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Nutrition: Iron
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Total 27491 results found since Jan 2013.
The health impacts of blood donation: a systematic review of donor and non-donor perceptions
DISCUSSION: Findings reinforce that lay perspectives on how donation impacts health are under-researched, and it is difficult to know how important these are in informing critical decisions about donation for donors and non-donors. We suggest that further research with donation-related health beliefs and experiences as the central focus is needed to provide insights to inform communications with donors and the public.PMID:37677092 | DOI:10.2450/BloodTransfus.494
Source: Blood Transfusion - September 7, 2023 Category: Hematology Authors: Rachel Thorpe Barbara Masser Sarah P Coundouris Melissa K Hyde Sarah P Kruse Tanya E Davison Source Type: research
A low-coordinate iron organoazide complex
Chem. Commun., 2023, Advance Article DOI: 10.1039/D3CC03765G, CommunicationAndres Gonzalez, Serhiy Demeshko, Franc Meyer, C. Gunnar Werncke The isolation and behaviour of a labile iron organoazide adduct is reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - September 6, 2023 Category: Chemistry Authors: Andres Gonzalez Source Type: research
Synthesis of Fe3O4/Fe2O3 nanoparticles modified with peroxidase with incorporated chromium and manganese ions
New J. Chem., 2023, Advance Article DOI: 10.1039/D3NJ01767B, PaperOlga D ługosz, Julia Matysik, Wiktoria Matyjasik, Krzysztof Szostak, Marcin Banach This paper presents a process for synthesising iron oxide nanoparticles modified with Cr(II), Cr(III) and Mn(II) ions and immobilised peroxidase. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - September 6, 2023 Category: Chemistry Authors: Olga D ługosz Source Type: research
NIR Light-activated and RGD-conjugated Ultrasmall Fe/PPy Nanopolymers for Enhanced Tumor Photothermal Ferrotherapy and MR Imaging
Chemistry. 2023 Sep 6:e202302125. doi: 10.1002/chem.202302125. Online ahead of print.ABSTRACTIron-based nanomaterials have shown great promise for tumor ferrotherapy in recent years. However, nanoparticle-induced ferroptosis has low therapeutic efficacy owing to unsatisfactory Fenton reaction activity in a typical tumor microenvironment. We herein developed NIR light-activated Fe/PPy-RGD nanopolymers to combine photothermal therapy and ferrotherapy and achieve enhanced antitumor activity. Importantly, Fe/PPy-RGD exhibited excellent therapeutic performance under NIR light activation both in vitro and in vivo. Under irradiat...
Source: Chemistry - September 6, 2023 Category: Chemistry Authors: Xu Zhang Teng Wang Zijian Zhou Tingting Zhao Yuxian Shen Weijun Fang Source Type: research
Intravenous ferric carboxymaltose and ferric derisomaltose alter the intestinal microbiome in female iron-deficient anemic mice
In conclusion, replenishing iron stores with IV iron preparations in clinical conditions, such as inflammatory bowel disease or chronic kidney disease, could affect gut microbiome composition and consequently contribute to an altered disease outcome.PMID:37671923 | DOI:10.1042/BSR20231217
Source: Bioscience Reports - September 6, 2023 Category: Biomedical Science Authors: Timo Rieg Jianxiang Xue Monica Stevens Linto Thomas James Robert White Jessica A Dominguez Rieg Source Type: research
X-ray-controllable release of carbon monoxide potentiates radiotherapy by ultrastable hybrid nanoreservoirs
Biomaterials. 2023 Sep 2;302:122313. doi: 10.1016/j.biomaterials.2023.122313. Online ahead of print.ABSTRACTCarbon monoxide (CO) exhibits unique abilities in sensitizing cancer radiotherapy (RT). However, the development of a highly stable CO-delivery nanosystem with sustained CO release in tumor tissues and the prevention of CO leakage into normal tissues remains a challenge. Herein, an organic-inorganic hybrid strategy is proposed to create ultrastable CO nanoreservoirs by locking an unstable iron carbonyl (FeCO) prodrug in a stable mesoporous silica matrix. Different from traditional FeCO-loading nanoplatforms, FeCO-bri...
Source: Biomaterials - September 6, 2023 Category: Materials Science Authors: Junna Lu Fangman Chen Xiaochun Xie Ziping Wu Yinglu Chen Yidan Zhang Hui Fang Feixia Ruan Dan Shao Zheng Wang Renjun Pei Source Type: research
Gut microbiota-induced CXCL1 elevation triggers early neuroinflammation in the substantia nigra of Parkinsonian mice
This study may pave the way for understanding the "brain-gut-microbiota" molecular regulatory networks in PD pathogenesis. The aged C57BL/6 male mice with rotenone intragastric administration showed altered gut microbiota, which caused systemic inflammation, PPARγ signalling inhibition and neuroinflammation, brain iron deposition and ferroptosis, and eventually dopaminergic neurodegeneration in PD.PMID:37674043 | DOI:10.1038/s41401-023-01147-x
Source: Acta Pharmacologica Sinica - September 6, 2023 Category: Drugs & Pharmacology Authors: Xi-Zhen Ma Lei-Lei Chen Le Qu Hui Li Jun Wang Ning Song Jun-Xia Xie Source Type: research
Cell senescence induced by toxic interaction between α-synuclein and iron precedes nigral dopaminergic neuron loss in a mouse model of Parkinson's disease
In this study, we investigated the involvement of α-synuclein and iron in the process of cell senescence in a mouse model of PD. In order to overexpress α-syn-A53T in the substantia nigra pars compacta (SNpc), human α-syn-A53T was microinjected into both sides of the SNpc in mice. We found that overexpression of α-syn-A53T for one week induced significant pro-inflammatory senescence-associated secretory phenotype (SASP), increased cell senescence-related proteins (β-gal, p16, p21, H2A.X and γ-H2A.X), mitochondrial dysfunction accompanied by dysregulation of iron-related proteins (L-ferritin, H-ferritin, DMT1, IRP1 an...
Source: Acta Pharmacologica Sinica - September 6, 2023 Category: Drugs & Pharmacology Authors: Qing-Qing Shen Xian-Hui Jv Xi-Zhen Ma Chong Li Lin Liu Wen-Ting Jia Le Qu Lei-Lei Chen Jun-Xia Xie Source Type: research
Semiconducting iron-chelated nano-immunomodulator for specific and sensitized sono-metallo-immunotherapy of cancer
Angew Chem Int Ed Engl. 2023 Sep 6:e202310178. doi: 10.1002/anie.202310178. Online ahead of print.ABSTRACTSono-immunotherapy holds great potential for deep tumor inhibition; however, smart sono-therapeutic agents to simultaneously eliminate 'domestic' tumor cells and regulate the 'community' tumor immune microenvironment have rarely been developed. Herein, we report a spatiotemporally controllable semiconducting iron-chelated nano-metallomodulator (SINM) for hypersensitive sono-metallo-immunotherapy of cancer. SINM consists of a semiconducting polymer (SP) backbone chelating iron ions (Fe3+) with thiophene-based Schiff bas...
Source: Angewandte Chemie - September 6, 2023 Category: Chemistry Authors: Shasha He Jie Yu Mengke Xu Chi Zhang Cheng Xu Penghui Cheng Kanyi Pu Source Type: research
A low-coordinate iron organoazide complex
Chem Commun (Camb). 2023 Sep 6. doi: 10.1039/d3cc03765g. Online ahead of print.ABSTRACTA labile organoazide iron complex is reported. Under ambient conditions, the azide adduct is subject to a dissociation equilibrium in solution, yet also undergoes intramolecular C-H bond amination. Single-crystal irradiation of the azide at 80 K leads to partial N2-extrusion and formation of a putative imido iron intermediate, which was computationally identified as a highly covalent {FeNR}8 species.PMID:37672291 | DOI:10.1039/d3cc03765g
Source: Chemical Communications - September 6, 2023 Category: Chemistry Authors: Andres Gonzalez Serhiy Demeshko Franc Meyer C Gunnar Werncke Source Type: research
Research Progress in the Molecular Mechanism of Ferroptosis in Parkinson's Disease and Regulation by Natural Plant Products
Ageing Res Rev. 2023 Sep 4:102063. doi: 10.1016/j.arr.2023.102063. Online ahead of print.ABSTRACTParkinson's disease (PD) is the second most prevalent neurodegenerative disorder of the central nervous system after Alzheimer's disease. The current understanding of PD focuses mainly on the loss of dopamine neurons in the substantia nigra region of the midbrain, which is attributed to factors such as oxidative stress, alpha-synuclein aggregation, neuroinflammation, and mitochondrial dysfunction. These factors together contribute to the PD phenotype. Recent studies on PD pathology have introduced a new form of cell death known...
Source: Ageing Research Reviews - September 6, 2023 Category: Genetics & Stem Cells Authors: Kailin Yang Liuting Zeng Jinsong Zeng Ying Deng Shanshan Wang Hao Xu Qi He Mengxia Yuan Yanfang Luo Anqi Ge Jinwen Ge Source Type: research
Fe-hydrogenase, cofactor biosynthesis and engineering
Chembiochem. 2023 Sep 6:e202300330. doi: 10.1002/cbic.202300330. Online ahead of print.ABSTRACT[Fe]-hydrogenase catalyzes the heterolytic cleavage of H2 and reversible hydride transfer to methenyl-tetrahydromethanopterin. The iron-guanylylpyridinol (FeGP) cofactor is the prosthetic group of this enzyme, in which mononuclear Fe(II) is ligated with a pyridinol and two CO ligands. The pyridinol ligand fixes the iron by an acyl carbon and a pyridinol nitrogen. Biosynthetic proteins for this cofactor are encoded in the hmd co-occurring (hcg) genes. The function of HcgB, HcgC, HcgD, HcgE, and HcgF was studied by using structure ...
Source: Chembiochem - September 6, 2023 Category: Biochemistry Authors: Francisco J Arriaza-Gallardo Yu-Cong Zheng Manuel Gehl Shunsuke Nomura Joao Pedro Fernandes Queiroz Seigo Shima Source Type: research
