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Vaccination: Malaria Vaccine

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Total 1513 results found since Jan 2013.

Inadvertent transfer of a mammalian retrovirus into birds
Reticuloendotheliosis viruses (REVs) are retroviruses that cause a rare disease of gamebirds and waterfowl that includes anemia, immunosuppression, neoplasia, runting, and abnormal feathering. Since the first isolation of REV from a turkey in 1957, REVs were believed to be strictly avian viruses. It now appears that REVs are mammalian viruses that were accidentally introduced into birds in the 1930s during research on malaria. During an investigation of endogenous retrovirus diversity in Malagasy mammals, the authors found sequences related to REVs in the genomes of the ring-tailed mongoose and the narrow-striped mongoose....
Source: virology blog - August 27, 2013 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information bird fowlpox virus gallid herpesvirus iatrogenic reticuloendotheliosis virus viral Source Type: blogs

Chalcone and Curcumin Derivatives: A Way ahead for Malarial Treatment.
Abstract Malaria has been a major cause of morbidity and mortality in developing countries, particularly in Sub-Saharan Africa and South Asia. The global malaria situation is increasingly being challenging owing to lack of credible malaria vaccine and the emergence of drug resistance to most of the available Antimalarial. They demand search for novel generation of drugs. Versatility and flexibility for structural modification of natural and synthetic analogues of curcumin and chalcone have been explored extensively for designing new antimalarial agent. Recent advances to our knowledge of parasite biology as well a...
Source: Mini Reviews in Medicinal Chemistry - October 25, 2013 Category: Chemistry Authors: Kumar D, Kumar M, Kumar A, Singh SK Tags: Mini Rev Med Chem Source Type: research

Malaria vaccines: past, present and future
The currently available malaria control tools have allowed malaria elimination in many regions but there remain many regions where malaria control has made little progress. A safe and protective malaria vaccine would be a huge asset for malaria control. Despite the many challenges, efforts continue to design and evaluate malaria vaccine candidates. These candidates target different stages in the life cycle of Plasmodia. The most advanced vaccine candidates target the pre-erythrocytic stages in the life cycle of the parasite and include RTS,S/AS01, which has progressed through clinical development to the stage that it may b...
Source: Archives of Disease in Childhood - November 12, 2013 Category: Pediatrics Authors: von Seidlein, L., Bejon, P. Tags: Immunology (including allergy), Drugs: infectious diseases, ADC Global child health, Travel medicine, Tropical medicine (infectious diseases), Vaccination / immunisation Source Type: research

Challenges and prospects for dengue and malaria control in Thailand, Southeast Asia.
Abstract Despite significant advances in the search for potential dengue vaccines and new therapeutic schemes for malaria, the control of these diseases remains difficult. In Thailand, malaria incidence is falling whereas that of dengue is rising, with an increase in the proportion of reported severe cases. In the absence of antiviral therapeutic options for acute dengue, appropriate case management reduces mortality. However, the interruption of transmission still relies on vector control measures that are currently insufficient to curtail the cycle of epidemics. Drug resistance in malaria parasites is increasing...
Source: Trends in Parasitology - November 8, 2013 Category: Parasitology Authors: Corbel V, Nosten F, Thanispong K, Luxemburger C, Kongmee M, Chareonviriyaphap T Tags: Trends Parasitol Source Type: research

TREM2 controls malaria liver stage infection Medical Sciences
Plasmodium liver stage infection is a target of interest for the treatment of and vaccination against malaria. Here we used forward genetics to search for mechanisms underlying natural host resistance to infection and identified triggering receptor expressed on myeloid cells 2 (TREM2) and MHC class II molecules as determinants of...
Source: Proceedings of the National Academy of Sciences - November 26, 2013 Category: Science Authors: Goncalves, L. A., Rodrigues–Duarte, L., Rodo, J., Vieira de Moraes, L., Marques, I., Penha–Goncalves, C. Tags: Biological Sciences Source Type: research

Oxygen distribution in proteins defines functional significance of the genome and proteome of the malaria parasite Plasmodium falciparum 3D7
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Source: FEMS Microbiology Letters - December 1, 2013 Category: Microbiology Authors: Balamurugan Palanisamy, Klaus Heese Tags: Research Letter Source Type: research

Do You Believe More Vaccines or Better Nutrition Prevents Disease?
Conclusion Tremendous government financial and medical resources are wasted on the development of more vaccinations to prevent diseases. No research has proven the effectiveness of vaccinations in preventing illness. Overwhelming evidence exists to show vaccines are dangerous to health and contribute to illness, injury and death. To prevent disease, one should avoid vaccinations, mercury dental fillings and toxic food. Following a nutrient-dense diet of whole, organic foods and removing toxic metals from the body are the best avenues to try and prevent illness and enhance health. References http://www.fierce...
Source: vactruth.com - December 20, 2013 Category: Health Medicine and Bioethics Commentators Authors: Michelle Goldstein Tags: Michelle Goldstein Top Stories Dr. Russell Blaylock National Institutes of Health (NIH) Nutrition truth about vaccines Weston Price Source Type: blogs

Attacks on MSF health facilities in South Sudan obstruct aid efforts
Thousands of people are at risk of being left without desperately needed medical care after the international medical organization Médecins Sans Frontières/Doctors Without Borders (MSF) was forced to suspend activities in Malakal, South Sudan, following the looting of its compounds, says MSF. South Sudan © Phil Moore. A girl carries water past the Médecins Sans Frontières (MSF) clinic set up at the camp for displaced people in the grounds of the United Nations Mission to South Sudan (UNMISS) base in Juba, South Sudan, on January 12, 2014. “Armed men entered the MSF compound in Malakal twice yesterday, where they l...
Source: MSF News - January 17, 2014 Category: Global & Universal Tags: South Sudan Frontpage NEWS Source Type: news

Press Release South Sudan: MSF Forced to Suspend Activities in Malakal
2014 © Google The town of Malakal, where MSF was forced to suspend activities after its compound was looted JUBA, SOUTH SUDAN, JANUARY 17, 2014—Thousands of people are going without desperately needed medical care after the international medical humanitarian organization Doctors Without Borders/Médecins Sans Frontières (MSF) was forced to suspend activities in Malakal, South Sudan, following the looting of its compound yesterday. MSF condemns the incident in the strongest possible terms. The suspension of medical activities comes barely one week after the looting of another MSF facility in...
Source: MSF News - January 21, 2014 Category: Global & Universal Source Type: news

Vitamin B6-Dependent Enzymes in the Human Malaria Parasite Plasmodium falciparum: A Druggable Target?
Abstract Malaria is a deadly infectious disease which affects millions of people each year in tropical regions. There is no effective vaccine available and the treatment is based on drugs which are currently facing an emergence of drug resistance and in this sense the search for new drug targets is indispensable. It is well established that vitamin biosynthetic pathways, such as the vitamin B6 de novo synthesis present in Plasmodium, are excellent drug targets. The active form of vitamin B6, pyridoxal 5-phosphate, is, besides its antioxidative properties, a cofactor for a variety of essential enzymes present in th...
Source: Biomed Res - February 18, 2014 Category: Research Authors: Kronenberger T, Lindner J, Meissner KA, Zimbres FM, Coronado MA, Sauer FM, Schettert I, Wrenger C Tags: Biomed Res Int Source Type: research

Malaria: Hitches and Hopes.
Abstract Malaria, a devastating infectious disease caused by parasites of Plasmodium genera is transmitted from person to person through bites of infected mosquitoes. It generally traps underdeveloped nations with poor infrastructure and high population density. It has attracted considerable attention from academic institutions, pharmaceutical industries and government agencies but the efforts to eradicate this threat face a number of technical, economic, financial and institutional hurdles. In the absence of clinically proven vaccines to combat malaria,chemotherapy continues to be the best available option, altho...
Source: Mini Reviews in Medicinal Chemistry - April 28, 2014 Category: Chemistry Authors: Marella A, Verma G, Shaquiquzzaman M, Akhter M, Alam MM Tags: Mini Rev Med Chem Source Type: research

First controlled malaria infection trial in Africa paves way for drug and vaccine development
(Burness Communications) An international research team today reports the first-ever clinical trial demonstrating controlled malaria infection in an African nation in the modern era. The study, published online in the American Journal of Tropical Medicine and Hygiene represents a significant milestone in the search for new malaria drugs and vaccines.
Source: EurekAlert! - Infectious and Emerging Diseases - July 28, 2014 Category: Infectious Diseases Source Type: news

New malaria vaccine candidates identified
Researchers have discovered new vaccine targets that could help in the battle against malaria. Taking a new, large-scale approach to this search, researchers tested a library of proteins from the Plasmodium falciparum parasite with antibodies produced by the immune systems of a group of infected children.
Source: ScienceDaily Headlines - July 30, 2014 Category: Science Source Type: news

Kenya: Kenyan Awarded for Malaria Vaccine Study
[The Star]A Kenyan scientist has been awarded for her pioneering research that boosts the search for malaria vaccine. Dr Faith Osier, a research programme scientist at the Kenya Medical Research Institute (Kemri) -Wellcome Trust, received the 2014 Royal Society Pfizer Prize.
Source: AllAfrica News: Malaria - August 11, 2014 Category: Infectious Diseases Source Type: news

Rwanda: Is Long Search for Malaria Vaccine Finally Ending?
[New Times]For the last 70 years, several research projects on a potential Malaria vaccine have been launched and executed at a cost of millions of dollars, but without any breakthrough.
Source: AllAfrica News: Malaria - August 25, 2014 Category: Infectious Diseases Source Type: news