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Nutrition: Antidoxidants
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Oxidative stress may be a contributing factor in fibromyalgia patients' pain mechanisms
CONCLUSIONS: Reactive oxygen species have several negative impacts on the human body. As a result of the measurements we analyzed, the relationship between FM and oxidative stress should be studied in terms of disease progression and may help improve the treatment process.PMID:37721351 | DOI:10.4081/reumatismo.2023.1550
Source: Reumatismo - September 18, 2023 Category: Rheumatology Authors: H Beyaztas S Aktas E M Guler E Ata Source Type: research
Air nanobubble water improves plant uptake and tolerance toward cadmium in phytoremediation
This study found that diluted air NBs (25% concentration) boosted cadmium uptake of A. philoxeroides by 17.39%. They also enhanced growth (25-50%) and photosynthetic pigments (10-20%) even at low cadmium levels (0.1 mM). Furthermore, the incorporation of 25% air NBs has been demonstrated to significantly amplify the performance of key antioxidant enzymes, such as superoxide dismutase and catalase, alongside heightened levels of crucial antioxidants such as malondialdehyde. This heightened activity of antioxidant defenses offers a compelling explanation for the potential amelioration of cadmium toxicity and concurrent enhan...
Source: Environmental Pollution - September 18, 2023 Category: Environmental Health Authors: Dajiang Yan Shan Xue Zhibin Zhang Guodong Xu Yanhao Zhang Jianan Gao Wen Zhang Source Type: research
In silico and in vitro evaluation of a safety profile of a cosmetic ingredient: 4-methoxychalcone (4-MC)
Toxicol In Vitro. 2023 Sep 16:105696. doi: 10.1016/j.tiv.2023.105696. Online ahead of print.ABSTRACTChalcone is an important scaffold within medicinal and cosmetic chemistry. The structure enables multiple modifications which may result in obtaining compounds with desirable bioactivity. One of the chalcone derivatives, 4-methoxychalcone is a known cosmetic ingredient indexed in Cosing database as an antioxidant, bleaching, and skin conditioning substance. We investigated its in silico and in vitro safety profile. In silico study using Derek Nexus showed its potential of skin sensitisation, equivocal nature of chromosome da...
Source: Toxicology in Vitro - September 18, 2023 Category: Toxicology Authors: Agnieszka Gunia-Krzy żak Justyna Popi ół Karolina S łoczyńska Dorota Żelaszczyk Katarzyna Orze ł Paulina Koczurkiewicz-Adamczyk Katarzyna W ójcik-Pszczoła Patryk Kasza Magda Borczuch-Kosta ńska El żbieta Pękala Source Type: research
Subacute administration of cilostazol modulates PLC- γ/PKC-α/p38/NF-kB pathway and plays vascular protective effects through eNOS activation in early stages of atherosclerosis development
This study aimed to investigate the effects of subacute administration of cilostazol on the aortas of hypercholesterolemic rats, focusing on the signaling pathways involved in these actions.MAIN METHODS: A murine model of hypercholesterolemia was employed to mimic the early stages of atherosclerosis development. Vascular reactivity assays were performed on thoracic aorta rings to assess the vascular response, as well as the non-invasive blood pressure was evaluated by plethysmography method. Pro-inflammatory markers and malondialdehyde (MDA) levels were measured to investigate the anti-inflammatory and antioxidant effects ...
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Stephani Correia Braz ão Gabriel Ferreira Lima Lis Jappour Autran Ana Beatriz Ara újo Mendes Beatriz Alexandre Dos Santos Dangelo Carlo Magliano Fernanda Carla Ferreira de Brito Nadia Alice Vieira Motta Source Type: research
Melatonin as a therapeutic agent for alleviating endothelial dysfunction in cardiovascular diseases: Emphasis on oxidative stress
Biomed Pharmacother. 2023 Sep 16;167:115475. doi: 10.1016/j.biopha.2023.115475. Online ahead of print.ABSTRACTThe vascular endothelium is vital in maintaining cardiovascular health by regulating vascular permeability and tone, preventing thrombosis, and controlling vascular inflammation. However, when oxidative stress triggers endothelial dysfunction, it can lead to chronic cardiovascular diseases (CVDs). This happens due to oxidative stress-induced mitochondrial dysfunction, inflammatory responses, and reduced levels of nitric oxide. These factors cause damage to endothelial cells, leading to the acceleration of CVD progr...
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Xiaolu Zhang Yujia Zheng Ziyu Wang Jiali Gan Bin Yu Bin Lu Xijuan Jiang Source Type: research
Exploration of the anti-diabetic potential of hydro-ethanolic leaf extract of Koenigia polystachya L.: an edible wild plant from Northeastern India
CONCLUSIONS: Based on the outcomes of this study, the HELeKP-treated rats have significant free radical scavenging and anti-diabetic potential. Therefore, it can be recommended as a beneficial functional vegetable for consumption.PMID:37723570 | PMC:PMC10506326 | DOI:10.1186/s42826-023-00174-3
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Alokali Kiba Dipankar Saha Bhrigu Kumar Das Source Type: research
Multifunctional nanozyme-reinforced copper-coordination polymer nanoparticles for drug-resistance bacteria extinction and diabetic wound healing
CONCLUSIONS: The Cu-CPNs@EPL complex has impressive antioxidant properties and antibacterial effects, making it a promising solution for treating drug-resistant bacterial infections in chronic wounds. The complex's ability to neutralize multiple ROS and reduce ROS-induced inflammation can help relieve inflammation at the wound site. Schematic illustration of the ROS scavenging and bacteriostatic function induced by Cu-CPNs@EPL nanozyme in the treatment of MRSA-infected wounds.PMID:37723499 | PMC:PMC10506277 | DOI:10.1186/s40824-023-00429-z
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Jiahui Zhao Tengfei Xu Jichao Sun Haitao Yuan Mengyun Hou Zhijie Li Jigang Wang Zhen Liang Source Type: research
Dimethyl fumarate attenuates cholestatic liver injury by activating the NRF2 and FXR pathways and suppressing NLRP3/GSDMD signaling in mice
Exp Cell Res. 2023 Sep 16:113781. doi: 10.1016/j.yexcr.2023.113781. Online ahead of print.ABSTRACTThe progression of cholestasis is characterized by excessive accumulation of bile acids (BAs) in the liver, which leads to oxidative stress (OS), inflammation and liver injury. There are currently limited treatments for cholestasis. Therefore, appropriate drugs for cholestasis treatment need to be developed. Dimethyl fumarate (DMF) has been widely used in the treatment of various diseases and exerts antioxidant and anti-inflammatory effects, but its effect on cholestatic liver disease remains unclarified. We fed mice 3,5-dieth...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Ziqian Xu Wan Tang Qiaoling Xie Xinyu Cao Mengni Zhang Xiaoxun Zhang Jin Chai Source Type: research
Protective effect of cornuside on OGD/R injury in SH-SY5Y cells and its underlying mechanism
In this study, we treated SH-SY5Y cells with OGD/R to simulated ischemia/reperfusion (I/R) injury. Using high-throughput transcriptome sequencing, differentially expressed genes were analyzed in the OGD/R group versus the OGD/R + Cornuside (10 μmol/L) group to explore the neuroprotective mechanisms of Cornuside. The differentially expressed genes were mainly enriched in apoptosis signaling pathway, cell cycle, DNA damage and repair, and p38/JNK MAPK and p53 signaling pathways. The results showed that OGD/R significantly reduced the survival of SH-SY5Y cells, induced apoptosis, disrupted the nucleus, promoted the release o...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Xinyu Wang Chao Yan Chaoyun Wang Xiaoyan Xu Zhihao Liu Wang Xin Jianwei Gong Source Type: research
Biomonitoring of manganese metal pollution in water and its impacts on biological activities of Biomphalaria alexandrina snail and larvicidal potencies
Environ Sci Pollut Res Int. 2023 Sep 18. doi: 10.1007/s11356-023-29786-x. Online ahead of print.ABSTRACTMetal pollution has many dangerous environmental and human health consequences due to the bioaccumulation in the tissues. The present study aims to measure the bioaccumulation factor of the manganese (Mn) heavy metal in Biomphalaria alexandrina snails' tissues and water samples. The current results showed the concentration of Mn heavy metal in water (87.5 mg/l) and its bioaccumulation factor in Helisoma duryi tissue was higher than that in tissues of Physa acuta and B. alexandrina snails. Results showed that 87.5 mg/l Mn...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Amina Mohamed Ibrahim Ahmed Abdel-Salam Abdel-Haleem Rania Gamal Taha Source Type: research
Protective effect of cornuside on OGD/R injury in SH-SY5Y cells and its underlying mechanism
In this study, we treated SH-SY5Y cells with OGD/R to simulated ischemia/reperfusion (I/R) injury. Using high-throughput transcriptome sequencing, differentially expressed genes were analyzed in the OGD/R group versus the OGD/R + Cornuside (10 μmol/L) group to explore the neuroprotective mechanisms of Cornuside. The differentially expressed genes were mainly enriched in apoptosis signaling pathway, cell cycle, DNA damage and repair, and p38/JNK MAPK and p53 signaling pathways. The results showed that OGD/R significantly reduced the survival of SH-SY5Y cells, induced apoptosis, disrupted the nucleus, promoted the release o...
Source: Brain Research - September 18, 2023 Category: Neurology Authors: Xinyu Wang Chao Yan Chaoyun Wang Xiaoyan Xu Zhihao Liu Wang Xin Jianwei Gong Source Type: research
Biochar supported nano core-shell (TiO < sub > 2 < /sub > /CoFe < sub > 2 < /sub > O < sub > 4 < /sub > ) for wastewater treatment
Environ Res. 2023 Sep 16:117169. doi: 10.1016/j.envres.2023.117169. Online ahead of print.ABSTRACTThe porous structure of biochar, its large surface area, and its anti-oxidant properties are extensively used for pollutant removal strategies. The literature to date has reported that the biochar assisted metal-oxide core-shells have a dominating degradation ability under solar irradiation. Therefore, this study is significantly focused on cinnamon biochar as an active anti-oxidant agent incorporated in titania-cobalt ferrite nanocore-shell (Biochar/TiO2/CoFe2O4) structures for the first time in wastewater treatment against c...
Source: Environmental Research - September 18, 2023 Category: Environmental Health Authors: Sultan Alomairy Lalitha Gnanasekaran Saravanan Rajendran Walaa F Alsanie Source Type: research
Tubulin as a potential molecular target for resveratrol in Giardia lamblia trophozoites, in vitro and in silico approaches
Acta Trop. 2023 Sep 16:107026. doi: 10.1016/j.actatropica.2023.107026. Online ahead of print.ABSTRACTGiardia lamblia is a globally distributed protozoan parasite that causes intestinal disease. Recently, there is an increase in refractory cases of giardiasis to chemotherapeutic agents, and drugs available cause side effects that may limit its use or cause therapeutic non-compliance. Therefore, search for alternative and less harmful drugs to treat giardiasis is an important task. In this sense, resveratrol (RSV) is a polyphenol with a wide range of pharmacological effects such as antimicrobial, anticarcinogenic and antioxi...
Source: Acta Tropica - September 18, 2023 Category: Infectious Diseases Authors: Jos é Roberto Vargas-Villanueva Filiberto Guti érrez-Gutiérrez Mariana Garza-Ontiveros Sendar Daniel Nery-Flores Lizeth Guadalupe Campos-M úzquiz Dagoberto Vazquez-Obreg ón Raul Rodriguez-Herrera Lissethe Palomo-Ligas Source Type: research
Climbazole causes cell apoptosis and lipidosis in the liver of grass carp
In this study, grass carp (Ctenopharyngodon idella) and liver cell lines (L8824 cells) were treated with climbazole at concentrations ranging from 0.2 to 20 μg/L for 42 days in vivo and 24 h in vitro to evaluate the effects on the liver, respectively. Pathological, biochemical, and gene transcription and expression analyses were conducted to examine the hepatotoxicity. Our results showed that climbazole significantly decreased the hepatosomatic index, caused cell apoptosis in vivo and in vitro, and finally accumulated lipids in the liver. Beside, climbazole increased ROS levels, reduced Nrf2 and Keap1 mRNA and protein lev...
Source: Aquatic Toxicology - September 18, 2023 Category: Toxicology Authors: Zhi-Jie Lu Wen-Jun Shi Fang-Zhou Gao Dong-Dong Ma Jin-Ge Zhang Si-Ying Li Xiao-Bing Long Qian-Qian Zhang Guang-Guo Ying Source Type: research
