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Nutrition: Iron

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Intravenous Iron Sucrose for Treatment of Iron Deficiency Anemia in Pediatric Inflammatory Bowel Disease
ABSTRACTObjectives:Iron deficiency anemia (IDA) is a common complication of pediatric inflammatory bowel disease (IBD), yet the effectiveness of oral iron supplementation is limited. Intravenous iron sucrose is an effective and safe alternative treatment for IDA in adults with IBD, but its role in the treatment of IDA in pediatric IBD is unclear. The primary aim of this study was to evaluate the use of iron sucrose in pediatric IBD subjects with IDA and determine the clinical response as measured by improvement in hemoglobin concentration. The secondary aim was to describe adverse events associated with iron sucrose use in...
Source: Journal of Pediatric Gastroenterology and Nutrition - January 23, 2018 Category: Gastroenterology Tags: Original Article: Gastroenterology: Inflammatory Bowel Disease Source Type: research

Feasibility of the use of a handheld XRF analyzer to measure skin iron to monitor iron levels in critical organs
In conclusion, skin iron XRF measurements can act as a surrogate marker for liver iron content, and can be measured using a commercial XRF device for a portable, fast, and non-invasive measurement.
Source: Journal of Trace Elements in Medicine and Biology - July 27, 2018 Category: Biochemistry Source Type: research

The effects of iron and zinc status on prognosis in pediatric Wilson’s disease
ConclusionOur study suggests that SFr, SCu, SZn levels might have prognostic importance for WD.
Source: Journal of Trace Elements in Medicine and Biology - May 25, 2019 Category: Biochemistry Source Type: research

Red cell exchange transfusions lower cerebral blood flow and oxygen extraction fraction in pediatric sickle cell anemia
Blood transfusions are the mainstay of stroke prevention in pediatric sickle cell anemia (SCA), but the physiology conferring this benefit is unclear. Cerebral blood flow (CBF) and oxygen extraction fraction (OEF) are elevated in SCA, likely compensating for reduced arterial oxygen content (CaO2). We hypothesized that exchange transfusions would decrease CBF and OEF by increasing CaO2, thereby relieving cerebral oxygen metabolic stress. Twenty-one children with SCA receiving chronic transfusion therapy (CTT) underwent magnetic resonance imaging before and after exchange transfusions. Arterial spin labeling and asymmetric s...
Source: Blood - March 1, 2018 Category: Hematology Authors: Guilliams, K. P., Fields, M. E., Ragan, D. K., Eldeniz, C., Binkley, M. M., Chen, Y., Comiskey, L. S., Doctor, A., Hulbert, M. L., Shimony, J. S., Vo, K. D., McKinstry, R. C., An, H., Lee, J.-M., Ford, A. L. Tags: Pediatric Hematology, Sickle Cell Disease, Transfusion Medicine, Free Research Articles, Red Cells, Iron, and Erythropoiesis Source Type: research

Effectiveness of Clinical Decision Support Based Intervention in the Improvement of Care for Adult Sickle Cell Disease Patients in Primary Care
Conclusion: A CDS tool can improve management of SCD patients in primary care.
Source: Journal of the American Board of Family Medicine - September 10, 2018 Category: Primary Care Authors: Mainous, A. G., Carek, P. J., Lynch, K., Tanner, R. J., Hulihan, M. M., Baskin, J., Coates, T. D. Tags: Brief Reports Source Type: research

Does Improvement of Low Serum Ferritin Improve Symptoms of Restless Legs Syndrome in a Cohort of Pediatric Patients?
Conclusions:In preliminary findings, we found a modest, yet nonsignificant improvement in children exhibiting restless sleep and RLS symptomatology, despite significant improvement in ferritin levels. Though not statistically significant, the findings can lend to the suggested benefit of iron supplementation in patients with RLS; however, clinical judgment and further research is necessary.Citation:Rosen GM, Morrissette S, Larson A, Stading P, Barnes TL. Does improvement of low serum ferritin improve symptoms of restless legs syndrome in a cohort of pediatric patients?J Clin Sleep Med. 2019;15(8):1149–1154.
Source: Journal of Clinical Sleep Medicine : JCSM - August 14, 2019 Category: Sleep Medicine Source Type: research

Reliability of transcutaneous hemoglobin measurements in an outpatient pediatric clinic
CONCLUSIONS: The measurement of a transcutaneous Hgb is less invasive for pediatric patients but has significant limitations. Smaller children (probe specifications) and movement limited the ability to obtain a tcHgb measurement in ~75% of children tested. Falsely normal tcHgb values occurred due to overestimation of hemoglobin when compared to the traditional cHgb device. The suboptimal sensitivity of the tcHgb device may cause providers to miss a diagnosis of anemia. Future research should compare both methods of Hgb assessment to the gold standard laboratory-analyzed complete blood count and use a smaller probe for chil...
Source: Postgraduate Medicine - December 13, 2021 Category: Internal Medicine Authors: Shae Margulies Molly Posa Melissa Fitzgerald Stephanie Filipp Diane Howell Puneet Tung Maria Kelly Source Type: research

Does IV Iron Induce Plasma Oxidative Stress in Critically Ill Patients? A Comparison With Healthy Volunteers*
Conclusions: In our observation, IV iron infusion does not induce more nontransferrin bound iron, lipid, or protein oxidation in patients compared with volunteers, despite higher inflammation, oxidative stress, and hepcidin levels and lower antioxidant at baseline. In contrary, iron induces a greater decrease in antioxidant, compatible with higher oxidative stress in volunteers than in critically ill patients.
Source: Critical Care Medicine - February 24, 2016 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

RNA-seq analysis of blood of valproic acid-responsive and non-responsive pediatric patients with epilepsy.
Authors: Wang Y, Li Z Abstract Epilepsy is the most common chronic neurological disorder, affecting ~70 million individuals worldwide. However, approximately one-third of the patients are refractory to epilepsy medication. Of note, 100% of patients with genetic epilepsy who are resistant to the traditional drug, valproic acid (VPA), are also refractory to the other anti-epileptic drugs. The aim of the present study was to compare the transcriptomes in VPA responders and non-responders, to explore the mechanism of action of VPA and identify possible biomarkers to predict VPA resistance. Thus, RNA-seq was employed fo...
Source: Experimental and Therapeutic Medicine - July 3, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

27 utilization of an electonic medical record (emr)-integrated dashboard improves identification and treatment of iron deficiency in pediatric inflammatory bowel disease
Anemia is frequently encountered in inflammatory bowel disease (IBD) with studies reporting an even greater prevalence among children (16-72%) than adults (4-67%) at any given time during disease course. Anemia is commonly a result of chronic iron deficiency (ID) and inflammation, with the two conditions often overlapping. Many studies have shown that gastroenterologists underecognize and undertreat these conditions. Moreover, there are currently no pediatric-specific guidelines. To align clinical practice with adult guideline recommendations and evidence-based publications, we developed a quality improvement (QI) initiati...
Source: Gastroenterology - January 25, 2020 Category: Gastroenterology Authors: Jessica Breton, Zhang Yuchen, Trusha Patel, Janine McDermott, Jamie Stevenson, Erica Schwab, Maura Downing, Elizabeth Maxwell, Shazia Siddique, Andrew Grossman Tags: Practice Management/Quality of Care/Quality Assurance Source Type: research

North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Position Paper: Plant-based Milks
Parents and caretakers are increasingly feeding infants and young children plant-based “milk” (PBM) alternatives to cow milk (CM). The US Food and Drug Administration currently defines “milk” and related milk products by the product source and the inherent nutrients provided by bovine milk. Substitution of a milk that does not provide a similar nutritional profile to CM can be deleterious to a child's nutritional status, growth, and development. Milk's contribution to the protein intake of young children is especially important. For almond or rice milk, an 8 oz serving provides only about 2% or 8%, respectively, of...
Source: Journal of Pediatric Gastroenterology and Nutrition - July 30, 2020 Category: Gastroenterology Tags: Society Paper Source Type: research

The relationship between iron bone marrow stores and response to treatment in pediatric acute lymphoblastic leukemia
This study examines the effect of iron on pediatric acute lymphoblastic leukemia (ALL) and its “response to treatment.” At the end of the first year of treatment, bone marrow iron store (BMIS) was evaluated in children with ALL and the relationship between iron store and minimal residual disease was investigated. Moreover, the 3-year disease-free survival (3-DFS) of patients was determined. Patients’ BMIS were compared with that of subjects with normal bone marrow. The study examined 93 children, including 78 Pre-B and 15 T-cell ALL patients. BMIS did not differ between the children with ALL and those with no evidenc...
Source: Medicine - November 1, 2017 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Efficient zinc uptake is critical for the ability of Pseudomonas aeruginosa to express virulence traits and colonize the human lung
Publication date: Available online 14 March 2018 Source:Journal of Trace Elements in Medicine and Biology Author(s): Maria Chiara Mastropasqua, Iain Lamont, Lois W. Martin, David W. Reid, Melania D’Orazio, Andrea Battistoni We have recently shown that Pseudomonas aeruginosa, an opportunistic pathogen that chronically infects the lungs of patients with cystic fibrosis (CF) and other forms of lung disease, is extremely efficient in recruiting zinc from the environment and that this capability is required for its ability to cause acute lung infections in mice. To verify that P. aeruginosa faces zinc shortage when colonizin...
Source: Journal of Trace Elements in Medicine and Biology - March 15, 2018 Category: Biochemistry Source Type: research