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Nutrition: Antidoxidants
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Oxidative stress in breast cancer after chemotherapy
Bioinformation. 2022 Dec 31;18(12):1141-1145. doi: 10.6026/973206300181141. eCollection 2022.ABSTRACTIt is of interest to evaluate the influence of breast cancer on oxidative stress, liver function tests, renal biomarkers, action of doxorubicin, cyclophosphamide and paclitaxel (AC-T) in the treatment and mechanism over altering the measured markers in breast cancer. Sixty histopathological confirmed cases of female patients suffering with breast carcinoma from the Department of Oncology at Omega Cancer Hospital, Visakhapatnam were included in the study. The investigation was performed in 3 groups: a control group containin...
Source: Bioinformation - September 13, 2023 Category: Bioinformatics Authors: Tejaswi Pullakanam Sri Phani Murugan Mannangatti Ramakrishna Nekkala Venkata Madhavi Bellala Ravi Shankar Bellala Vijayalakshmi Payala Source Type: research
ROS/RNS as molecular signatures of chronic liver diseases
Trends Mol Med. 2023 Sep 11:S1471-4914(23)00186-7. doi: 10.1016/j.molmed.2023.08.001. Online ahead of print.ABSTRACTThe liver can succumb to oxidant damage during the development of chronic liver diseases. Despite their physiological relevance to hepatic homeostasis, excessive reactive oxygen/nitrogen species (ROS/RNS) production under pathological conditions is detrimental to all liver constituents. Chronic oxidative stress coupled to unresolved inflammation sets in motion the activation of profibrogenic hepatic stellate cells (HSCs) and later pathogenesis of liver fibrosis, cirrhosis, and liver cancer. The liver antioxid...
Source: Trends in Molecular Medicine - September 13, 2023 Category: Molecular Biology Authors: Zhaodi Che Ziyuan Zhou Si-Qi Li Lei Gao Jia Xiao Nai-Kei Wong Source Type: research
Association between Expanded Disability Status Scale score and dietary antioxidant capacity in patients with multiple sclerosis
Braz J Med Biol Res. 2023 Sep 8;56:e12776. doi: 10.1590/1414-431X2023e12776. eCollection 2023.ABSTRACTMultiple sclerosis (MS), a neuroinflammation that results in neurodegeneration, is the most prevalent central nervous system inflammatory disease in young people. A diet rich in antioxidants is known to decrease the production/activity of pro-inflammatory cytokines and have a positive impact on the prognosis of MS. The purpose of this study was to assess if dietary antioxidant capacity is related to Expanded Disability Status Scale (EDSS) scores in patients with MS. Patients with MS (n=220; 137 women and 83 men) were asked...
Source: Braz J Med Biol Res - September 13, 2023 Category: Research Authors: S Mungan I Guzel B C Demirdogen Source Type: research
Nrf2: Therapeutic target of islet function protection in diabetes and islet transplantation
Biomed Pharmacother. 2023 Sep 11;167:115463. doi: 10.1016/j.biopha.2023.115463. Online ahead of print.ABSTRACTNuclear factor-erythroid 2-related factor 2 (Nrf2) has been reported as a major intracellular regulator of antioxidant stress, notably in islet β cells with low antioxidant enzyme content. Nrf2 is capable of regulating antioxidant function, while it can also regulate insulin secretion, proliferation, and differentiation of β cells, ER stress, as well as mitochondrial function. Thus, Nrf2 pharmacological activators have been employed in the laboratory for the treatment of diabetic mice. Islet cells are exposed to ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 13, 2023 Category: Drugs & Pharmacology Authors: Butian Wei Xin Zhang Jiwei Qian Zhe Tang Bo Zhang Source Type: research
The effect of selected aminoglycoside antibiotics on human serum albumin antioxidant activity: a spectroscopic and calorimetric comparative study
CONCLUSIONS: Based on the spectroscopic and microcalorimetric data, both KAN and NEO can be considered modulators of the HSA antioxidant activity.PMID:37704832 | DOI:10.1007/s43440-023-00529-6
Source: Pharmacological Reports - September 13, 2023 Category: Drugs & Pharmacology Authors: Wojciech Rog óż Kinga Mac Aleksandra Owczarzy Karolina Kulig Jadwiga Po życka Ma łgorzata Maciążek-Jurczyk Source Type: research
Quercetin attenuates environmental Avermectin-induced ROS accumulation and alleviates gill damage in carp through activation of the Nrf2 pathway
In this study, four groups were created: the Control group, the Que group (400 mg/kg), the AVM group (2.404 μg/L), and the Que plus AVM group. The analytical methods used in this study were pathological structure examination, QPCR, Reactive Oxygen Species (ROS) and Western blot. The results showed that Que alleviated AVM-induced oxidative stress, inflammatory damage and apoptosis in the gill tissues of carp by activating the Nrf2 pathway. The mechanism was that Que alleviated the accumulation of ROS, reduced the balance between oxidation and antioxidant disrupted by AVM exposure, lowered the content of lipid peroxidation ...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - September 13, 2023 Category: Biochemistry Authors: Mengyuan Zhou Jingchao Qiang Jiajie Gan Xuhui Xu Xing Li Shuai Zhang Baoshi Xu Zibo Dong Source Type: research
ROS/RNS as molecular signatures of chronic liver diseases
Trends Mol Med. 2023 Sep 11:S1471-4914(23)00186-7. doi: 10.1016/j.molmed.2023.08.001. Online ahead of print.ABSTRACTThe liver can succumb to oxidant damage during the development of chronic liver diseases. Despite their physiological relevance to hepatic homeostasis, excessive reactive oxygen/nitrogen species (ROS/RNS) production under pathological conditions is detrimental to all liver constituents. Chronic oxidative stress coupled to unresolved inflammation sets in motion the activation of profibrogenic hepatic stellate cells (HSCs) and later pathogenesis of liver fibrosis, cirrhosis, and liver cancer. The liver antioxid...
Source: Molecular Medicine - September 13, 2023 Category: Molecular Biology Authors: Zhaodi Che Ziyuan Zhou Si-Qi Li Lei Gao Jia Xiao Nai-Kei Wong Source Type: research
Impact of Colored Shade Nets on Biomass Production, Essential Oil Composition and Orientin and Isoorientin Content in Lippia gracilis Schauer
The objective of this study was to evaluate the effect of ChromatiNet on vegetative growth, total antioxidant capacity, phenolic and essential oils (EOs) composition of Lippia gracilis. The plants were cultivated under full sunlight, black, blue and red ChromatiNet. The flavonoid content and antioxidant capacity were quantified spectrophotometrically. The C-glycosylflavone isomers (orientin and isoorientin) were isolated and identified by conventional spectroscopic techniques and measured using high-performance liquid chromatography-diode array detection. The EO was analysed by gas chromatography and gas chromatography-mas...
Source: Chemistry and Biodiversity - September 13, 2023 Category: Biochemistry Authors: Abra ão José Silva Viana Alexandre Alves de Carvalho Rafael Marlon Alves de Assis Simony Carvalho Mendon ça Jo ão Pedro Miranda Rocha Jos é Eduardo Brasil Pereira Pinto Suzan Kelly Vilela Bertolucci Source Type: research
Role of Vitamins in Cardiovascular Health: Know Your Facts - Part 1
Curr Vasc Pharmacol. 2023 Sep 12. doi: 10.2174/1570161121666230912155548. Online ahead of print.ABSTRACTCardiovascular (CV) disease (CVD) is a major cause of morbidity and mortality world-wide, thus it is important to adopt preventive interventions. Observational data demonstrating CV benefits of vitamin supplements, advanced by self-proclaimed experts have resulted in ~50% of Americans reporting the use of multivitamins for health promotion; this practice has led to a multi-billion-dollar business of the multivitamin-industry. However, the data on the extensive use of multivitamins show no consistent benefit for CVD preve...
Source: Current Vascular Pharmacology - September 13, 2023 Category: Drugs & Pharmacology Authors: Antonis A Manolis Theodora A Manolis Helen Melita Antonis S Manolis Source Type: research
Anti-inflammatory effect of < em > Lactiplantibacillus plantarum < /em > T1 cell-free supernatants through suppression of oxidative stress and NF- κB- and MAPK-signaling pathways
This study showed the excellent antioxidant and anti-inflammatory properties of L. plantarum T1 through multiple pathways, highlighting its potential for further research and application as a probiotic strain. IMPORTANCE L. plantarum T1 stood out in a series of acid and bile salt tolerance and bacterial inhibition tests as a probiotic isolated from paocai, which provides many health benefits to the host by inhibiting the growth of harmful pathogenic microorganisms and suppressing excessive levels of oxidative stress and inflammation. Not all LAB have good probiotic functions and are used in various applications. The anti-i...
Source: Applied and Environmental Microbiology - September 13, 2023 Category: Microbiology Authors: Rui Hao Qianqian Liu Lu Wang Wenwen Jian Yu Cheng Qiuyue Zhang Kim Hayer Raja Kamarudin Raja Idris Yi Zhang He Lu Zeng Tu Source Type: research
Quercetin attenuates environmental Avermectin-induced ROS accumulation and alleviates gill damage in carp through activation of the Nrf2 pathway
In this study, four groups were created: the Control group, the Que group (400 mg/kg), the AVM group (2.404 μg/L), and the Que plus AVM group. The analytical methods used in this study were pathological structure examination, QPCR, Reactive Oxygen Species (ROS) and Western blot. The results showed that Que alleviated AVM-induced oxidative stress, inflammatory damage and apoptosis in the gill tissues of carp by activating the Nrf2 pathway. The mechanism was that Que alleviated the accumulation of ROS, reduced the balance between oxidation and antioxidant disrupted by AVM exposure, lowered the content of lipid peroxidation ...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - September 13, 2023 Category: Biochemistry Authors: Mengyuan Zhou Jingchao Qiang Jiajie Gan Xuhui Xu Xing Li Shuai Zhang Baoshi Xu Zibo Dong Source Type: research
Higher cadmium and zinc accumulation in parsley (Petroselinum crispum) roots activates its antioxidants defense system
Biometals. 2023 Sep 13. doi: 10.1007/s10534-023-00529-2. Online ahead of print.ABSTRACTParsley (Petroselinum crispum) is herb with many biological and medicinal benefits for humans. However, growth on zinc (Zn) and cadmium (Cd) contaminated sites might get severely affected due to over accumulation of heavy metals (HM) in different plant tissues. Antioxidants play a crucial role in minimizing the negative effects of HM. The present study investigates the effects of Zn and Cd stress on P. crispum morphological parameters, enzymatic/non-enzymatic antioxidant profiling and metal accumulation in shoot/root. Plants were exposed...
Source: Biometals - September 13, 2023 Category: Biochemistry Authors: Ismat Nawaz Atifa Mehboob Aqib Hassan Ali Khan Tatheer Alam Naqvi Nazneen Bangash Sadia Aziz Wajiha Khan Irum Shahzadi Roc ío Barros Kifayat Ullah Mohammad Maroof Shah Source Type: research
Kaempferol stimulation of autophagy regulates the ferroptosis under the oxidative stress as mediated with AMP-activated protein kinase
In conclusion, KP provides hepatoprotective effects against oxidative stress induced by AA + iron treatment in vitro and CCl4 treatment in vivo.PMID:37703935 | DOI:10.1016/j.freeradbiomed.2023.09.008
Source: Free Radical Biology and Medicine - September 13, 2023 Category: Biology Authors: Min-Jin Kim Yu-Rim Song Young Eun Kim Su-Jin Bae Won-Yung Lee Seon-Been Bak Young Woo Kim Source Type: research
Anti-inflammatory effect of < em > Lactiplantibacillus plantarum < /em > T1 cell-free supernatants through suppression of oxidative stress and NF- κB- and MAPK-signaling pathways
This study showed the excellent antioxidant and anti-inflammatory properties of L. plantarum T1 through multiple pathways, highlighting its potential for further research and application as a probiotic strain. IMPORTANCE L. plantarum T1 stood out in a series of acid and bile salt tolerance and bacterial inhibition tests as a probiotic isolated from paocai, which provides many health benefits to the host by inhibiting the growth of harmful pathogenic microorganisms and suppressing excessive levels of oxidative stress and inflammation. Not all LAB have good probiotic functions and are used in various applications. The anti-i...
Source: Applied and Environmental Microbiology - September 13, 2023 Category: Microbiology Authors: Rui Hao Qianqian Liu Lu Wang Wenwen Jian Yu Cheng Qiuyue Zhang Kim Hayer Raja Kamarudin Raja Idris Yi Zhang He Lu Zeng Tu Source Type: research
