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Total 101966 results found since Jan 2013.

Transcription factor-based biosensors for detection of naturally occurring phenolic acids
N Biotechnol. 2023 Sep 13:S1871-6784(23)00047-X. doi: 10.1016/j.nbt.2023.09.004. Online ahead of print.ABSTRACTPhenolic acids including hydroxybenzoic and hydroxycinnamic acids are secondary plant and fungal metabolites involved in many physiological processes offering health and dietary benefits. They are often utilised as precursors for production of value-added compounds. The limited availability of synthetic biology tools, such as whole-cell biosensors suitable for monitoring the dynamics of phenolic acids intracellularly and extracellularly, hinders the capabilities to develop high-throughput screens to study their me...
Source: New Biotechnology - September 15, 2023 Category: Biotechnology Authors: Ernesta Augustiniene Ingrida Kutraite Egle Valanciene Paulius Matulis Ilona Jonuskiene Naglis Malys Source Type: research

A transcriptomic study of osteoporosis induced by ketogenic diet in mice
CONCLUSION: The differentially expressed genes and enriched pathways identified in the mouse models provide new clues for studying the molecular mechanism and prevention of KD-induced osteoporosis.PMID:37712283 | PMC:PMC10505562 | DOI:10.12122/j.issn.1673-4254.2023.08.23
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: X Wu Y Fan Y Ye P Li Q Zhu Z Chen B Li W Wang L Zheng Source Type: research

< em > Erchen < /em > Decoction improves iron homeostasis in mice with non-alcoholic fatty liver disease by regulating iron transport capacity in the spleen
CONCLUSION: Erchen Decoction can alleviate high-fat diet-induced iron metabolism disorder by improving the iron ion transport ability of the spleen cells to delay the progression of NAFLD.PMID:37712264 | PMC:PMC10505571 | DOI:10.12122/j.issn.1673-4254.2023.08.04
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: G Deng H Jia Y Li J Li C Wu H Shi M Qin J Zhao C Liu Y Liao L Gao Source Type: research

Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management
World Psychiatry. 2023 Oct;22(3):366-387. doi: 10.1002/wps.21110.ABSTRACTPopulations with common physical diseases - such as cardiovascular diseases, cancer and neurodegenerative disorders - experience substantially higher rates of major depressive disorder (MDD) than the general population. On the other hand, people living with MDD have a greater risk for many physical diseases. This high level of comorbidity is associated with worse outcomes, reduced adherence to treatment, increased mortality, and greater health care utilization and costs. Comorbidity can also result in a range of clinical challenges, such as a more com...
Source: World Psychiatry - September 15, 2023 Category: Psychiatry Authors: Michael Berk Ole K öhler-Forsberg Megan Turner Brenda W J H Penninx Anna Wrobel Joseph Firth Amy Loughman Nicola J Reavley John J McGrath Natalie C Momen Oleguer Plana-Ripoll Adrienne O'Neil Dan Siskind Lana J Williams Andre F Carvalho Lianne Schmaal Ada Source Type: research

Energy expenditure deficits drive obesity in a mouse model of Alstr öm syndrome
CONCLUSIONS: Either loss of ALMS1 causes a developmental delay in the mechanisms controlling early life EE or activation of compensatory mechanisms occurs after obesity is established in AS. Future studies will determine how ALMS1 modulates EE and how sex moderates this process.PMID:37712194 | DOI:10.1002/oby.23877
Source: Obesity - September 15, 2023 Category: Eating Disorders & Weight Management Authors: Erin J Stephenson Clint E Kinney Amanda S Stayton Joan C Han Source Type: research

A transcriptomic study of osteoporosis induced by ketogenic diet in mice
CONCLUSION: The differentially expressed genes and enriched pathways identified in the mouse models provide new clues for studying the molecular mechanism and prevention of KD-induced osteoporosis.PMID:37712283 | PMC:PMC10505562 | DOI:10.12122/j.issn.1673-4254.2023.08.23
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: X Wu Y Fan Y Ye P Li Q Zhu Z Chen B Li W Wang L Zheng Source Type: research

Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management
World Psychiatry. 2023 Oct;22(3):366-387. doi: 10.1002/wps.21110.ABSTRACTPopulations with common physical diseases - such as cardiovascular diseases, cancer and neurodegenerative disorders - experience substantially higher rates of major depressive disorder (MDD) than the general population. On the other hand, people living with MDD have a greater risk for many physical diseases. This high level of comorbidity is associated with worse outcomes, reduced adherence to treatment, increased mortality, and greater health care utilization and costs. Comorbidity can also result in a range of clinical challenges, such as a more com...
Source: World Psychiatry - September 15, 2023 Category: Psychiatry Authors: Michael Berk Ole K öhler-Forsberg Megan Turner Brenda W J H Penninx Anna Wrobel Joseph Firth Amy Loughman Nicola J Reavley John J McGrath Natalie C Momen Oleguer Plana-Ripoll Adrienne O'Neil Dan Siskind Lana J Williams Andre F Carvalho Lianne Schmaal Ada Source Type: research

< em > Erchen < /em > Decoction improves iron homeostasis in mice with non-alcoholic fatty liver disease by regulating iron transport capacity in the spleen
CONCLUSION: Erchen Decoction can alleviate high-fat diet-induced iron metabolism disorder by improving the iron ion transport ability of the spleen cells to delay the progression of NAFLD.PMID:37712264 | PMC:PMC10505571 | DOI:10.12122/j.issn.1673-4254.2023.08.04
Source: Journal of Southern Medical University - September 15, 2023 Category: Universities & Medical Training Authors: G Deng H Jia Y Li J Li C Wu H Shi M Qin J Zhao C Liu Y Liao L Gao Source Type: research

Reviewing Evidence for Urolithin A Supplementation
Mitochondria are the power plants of the cell, responsible for generating chemical energy store molecules to power cell processes. Urolithin A is one of a number of supplements shown to improve mitochondrial function, though as for the others it isn't all that impressive when compared to the effects of regular exercise. Nonetheless, this and other approaches to modestly attenuate age-related declines in mitochondrial function are under active development. They are not solutions to the problem of mitochondrial aging, however. For that we must look to more radical approaches to therapy, such as mitochondrial transplantation,...
Source: Fight Aging! - September 14, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Dietary intake in individuals with phenylketonuria: an integrative review
CONCLUSION: most individuals with PKU have low energy, protein and fiber intake, adequate lipid intake, and high carbohydrate intake. Metabolic control of the disease is still a challenge in all countries. Nutritional strategies to improve dietary nutritional composition and phenylalanine blood levels in individuals with PKU remain an urgent issue.PMID:37705455 | DOI:10.20960/nh.04579
Source: Nutricion Hospitalaria - September 14, 2023 Category: Nutrition Authors: Thais Regina Mezzomo Marcia Regina Messaggi Gomes Dias Tatiane Santos Rosana Marques Pereira Source Type: research

Effect of a personalized nutritional intervention program on nutritional status, quality of life and mortality in hemodialysis patients
CONCLUSION: the results of this study suggest that personalized NIP contributed to improved nutritional status, QoL and survival in HD patients.PMID:37705451 | DOI:10.20960/nh.04756
Source: Nutricion Hospitalaria - September 14, 2023 Category: Nutrition Authors: Luc ía Visiedo Francisca L ópez Francisco Rivas-Ruiz Bego ña Tortajada Rafael Gim énez Martínez Jimena Abil és Source Type: research

Optimizing carbohydrate intake from drugs in epileptic patients on a ketogenic diet
Nutr Hosp. 2023 Sep 1. doi: 10.20960/nh.04798. Online ahead of print.NO ABSTRACTPMID:37705443 | DOI:10.20960/nh.04798
Source: Nutricion Hospitalaria - September 14, 2023 Category: Nutrition Authors: Javier Coraz ón Villanueva Mar ía de la Torre Ortíz Virg ínia Puebla García Jos é Manuel Martínez Sesmero Source Type: research

Confounding Effects of Tamoxifen: Cautionary and Practical Considerations for the Use of Tamoxifen-Inducible Mouse Models in Atherosclerosis Research
CONCLUSIONS: In this study, we establish that tamoxifen administration results in decreased serum cholesterol, decreased plaque formation, and increased hepatic lipid accumulation. These alterations represent significant confounding variables in atherosclerosis research, and we urge future investigators to take these findings into consideration when planning and executing their own atherosclerosis experiments.PMID:37706321 | DOI:10.1161/ATVBAHA.123.319922
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 14, 2023 Category: Cardiology Authors: Allison M Dubner Sizhao Lu Austin J Jolly Tysen Noble Tyler Hinthorn Raphael A Nemenoff Karen S Moulton Mark W Majesky Mary C M Weiser-Evans Source Type: research