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Nutrition: Herbs
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Total 24253 results found since Jan 2013.
Aloperine Protects Pulmonary Hypertension via Triggering PPAR γ Signaling and Inhibiting Calcium Regulatory Pathway in Pulmonary Arterial Smooth Muscle Cells
In this study, monocrotaline-induced PH (MCT-PH) rat model and primarily cultured rat distal pulmonary arterial smooth muscle cells (PASMCs) were used to investigate the mechanisms of ALO on experimental PH, pulmonary vascular remodeling and excessive proliferation of PASMCs. Results showed that: Firstly, ALO significantly prevented the disease development of MCT-PH by inhibiting right ventricular systolic pressure (RVSP) and right ventricular hypertrophy indexed by Fulton Index, normalizing the pulmonary arterials (PAs) remodeling and improving the right ventricular function indexed by transthoracic echocardiography. ALO ...
Source: Am J Physiol Cell Ph... - September 4, 2023 Category: Cytology Authors: Xiaoqian Shan Jing Wang Huazhuo Feng Zizhou Zhang Qiuyu Zheng Qing Zhang Kai Yang Jian Wang Lei Xu Source Type: research
Transcriptome analysis provides insights into coumarin biosynthesis in the medicinal plant Angelica dahurica cv. Yubaizhi
In this study, we utilized Hiseq2500 sequencing to analyze the transcriptomes of A. dahurica at different growth stages while concurrently quantifying coumarin content. Differentially expressed gene (DEG) analysis was employed to identify key genes involved in coumarin and terpenoid backbone biosynthesis. Weighted gene co-expression network analysis (WGCNA) was applied to identify gene modules strongly associated with coumarin content, elucidating the regulatory relationships between transcription factors (TFs) and pathway genes. Furthermore, KEGG enrichment analysis was used to explore essential pathways governing coumari...
Source: Gene - September 3, 2023 Category: Genetics & Stem Cells Authors: Xiaodong Zhang Caixia Li Zhanchao Hao Yongjiang Liu Source Type: research
The not-so-natural herb: a case of exogenous Cushing syndrome
Med J Aust. 2023 Sep 1. doi: 10.5694/mja2.52095. Online ahead of print.NO ABSTRACTPMID:37658579 | DOI:10.5694/mja2.52095
Source: Med J Aust - September 2, 2023 Category: General Medicine Authors: Yi-An Pan David Roberts Source Type: research
Meta-analysis of the anti-oxidative and anti-inflammatory effects of hypoglycaemic plant-derived medicines
ConclusionsSeveral hypoglycaemic plant-based treatments appear to positively affect T2DM patients by concurrently lowering oxidative stress and inflammatory indicators and boosting antioxidant enzyme activity.Clinical Trail RegistryPROSPERO ID: CRD42021226147.
Source: Inflammopharmacology - September 2, 2023 Category: Drugs & Pharmacology Source Type: research
Verbascoside: A neuroprotective phenylethanoid glycosides with anti-depressive properties
CONCLUSIONS: These findings provide strong evidence that verbascoside exerts its antidepressant effects through various pharmacological mechanisms. However, further multicentre clinical case-control and molecularly targeted fishing studies are required to confirm the clinical efficacy of verbascoside and its underlying direct targets.PMID:37657207 | DOI:10.1016/j.phymed.2023.155027
Source: Atherosclerosis - September 1, 2023 Category: Cardiology Authors: Yi Zhao Sijia Wang Jin Pan Ke Ma Source Type: research
Fennel affects porcine ovarian cell functions: The interrelationships with the environmental contaminant benzene
The objective of this study was to examine the direct effects of the medicinal plant fennel on basic functions of ovarian cells, including proliferation, apoptosis, and release of progesterone and insulin-like growth factor I (IGFI), as well as to prevent the influence of the environmental contaminant benzene on these cells. Porcine ovarian granulosa cells were cultured with or without fennel extract alone or in combination with benzene. The expression of the proliferation marker PCNA and the apoptosis marker bax was analyzed by quantitative immunocytochemistry and enzyme-linked immunosorbent assay (ELISA). Fennel was able...
Source: Cell Research - September 1, 2023 Category: Cytology Authors: Alexander V Sirotkin Richard Alexa Abdullah Alshamrani Abdel Halim Harrath Source Type: research
Biomacromolecule-based nanocarrier strategies to deliver plant-derived bioactive components for cancer treatment: A recent review
Int J Biol Macromol. 2023 Aug 30:126623. doi: 10.1016/j.ijbiomac.2023.126623. Online ahead of print.ABSTRACTThe quest for safe chemotherapy has attracted researchers to explore anticancer potential of herbal medicines. Owing to upsurging evidence of herbal drug's beneficial effects, hopes are restored for augmenting survival rates in cancer patients. However, phytoconstituents confronted severe limitations in terms of poor absorption, low-stability, and low bioavailability. Along with toxicity issues associated with phytoconstituents, quality control and limited regulatory guidance also hinder the prevalence of herbal medi...
Source: International Journal of Biological Macromolecules - September 1, 2023 Category: Biochemistry Authors: Bapi Gorain Varnita Karmakar Biswatrish Sarkar Monika Dwivedi Janelle Tsui Lyn Leong Jing Hen Toh Even Seah Kang Yi Ling Kah Yee Chen Hira Choudhury Manisha Pandey Source Type: research
Preparation of medicinally active extracts and phytochemical characterisation of phytoconstituents from medicinal plants
This study described the Soxhlet and the maceration methods that are used to process extracts from the inert materials of medicinal plants using appropriate biocompatible solvents, the phytochemical screening assays, and TLC, UV spectrometry, FT-IR, and GC-MS techniques used in phytochemical studies. These techniques are crucial in studies that are meant to explore the active components of medicinal plants and their relative pharmacological effects. This information can be used as a guide when formulating effective yet less toxic plant-derived drugs and provide opportunities to upgrade while reducing further complexity in ...
Source: Natural Product Research - September 1, 2023 Category: Biochemistry Authors: Festus S Shafodino Julien M Lusilao Lamech M Mwapagha Source Type: research
Molecular docking analysis of GC-MS analyzed bioactive compounds from the rhizome of Hedychium rubrum with four protein targets
Bioinformation. 2022 Oct 31;18(10):943-950. doi: 10.6026/97320630018943. eCollection 2022.ABSTRACTHedychium rubrum, a traditional medicinal plant of Manipur belonging to the family Zingeberaceae was screened for its biological activity. The methanolic extract of its rhizome was prepared by Soxhlet extraction method and was further subjected to GC-MS to know its bioactive compounds. The in vitro antimicrobial activity assay was tested against five bacteria causing UTI. Klebseilla pneumoniae showed most sensitive followed by Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus and Enterococcus faecalis in the orde...
Source: Bioinformation - September 1, 2023 Category: Bioinformatics Authors: Ksh Sangeeta Devi M Damayanti Devi N Chetan Das D Velmurugan N Rajen Singh Source Type: research
