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Nutrition: Calcium
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Total 38423 results found since Jan 2013.
Rare Causes of Hypercalcemia: 2021 Update
CONCLUSIONS: The ever-expanding reports of patients with rare and even unknown mechanisms of hypercalcemia illustrate the need for continued investigation into the complexities of human calcium metabolism.PMID:34240162 | DOI:10.1210/clinem/dgab504
Source: The Journal of Clinical Endocrinology and Metabolism - July 9, 2021 Category: Endocrinology Authors: Yasaman Motlaghzadeh John P Bilezikian Deborah E Sellmeyer Source Type: research
Calcium channel blockers for pulmonary arterial hypertension.
CONCLUSIONS: Currently, as there is lack of valid evidence, the efficacy and safety of CCBs is unproven in the treatment of PAH. However, the search strategy used for this review did identify four controlled clinical trials without randomization, three of which suggested treatment with CCBs may be beneficial in PAH. No adverse side effects of CCBs were reported. Confirmation of these findings by RCTs is recommended.
PMID: 26407098 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - September 25, 2015 Category: Journals (General) Authors: Fan Z, Chen Y, Liu H Tags: Cochrane Database Syst Rev Source Type: research
In search for globally disordered apo-parvalbumins: Case of parvalbumin β-1 from coho salmon.
Abstract
Parvalbumin (PA) is a classical EF-hand calcium-binding protein of muscle, neuronal, and other tissues, and a major fish allergen. Although certain apo-PAs lack tertiary structure, functional implications of that feature and its structural prerequisites remain unclear. In a search for unstable PAs, we probed conformational stability of parvalbumin β-1 from coho salmon (csPA), a cold water fish species, using circular dichroism, scanning calorimetry, hydrophobic probe fluorescence, limited proteolysis, chemical crosslinking and dynamic light scattering techniques. Apo-csPA is shown to be mainly monomeric ...
Source: Cell Calcium - October 17, 2017 Category: Cytology Authors: Vologzhannikova AA, Khorn PA, Kazakov AS, Ismailov RG, Sokolov AS, Uversky VN, Permyakov EA, Permyakov SE Tags: Cell Calcium Source Type: research
Calcium Phosphate Carrying Simvastatin Enhances Bone Regeneration: A Systematic Review.
In conclusion, the pertinent pre-clinical studies evidenced the calcium phosphate biocompatibility and its effectiveness in delivering SIM to improve the repair of bone defects. So, clinical trials are encouraged to investigate the impact of SIM associated with calcium phosphate bone graft in repairing bone defect in humans.
PMID: 32556021 [PubMed - in process]
Source: Braz Dent J - February 29, 2020 Category: Dentistry Authors: Cruz R, Pesce G, Calasans-Maia J, Moraschini V, Calasans-Maia MD, Granjeiro JM Tags: Braz Dent J Source Type: research
Treating axial and peripheral spondyloarthritis, including psoriatic arthritis, to target: results of a systematic literature search to support an international treat-to-target recommendation in spondyloarthritis
Conclusions
There is a need for randomised trials that investigate the value of treat-to-target recommendations in SpA and psoriasis. Several trials have used thresholds of disease activity measures to guide treatment decisions. However, evidence on the effect of these data on long-term outcome is scarce. The search data informed the expert committee regarding the formulation of recommendations and a research agenda.
Source: Annals of the Rheumatic Diseases - December 4, 2013 Category: Rheumatology Authors: Schoels, M. M., Braun, J., Dougados, M., Emery, P., Fitzgerald, O., Kavanaugh, A., Kvien, T. K., Landewe, R., Luger, T., Mease, P., Olivieri, I., Reveille, J., Ritchlin, C., Rudwaleit, M., Sieper, J., Smolen, J. S., Wit, M. d., van der Heijde, D. Tags: Open access, Immunology (including allergy), Ankylosing spondylitis, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Calcium and bone Clinical and epidemiological research Source Type: research
Rational search for genes in familial cortical myoclonic tremor with epilepsy, clues from recent advances
Publication date: January 2016 Source:Seizure, Volume 34 Author(s): Zhi-dong Cen, Fei Xie, Jian-feng Xiao, Wei Luo Familial cortical myoclonic tremor with epilepsy (FCMTE) is an autosomal dominant epilepsy syndrome with considerable clinical and genetic heterogeneity. The most important clinical manifestations include adult onset, cortical myoclonic tremor, with or without epileptic seizures. Of the four loci reported, which included 8q24 (FCMTE1), 2p11.1-q12.2 (FCMTE2), 5p15.31-p15.1 (FCMTE3), and 3q26.32-3q28 (FCMTE4), only one probably causative mutation was found co-segregated in two FCMTE2 pedigrees in the α2-a...
Source: Seizure - January 13, 2016 Category: Neurology Source Type: research
In Search of the Mutual Relationship Between the Structure, Solid-State Spectroscopy and Molecular Dynamics in Selected Calcium Channel Blockers.
Abstract
Three isostructural 1,4-dihydropyridines (DHPs), namely, nifedipine, nitrendipine and nimodipine were selected to characterize their structure, intermolecular interactions and molecular dynamics. The studied samples were analyzed by using powder X-ray diffraction (XRD), neutron (INS) and infrared spectroscopy (FT-IR) as well as solid-state NMR, where each technique was supported by the state-of-the-art theoretical calculations for solid-state. By combining multiple experimental techniques with advances theoretical calculations we were able to shed light on the mutual relation between the structure, stabil...
Source: European Journal of Pharmaceutical Sciences - January 28, 2016 Category: Drugs & Pharmacology Authors: Drużbicki K, Pajzderska A, Kiwilsza A, Jenczyk J, Chudoba D, Jarek M, Mielcarek J, Wąsicki J Tags: Eur J Pharm Sci Source Type: research
Comparison of the Effect of Combination Therapy with an Angiotensin II Receptor Blocker and Either a Low-Dose Diuretic or Calcium Channel Blocker on Cardiac Hypertrophy in Patients with Hypertension.
Abstract
Left ventricular hypertrophy (LVH) regression is an important issue in hypertensive patients. Patients with LVH who had received the angiotensin receptor blocker (ARB) treatment for 8 weeks and had not reached the target blood pressure level were enrolled in the study. Patients were assigned to either losartan (50 mg)/hydrochlorothiazide (HCTZ, 12.5 mg) group or ARB + CCB group (usual dose of ARB and calcium channel blocker, CCB). After 48 weeks, LV mass index was found to be reduced significantly in the losartan/HCTZ group but not in the ARB + CCB group. These results suggest that combination thera...
Source: Clinical and Experimental Hypertension - February 12, 2013 Category: Cardiology Authors: Okura T, Miyoshi KI, Irita J, Enomoto D, Jotoku M, Nagao T, Watanabe K, Matsuoka H, Ashihara T, Higaki J, for Ehime Study, Effect of Anti-hypertensive therapy on Regression of Cardiac Hypertrophy (E-SEARCH) trial investigators Tags: Clin Exp Hypertens Source Type: research
What Causes Hypercalcemia?
Discussion
Calcium homeostasis is regulated by mechanisms involving the absorption from the gastrointestinal tract, bone deposition and resorption, and renal excretion. To review Vitamin D homeostasis click here.
Serum calcium is found in three forms: free (47%), protein bound (43%) and diffusable calcium complexes (10%). The protein binding proteins are albumin (80%) and globulin (20%). The free calcium is the most important biologically. Acidosis also increases free calcium and alkalosis decreases free calcium.
Problems associated with hypercalcemia include nausea, emesis, abdominal pain, constipation, polyuria, dehydra...
Source: PediatricEducation.org - March 25, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news
Relationship between serum 25-hydroxyvitamin D and parathyroid hormone in the search for a biochemical definition of vitamin D deficiency in children.
Conclusions:Vitamin D deficiency, based on PTH elevation, was best defined by a 25OHD level of < 34 nmol/l. Since deficient calcium supply often co-exists with vitamin D deficiency and both can independently cause nutritional rickets, a threshold for the skeletal effects of vitamin D should not be based purely on 25OHD levels.Pediatric Research (2013); doi:10.1038/pr.2013.139.
PMID: 23999068 [PubMed - as supplied by publisher]
Source: Pediatric Research - September 2, 2013 Category: Pediatrics Authors: Atapattu N, Shaw N, Högler W Tags: Pediatr Res Source Type: research
A comparison of the in vitro cyto- and neurotoxicity of brominated and halogen-free flame retardants: prioritization in search for safe(r) alternatives.
Abstract
Brominated flame retardants (BFRs) are abundant persistent organic pollutants with well-studied toxicity. The toxicological and ecological concerns associated with BFRs argue for replacement by safe(r) alternatives. Though previous research identified the nervous system as a sensitive target organ for BFRs, the (neuro) toxic potential of alternative halogen-free flame retardants (HFFRs) is largely unknown. We therefore investigated the in vitro (neuro) toxicity of 13 HFFRs and three BFRs in dopaminergic pheochromocytoma (PC12) and neuroblastoma (B35) cells by assessing several cytotoxic and neurotoxic end...
Source: Archives of Toxicology - January 7, 2014 Category: Toxicology Authors: Hendriks HS, Meijer M, Muilwijk M, van den Berg M, Westerink RH Tags: Arch Toxicol Source Type: research
Mutational Analysis of the Adaptor Protein 2 Sigma Subunit (AP2S1) gene: Search for Autosomal Dominant Hypocalcemia Type 3 (ADH3).
Conclusion: The absence of AP2S1 abnormalities in hypocalcemic patients, suggests that ADH3 may not occur, or otherwise represents a rare hypocalcemic disorder.
PMID: 24708097 [PubMed - as supplied by publisher]
Source: Diabetes Metab - April 7, 2014 Category: Endocrinology Authors: Rogers A, Nesbit MA, Hannan FM, Howles SA, Gorvin CM, Cranston T, Allgrove J, Bevan JS, Bano G, Brain C, Datta V, Grossman AB, Hodgson SV, Izatt L, Millar-Jones L, Pearce SH, Robertson L, Selby PL, Shine B, Snape K, Warner J, Thakker RV Tags: J Clin Endocrinol Metab Source Type: research
Infrapopliteal calcification patterns in critical limb ischemia: diagnostic, pathologic and therapeutic implications in the search for the endovascular holy grail.
This article attempts to review the implications of the diverse pathologic patterns of calcium distribution in infrapopliteal vessels of CLI patients, on the diagnostic modalities, technological developments, and the evolution of therapeutic approaches to improve outcomes among these patients. A critical analysis of the currently available data is provided, pointing to the surprising omission on the role of calcium on outcomes, and future directions are discussed. Is infrapopliteal calcium a roadblock or the avenue towards new paths? Necessity remains the mother of invention.
PMID: 28240525 [PubMed - as supplied by publisher]
Source: The Journal of Cardiovascular Surgery - February 26, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Mustapha JA, Diaz-Sandoval LJ, Saab F Tags: J Cardiovasc Surg (Torino) Source Type: research
Serum 25-Hydroxyvitamin D Insufficiency in Search of a Bone Disease.
Conclusion: At a threshold of 25(OH)D of 30 nmol/L or below, abnormalities in biochemical features are supportive of the notion of a 'deficiency' state predisposing to bone disease. However, no deleterious effects are found in subjects within an 'insufficient' threshold of 25(OH)D of 30 to 75 nmol/L which challenges the rationale in using supplementation of these individuals.
PMID: 28379394 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - March 30, 2017 Category: Endocrinology Authors: Shah S, Chiang C, Sikaris K, Lu Z, Bui M, Zebaze R, Seeman E Tags: J Clin Endocrinol Metab Source Type: research
