common causes of shoulder pain and affects people of all ages. The purpose of this review is to discuss the role of conservative and surgical treatment in the management of rotator cuff tear injuries.Recent FindingsConservative means of treatment include oral medications, physical therapy, and injections. Newer injections are being seen used more often, such as prolotherapy, platelet-rich plasma, and stem cells. While conservative treatment still is generally the first-line treatment, surgery is considered the most definitive form of repair.SummaryConservative t...
Source: Current Physical Medicine and Rehabilitation Reports - March 20, 2023 Category: Rehabilitation Source Type: research

Bone marrow derived mesenchymal stem cells therapy for rheumatoid arthritis - a concise review of past ten years
Mol Biol Rep. 2023 Mar 16. doi: 10.1007/s11033-023-08277-9. Online ahead of print.ABSTRACTRheumatoid arthritis is an autoimmune disorder characterized by swelling in synovial joints and erosion of bones. The disease is normally treated with conventional drugs which provide only temporary relief to the symptoms. Over the past few years, mesenchymal stromal cells have become the center of attention for treating this disease due to their immuno-modulatory and anti-inflammatory characteristics. Various studies on treatment of rheumatoid arthritis by using these cells have shown positive outcomes in terms of reduction in the le...
Source: Molecular Biology Reports - March 17, 2023 Category: Molecular Biology Authors: Maria Arshad Fazal Jalil Hadiqa Jaleel Farkhanda Ghafoor Source Type: research

Gene-editing summit touts sickle cell success, while questions on embryo editing linger
After decades of living with often excruciating pain, Victoria Gray had to get used to a new sensation in recent years: waking up without it. “It may sound crazy, but I had to pinch myself to see was I still able to feel pain,” she says. Gray, a 37-year-old mother of four from Forest, Mississippi, who was born with sickle cell disease, arguably became the star of last week’s International Summit on Human Genome Editing in London when she spoke about her transformation. In 2019, she was the first person to undergo an experimental therapy in which blood stem cells were taken from her, altered with the ...
Source: Science of Aging Knowledge Environment - March 13, 2023 Category: Geriatrics Source Type: research

Allogenic bone marrow-derived mesenchymal stem cells and its conditioned media for repairing acute and sub-acute peripheral nerve injuries in a rabbit model
Tissue Cell. 2023 Mar 2;82:102053. doi: 10.1016/j.tice.2023.102053. Online ahead of print.ABSTRACTThe present study evaluated healing potential of bone marrow-derived mesenchymal stem cells (BM-MSCs) and BM-MSCs-conditioned medium (BM-MSCs-CM) for acute and subacute injuries in the rabbit peripheral nerve injury model. The regenerative capacity of MSCs was evaluated in 40 rabbits divided into eight groups, four groups each for acute and subacute injury models. BM-MSCs and BM-MSCS-CM were prepared by isolating allogenic bone marrow from the iliac crest. After inducing sciatic nerve crush injury, different treatments consist...
Source: Tissue and Cell - March 12, 2023 Category: Cytology Authors: T B Sivanarayanan Irfan Ahmad Bhat Khan Sharun Sangeetha Palakkara Rashmi Singh None Remya Mehtab Singh Parmar Rahul Bhardwaj Vikash Chandra Palanivelu Munuswamy Prakash Kinjavdekar A M Pawde None Amarpal G Taru Sharma Source Type: research

Long term functional outcome evaluation in post flexor digitorum profundus tendon zone I rupture repaired by palmaris longus tendon grafting augmented with human amniotic membranes and adipose derived mesenchymal stem cell: A case report
CONCLUSION: The combination of our technique and regenerative therapy effectively prevents adhesions and modulates tendon healing.PMID:36893703 | DOI:10.1016/j.ijscr.2023.107960
Source: Hand Surgery - March 9, 2023 Category: Surgery Authors: Heri Suroto Benedictus Anindita Satmoko Twindy Rarasati Tabita Prajasari Source Type: research

Heinz body hemolysis following extended use phenazopyridine in a post ‐HCT patient with hemorrhagic cystitis: An old problem for a new generation
We present a case of Heinz body hemolysis following prolonged administration of phenazopyridine to treat cyclophosphamide-induced hemorrhagic cystitis following hematopoietic stem cell transplant. Prolonged phenazopyridine use should be carefully monitored for hematologic side effects. AbstractHemorrhagic cystitis is a common complication following the use of cyclophosphamide. Associated dysuria can be painful and there are few good options to relieve pain. Phenazopyridine has historically been utilized for dysuria and is available over the counter. However, it is associated with hematologic side effects with prolonged use...
Source: Clinical Case Reports - March 7, 2023 Category: General Medicine Authors: Asmaa Ferdjallah, Susie Long, Vanessa Dayton, Ashish O. Gupta Tags: CASE REPORT Source Type: research

Chronic myelomonocytic leukemia in a 72-year-old male from Nepal: A case report
CONCLUSION: Despite various treatment options, the treatment is still unsatisfactory, demanding standard management strategies.PMID:36845813 | PMC:PMC9949813 | DOI:10.1097/MS9.0000000000000198
Source: Annals of Medicine - February 27, 2023 Category: Internal Medicine Authors: Shekhar Gurung Saurab Karki Manoj Khadka Bhuwan Bhatta Ayush Adhikari Amar N Shrestha Source Type: research

Pain and discomfort in children with gastrostomy tubes – In the context of hematopoietic stem cell transplantation
In children with malignant and severe non-malignant disorders undergoing hematopoietic stem cell transplantation (HSCT), treatment related pain and discomfort are common. Food consumption may become troublesome, making the use of a gastrostomy tube (G-tube) necessary and resulting in complications, why the purpose was to explore pain and discomfort during the transplantation and post-transplantation time.
Source: Journal of Pediatric Nursing - February 25, 2023 Category: Nursing Authors: Ulrika M årtensson, Stefan Nilsson, Margaretha Jenholt Nolbris, Helle Wijk, Karin Mellgren Source Type: research

Mesenchymal stem cell-based therapy for non-healing wounds due to chronic limb-threatening ischemia: A review of preclinical and clinical studies
Front Cardiovasc Med. 2023 Feb 1;10:1113982. doi: 10.3389/fcvm.2023.1113982. eCollection 2023.ABSTRACTProgressive peripheral arterial disease (PAD) can result in chronic limb-threatening ischemia (CLTI) characterized by clinical complications including rest pain, gangrene and tissue loss. These complications can propagate even more precipitously in the setting of common concomitant diseases in patients with CLTI such as diabetes mellitus (DM). CLTI ulcers are cutaneous, non-healing wounds that persist due to the reduced perfusion and dysfunctional neovascularization associated with severe PAD. Existing therapies for CLTI a...
Source: Atherosclerosis - February 23, 2023 Category: Cardiology Authors: Carlos Theodore Huerta Francesca A Voza Yulexi Y Ortiz Zhao-Jun Liu Omaida C Velazquez Source Type: research