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Characterization of a Deep-Sea Actinobacterium Strain Uncovers Its Prominent Capability of Utilizing Taurine and Polyvinyl Alcohol
Actinobacteria represent a large group of important prokaryotes with great application potentials and widely distribute in diverse natural environments including the ocean. However, compared to their terrestrial cultured members, there are much less available marine Actinobacteria, especially deep-sea counterparts. Here, we cultured a bacterial strain of deep-sea actinobacterium, Marmoricola sp. TYQ2, by using a basal medium supplemented with taurine. Consistently, the growth of strain TYQ2 was significantly promoted by the supplement of taurine. Transcriptomic analysis showed that the expressions of genes encoding protein...
Source: Frontiers in Microbiology - May 23, 2022 Category: Microbiology Source Type: research

FAM96A is essential for maintaining organismal energy balance and adipose tissue homeostasis in mice
Free Radic Biol Med. 2022 Sep 20:S0891-5849(22)00593-7. doi: 10.1016/j.freeradbiomed.2022.09.011. Online ahead of print.ABSTRACTThe iron (Fe) metabolism plays important role in regulating systemic metabolism and obesity development. The Fe inside cells can form iron-sulfur (Fe-S) clusters, which are usually assembled into target proteins with the help of a conserved cluster assembly machinery. Family with sequence similarity 96A (FAM96A; also designated CIAO2A) is a cytosolic Fe-S assembly protein involved in the regulation of cellular Fe homeostasis. However, the biological function of FAM96A in vivo is still incompletely...
Source: Free Radical Biology and Medicine - September 23, 2022 Category: Biology Authors: Zhuanzhuan Liu Shihong Xu Zhiwei Zhang Hanying Wang Qiyue Jing Shenghan Zhang Mengnan Liu Jinzhi Han Yanbo Kou Yanxia Wei Lu Wang Yugang Wang Source Type: research

Exosomal thioredoxin-1 from hypoxic human umbilical cord mesenchymal stem cells inhibits ferroptosis in doxorubicin-induced cardiotoxicity via mTORC1 signaling
In conclusion, Hypo-Exo exhibited a better suppression of ferroptosis in DOX-induced cardiotoxicity. Trx1-mediated mTORC1 activation is critical for the Hypo-Exo anti-ferroptosis process, which involves increased GPX4 protein synthesis and decreased iron overload. This study indicated that Hypo-Exo may present a potential strategy against ferroptosis in DOX-induced cardiotoxicity.PMID:36241072 | DOI:10.1016/j.freeradbiomed.2022.10.268
Source: Free Radical Biology and Medicine - October 14, 2022 Category: Biology Authors: Yue Yu Tianyu Wu Yao Lu Wei Zhao Jian Zhang Qiushi Chen Gaoyuan Ge Yan Hua Kaiyan Chen Inam Ullah Fengxiang Zhang Source Type: research

The future of EU workers is ‘ a fight that ’ s too important to lose ’
As hundreds of EU migrants, including UNISON members, rallied in Trafalgar Square last night in defence of their rights, London Mayor Sadiq Khan told them: “This is a fight that’s too important to lose.” The rally followed a Westminster lobby, during which dozens of MPs and peers signed a pledge to guarantee the rights of both EU citizens in the UK and British citizens in the EU. It was the second lobby of Parliament this year, with UNISON members from all over the country and from all walks of the public sector again urging their MPs to end the uncertainty of EU citizens over whether they will be able to continue th...
Source: UNISON Health care news - September 14, 2017 Category: UK Health Authors: Demetrios Matheou Tags: Article News BREXIT eu migrant migrant workers NHS NHS staff Source Type: news

Anemia in Childhood.
This article gives a basic overview of anemia in children with a focus on iron deficiency. [Pediatr Ann. 2018;47(2):e42-e47.]. PMID: 29446792 [PubMed - in process]
Source: Pediatric Annals - February 1, 2018 Category: Pediatrics Authors: Khan L Tags: Pediatr Ann Source Type: research

Funtabulously Frivolous Friday Five 227
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 227. Question 1 In 1979 a study was conducted at a tea plantation in Sri Lanka, what was given to the tea pickers to increase their productivity? + Reveal the Funtabulous Answer expand(document.getElementById('ddet758252362'));expand(document.getElementById('ddetlink7...
Source: Life in the Fast Lane - February 22, 2018 Category: Emergency Medicine Authors: Neil Long Tags: Frivolous Friday Five art Doctor Duncan florence Francis Galton iron deficiency anaemia kings evil medical officer of health monarch prayer radiaid scrofula Sri Lanka Stendhal syndrome TB tea pickers tuberculous lymphadenop Source Type: blogs

Poor Access to Care Is a Risk Factor for Iron Overload in Adults with Sickle Cell Disease in Southern California
We examined records from 2013-2018 from CIBD and from 2016-2018 from MLK. Patients were considered evaluable if they had a least one visit to clinic with labs that included iron studies and /or MRI. Iron saturations greater than 50% and /or a ferritin greater than 1000 was deemed indicative of iron overload when combined with a history of prior transfusions. Lack of access was defined as the absence of appropriate care for SCD for at least 12 months prior to the initial visit in our clinics. Patients were deemed in good SCD care if they had been transitioned from a pediatric SCD program or another adult SCD program where t...
Source: Blood - November 21, 2018 Category: Hematology Authors: Claster, S., Roland, M., Tucker, J., Espinoza, M., Rothman, E., Baker, J., Nugent, D. J. Tags: 901. Health Services Research-Non-Malignant Conditions: Poster II Source Type: research

Evaluation of Thalassaemia Screening Tests in the Antenatal and Non-Antenatal Populations in Singapore.
CONCLUSION: MCH/MCV thresholds have adequate sensitivity for α-thalassaemia in the antenatal population, and genotyping plays an important role as HbH inclusion test shows low sensitivity. CE without AGE, may be used as initial screening for haemoglobin variants. Our study provides contemporary data to guide thalassaemia screening algorithms in Singapore. PMID: 30788489 [PubMed - in process]
Source: Annals of the Academy of Medicine, Singapore - January 1, 2019 Category: General Medicine Authors: Lee SY, Yap ES, Lee EY, Goh JH, Liu TC, Yip C Tags: Ann Acad Med Singapore Source Type: research

Zimbabwe: UNFPA Supports Sexual and Reproductive Health After Floods Cut Off Zimbabwe Districts
[UNFPA] Harare -Displaced women, among them pregnant women, have lost critical health supplies including ante-natal care records, iron supplements and ARVs, which have been washed away with their belongings in flooding across two provinces.
Source: AllAfrica News: Health and Medicine - March 25, 2019 Category: African Health Source Type: news

Nutrition and Altitude: Strategies to Enhance Adaptation, Improve Performance and Maintain Health: A Narrative Review
AbstractTraining at low to moderate altitudes (~  1600–2400 m) is a common approach used by endurance athletes to provide a distinctive environmental stressor to augment training stimulus in the anticipation of increasing subsequent altitude- and sea-level-based performance. Despite some scientific progress being made on the impact of various nutrition-related changes in physiology and associated interventions at mountaineering altitudes (>  3000 m), the impact of nutrition and/or supplements on further optimization of these hypoxic adaptations at low–moderate altitudes is only an emerging topic. Within this n...
Source: Sports Medicine - November 5, 2019 Category: Sports Medicine Source Type: research

Current advances in transfusion medicine: a 2019 review of selected topics from the AABB Clinical Transfusion Medicine Committee.
CONCLUSION: This synopsis provides easy access to relevant topics and may be useful as an educational tool. PMID: 32472580 [PubMed - as supplied by publisher]
Source: Transfusion - May 28, 2020 Category: Hematology Authors: Pagano MB, Allen ES, Chou ST, Dunbar NM, Gniadek T, Goel R, Harm SK, Hopkins CK, Jacobson J, Lokhandwala PM, Metcalf RA, Raval JS, Schwartz J, Shan H, Spinella PC, Storch E, Cohn CS Tags: Transfusion Source Type: research

What Are Systemic Disease Causes of Oral Ulcers?
Discussion Oral ulcers are common problems seen by dentists but pediatricians also see them. Usually families have are concerned because they are painful and acute. Ulcers are sometime noticed by the physician and not the family as in the case of herpangina or hand-foot and mouth disease. Chronic or recurrent ulcerations present less commonly and therefore it may be more difficult to determine their etiology. Many of the systemic disease causes of oral ulcers are overall infrequent and/or not common in the pediatric age range. Ulcers can be classified in several ways but acute ulcers are usually painful and last less tha...
Source: PediatricEducation.org - September 21, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

What are Potential Problems Associated with Helicobacter pylori?
Discussion Helicobacter pylori (H. pylori) is a microaerophilis, spiral bacterium that is a prevalent human pathogen. How this infection affects individuals is different in adults and children. Overall seroprevalence rate in children world-wide was estimated to be ~33%, but this seroprevalence rate is decreasing in the developed world for both adults and children. It is acquired in childhood and can persist through colonization throughout life if untreated. Fortunately, it often is asymptomatic and generally does not cause serious disease in children. Some serotyping data shows that within families children acquire it more...
Source: PediatricEducation.org - November 23, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

The Association between Nutritional Alterations and Oral Lesions in a Pediatric Population: An Epidemiological Study
Biomed Res Int. 2021 Oct 29;2021:9992451. doi: 10.1155/2021/9992451. eCollection 2021.ABSTRACTThe oral conditions of an individual are the result of different factors, including the subject's genotype, oral hygiene habits, the type of diet, and lifestyle, such as smoking. Nutrition in the first years of life can affect dental health for a long time. To prevent mouth diseases, it is also important to eliminate unfavorable eating behaviour and to amplify protective ones. Eating habits, especially in pediatric age, are an easily modifiable and controllable factor, and diet, in addition to influencing the health of the oral ca...
Source: Biomed Res - November 8, 2021 Category: Research Authors: Angela Pia Cazzolla Michele Di Cosola Andrea Ballini Luigi Santacroce Roberto Lovero Nunzio Francesco Testa Vitantonio Lacarbonara Annarosa De Franco Giuseppe Troiano Stefania Cantore Mariasevera Di Comite Riccardo Nocini Lorenzo Lo Muzio Vito Crincoli Ma Source Type: research

Analysis of Transition from Intravenous Iron Sucrose to Ferric Carboxymaltose Infusions in Pediatric Intestinal Failure Patients
CONCLUSIONS: IS and FCM infusions both maintained hematologic and iron parameters with no significant difference noted between the two types of iron though the number of FCM infusions was significantly less. No significant adverse effects were noted.CLINICAL RELEVANCY STATEMENT: Pediatric patients with intestinal failure dependent on parenteral nutrition require ongoing iron supplementation. Though there are a variety of iron formulations available, there is a paucity of literature on how iron should be administered in this patient population. Practice varies widely among different institutions. In this study, pediatric pa...
Source: JPEN Journal Of Parenteral And Enteral Nutrition - May 26, 2022 Category: Nutrition Authors: Tanyaporn K Kaenkumchorn Beatrice E Rosete Kristen Carlin Shiho Fukasawa Simon P Horslen Danielle Wendel Source Type: research