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Real-world evidence of neoadjuvant chemotherapy for breast cancer treatment in a Brazilian multicenter cohort: Correlation of pathological complete response with overall survival
CONCLUSION: The pCR rate and its prognostic value varied across BC subtypes. In our study, pCR could be used as a surrogate of favorable clinical outcome, as it was associated with higher OS and DFS rates.PMID:37722319 | DOI:10.1016/j.breast.2023.103577
Source: Breast - September 18, 2023 Category: Cancer & Oncology Authors: Marcelo Antonini Andr é Mattar Fernanda Grace Bauk Richter Gabriel Duque Pannain Marina Di ógenes Teixeira Andressa Gon çalves Amorim Odair Ferraro Reginaldo Coelho Guedes Lopes Luiz Henrique Gebrim Juliana Monte Real Source Type: research
Clinical analysis of bacterial infection characteristics in lymphoma patients with high-dose chemotherapy combined with autologous hematopoietic stem cell transplantation-a single-centered retrospective study
CONCLUSION: High-dose chemotherapy combined with autologous hematopoietic stem cell transplantation (HDT/AHSCT) is used to treat lymphoma. Although AHSCT has made considerable strides and become safer, HDT-AHSCT infection continues to be a leading cause of morbidity and mortality associated with transplantation.PMID:37718527 | DOI:10.2174/1386207326666230915115056
Source: Combinatorial Chemistry and High Throughput Screening - September 18, 2023 Category: Chemistry Authors: Dan-Hui Sun Di Mei Xiao-Qin Yaoz Yi-Hui Rong Gui-Qiang Wang Source Type: research
Case Report: Case Series of Kocuria palustris Bacteremia among Immunocompromised Patients
We present three cases of bacteremia in immunocompromised patients admitted to our hospital; one patient was receiving chemotherapy for gall bladder carcinoma, the second was on maintenance hemodialysis for chronic kidney disease, and the third was receiving chemotherapy for acute myeloid leukemia. All three patients presented with a fever in the setting of neutropenia during the course of treatment with chemotherapy (in Cases 1 and 3) or hemodialysis (in Case 2). The blood culture samples of all the patients had pure isolates of Kocuria species K. palustris, which was identified by matrix assisted laser desorption ionisat...
Source: The American Journal of Tropical Medicine and Hygiene - September 18, 2023 Category: Tropical Medicine Authors: Gerlin Varghese Ashima Jamwal Deepika Sarawat Chinmoy Sahu Sangram Singh Patel Nidhi Tejan Source Type: research
Testicular tumours in children: a single-centre experience
CONCLUSION: Primary testicular tumours follow a bimodal age distribution pattern. Majority of patients can be cured with platinum-based chemotherapy despite having advanced disease at presentation.PMID:37721303 | DOI:10.4103/singaporemedj.SMJ-2021-380
Source: Singapore Medical Journal - September 18, 2023 Category: General Medicine Authors: Sajid Ali Tariq Latif Muhammad Ali Sheikh Shazia Perveen Muhammad Bilal Albash Sarwar Source Type: research
Integration of palliative care in the management of oral squamous cell carcinoma
Bioinformation. 2023 Jan 31;19(1):1-4. doi: 10.6026/97320630019001. eCollection 2023.ABSTRACTOral Squamous cell Cancers (OSCC) is strongly associated with tobacco consumption. We here in present a case study of a OSCC patient who refused standard oncological care (SOC), to highlight the importance of integrating palliative care (PC) for improved patient outcomes. A 61 years male patient, with history of chewing tobacco for more than 20 years and diagnosed to have OSCC for 1.5 years presented with severe anaemia and a cauliflower-like growth (12 x 10 cm) in the left oral cavity and cheek with greenish-yellow discharge. Pus ...
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Republica Sridhar Huwait Etimad Peter Natesan Pushparaj Gauthaman Kalamegam Source Type: research
Crocin Combined With Cisplatin Regulates Proliferation, Apoptosis And Emt Of Gastric Cancer Cells Via The Fgfr3/Mapk/Erk Pathway In Vitro And In Vivo
CONCLUSION: Our results showed that up-regulation of FGFR3 reversed the inhibitory effect of crocin+DDP on the MAPK/ERK signaling pathway. Still, this effect could be counteracted by PD184352, which simultaneously regulated the proliferation, apoptosis, and EMT of AGS cells. In conclusion, crocin, combined with DDP, inhibits proliferation, apoptosis, and EMT of GC through the FRFR3/MAPK/ERK pathway.PMID:37718528 | DOI:10.2174/1568009624666230915111239
Source: Current Cancer Drug Targets - September 18, 2023 Category: Cancer & Oncology Authors: Yan Li Qi-Jing Guo Rong Chen LingLin Zhao Xianshu Cui Yingfang Deng Yu-Shuang Luo Source Type: research
Circadian Regulation of Drug Responses: Toward Sex-Specific and Personalized Chronotherapy
Annu Rev Pharmacol Toxicol. 2023 Sep 18. doi: 10.1146/annurev-pharmtox-051920-095416. Online ahead of print.ABSTRACTToday's challenge for precision medicine involves the integration of the impact of molecular clocks on drug pharmacokinetics, toxicity, and efficacy, toward personalized chronotherapy. Meaningful improvements of tolerability and/or efficacy of medications through proper administration timing have been confirmed over the past decade for immunotherapy and chemotherapy against cancer, as well as for commonly used pharmacological agents in cardiovascular, metabolic, inflammatory, and neurological conditions. Expe...
Source: Pharmacological Reviews - September 18, 2023 Category: Drugs & Pharmacology Authors: Francis A L évi Alper Okyar Eva Hadadi Pasquale F Innominato Annabelle Ballesta Source Type: research
Prevalence and clinical correlations of SF3B1 variants in lactotroph tumours
CONCLUSIONS: SF3B1 variants are uncommon in lactotroph tumours but may be frequent in metastatic lactotroph tumours. When present, they associate with aggressive tumour behaviour and worse clinical outcome.PMID:37721395 | DOI:10.1093/ejendo/lvad114
Source: European Journal of Endocrinology - September 18, 2023 Category: Endocrinology Authors: Julia Simon Luis Gustavo Perez-Rivas Yining Zhao Fanny Chasseloup Helene Lasolle Christine Cortet Francoise Descotes Chiara Villa Bertrand Baussart Pia Burman Dominique Maiter Vivian von Selzam Roman Rotermund J örg Flitsch Jun Thorsteinsdottir Emmanuel Source Type: research
Circadian Regulation of Drug Responses: Toward Sex-Specific and Personalized Chronotherapy
Annu Rev Pharmacol Toxicol. 2023 Sep 18. doi: 10.1146/annurev-pharmtox-051920-095416. Online ahead of print.ABSTRACTToday's challenge for precision medicine involves the integration of the impact of molecular clocks on drug pharmacokinetics, toxicity, and efficacy, toward personalized chronotherapy. Meaningful improvements of tolerability and/or efficacy of medications through proper administration timing have been confirmed over the past decade for immunotherapy and chemotherapy against cancer, as well as for commonly used pharmacological agents in cardiovascular, metabolic, inflammatory, and neurological conditions. Expe...
Source: Annual Review of Pharmacology and Toxicology - September 18, 2023 Category: Drugs & Pharmacology Authors: Francis A L évi Alper Okyar Eva Hadadi Pasquale F Innominato Annabelle Ballesta Source Type: research
Carboplatin-induced upregulation of pan β-tubulin and class III β-tubulin is implicated in acquired resistance and cross-resistance of ovarian cancer
Cell Mol Life Sci. 2023 Sep 17;80(10):294. doi: 10.1007/s00018-023-04943-0.ABSTRACTResistance to platinum- and taxane-based chemotherapy represents a major obstacle to long-term survival in ovarian cancer (OC) patients. Here, we studied the interplay between acquired carboplatin (CBP) resistance using two OC cell models, MES-OV CBP and SK-OV-3 CBP, and non-P-glycoprotein-mediated cross-resistance to paclitaxel (TAX) observed only in MES-OV CBP cells. Decreased platination, mesenchymal-like phenotype, and increased expression of α- and γ-tubulin were observed in both drug-resistant variants compared with parental cells. B...
Source: Cellular and Molecular Life Sciences : CMLS - September 17, 2023 Category: Cytology Authors: Margareta Pernar Kova č Vanja Tadi ć Juran Kralj George E Duran Alessia Stefanelli Darija Stupin Polan čec Sanja Dabeli ć Niko Ba čić Maja T Tomicic Petra Heffeter Branimir I Sikic Anamaria Brozovic Source Type: research
High-throughput screening as a drug repurposing strategy for poor outcome subgroups of pediatric B-cell precursor Acute Lymphoblastic Leukemia
Biochem Pharmacol. 2023 Sep 15:115809. doi: 10.1016/j.bcp.2023.115809. Online ahead of print.ABSTRACTAlthough a great cure rate has been achieved for pediatric BCP-ALL, approximately 15% of patients do not respond to conventional chemotherapy and experience disease relapse. A major effort to improve the cure rates by treatment intensification would result in an undesirable increase in treatment-related toxicity and mortality, raising the need to identify novel therapeutic approaches. High-throughput (HTP) drug screening enables the profiling of patients' responses in vitro and allows the repurposing of compounds currently ...
Source: Biochemical Pharmacology - September 17, 2023 Category: Drugs & Pharmacology Authors: Athanasios Oikonomou Luigia Valsecchi Manuel Quadri Titus Watrin Katerina Scharov Simona Procopio Jia-Wey Tu Melina Vogt Angela Maria Savino Daniela Silvestri Maria Grazia Valsecchi Andrea Biondi Arndt Borkhardt Sanil Bhatia Giovanni Cazzaniga Grazia Fazi Source Type: research
Management of chemotherapy hypersensitivity reactions and desensitization: An SGO clinical practice statement
CONCLUSION: Incorporating a review of the literature and clinical experience from the SGO Education Committee, this paper provides an overview of current approaches for prevention and management of reactions to commonly used chemotherapy agents for gynecologic cancers.PMID:37717346 | DOI:10.1016/j.ygyno.2023.08.017
Source: Gynecologic Oncology - September 17, 2023 Category: Cancer & Oncology Authors: T R Hall J E MacDonald K M Bylinowski E A Alvarez M M Hardesty J A Smith Source Type: research
DNA repair biomarkers to guide usage of combined PARP inhibitors and chemotherapy: a meta-analysis and systematic review
CONCLUSIONS: Combination therapy only improves PFS in patients with identifiable DNA repair biomarkers. This indicates that PARP inhibitors do not sensitise patients to chemotherapy treatment, except where their cancer has a homologous recombination defect, or an alternative biomarker of altered DNA repair. While effective in patients with DNA repair biomarkers, there is a risk of high-grade haematological side-effects with the use of combination therapy. Thus, the benefit in PFS from combination therapy must be weighed against potential adverse effects, as individual arms of treatment can also confer benefit.PMID:37717683...
Source: Cell Research - September 17, 2023 Category: Cytology Authors: Zoe Phan Caroline E Ford C Elizabeth Caldon Source Type: research
Initial versus early switch to targeted therapy during first-line treatment among patients with biomarker-positive advanced or metastatic non-small cell lung cancer in the United States
CONCLUSION: In both unadjusted and adjusted analyses, there were no differences in the clinical outcomes observed among patients with a/mNSCLC in this study. This study found that initiating chemotherapy with an early switch to targeted therapy (within 56 days) of receiving biomarker positive results may be an acceptable strategy for a patient for whom immediate care is needed.PMID:37717466 | DOI:10.1016/j.ctarc.2023.100761
Source: Cell Research - September 17, 2023 Category: Cytology Authors: Lisa M Hess Patrick Peterson Tomoko Sugihara Naleen Raj Bhandari Peter M Krein Anthony Sireci Source Type: research
Carboplatin-induced upregulation of pan β-tubulin and class III β-tubulin is implicated in acquired resistance and cross-resistance of ovarian cancer
Cell Mol Life Sci. 2023 Sep 17;80(10):294. doi: 10.1007/s00018-023-04943-0.ABSTRACTResistance to platinum- and taxane-based chemotherapy represents a major obstacle to long-term survival in ovarian cancer (OC) patients. Here, we studied the interplay between acquired carboplatin (CBP) resistance using two OC cell models, MES-OV CBP and SK-OV-3 CBP, and non-P-glycoprotein-mediated cross-resistance to paclitaxel (TAX) observed only in MES-OV CBP cells. Decreased platination, mesenchymal-like phenotype, and increased expression of α- and γ-tubulin were observed in both drug-resistant variants compared with parental cells. B...
Source: Cellular and Molecular Life Sciences : CMLS - September 17, 2023 Category: Cytology Authors: Margareta Pernar Kova č Vanja Tadi ć Juran Kralj George E Duran Alessia Stefanelli Darija Stupin Polan čec Sanja Dabeli ć Niko Ba čić Maja T Tomicic Petra Heffeter Branimir I Sikic Anamaria Brozovic Source Type: research
