TREM2 controls malaria liver stage infection [Medical Sciences]

Plasmodium liver stage infection is a target of interest for the treatment of and vaccination against malaria. Here we used forward genetics to search for mechanisms underlying natural host resistance to infection and identified triggering receptor expressed on myeloid cells 2 (TREM2) and MHC class II molecules as determinants of...

Source: Proceedings of the National Academy of Sciences - November 26, 2013 Category: Science Authors: Goncalves, L. A., Rodrigues–Duarte, L., Rodo, J., Vieira de Moraes, L., Marques, I., Penha–Goncalves, C. Tags: Biological Sciences Source Type: research