Filtered By:
Therapy: Statin Therapy

This page shows you your search results in order of relevance. This is page number 9.

Order by Relevance | Date

Total 12097 results found since Jan 2013.

Diagnosis, Phenotype, and Molecular Genetics of Congenital Analbuminemia
Conclusion Figure 4 shows that the 27 different molecular defects within the ALB so far reported to cause CAA are located in ten different exons (1, 3, 4, 5, 7, 8, 9, 10, 11, and 12) and in seven different introns (1, 2, 3, 6, 10, 11, and 12) (The Albumin Website, 2018; Caridi et al., 2019). Variations in the last two coding exons (13 and 14) would probably cause the presence of a circulating C-terminal variant of the protein and not CAA. The first twelve exons of ALB, with the exception of the two shortest, exons 2 and 6, were reported to contain at least one molecular defect resulting in CAA (The Albumin Website, 2018; ...
Source: Frontiers in Genetics - April 16, 2019 Category: Genetics & Stem Cells Source Type: research

Fight Aging! Newsletter, April 18th 2022
In conclusion, our results suggest that SAH extends lifespan by inducing MetR or mimicking its downstream effects. Since the lifespan-extending effects of SAH are conserved in yeast and nematodes, and MetR extends the lifespan of many species, exposure to SAH is expected to have multiple benefits across evolutionary boundaries. Our findings offer the enticing possibility that in humans the benefits of a MetR diet can be achieved by promoting Met reduction with SAH. The use of endogenous metabolites, such as SAH, is considered safer than drugs and other substances, suggesting that it may be one of the most feasible ways to ...
Source: Fight Aging! - April 17, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

ProPublica Publishes Medicare Part D Prescriber Data
In 2010, the "investigative journalist organization" known as ProPubilca, through donations from the Pew Foundation and several other organizations geared towards attacking industry, began the "Dollars for Docs" campaign. As we have covered extensively since the launch of that campaign, ProPublica aggregated the payment reporting data of approximately 15 manufacturers who were reporting their payments publicly—either as a requirement of a corporate integrity agreement (CIA) with HHS-OIG, or voluntarily—and then created a searchable, aggregated website. Additionally, ProPublica teamed up with national and local medi...
Source: Policy and Medicine - June 13, 2013 Category: Health Medicine and Bioethics Commentators Authors: Thomas Sullivan Source Type: blogs

UK health IT ' glitch ' : Hundreds of thousands of patients have potentially been given an incorrect cardiovascular risk estimation after a major IT system error
This in the UK. What is euphemistically referred to as an " IT system error " is, in reality, the mass delivery of a grossly defective medical device adversely affecting hundreds of thousands of patients.   I ' m surprised not to see that other kindly euphemism, " glitch " ( http://hcrenewal.blogspot.com/search/label/glitch ): http://www.pulsetoday.co.uk/your-practice/practice-topics/it/gps-told-to-review-patients-at-risk-as-it-error-miscalculates-cv-score-in-thousands/20031807.article 11 May 2016   By Alex Matthews-King Hundreds of thousands of patients have potentially been given an incorrect cardiova...
Source: Health Care Renewal - May 31, 2016 Category: Health Management Tags: Alex Matthews-King Clinical Safety Incident Dr Grant Ingrams glitch Harry Potter Patient care has not been compromised Source Type: blogs

Proton Pump Inhibitors: Risk for Myopathy?
CONCLUSION: A limited body of published data suggests that PPI use has been associated with myopathy-like symptoms without long-term effects following discontinuation. Although myopathy is a rare adverse effect observed with PPIs, it can be a serious side effect to be considered when starting a patient on acid suppression therapy. PMID: 27539734 [PubMed - as supplied by publisher]
Source: The Annals of Pharmacotherapy - August 17, 2016 Category: Drugs & Pharmacology Authors: Colmenares EW, Pappas AL Tags: Ann Pharmacother Source Type: research

Calcium Phosphate Carrying Simvastatin Enhances Bone Regeneration: A Systematic Review.
In conclusion, the pertinent pre-clinical studies evidenced the calcium phosphate biocompatibility and its effectiveness in delivering SIM to improve the repair of bone defects. So, clinical trials are encouraged to investigate the impact of SIM associated with calcium phosphate bone graft in repairing bone defect in humans. PMID: 32556021 [PubMed - in process]
Source: Braz Dent J - February 29, 2020 Category: Dentistry Authors: Cruz R, Pesce G, Calasans-Maia J, Moraschini V, Calasans-Maia MD, Granjeiro JM Tags: Braz Dent J Source Type: research

Impact of Interferons and Biological Drug Inhibitors of IL-2 and IL-6 on Small-Molecule Drug Metabolism Through the Cytochrome P450 System
CONCLUSIONS: Interferon therapy or inflammatory suppression via IL-2 or IL-6 can alter steady-state concentrations of CYP-metabolized small-molecule drugs.PMID:34078115 | DOI:10.1177/10600280211022281
Source: The Annals of Pharmacotherapy - June 3, 2021 Category: Drugs & Pharmacology Authors: C Michael White Dakota J Sicignano Kimberly Smith Source Type: research

Inclisiran for the Treatment of Hyperlipidemia and for Atherosclerotic Cardiovascular Disease Risk Reduction: A Narrative Review
Clin Ther. 2023 Jul 12:S0149-2918(23)00205-9. doi: 10.1016/j.clinthera.2023.06.011. Online ahead of print.ABSTRACTPURPOSE: Inclisiran is a novel nonstatin therapy providing significant reduction in low-density lipoprotein cholesterol (LDL-C) as well as improvements in other lipid biomarkers. This review summarizes data from postapproval publications regarding the impact of inclisiran on lipids and cardiovascular risk reduction, as well as its tolerability and cost-effectiveness.METHODS: A search of PubMed for inclisiran was used to identify articles published since its approval by the US Food and Drug Administration (FDA)....
Source: Clinical Therapeutics - July 14, 2023 Category: Drugs & Pharmacology Authors: Kevin Cowart Jerica Singleton Nicholas W Carris Source Type: research

Effects of Adding Statins Before Surgery on Mortality and Major Morbidity: A Meta-Analysis
Objective: To re-evaluate the effects of adding a statin before surgery on mortality at 30 days and at 1 year and on major morbidity at 0-30 days.Design: A meta-analysis of parallel, randomized, controlled trials published in English.Setting: A university-based electronic search.Participants: Adult patients undergoing any type of procedure.Intervention: Adding a statin before a procedure compared to a placebo or no intervention.Measurements and Main Results: A search for all randomized controlled trials (RCT) was done in PubMed, Embase, Ovid MEDLINE and the Cochrane Central Register of Controlled Trials in November 2012. T...
Source: Journal of Cardiothoracic and Vascular Anesthesia - September 9, 2013 Category: Anesthesiology Authors: Joanne Guay, E. Andrew Ochroch Tags: Original Articles Source Type: research

Sex/Gender disparities in randomized controlled trials of statins: the impact of awareness efforts.
Conclusion: This study demonstrates significant progress in the inclusion of women in RCTs on statins. This finding reflects the efforts of different agencies and groups to increase the representation of women in clinical trials. PMID: 24895990 [PubMed - in process]
Source: Clinical and Investigative Medicine - June 10, 2014 Category: Biomedical Science Authors: Farahani P Tags: Clin Invest Med Source Type: research

Statins for acute coronary syndrome.
CONCLUSIONS: Based on moderate quality evidence, due to concerns about risk of bias and imprecision, initiation of statin therapy within 14 days following ACS does not reduce death, myocardial infarction, or stroke up to four months, but reduces the occurrence of unstable angina at four months following ACS. Serious side effects were rare. PMID: 25178118 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - September 1, 2014 Category: Journals (General) Authors: Vale N, Nordmann AJ, Schwartz GG, de Lemos J, Colivicchi F, den Hartog F, Ostadal P, Macin SM, Liem AH, Mills EJ, Bhatnagar N, Bucher HC, Briel M Tags: Cochrane Database Syst Rev Source Type: research

Statins for age-related macular degeneration.
CONCLUSIONS: Evidence from currently available RCTs is insufficient to conclude that statins have a role in preventing or delaying the onset or progression of AMD. PMID: 25675254 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - February 11, 2015 Category: Journals (General) Authors: Gehlbach P, Li T, Hatef E Tags: Cochrane Database Syst Rev Source Type: research

Importance of assessing the effect of statins on the function of high- density lipoproteins on coronary plaque.
In conclusion, the best coronary plaque regression index attributed to HDL-cholesterol elevation (PH index) was found in pitavastatin treatment, in comparison with the other 4 statins (atorvastatin, pravastatin, simvastatin, rosuvastatin) investigated in the articles scanned by their search. PMID: 22524170 [PubMed - indexed for MEDLINE]
Source: Cardiovascular and Hematological Disorders Drug Targets - June 4, 2015 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Simvastatin, dosage and delivery system for supporting bone regeneration, an update review
Conclusion Local delivery of simvastatin from carriers appears to be an attractive solution to the problem of maintaining therapeutic doses to treat severe bone defects and to minimize the undesired side effects. Locally delivered simvastatin can increase the bone formation and accelerate healing process of bony defect. Another advantage of local delivery system is that it can stimulate new bone formation in a dose-dependent manner. Further evidence-based studies will be required to determine local delivery concentrations to promote bone regeneration.
Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology - December 2, 2015 Category: ENT & OMF Source Type: research