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Nutrition: Sodium

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Common changes in rat cortical gene expression after valproate or lithium treatment particularly affect pre- and post-synaptic pathways that regulate four neurotransmitters systems
CONCLUSIONS: Our study suggests that treating with mood stabilisers cause many common changes in levels of RNA which will impact on CNS function, particularly affecting post-synaptic muscarinic receptor functioning and the release of multiple neurotransmitters.PMID:37722808 | DOI:10.1080/15622975.2023.2258972
Source: The World Journal of Biological Psychiatry - September 18, 2023 Category: Psychiatry Authors: Brian Dean Elizabeth Scarr Source Type: research

Ultrasound improves the low-sodium salt curing of sea bass: Insights into the effects of ultrasound on texture, microstructure, and flavor characteristics
Ultrason Sonochem. 2023 Sep 11;100:106597. doi: 10.1016/j.ultsonch.2023.106597. Online ahead of print.ABSTRACTThe purpose of this study was to evaluate the effects of ultrasonic pretreatment on the quality of cured sea bass. Compared to static marination, ultrasonication significantly increased the rate of NaCl transfer, reduced the hardness and chewiness of fish, and improved water retention. Microstructural observations revealed that the sea bass muscle fibers were severely fragmented, with their borders becoming increasingly blurred with increasing ultrasonic intensity. In addition, ultrasound-assisted marination signif...
Source: Ultrasonics Sonochemistry - September 18, 2023 Category: Chemistry Authors: Hengli Bai Laihao Li Yanyan Wu Shengjun Chen Yongqiang Zhao Qiuxing Cai Yueqi Wang Source Type: research

Principles of the pharmacology of local anesthetics
Schmerz. 2023 Sep 18. doi: 10.1007/s00482-023-00751-4. Online ahead of print.ABSTRACTThe development of local anesthetics revolutionized the performance of painful interventions. Local anesthetics have an effect on voltage-gated sodium channels in nerve fibers and modulate the conduction of impulses. With respect to the chemical structure, local anesthetics can be divided into amide and ester types. The structural differences of local anesthetics have an influence on the duration of action, the degradation pathways and specific side effects. Severe adverse events include cardiotoxicity and neurotoxicity. In addition to bas...
Source: Schmerz - September 18, 2023 Category: Anesthesiology Authors: Rebecca Bockholt Martin Mirus Source Type: research

Investigating dynamics of lentiviral vector secretion from HEK293T producer cells using a fractionated perfusion system
This article is protected by copyright. All rights reserved.PMID:37718481 | DOI:10.1002/biot.202300097
Source: Biotechnology Journal - September 18, 2023 Category: Biotechnology Authors: Lauren M Timmins Patrick Erickson Biju Parekkadan Source Type: research

Outcomes of Hospital-Acquired Hypernatremia
CONCLUSIONS: Hospital-acquired hypernatremia is associated with in-hospital mortality as well as discharge to hospice or to nursing facility in all stages of CKD.PMID:37722368 | DOI:10.2215/CJN.0000000000000250
Source: Clinical Journal of the American Society of Nephrology : CJASN - September 18, 2023 Category: Urology & Nephrology Authors: Soraya Arzhan Maria-Eleni Roumelioti Igor Litvinovich Cristian G Bologa Mark L Unruh Source Type: research

How to optimize the use of diuretics in patients with heart failure?
Kardiol Pol. 2023 Sep 18. doi: 10.33963/v.kp.97315. Online ahead of print.ABSTRACTConsidering the pathophysiology and the clinical presentation of heart failure, the use of diuretics or drugs with diuretic properties are indispensable for an adequate management of heart failure patients. However, in clinical practice, fluid expansion is often undiagnosed and diuretic therapy is not always adequately titrated. Today, several drug classes with diuretic properties are available in addition to classical thiazides, thiazide-like and loop diuretics. The purpose of this short review is to discuss the different ways to optimize di...
Source: Polish Heart Journal - September 18, 2023 Category: Cardiology Authors: Michel Burnier Krzysztof Narkiewicz Sverre E Kjeldsen Source Type: research

Ultrasound improves the low-sodium salt curing of sea bass: Insights into the effects of ultrasound on texture, microstructure, and flavor characteristics
Ultrason Sonochem. 2023 Sep 11;100:106597. doi: 10.1016/j.ultsonch.2023.106597. Online ahead of print.ABSTRACTThe purpose of this study was to evaluate the effects of ultrasonic pretreatment on the quality of cured sea bass. Compared to static marination, ultrasonication significantly increased the rate of NaCl transfer, reduced the hardness and chewiness of fish, and improved water retention. Microstructural observations revealed that the sea bass muscle fibers were severely fragmented, with their borders becoming increasingly blurred with increasing ultrasonic intensity. In addition, ultrasound-assisted marination signif...
Source: Ultrasonics Sonochemistry - September 18, 2023 Category: Chemistry Authors: Hengli Bai Laihao Li Yanyan Wu Shengjun Chen Yongqiang Zhao Qiuxing Cai Yueqi Wang Source Type: research

Early-life sodium deprivation programs long-term changes in ingestive behaviors and energy expenditure in C57BL/6J mice
Am J Physiol Regul Integr Comp Physiol. 2023 Sep 18. doi: 10.1152/ajpregu.00137.2023. Online ahead of print.ABSTRACTPostnatal growth failure remains a significant problem for infants born prematurely, despite aggressive efforts to improve perinatal nutrition. Though often dysregulated in early life when children are born preterm, sodium (Na) homeostasis is vital to achieve optimal growth. We hypothesize that insufficient Na supply in this critical period contributes to growth restriction and programmed risks for cardiometabolic disease in later adulthood. Thus, we sought to ascertain the effects of prolonged versus early-l...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - September 18, 2023 Category: Physiology Authors: Alisha A Ziegler Samuel B R Lawton Connie C Grobe John J Reho Bonnie P Freudinger Colin M L Burnett Pablo Nakagawa Justin L Grobe Jeffrey L Segar Source Type: research

Green preparation of magnetic ferroferric oxide-polyvinyl alcohol-alginate coated UiO-67 nanospheres: Characterization, adsorption properties and adsorption mechanism of methylene blue
Int J Biol Macromol. 2023 Sep 16;253(Pt 3):126967. doi: 10.1016/j.ijbiomac.2023.126967. Online ahead of print.ABSTRACTIn this paper, a kind of magnetic ferric oxide/polyvinyl alcohol/calcium alginate/UiO-67 (Fe3O4/PVA/CA/UiO-67) nanospheres with homogeneous surface interconnecting structures was prepared by using macromolecular polymer polyvinyl alcohol and sodium alginate as carriers and zirconium organic skeleton as nanocrystals. The properties of magnetic nanospheres were studied by SEM, FT-IR, TGA, XRD, BET, VSM and Zeta potential. The impression of diverse temperatures, MB concentrations, interaction time, pH, and mag...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Zhenyu Jing Yanhui Li Qiuju Du Xinxin Pi Yuqi Wang Shiyong Zhao Yonghui Jin Source Type: research

2023 American Heart Association Focused Update on the Management of Patients With Cardiac Arrest or Life-Threatening Toxicity Due to Poisoning: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care
Circulation. 2023 Sep 18. doi: 10.1161/CIR.0000000000001161. Online ahead of print.ABSTRACTIn this focused update, the American Heart Association provides updated guidance for resuscitation of patients with cardiac arrest, respiratory arrest, and refractory shock due to poisoning. Based on structured evidence reviews, guidelines are provided for the treatment of critical poisoning from benzodiazepines, β-adrenergic receptor antagonists (also known as β-blockers), L-type calcium channel antagonists (commonly called calcium channel blockers), cocaine, cyanide, digoxin and related cardiac glycosides, local anesthetics, meth...
Source: Circulation - September 18, 2023 Category: Cardiology Authors: Eric J Lavonas Peter D Akpunonu Ann M Arens Kavita M Babu Dazhe Cao Robert S Hoffman Christopher O Hoyte Maryann E Mazer-Amirshahi Andrew Stolbach Maude St-Onge Trevonne M Thompson George Sam Wang Amber V Hoover Ian R Drennan American Heart Association Source Type: research

Green preparation of magnetic ferroferric oxide-polyvinyl alcohol-alginate coated UiO-67 nanospheres: Characterization, adsorption properties and adsorption mechanism of methylene blue
Int J Biol Macromol. 2023 Sep 16:126967. doi: 10.1016/j.ijbiomac.2023.126967. Online ahead of print.ABSTRACTIn this paper, a kind of magnetic ferric oxide/polyvinyl alcohol/calcium alginate/UiO-67 (Fe3O4/PVA/CA/UiO-67) nanospheres with homogeneous surface interconnecting structures was prepared by using macromolecular polymer polyvinyl alcohol and sodium alginate as carriers and zirconium organic skeleton as nanocrystals. The properties of magnetic nanospheres were studied by SEM, FT-IR, TGA, XRD, BET, VSM and Zeta potential. The impression of diverse temperatures, MB concentrations, interaction time, pH, and magnetic aero...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Zhenyu Jing Yanhui Li Qiuju Du Xinxin Pi Yuqi Wang Shiyong Zhao Yonghui Jin Source Type: research

Early-life sodium deprivation programs long-term changes in ingestive behaviors and energy expenditure in C57BL/6J mice
Am J Physiol Regul Integr Comp Physiol. 2023 Sep 18. doi: 10.1152/ajpregu.00137.2023. Online ahead of print.ABSTRACTPostnatal growth failure remains a significant problem for infants born prematurely, despite aggressive efforts to improve perinatal nutrition. Though often dysregulated in early life when children are born preterm, sodium (Na) homeostasis is vital to achieve optimal growth. We hypothesize that insufficient Na supply in this critical period contributes to growth restriction and programmed risks for cardiometabolic disease in later adulthood. Thus, we sought to ascertain the effects of prolonged versus early-l...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - September 18, 2023 Category: Physiology Authors: Alisha A Ziegler Samuel B R Lawton Connie C Grobe John J Reho Bonnie P Freudinger Colin M L Burnett Pablo Nakagawa Justin L Grobe Jeffrey L Segar Source Type: research

How to optimize the use of diuretics in patients with heart failure?
Kardiol Pol. 2023 Sep 18. doi: 10.33963/v.kp.97315. Online ahead of print.ABSTRACTConsidering the pathophysiology and the clinical presentation of heart failure, the use of diuretics or drugs with diuretic properties are indispensable for an adequate management of heart failure patients. However, in clinical practice, fluid expansion is often undiagnosed and diuretic therapy is not always adequately titrated. Today, several drug classes with diuretic properties are available in addition to classical thiazides, thiazide-like and loop diuretics. The purpose of this short review is to discuss the different ways to optimize di...
Source: Kardiologia Polska - September 18, 2023 Category: Cardiology Authors: Michel Burnier Krzysztof Narkiewicz Sverre E Kjeldsen Source Type: research