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Nutrition: Iron
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Total 27491 results found since Jan 2013.
Kaempferol stimulation of autophagy regulates the ferroptosis under the oxidative stress as mediated with AMP-activated protein kinase
In conclusion, KP provides hepatoprotective effects against oxidative stress induced by AA + iron treatment in vitro and CCl4 treatment in vivo.PMID:37703935 | DOI:10.1016/j.freeradbiomed.2023.09.008
Source: Free Radical Biology and Medicine - September 13, 2023 Category: Biology Authors: Min-Jin Kim Yu-Rim Song Young Eun Kim Su-Jin Bae Won-Yung Lee Seon-Been Bak Young Woo Kim Source Type: research
Augmented degradation of dyed organic pollutant using Fe < sub > 2 < /sub > O < sub > 3 < /sub > supported on char formed from poultry slaughterhouse waste
Environ Sci Pollut Res Int. 2023 Sep 12. doi: 10.1007/s11356-023-29783-0. Online ahead of print.ABSTRACTIn this work, a novel support for an iron-based catalyst was prepared and employed for Ponceau 4R degradation by photo-Fenton reaction. To this, poultry waste was used for producing char, which was subsequently used to prepare the Fe2O3/Char composite. Process parameters, including catalyst dosage, pH, and hydrogen peroxide concentration, were investigated. The characterization analysis indicated that the textural properties of the composite were improved after impregnation with Fe2O3. The composite exhibited excellent c...
Source: Environmental Science and Pollution Research International - September 12, 2023 Category: Environmental Health Authors: Patr ícia Grassi Ang élica Fátima Mantelli Streit Luana Rabelo Hollanda Guilherme Luiz Dotto Edson Luiz Foletto Source Type: research
Modular and Practical 1,2-Aryl(alkenyl) Heteroatom Functionalization of Alkenes through Iron/Photoredox Dual Catalysis
In this study, we present a mild, versatile and practical photoredox/iron dual catalytic system that enables access to highly privileged 1,2-aryl(alkenyl) heteroatomic pharmacophores with exceptional efficiency and site selectivity. Our approach exhibits an extensive scope, allowing for the direct utilization of a wide range of commodity or commercially available (hetero)arenes as well as activated and unactivated alkenes with diverse functional groups, drug scaffolds, and natural product motifs as substrates. By merging iron catalysis with the photoredox cycle, a vast array of alkene 1,2-aryl(alkenyl) functionalization pr...
Source: Angewandte Chemie - September 12, 2023 Category: Chemistry Authors: Weigang Zhang Tao Liu Hwee Ting Ang Penghao Luo Zhexuan Lei Xiaohua Luo Ming Joo Koh Jie Wu Source Type: research
Expression of V-nitrogenase and Fe-nitrogenase in < em > Methanosarcina acetivorans < /em > is controlled by molybdenum, fixed nitrogen, and the expression of Mo-nitrogenase
This study investigated nitrogenase expression and growth by M. acetivorans in response to fixed nitrogen, Mo/V availability, and CRISPRi repression of the nif, vnf, and/or anf gene clusters. The availability of Mo and V significantly affected growth of M. acetivorans with N2 but not with NH4Cl. M. acetivorans exhibited the fastest growth rate and highest cell yield during growth with N2 in medium containing Mo, and the slowest growth in medium lacking Mo and V. qPCR analysis revealed the transcription of the nif operon is only moderately affected by depletion of fixed nitrogen and Mo, whereas vnf and anf transcription inc...
Source: Applied and Environmental Microbiology - September 11, 2023 Category: Microbiology Authors: Melissa Chanderban Christopher A Hill Ahmed E Dhamad Daniel J Lessner Source Type: research
Macrophage ferroptosis promotes MMP2/9 overexpression induced by hemin in hemorrhagic plaque
Conclusions Our results suggested that hemin-induced macrophage ferroptosis promotes p38 pathway activation and MMP2/9 overexpression, which may play a crucial role in increasing hemorrhagic plaque vulnerability. These findings provide insights into the pathogenesis of hemorrhagic plaques and suggest that targeting macrophage ferroptosis may be a promising strategy for stabilizing vulnerable plaque.PMID:37696298 | DOI:10.1055/a-2173-3602
Source: Thrombosis and Haemostasis - September 11, 2023 Category: Hematology Authors: Bicheng Li Minqiao Lu Hui Wang Siqi Sheng Shuyuan Guo Jia Li Ye Tian Source Type: research
Mechanism of CO2 reduction to methanol with H2 on an iron(II)scorpionate catalyst
Chemistry. 2023 Sep 11:e202302832. doi: 10.1002/chem.202302832. Online ahead of print.ABSTRACTCO2 utilization is an important process in the chemical industry with great environmental power. In this work we show how CO2 and H2 can be reacted to form methanol on an iron(II) center and highlight the bottlenecks for the reaction and what structural features are essential for efficient turnover. The calculations predict the reactions to proceed through three successive reaction cycles that start with heterolytic cleavage of H2 followed by sequential hydride and proton transfer processes. The H2 splitting process is an endergon...
Source: Chemistry - September 11, 2023 Category: Chemistry Authors: Chengxu Zhu Carmine D'Agostino Samuel P de Visser Source Type: research
Exploring Sorafenib and Simvastatin Combination for Ferroptosis-Induced Cancer Treatment: Cytotoxicity Screening, In Vivo Efficacy, and Safety Assessment
In this study, we conducted a screening of drug combinations, including sorafenib (SOR) with simvastatin (SIM), phenethyl isothiocyanate, and trigonelline, in MDA-MB-231, A549, and HeLa cells to assess their cytotoxicity. The SOR-SIM combination exhibited a synergistic effect in MDA-MB-231, A549, and HeLa cells, with calculated CI values of ~ 0.66, 0.53, and 0.59, respectively. Furthermore, co-treatment with ferrostatin-1 resulted in a concentration-dependent increase in the IC50 values. Additionally, SOR + SIM demonstrated a significant reduction in GSH levels, an increase in MDA levels, and mitochondrial membrane depolar...
Source: Cancer Control - September 11, 2023 Category: Cancer & Oncology Authors: Kaushik Kuche Vivek Yadav Meet Patel Rohan Ghadi Sanyog Jain Source Type: research
Comparison of Blood Lead Levels in Children and Adolescents with and without Functional Abdominal Pain
CONCLUSION: We found that the lead level was higher in patients with FGID than in the controls; however, this difference was not significantly different. This might be because of elevated lead levels in both groups. Future ecological studies with a large sample size are necessary in this regard.PMID:37694233 | PMC:PMC10492617 | DOI:10.4103/abr.abr_250_22
Source: Biomed Res - September 11, 2023 Category: Research Authors: Fatemeh Famouri Maryam Yazdi Awat Feizii Hossein Saneian Peiman Nasri Roya Kelishadi Source Type: research
Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosis
In this study, we investigated the therapeutic effects of fisetin against fibrotic kidney disease and the underlying mechanisms. We established adenine diet-induced and unilateral ureteral obstruction (UUO)-induced CKD models in adult male mice. The two types of mice were administered fisetin (50 or 100 mg·kg-1·d-1, i.g.) for 3 weeks or 7 days, respectively. At the end of the experiments, the mice were euthanized, and blood and kidneys were gathered for analyzes. We showed that fisetin administration significantly ameliorated tubular injury, inflammation, and tubulointerstitial fibrosis in the two types of CKD mice. In m...
Source: Acta Pharmacologica Sinica - September 11, 2023 Category: Drugs & Pharmacology Authors: Bo Wang Li-Na Yang Le-Tian Yang Yan Liang Fan Guo Ping Fu Liang Ma Source Type: research
Comparison of Blood Lead Levels in Children and Adolescents with and without Functional Abdominal Pain
CONCLUSION: We found that the lead level was higher in patients with FGID than in the controls; however, this difference was not significantly different. This might be because of elevated lead levels in both groups. Future ecological studies with a large sample size are necessary in this regard.PMID:37694233 | PMC:PMC10492617 | DOI:10.4103/abr.abr_250_22
Source: Biomed Res - September 11, 2023 Category: Research Authors: Fatemeh Famouri Maryam Yazdi Awat Feizii Hossein Saneian Peiman Nasri Roya Kelishadi Source Type: research
Exploring Sorafenib and Simvastatin Combination for Ferroptosis-Induced Cancer Treatment: Cytotoxicity Screening, In Vivo Efficacy, and Safety Assessment
In this study, we conducted a screening of drug combinations, including sorafenib (SOR) with simvastatin (SIM), phenethyl isothiocyanate, and trigonelline, in MDA-MB-231, A549, and HeLa cells to assess their cytotoxicity. The SOR-SIM combination exhibited a synergistic effect in MDA-MB-231, A549, and HeLa cells, with calculated CI values of ~ 0.66, 0.53, and 0.59, respectively. Furthermore, co-treatment with ferrostatin-1 resulted in a concentration-dependent increase in the IC50 values. Additionally, SOR + SIM demonstrated a significant reduction in GSH levels, an increase in MDA levels, and mitochondrial membrane depolar...
Source: AAPS PharmSciTech - September 11, 2023 Category: Drugs & Pharmacology Authors: Kaushik Kuche Vivek Yadav Meet Patel Rohan Ghadi Sanyog Jain Source Type: research
Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosis
In this study, we investigated the therapeutic effects of fisetin against fibrotic kidney disease and the underlying mechanisms. We established adenine diet-induced and unilateral ureteral obstruction (UUO)-induced CKD models in adult male mice. The two types of mice were administered fisetin (50 or 100 mg·kg-1·d-1, i.g.) for 3 weeks or 7 days, respectively. At the end of the experiments, the mice were euthanized, and blood and kidneys were gathered for analyzes. We showed that fisetin administration significantly ameliorated tubular injury, inflammation, and tubulointerstitial fibrosis in the two types of CKD mice. In m...
Source: Acta Pharmacologica Sinica - September 11, 2023 Category: Drugs & Pharmacology Authors: Bo Wang Li-Na Yang Le-Tian Yang Yan Liang Fan Guo Ping Fu Liang Ma Source Type: research
Exploration of the novel phthalimide-hydroxypyridinone derivatives as multifunctional drug candidates against Alzheimer's disease
In conclusion, these favorable experimental results suggested compound 11n deserved further investigation as an anti-AD lead compound.PMID:37690318 | DOI:10.1016/j.bioorg.2023.106817
Source: Bioorganic Chemistry - September 10, 2023 Category: Chemistry Authors: Xi Zhu Yangjing Lv Miaoliang Fan Jianan Guo Yujia Zhang Bianbian Gao Changjun Zhang Yuanyuan Xie Source Type: research
Association of maternal metals exposure, metabolites and birth outcomes in newborns: A prospective cohort study
CONCLUSION: This study provides new epidemiological evidence indicating the associations of metals exposure and neonatal birth outcomes, and emphasizes the potential role of metabolite biomarkers and their importance in monitoring adverse birth outcomes.PMID:37690219 | DOI:10.1016/j.envint.2023.108183
Source: Environment International - September 10, 2023 Category: Environmental Health Authors: Shuangshuang Zhao Xu Yang Qing Xu Hang Li Yan Su Qiaoqiao Xu Qing X Li Yankai Xia Rong Shen Source Type: research
