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In Search of Calcifications : Histologic Analysis and Diagnostic Yield of Stereotactic Core Needle Breast Biopsies
CONCLUSIONS: We determined the up-to-date detection rates of calcification and DCIS in SCNB, as well as the common benign and malignant breast lesions associated with calcifications. Additional levels significantly increase the detection rate when standard levels show only stromal or scant/absent calcifications. Lobular neoplasia is often an incidental finding in SCNB for calcifications. When calcifications are present with LN, they are commonly florid, pleomorphic LCIS, or with concurrent invasive carcinoma.PMID:37167599 | DOI:10.1093/ajcp/aqad037
Source: Clinical Genitourinary Cancer - May 11, 2023 Category: Cancer & Oncology Authors: Fazilet Yilmaz Sean M Hacking Linda Donegan Lijuan Wang Evgeny Yakirevich Yihong Wang Source Type: research

Conscious and unconscious memory and eye movements in context-guided visual search: A computational and experimental reassessment of Ramey, Yonelinas, and Henderson (2019)
Cognition. 2023 Aug 12;240:105539. doi: 10.1016/j.cognition.2023.105539. Online ahead of print.ABSTRACTAre eye movements unconsciously guided towards target locations in familiar scenes? In a recent eyetracking study, Ramey, Yonelinas, and Henderson (2019) measured eye-movement efficiency (scanpath ratio) and memory judgments when participants searched for targets in repeated and novel scenes. When trials judged new with high confidence were selected, scanpath ratio was lower for old scenes (misses) than for new scenes (correct rejections). In addition, familiarity as measured by recognition confidence did not significantl...
Source: Cognition - August 14, 2023 Category: Neurology Authors: Daryl Y H Lee David R Shanks Source Type: research

The value of 18F-FDG PET/CT-based radiomics in predicting perineural invasion and outcome in non-metastatic colorectal cancer
ConclusionThe nomogram, integrating clinical data, PET/CT features, metabolic parameters, and radiomics, performs well in predicting PNI status and is associated with the outcome in patients with non-metastatic CRC.Graphical abstract
Source: Abdominal Imaging - March 17, 2022 Category: Radiology Source Type: research

Holistic review and meta-analysis of independent impact of the residual SYNTAX score on prognosis in patients with acute coronary syndrome
Conclusion. The meta-analysis indicated that an rSS value of 8 could be a reasonable cut-off for incomplete revascularization after ACS and is an efficient tool to guide revascularization. In future, detailed research should focus on investigation of the optimal value of the rSS score.PMID:35788166 | DOI:10.1080/14017431.2022.2095434
Source: Scandinavian Cardiovascular Journal - July 5, 2022 Category: Cardiology Authors: Chuang Li Jiang-Yuan Li De-Jing Feng Xin-Chun Yang Le-Feng Wang Kun Xia Source Type: research

BNC-rSS, a bivalent subunit nanovaccine affords the cross-protection against Streptococcus agalactiae and Streptococcus iniae infection in tilapia
In this study, a multi-epitope subunit vaccine Sip-Srr (SS) was prepared based on the B-cell antigenic epitopes prediction and multiple sequence alignment analysis of Sip and Srr sequences. Furthermore, the BNC-rSS nanocarrier vaccine system was constructed by connecting the rSS protein with modified bacterial nanocellulose (BNCs) and characterized by Fourier Transform Infrared Spectroscopy and Scanning Electron Microscope, the immersion immune effect against S. agalactiae and S. iniae infection was evaluated. The results showed that compared with the control group, BNC-rSS significantly enhanced serum antibody production,...
Source: International Journal of Biological Macromolecules - September 3, 2023 Category: Biochemistry Authors: Jia Liu Gaoyang Liu Ye Cao Hui Du Tianqiang Liu Mingzhu Liu Pengfei Li Yang He Gaoxue Wang Qing Yu Erlong Wang Source Type: research

Recognition of human faces by dogs (Canis familiaris) requires visibility of head contour.
Abstract Researchers have suggested that dogs are able to recognise human faces, but conclusive evidence has yet to be found. Experiment 1 of this study investigated whether dogs can recognise humans using visual information from the face/head region, and whether this also occurs in conditions of suboptimal visibility of the face. Dogs were presented with their owner's and a stranger's heads, protruding through openings of an apparatus in opposite parts of the experimental setting. Presentations occurred in conditions of either optimal or suboptimal visibility; the latter featured non-frontal orientation, uneven i...
Source: Animal Cognition - June 26, 2017 Category: Zoology Authors: Mongillo P, Scandurra A, Kramer RSS, Marinelli L Tags: Anim Cogn Source Type: research

Beyond BMI for self-estimates of body size and shape: A new method for developing stimuli correctly calibrated for body composition.
Abstract Accurate self-assessment of body shape and size plays a key role in the prevention, diagnosis, and treatment of both obesity and eating disorders. These chronic conditions cause significant health problems, reduced quality of life, and represent a major problem for health services. Variation in body shape depends on two aspects of composition: adiposity and muscularity. However, most self-assessment tools are unidimensional. They depict variation in adiposity only, typically quantified by the body mass index. This can lead to substantial, and clinically meaningful, errors in estimates of body shape and si...
Source: Behavior Research Methods - October 13, 2020 Category: Psychiatry & Psychology Authors: Maalin N, Mohamed S, Kramer RSS, Cornelissen PL, Martin D, Tovée MJ Tags: Behav Res Methods Source Type: research

Title: Genistein Disrupts Glucocorticoid Receptor Signaling in Human Uterine Endometrial Ishikawa Cells
Conclusions: Using Ishikawa cells, we observed that exposure to genistein resulted in distinct changes in gene expression and unique differences in the GR transcriptome. Citation: Whirledge S, Senbanjo LT, Cidlowski JA. 2015. Genistein disrupts glucocorticoid receptor signaling in human uterine endometrial Ishikawa cells. Environ Health Perspect 123:80–87; http://dx.doi.org/10.1289/ehp.1408437 Address correspondence to J.A. Cidlowski, NIH/NIEHS, MD F3-07, P.O. Box 12233, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-1564. E-mail: cidlows1@niehs.nih.gov We thank X. Xu (Integrative Bioinformatic...
Source: EHP Research - December 31, 2014 Category: Environmental Health Authors: Web Admin Tags: Research Article January 2015 Source Type: research

IFIT5 Participates in the Antiviral Mechanisms of Rainbow Trout Red Blood Cells
We described a new defense mechanism based on IFIT5 antiviral activity in nucleated RBCs that appeared to contribute to halting the VHSV infection. This finding sheds light into novel antiviral therapeutics to mitigate the economic losses and social impact caused by viral infections in the aquaculture industry. This work broadens the knowledge of fish nucleated RBCs functions and their role in the immune response to viral infections. Ethics Statement Experimental protocols and methods relating to experimental animals were reviewed and approved by the Animal Welfare Body and the Research Ethics Committee at the University...
Source: Frontiers in Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research

Detailed Dissection of UBE3A-Mediated DDI1 Ubiquitination
Discussion Poly-ubiquitinated proteins targeted for degradation might be recognized directly by proteasomal receptors or by proteasomal shuttling proteins. The first shuttling proteins – Ddi1, Rad23 and Dsk2 – were identified and characterized in Saccharomyces cerevisiae (Lambertson et al., 1999; Kaplun et al., 2005). Proteasomal shuttles contain an N-terminal ubiquitin-like (UBL) domain that interacts with the 26S proteasome (Finley, 2009), and a C-terminal ubiquitin-binding domain domain (UBD) that binds to ubiquitin or poly-ubiquitin chains (Bertolaet et al., 2001). When ubiquitinated, substrates are capt...
Source: Frontiers in Physiology - May 2, 2019 Category: Physiology Source Type: research